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The map label for this gene is ilvC [H]

Identifier: 188527136

GI number: 188527136

Start: 328458

End: 329450

Strand: Direct

Name: ilvC [H]

Synonym: HPSH_01715

Alternate gene names: 188527136

Gene position: 328458-329450 (Clockwise)

Preceding gene: 188527133

Following gene: 188527137

Centisome position: 20.42

GC content: 41.59

Gene sequence:

>993_bases
TTGGCATTACCCGTTTATTATGATAAAGACATTGATTTAGGCGTTATCCAATCCTTACAAGTGGGTATTATCGGCTATGG
CGCGCAAGGAGAAGCCCAAGCGCTCAATTTGAGAGACTCTAAAGTAAAAGTGCGTATTGGCTTGTATCAAGGGAGTTTGA
GCGTTCCAAAAGCAAAAGCAGAGGGCTTTGAGGTGCTAGAAGTCAAAGAATTAGTCCAACAATCTGATCTGATCATGGCA
CTTCTTCCGGACGAATTGCATAAGGAAGTGTTAGAAAAAGAAGTGATCCCTTTTTTAAAAGAGGGGCAAATTGTGGGCTT
TGCCCATGGCTTTAGCGTGCATTTCAATCAGGTTGTTCTCCCAAAAGGCGTGGGCGCGATTTTAGTCGCGCCAAAAGGGC
CCGGGAGCGCTTTAAGAGAAGAATACCTTAAAAATAGGGGTTTATACCATTTGATCGCCATAGAGCAAGAAAGCTCAAAA
AATAACGCTAAAGCGGTGGCTTTAAGCTATGCTAAAGCGATGGGCGGGGGGAGAATGGGGGTTTTAGAAACGAGCTTTAA
AGAAGAATGCGAGAGCGATTTATTCGGCGAGCAAGCGGTTTTGTGCGGAGGGTTAGAAGCGATTATTAGGATGGGATTTG
AAACTTTAATTAAGGCAGGATACCCTGAAGAATTAGCCTATTTTGAATGCGTGCATGAAGTGAAATTAGTGGCGGATTTA
TTGCATTATAAGGGGGTAGAGGGCTTAAGGAAACACATTTCTAACACCGCTGAATTTGGAGCGATTAAAAATAGAGAGCC
TATGGGAAATCTGCTAGAAAAACGCATGCAAAAAATCTTAAAAAAGATTCAAAACGGCTCATTCGCTAAGGATTTTTTAC
TGGAAAAGAGTTTGAATTACCCCAGGTTAAACACAGAGAGGAAAGCCCTTAAAGAGACTAAAATAGAACAAATTGGGGAA
ATTTTACGCGCCCCATTCAATCATAAAAAATAA

Upstream 100 bases:

>100_bases
CCTCCGAGCACACCATTTTTTAATTCTGCATGTTTTTAAACATTATCGCTCCCATTATGGTAAAATAAATACTTGCTTAA
ACACGCTAGGAGATTTGATT

Downstream 100 bases:

>100_bases
ATCATTAAAAGGAATTATATGGCAATAGTAGTTACTATCACTTCAGGTAAGGGGGGCGTGGGTAAAAGCACCACCGCGGC
TAATTTAGCGATCGGCTTGG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MALPVYYDKDIDLGVIQSLQVGIIGYGAQGEAQALNLRDSKVKVRIGLYQGSLSVPKAKAEGFEVLEVKELVQQSDLIMA
LLPDELHKEVLEKEVIPFLKEGQIVGFAHGFSVHFNQVVLPKGVGAILVAPKGPGSALREEYLKNRGLYHLIAIEQESSK
NNAKAVALSYAKAMGGGRMGVLETSFKEECESDLFGEQAVLCGGLEAIIRMGFETLIKAGYPEELAYFECVHEVKLVADL
LHYKGVEGLRKHISNTAEFGAIKNREPMGNLLEKRMQKILKKIQNGSFAKDFLLEKSLNYPRLNTERKALKETKIEQIGE
ILRAPFNHKK

Sequences:

>Translated_330_residues
MALPVYYDKDIDLGVIQSLQVGIIGYGAQGEAQALNLRDSKVKVRIGLYQGSLSVPKAKAEGFEVLEVKELVQQSDLIMA
LLPDELHKEVLEKEVIPFLKEGQIVGFAHGFSVHFNQVVLPKGVGAILVAPKGPGSALREEYLKNRGLYHLIAIEQESSK
NNAKAVALSYAKAMGGGRMGVLETSFKEECESDLFGEQAVLCGGLEAIIRMGFETLIKAGYPEELAYFECVHEVKLVADL
LHYKGVEGLRKHISNTAEFGAIKNREPMGNLLEKRMQKILKKIQNGSFAKDFLLEKSLNYPRLNTERKALKETKIEQIGE
ILRAPFNHKK
>Mature_329_residues
ALPVYYDKDIDLGVIQSLQVGIIGYGAQGEAQALNLRDSKVKVRIGLYQGSLSVPKAKAEGFEVLEVKELVQQSDLIMAL
LPDELHKEVLEKEVIPFLKEGQIVGFAHGFSVHFNQVVLPKGVGAILVAPKGPGSALREEYLKNRGLYHLIAIEQESSKN
NAKAVALSYAKAMGGGRMGVLETSFKEECESDLFGEQAVLCGGLEAIIRMGFETLIKAGYPEELAYFECVHEVKLVADLL
HYKGVEGLRKHISNTAEFGAIKNREPMGNLLEKRMQKILKKIQNGSFAKDFLLEKSLNYPRLNTERKALKETKIEQIGEI
LRAPFNHKK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=311, Percent_Identity=33.7620578778135, Blast_Score=153, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6323387, Length=300, Percent_Identity=29.3333333333333, Blast_Score=109, Evalue=7e-25,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 36579; Mature: 36448

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALPVYYDKDIDLGVIQSLQVGIIGYGAQGEAQALNLRDSKVKVRIGLYQGSLSVPKAKA
CCCCCEECCCCCHHHHHHHEECEEEECCCCCCEEECCCCCEEEEEEEEEECCCCCCCCCC
EGFEVLEVKELVQQSDLIMALLPDELHKEVLEKEVIPFLKEGQIVGFAHGFSVHFNQVVL
CCCHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHCCHHHCCCEEEEECCCEEEECEEEE
PKGVGAILVAPKGPGSALREEYLKNRGLYHLIAIEQESSKNNAKAVALSYAKAMGGGRMG
CCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEE
VLETSFKEECESDLFGEQAVLCGGLEAIIRMGFETLIKAGYPEELAYFECVHEVKLVADL
EECHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LHYKGVEGLRKHISNTAEFGAIKNREPMGNLLEKRMQKILKKIQNGSFAKDFLLEKSLNY
HHHCCHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
PRLNTERKALKETKIEQIGEILRAPFNHKK
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ALPVYYDKDIDLGVIQSLQVGIIGYGAQGEAQALNLRDSKVKVRIGLYQGSLSVPKAKA
CCCCEECCCCCHHHHHHHEECEEEECCCCCCEEECCCCCEEEEEEEEEECCCCCCCCCC
EGFEVLEVKELVQQSDLIMALLPDELHKEVLEKEVIPFLKEGQIVGFAHGFSVHFNQVVL
CCCHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHCCHHHCCCEEEEECCCEEEECEEEE
PKGVGAILVAPKGPGSALREEYLKNRGLYHLIAIEQESSKNNAKAVALSYAKAMGGGRMG
CCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEE
VLETSFKEECESDLFGEQAVLCGGLEAIIRMGFETLIKAGYPEELAYFECVHEVKLVADL
EECHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LHYKGVEGLRKHISNTAEFGAIKNREPMGNLLEKRMQKILKKIQNGSFAKDFLLEKSLNY
HHHCCHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
PRLNTERKALKETKIEQIGEILRAPFNHKK
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA