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The map label for this gene is clpB [H]

Identifier: 188527070

GI number: 188527070

Start: 257578

End: 260148

Strand: Direct

Name: clpB [H]

Synonym: HPSH_01375

Alternate gene names: 188527070

Gene position: 257578-260148 (Clockwise)

Preceding gene: 188527069

Following gene: 188527071

Centisome position: 16.01

GC content: 41.31

Gene sequence:

>2571_bases
ATGAATTTATTTGAAAAAATGACTGACCAATTGCATGAAACTTTAGACAGCGCGCTCGCTCTAGCTTTACACCATAAAAA
CGCTGAAGTAACGCCCTTGCACATGCTTTTTGTCATGCTCAATAACTCCCAAGGCATCCTCATTCAAGCCTTACAAAAAA
TGTCTGTGGATATTCAAGCCTTAAGGCTTAGCGTTCAAAGCGAGTTGGATAAGTTTGTTAAAGTTTCACAAATCAACAAG
CAAAATATCCAGTTAAACCAAGCTCTAATCCAAAGTTTAGAAAACGCTCAAGGCTTGATGGCTAAAATGGGCGATTCTTT
TATCGCTACAGACGTGTATCTTTTGGCGAACATGAGCCTTTTTGAAAGCGTTCTAAAACCTTATTTAGACACTAAGCAAT
TGCAAAAAACTTTAGAGTCTTTGAGAAAGGGCGCGACTATCCAAAGTAAAAACGATGATTCTAATTTGGAAAGTTTGGAA
AAATTTGGCATTGATTTGACGCAAAAAGCCTTAGAAAATAAGCTCGATCCGGTGATTGGGAGGGATGAAGAAATCATTCG
CATGATGCAAATTTTGATAAGAAAAACAAAAAATAACCCTATTTTACTAGGTGAGCCTGGAGTGGGGAAAACGGCGGTTG
TGGAGGGTTTGGCTCAACGCATTGTGAATAAGGAAGTGCCTAAAACGCTTTTAAACAAACGAGTCGTCGCTTTAGATTTA
AGCTTATTGGTGGCTGGAGCCAAATACAGAGGCGAGTTTGAAGAGCGCTTGAAAAAGGTGATTGAAGAAGTTAAAAAAAG
TGCGAATGTGATTTTATTCATTGATGAAATCCACACGATTGTAGGGGCTGGGGCTAGTGAGGGGGGCATGGATGCGGCTA
ATATTTTAAAACCCGCACTCGCTAGGGGGGAATTGCACACGATTGGAGCGACCACTTTGAAAGAATACCGCAAGTATTTT
GAAAAAGACATGGCGTTACAAAGGCGTTTCCAACCCATTTTACTCAATGAGCCTAGCATCAATGAAGCTTTACAGATTTT
AAGGGGGTTAAAAGAAACTTTAGAAACGCACCATAATATCACTATCAATGACTCCGCGCTCATAGCGAGCGCCAAACTCT
CTAGCCGTTATATCACCGATAGGTTTTTACCCGATAAAGCGATTGATTTGATTGATGAGGGGGCGGCTCAATTAAAAATG
CAAATGGAATCAGAGCCGGCAAAGCTCTCTAGCGTTAAGCGCTCCATTCAAAGATTGGAAATGGAAAAACAAGCCCTTGA
AATGGAAAAAAAAGAGAGCAGTGCCAAACGCATGCAAGAAATCCTTAAAGAATTGAGCGATTTGAAAGAAGAAAAAATCC
AATTAGAAGCGCAATTTGAAAACGAAAAAGAAGTGTTTAGAGAAATTTCACGCTTGAAAATGGAAACGGAAAGCTTGAAA
AAAGAGGCTGAGAGGTTTAAGCGCAATGGGGATTACCAGCAAGCGGGTGAAATTGAATACTCTAAAATCCCTGAAAATAA
AAAGAAAGAAGAAGAATTGCAGCACAAATGGGAAGCGATGCAACAAAACGGGGCGTTATTGCAAAACGCTTTAACCGAAA
ACAACATCGCTGAGATCGTGAGCCAATGGACGCATATCCCGGTCCAAAAAATGCTCCAGAGCGAAAAAAATAGGGTTTTA
AACATTGAAAGCGAATTGCAAAAAAGAGTGGTGGGGCAAGAAAAAGCGATCAAAGCGATCGCTAAAGCGATTAAAAGGAA
TAAGGCCGGGCTTAGCGATAGCAATAAACCCATAGGGAGTTTTCTCTTTTTAGGGCCAACGGGCGTGGGTAAAACCGAGA
GCGCTAAAGCCTTGGCGCAATTCTTGTTTGATAGCGATAAAAATCTTATAAGAATTGACATGAGCGAATACCTAGAAAAG
CATGCCGTAAGCCGTCTTATTGGGGCCGCTCCTGGGTATGTGGGCTATGAAGAAGGCGGGCAATTGACCGAAGCGGTGCG
CAGAAAACCCTATAGCGTGGTGCTGTTAGATGAAGTGGAAAAAGCCCATCCGGATGTGTTTAACCTCTTGTTGCAGGTTT
TAGATGAAGGGCATTTAACCGATAGTAAGGGCGTGAGGGTGGATTTCAAAAACACGATCTTGATTTTAACCAGCAATGTG
GCTAGCGGCGCGCTTTTGGAAGAAAATTTGAGTGAAGCCGATAAACAAAAAGCGATCAAAGAGAGCTTGAGGCAATTCTT
CAAACCGGAATTTTTAAACCGCTTAGATGAAATCATCTCCTTTAACGCCCTAGATAGCCATGCTGTCGCTAATATCGTGG
GGATACTTTTTGAAAACATTCAAAAAAAAGCGCTTGAAAGAGGCATTAATATAACCCTAGACGAAGAGGCAAAAGAATTG
ATCGCTAAAGCGGGATTTGACAGATTTTATGGCGCTAGACCCTTGAAGCGTGCGCTCTATGAAATGGTAGAAGACAAACT
CGCTGAACTCATTTTAGAGGATAAAATTAAAGAGAATGGCAGCGTGGCGTTTGTGGCAGAAAATAACGAAATTGTGCCTA
AGATTAAGTGA

Upstream 100 bases:

>100_bases
TATTTTGGAGAGTTTGTCATTAGTGTGAGCGTTTTAAAAACCTTTGAGGGTTAAAATAGTGTAAAATAGTAAAAATTTTA
AAACTCAAAAAGGATTGATG

Downstream 100 bases:

>100_bases
GGTTTTGTTATCCTAAAAAAGATAAGAAATGGTTATTTTTAAAAAAGGATTGAATGATGTTTGATAACACGCTTATCAAT
TTATTTGAGACAGCGCCTCT

Product: ATP-dependent protease binding subunit (clpB)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 856; Mature: 856

Protein sequence:

>856_residues
MNLFEKMTDQLHETLDSALALALHHKNAEVTPLHMLFVMLNNSQGILIQALQKMSVDIQALRLSVQSELDKFVKVSQINK
QNIQLNQALIQSLENAQGLMAKMGDSFIATDVYLLANMSLFESVLKPYLDTKQLQKTLESLRKGATIQSKNDDSNLESLE
KFGIDLTQKALENKLDPVIGRDEEIIRMMQILIRKTKNNPILLGEPGVGKTAVVEGLAQRIVNKEVPKTLLNKRVVALDL
SLLVAGAKYRGEFEERLKKVIEEVKKSANVILFIDEIHTIVGAGASEGGMDAANILKPALARGELHTIGATTLKEYRKYF
EKDMALQRRFQPILLNEPSINEALQILRGLKETLETHHNITINDSALIASAKLSSRYITDRFLPDKAIDLIDEGAAQLKM
QMESEPAKLSSVKRSIQRLEMEKQALEMEKKESSAKRMQEILKELSDLKEEKIQLEAQFENEKEVFREISRLKMETESLK
KEAERFKRNGDYQQAGEIEYSKIPENKKKEEELQHKWEAMQQNGALLQNALTENNIAEIVSQWTHIPVQKMLQSEKNRVL
NIESELQKRVVGQEKAIKAIAKAIKRNKAGLSDSNKPIGSFLFLGPTGVGKTESAKALAQFLFDSDKNLIRIDMSEYLEK
HAVSRLIGAAPGYVGYEEGGQLTEAVRRKPYSVVLLDEVEKAHPDVFNLLLQVLDEGHLTDSKGVRVDFKNTILILTSNV
ASGALLEENLSEADKQKAIKESLRQFFKPEFLNRLDEIISFNALDSHAVANIVGILFENIQKKALERGINITLDEEAKEL
IAKAGFDRFYGARPLKRALYEMVEDKLAELILEDKIKENGSVAFVAENNEIVPKIK

Sequences:

>Translated_856_residues
MNLFEKMTDQLHETLDSALALALHHKNAEVTPLHMLFVMLNNSQGILIQALQKMSVDIQALRLSVQSELDKFVKVSQINK
QNIQLNQALIQSLENAQGLMAKMGDSFIATDVYLLANMSLFESVLKPYLDTKQLQKTLESLRKGATIQSKNDDSNLESLE
KFGIDLTQKALENKLDPVIGRDEEIIRMMQILIRKTKNNPILLGEPGVGKTAVVEGLAQRIVNKEVPKTLLNKRVVALDL
SLLVAGAKYRGEFEERLKKVIEEVKKSANVILFIDEIHTIVGAGASEGGMDAANILKPALARGELHTIGATTLKEYRKYF
EKDMALQRRFQPILLNEPSINEALQILRGLKETLETHHNITINDSALIASAKLSSRYITDRFLPDKAIDLIDEGAAQLKM
QMESEPAKLSSVKRSIQRLEMEKQALEMEKKESSAKRMQEILKELSDLKEEKIQLEAQFENEKEVFREISRLKMETESLK
KEAERFKRNGDYQQAGEIEYSKIPENKKKEEELQHKWEAMQQNGALLQNALTENNIAEIVSQWTHIPVQKMLQSEKNRVL
NIESELQKRVVGQEKAIKAIAKAIKRNKAGLSDSNKPIGSFLFLGPTGVGKTESAKALAQFLFDSDKNLIRIDMSEYLEK
HAVSRLIGAAPGYVGYEEGGQLTEAVRRKPYSVVLLDEVEKAHPDVFNLLLQVLDEGHLTDSKGVRVDFKNTILILTSNV
ASGALLEENLSEADKQKAIKESLRQFFKPEFLNRLDEIISFNALDSHAVANIVGILFENIQKKALERGINITLDEEAKEL
IAKAGFDRFYGARPLKRALYEMVEDKLAELILEDKIKENGSVAFVAENNEIVPKIK
>Mature_856_residues
MNLFEKMTDQLHETLDSALALALHHKNAEVTPLHMLFVMLNNSQGILIQALQKMSVDIQALRLSVQSELDKFVKVSQINK
QNIQLNQALIQSLENAQGLMAKMGDSFIATDVYLLANMSLFESVLKPYLDTKQLQKTLESLRKGATIQSKNDDSNLESLE
KFGIDLTQKALENKLDPVIGRDEEIIRMMQILIRKTKNNPILLGEPGVGKTAVVEGLAQRIVNKEVPKTLLNKRVVALDL
SLLVAGAKYRGEFEERLKKVIEEVKKSANVILFIDEIHTIVGAGASEGGMDAANILKPALARGELHTIGATTLKEYRKYF
EKDMALQRRFQPILLNEPSINEALQILRGLKETLETHHNITINDSALIASAKLSSRYITDRFLPDKAIDLIDEGAAQLKM
QMESEPAKLSSVKRSIQRLEMEKQALEMEKKESSAKRMQEILKELSDLKEEKIQLEAQFENEKEVFREISRLKMETESLK
KEAERFKRNGDYQQAGEIEYSKIPENKKKEEELQHKWEAMQQNGALLQNALTENNIAEIVSQWTHIPVQKMLQSEKNRVL
NIESELQKRVVGQEKAIKAIAKAIKRNKAGLSDSNKPIGSFLFLGPTGVGKTESAKALAQFLFDSDKNLIRIDMSEYLEK
HAVSRLIGAAPGYVGYEEGGQLTEAVRRKPYSVVLLDEVEKAHPDVFNLLLQVLDEGHLTDSKGVRVDFKNTILILTSNV
ASGALLEENLSEADKQKAIKESLRQFFKPEFLNRLDEIISFNALDSHAVANIVGILFENIQKKALERGINITLDEEAKEL
IAKAGFDRFYGARPLKRALYEMVEDKLAELILEDKIKENGSVAFVAENNEIVPKIK

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=322, Percent_Identity=36.9565217391304, Blast_Score=199, Evalue=9e-51,
Organism=Escherichia coli, GI1788943, Length=838, Percent_Identity=48.9260143198091, Blast_Score=818, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=425, Percent_Identity=38.5882352941176, Blast_Score=273, Evalue=4e-74,
Organism=Saccharomyces cerevisiae, GI6320464, Length=805, Percent_Identity=45.8385093167702, Blast_Score=692, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=872, Percent_Identity=39.3348623853211, Blast_Score=581, Evalue=1e-166,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 96407; Mature: 96407

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLFEKMTDQLHETLDSALALALHHKNAEVTPLHMLFVMLNNSQGILIQALQKMSVDIQA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
LRLSVQSELDKFVKVSQINKQNIQLNQALIQSLENAQGLMAKMGDSFIATDVYLLANMSL
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
FESVLKPYLDTKQLQKTLESLRKGATIQSKNDDSNLESLEKFGIDLTQKALENKLDPVIG
HHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCC
RDEEIIRMMQILIRKTKNNPILLGEPGVGKTAVVEGLAQRIVNKEVPKTLLNKRVVALDL
CCHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
SLLVAGAKYRGEFEERLKKVIEEVKKSANVILFIDEIHTIVGAGASEGGMDAANILKPAL
HHHHHCHHHCCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCCCHHHHHHHHH
ARGELHTIGATTLKEYRKYFEKDMALQRRFQPILLNEPSINEALQILRGLKETLETHHNI
HCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCE
TINDSALIASAKLSSRYITDRFLPDKAIDLIDEGAAQLKMQMESEPAKLSSVKRSIQRLE
EECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHH
MEKQALEMEKKESSAKRMQEILKELSDLKEEKIQLEAQFENEKEVFREISRLKMETESLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
KEAERFKRNGDYQQAGEIEYSKIPENKKKEEELQHKWEAMQQNGALLQNALTENNIAEIV
HHHHHHHHCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHH
SQWTHIPVQKMLQSEKNRVLNIESELQKRVVGQEKAIKAIAKAIKRNKAGLSDSNKPIGS
HHHHCCCHHHHHHHHCCCEECHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCCC
FLFLGPTGVGKTESAKALAQFLFDSDKNLIRIDMSEYLEKHAVSRLIGAAPGYVGYEEGG
EEEECCCCCCCCHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCC
QLTEAVRRKPYSVVLLDEVEKAHPDVFNLLLQVLDEGHLTDSKGVRVDFKNTILILTSNV
HHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEECCC
ASGALLEENLSEADKQKAIKESLRQFFKPEFLNRLDEIISFNALDSHAVANIVGILFENI
CCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
QKKALERGINITLDEEAKELIAKAGFDRFYGARPLKRALYEMVEDKLAELILEDKIKENG
HHHHHHCCCCEEECHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
SVAFVAENNEIVPKIK
CEEEEECCCCCCCCCC
>Mature Secondary Structure
MNLFEKMTDQLHETLDSALALALHHKNAEVTPLHMLFVMLNNSQGILIQALQKMSVDIQA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
LRLSVQSELDKFVKVSQINKQNIQLNQALIQSLENAQGLMAKMGDSFIATDVYLLANMSL
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
FESVLKPYLDTKQLQKTLESLRKGATIQSKNDDSNLESLEKFGIDLTQKALENKLDPVIG
HHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCC
RDEEIIRMMQILIRKTKNNPILLGEPGVGKTAVVEGLAQRIVNKEVPKTLLNKRVVALDL
CCHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
SLLVAGAKYRGEFEERLKKVIEEVKKSANVILFIDEIHTIVGAGASEGGMDAANILKPAL
HHHHHCHHHCCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCCCHHHHHHHHH
ARGELHTIGATTLKEYRKYFEKDMALQRRFQPILLNEPSINEALQILRGLKETLETHHNI
HCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCE
TINDSALIASAKLSSRYITDRFLPDKAIDLIDEGAAQLKMQMESEPAKLSSVKRSIQRLE
EECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHH
MEKQALEMEKKESSAKRMQEILKELSDLKEEKIQLEAQFENEKEVFREISRLKMETESLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
KEAERFKRNGDYQQAGEIEYSKIPENKKKEEELQHKWEAMQQNGALLQNALTENNIAEIV
HHHHHHHHCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHH
SQWTHIPVQKMLQSEKNRVLNIESELQKRVVGQEKAIKAIAKAIKRNKAGLSDSNKPIGS
HHHHCCCHHHHHHHHCCCEECHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCCC
FLFLGPTGVGKTESAKALAQFLFDSDKNLIRIDMSEYLEKHAVSRLIGAAPGYVGYEEGG
EEEECCCCCCCCHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCC
QLTEAVRRKPYSVVLLDEVEKAHPDVFNLLLQVLDEGHLTDSKGVRVDFKNTILILTSNV
HHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEECCC
ASGALLEENLSEADKQKAIKESLRQFFKPEFLNRLDEIISFNALDSHAVANIVGILFENI
CCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
QKKALERGINITLDEEAKELIAKAGFDRFYGARPLKRALYEMVEDKLAELILEDKIKENG
HHHHHHCCCCEEECHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
SVAFVAENNEIVPKIK
CEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]