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The map label for this gene is lpxC

Identifier: 188527205

GI number: 188527205

Start: 391435

End: 392322

Strand: Direct

Name: lpxC

Synonym: HPSH_02060

Alternate gene names: 188527205

Gene position: 391435-392322 (Clockwise)

Preceding gene: 188527204

Following gene: 188527206

Centisome position: 24.33

GC content: 40.88

Gene sequence:

>888_bases
ATGAAACAAACAACCATTAACCACTCTGTGGAATTAGTAGGGATAGGCTTGCACAAGGGCGTTCCTGTGAAGCTTGTTTT
AGAGCCTTTAGAAGAAAATCAAGGCATTGTTTTTTACCGATCTGATTTGGGCGTGAAGCTCCCCTTAAAACCTGAAAACA
TCGTGGATACCAAAATGGCAACCGTGTTGGGTAAGGATAATGCTAGAATTTCTACGATTGAGCATTTGCTTTCAGCTGTC
CATGCGTATGGTATTGACAACCTTAAGATCTCTGTGGATAACGAAGAAATCCCTATCATGGATGGGAGTGCTTTGGCTTA
TTGCATGCTTTTAGATGAAGCAGGGATTAAAGAATTAGACGCTCCTAAAAAGGTGATGGAAATCAAGCAAGTCGTTGAGG
TTAGAGAGGGCGATAAATTTGTTAAAATTGAGCCAGACAGCCAGCTTTCTTTGAACTTTGCGATTGATTTTAACCATCCG
GTTATCGCTAAGCAAGCCCATCATTTTGTCTTTAGTAAAACCGCTTATAAAGAGCAAGTCGCTAAAGCTCGCACCTTTGG
GTTTTTGCAAGAAGTGAATTACTTGCGATCTATTGGTTTGGCTAAAGGGGGGAGTTTGAATAATTGCATCGTGCTGGATG
AAAACAGCATTTTGAATAAAGAGGGCTTGAGATGCGAAAAGGAATTCGTGTGCCATAAGATTTTAGACGCTATGGGGGAT
CTAATGGTTTTAGGCATGCCTGTGATGGGTAAATACACTTCTTTTTCAGGGAGTCATAAGCTCAATTCCATGTTGGTTAA
AGCCATTTTAGCGGACGCTAAAAACTACGAAGTTTTGATCGCTACAGATCTGGCTAAAGAATTTGCGTTGCAAAAGGCTT
TCGCTTAA

Upstream 100 bases:

>100_bases
ATAAAATTTTATCTCTAAAAGAGGTTGAACGGCTTTTGGTAAATAAAAATATTAAAATAATCACTAAAAATGACGATATA
CTAGACATAAAGGAAGTATT

Downstream 100 bases:

>100_bases
TCCTAAATTAGGGTTTATTTTTGGAATTGGATTTAGCACTTATCTCTTTAGGCGAGGGGGTCTTGCTTGGGGTGTATCAA
AACAATTTTTTATGCACTTC

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MKQTTINHSVELVGIGLHKGVPVKLVLEPLEENQGIVFYRSDLGVKLPLKPENIVDTKMATVLGKDNARISTIEHLLSAV
HAYGIDNLKISVDNEEIPIMDGSALAYCMLLDEAGIKELDAPKKVMEIKQVVEVREGDKFVKIEPDSQLSLNFAIDFNHP
VIAKQAHHFVFSKTAYKEQVAKARTFGFLQEVNYLRSIGLAKGGSLNNCIVLDENSILNKEGLRCEKEFVCHKILDAMGD
LMVLGMPVMGKYTSFSGSHKLNSMLVKAILADAKNYEVLIATDLAKEFALQKAFA

Sequences:

>Translated_295_residues
MKQTTINHSVELVGIGLHKGVPVKLVLEPLEENQGIVFYRSDLGVKLPLKPENIVDTKMATVLGKDNARISTIEHLLSAV
HAYGIDNLKISVDNEEIPIMDGSALAYCMLLDEAGIKELDAPKKVMEIKQVVEVREGDKFVKIEPDSQLSLNFAIDFNHP
VIAKQAHHFVFSKTAYKEQVAKARTFGFLQEVNYLRSIGLAKGGSLNNCIVLDENSILNKEGLRCEKEFVCHKILDAMGD
LMVLGMPVMGKYTSFSGSHKLNSMLVKAILADAKNYEVLIATDLAKEFALQKAFA
>Mature_295_residues
MKQTTINHSVELVGIGLHKGVPVKLVLEPLEENQGIVFYRSDLGVKLPLKPENIVDTKMATVLGKDNARISTIEHLLSAV
HAYGIDNLKISVDNEEIPIMDGSALAYCMLLDEAGIKELDAPKKVMEIKQVVEVREGDKFVKIEPDSQLSLNFAIDFNHP
VIAKQAHHFVFSKTAYKEQVAKARTFGFLQEVNYLRSIGLAKGGSLNNCIVLDENSILNKEGLRCEKEFVCHKILDAMGD
LMVLGMPVMGKYTSFSGSHKLNSMLVKAILADAKNYEVLIATDLAKEFALQKAFA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=291, Percent_Identity=43.298969072165, Blast_Score=250, Evalue=8e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 32598; Mature: 32598

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQTTINHSVELVGIGLHKGVPVKLVLEPLEENQGIVFYRSDLGVKLPLKPENIVDTKMA
CCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCEEEEECCCCEECCCCCCCHHHHHHH
TVLGKDNARISTIEHLLSAVHAYGIDNLKISVDNEEIPIMDGSALAYCMLLDEAGIKELD
HHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEECCCHHEEEEEECCCCCCCCC
APKKVMEIKQVVEVREGDKFVKIEPDSQLSLNFAIDFNHPVIAKQAHHFVFSKTAYKEQV
CCHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
AKARTFGFLQEVNYLRSIGLAKGGSLNNCIVLDENSILNKEGLRCEKEFVCHKILDAMGD
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCC
LMVLGMPVMGKYTSFSGSHKLNSMLVKAILADAKNYEVLIATDLAKEFALQKAFA
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHCC
>Mature Secondary Structure
MKQTTINHSVELVGIGLHKGVPVKLVLEPLEENQGIVFYRSDLGVKLPLKPENIVDTKMA
CCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCEEEEECCCCEECCCCCCCHHHHHHH
TVLGKDNARISTIEHLLSAVHAYGIDNLKISVDNEEIPIMDGSALAYCMLLDEAGIKELD
HHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEECCCHHEEEEEECCCCCCCCC
APKKVMEIKQVVEVREGDKFVKIEPDSQLSLNFAIDFNHPVIAKQAHHFVFSKTAYKEQV
CCHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
AKARTFGFLQEVNYLRSIGLAKGGSLNNCIVLDENSILNKEGLRCEKEFVCHKILDAMGD
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCC
LMVLGMPVMGKYTSFSGSHKLNSMLVKAILADAKNYEVLIATDLAKEFALQKAFA
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA