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The map label for this gene is hemE

Identifier: 188527546

GI number: 188527546

Start: 750392

End: 751411

Strand: Reverse

Name: hemE

Synonym: HPSH_03840

Alternate gene names: 188527546

Gene position: 751411-750392 (Counterclockwise)

Preceding gene: 188527547

Following gene: 188527545

Centisome position: 46.71

GC content: 40.2

Gene sequence:

>1020_bases
ATGATTTTCATTGATGCATGTTTTAGAAAGGAAACACCCTATACGCCCATTTGGATGATGAGGCAAGCGGGGCGTTACCT
TAGCGAATACCAAGAGAGCCGTAAAAAAGCGGGGAGCTTCTTGGAATTGTGTAAAAATAGCGATTTAGCCACAGAAGTTA
CCTTACAGCCAGTAGAGATTTTAGGCGTGGATGCGGCTATTTTGTTTAGCGATATTTTAGTAGTGCCTTTGGAAATGGGC
TTGAATTTGGAGTTTATCCCCAAAAAAGGGCCGCATTTTTTAGAAACTATTACGGATTTAAAAAGCGTGGAAAGCCTGAA
AATAGAGGCTTATAAACAACTAAACTATGTCTATGATACGATTTCTCAAACGCGCCAAAAGCTTTCTAAAGAGAAAGCGT
TAATCGGTTTTTGCGGATCGCCTTGGACTTTAGCGACTTACATGATAGAAGGCGAAGGGAGCAAATCGTATGCTAAAAGC
AAAAAAATGCTCTATAGCGAGCCTGAAGTTTTAAAAGCGCTTTTAGAAAAATTAAGCCTTGAATTGATAGAGTATTTGAG
CCTTCAAATCCAAGCAGGGGTCAATGCGGTGATGATCTTTGACTCATGGGCTAGCGCTTTAGAAAAAGAAGCGTATTTGA
AATTCAGTTGGGATTATTTGAAAAAAATCTCTAAAGAGCTTAAAAAACGCTATGCGCATATCCCGGTTATCCTTTTCCCT
AAAGGCATTGGCGCTTATTTGGATAGCATAGACGGGGAATTTGATGTGTTTGGCGTGGATTGGGGCACGCCTTTAGAGGT
GGCAAAAAAGATTTTAGGCGATAAGTATGTTTTGCAAGGGAATTTAGAACCCACCCGCCTTTATGATAAAAACGCTTTAG
AAGAAGGGGTTGAAAGGATTCTAAAAGTCATGGGCAATCAAGGGCATATTTTTAATTTAGGGCATGGGATGTTACCGGAT
TTACCCAGAGAAAACGCGAAATATTTAGTGCAATTAGTGCATGCTAAAACCAGGCGATAG

Upstream 100 bases:

>100_bases
TCACCTTTTATGATTTTACTAGATTTTTAGGGTAAAATATTCATTTTAAAAATCTATAGAGTATAAAAACCATAATTAGA
CAAACCTTTAAGGATTTATG

Downstream 100 bases:

>100_bases
GGGGGGATTGATGAAAACTATTATAAGATATGTTAGTTTATGGGGCTTGTGTGCAGTTTTAGCTCTAGCCCAAGCCCCCT
CTAAAACCCCAGATGAAATC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MIFIDACFRKETPYTPIWMMRQAGRYLSEYQESRKKAGSFLELCKNSDLATEVTLQPVEILGVDAAILFSDILVVPLEMG
LNLEFIPKKGPHFLETITDLKSVESLKIEAYKQLNYVYDTISQTRQKLSKEKALIGFCGSPWTLATYMIEGEGSKSYAKS
KKMLYSEPEVLKALLEKLSLELIEYLSLQIQAGVNAVMIFDSWASALEKEAYLKFSWDYLKKISKELKKRYAHIPVILFP
KGIGAYLDSIDGEFDVFGVDWGTPLEVAKKILGDKYVLQGNLEPTRLYDKNALEEGVERILKVMGNQGHIFNLGHGMLPD
LPRENAKYLVQLVHAKTRR

Sequences:

>Translated_339_residues
MIFIDACFRKETPYTPIWMMRQAGRYLSEYQESRKKAGSFLELCKNSDLATEVTLQPVEILGVDAAILFSDILVVPLEMG
LNLEFIPKKGPHFLETITDLKSVESLKIEAYKQLNYVYDTISQTRQKLSKEKALIGFCGSPWTLATYMIEGEGSKSYAKS
KKMLYSEPEVLKALLEKLSLELIEYLSLQIQAGVNAVMIFDSWASALEKEAYLKFSWDYLKKISKELKKRYAHIPVILFP
KGIGAYLDSIDGEFDVFGVDWGTPLEVAKKILGDKYVLQGNLEPTRLYDKNALEEGVERILKVMGNQGHIFNLGHGMLPD
LPRENAKYLVQLVHAKTRR
>Mature_339_residues
MIFIDACFRKETPYTPIWMMRQAGRYLSEYQESRKKAGSFLELCKNSDLATEVTLQPVEILGVDAAILFSDILVVPLEMG
LNLEFIPKKGPHFLETITDLKSVESLKIEAYKQLNYVYDTISQTRQKLSKEKALIGFCGSPWTLATYMIEGEGSKSYAKS
KKMLYSEPEVLKALLEKLSLELIEYLSLQIQAGVNAVMIFDSWASALEKEAYLKFSWDYLKKISKELKKRYAHIPVILFP
KGIGAYLDSIDGEFDVFGVDWGTPLEVAKKILGDKYVLQGNLEPTRLYDKNALEEGVERILKVMGNQGHIFNLGHGMLPD
LPRENAKYLVQLVHAKTRR

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=348, Percent_Identity=39.367816091954, Blast_Score=253, Evalue=1e-67,
Organism=Escherichia coli, GI2367337, Length=338, Percent_Identity=46.4497041420118, Blast_Score=299, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6320252, Length=334, Percent_Identity=37.7245508982036, Blast_Score=228, Evalue=2e-60,
Organism=Drosophila melanogaster, GI19921920, Length=329, Percent_Identity=40.7294832826748, Blast_Score=235, Evalue=3e-62,
Organism=Drosophila melanogaster, GI221330099, Length=329, Percent_Identity=40.7294832826748, Blast_Score=235, Evalue=4e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 38567; Mature: 38567

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFIDACFRKETPYTPIWMMRQAGRYLSEYQESRKKAGSFLELCKNSDLATEVTLQPVEI
CEEEECHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHH
LGVDAAILFSDILVVPLEMGLNLEFIPKKGPHFLETITDLKSVESLKIEAYKQLNYVYDT
HCCCHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISQTRQKLSKEKALIGFCGSPWTLATYMIEGEGSKSYAKSKKMLYSEPEVLKALLEKLSL
HHHHHHHHHHHCCEEEECCCCCEEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
ELIEYLSLQIQAGVNAVMIFDSWASALEKEAYLKFSWDYLKKISKELKKRYAHIPVILFP
HHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHEEECHHHHHHHHHHHHHHHCCCCEEEEC
KGIGAYLDSIDGEFDVFGVDWGTPLEVAKKILGDKYVLQGNLEPTRLYDKNALEEGVERI
CCHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHH
LKVMGNQGHIFNLGHGMLPDLPRENAKYLVQLVHAKTRR
HHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIFIDACFRKETPYTPIWMMRQAGRYLSEYQESRKKAGSFLELCKNSDLATEVTLQPVEI
CEEEECHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHH
LGVDAAILFSDILVVPLEMGLNLEFIPKKGPHFLETITDLKSVESLKIEAYKQLNYVYDT
HCCCHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISQTRQKLSKEKALIGFCGSPWTLATYMIEGEGSKSYAKSKKMLYSEPEVLKALLEKLSL
HHHHHHHHHHHCCEEEECCCCCEEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
ELIEYLSLQIQAGVNAVMIFDSWASALEKEAYLKFSWDYLKKISKELKKRYAHIPVILFP
HHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHEEECHHHHHHHHHHHHHHHCCCCEEEEC
KGIGAYLDSIDGEFDVFGVDWGTPLEVAKKILGDKYVLQGNLEPTRLYDKNALEEGVERI
CCHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHH
LKVMGNQGHIFNLGHGMLPDLPRENAKYLVQLVHAKTRR
HHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA