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The map label for this gene is msrAB [H]

Identifier: 188527029

GI number: 188527029

Start: 217455

End: 218492

Strand: Direct

Name: msrAB [H]

Synonym: HPSH_01160

Alternate gene names: 188527029

Gene position: 217455-218492 (Clockwise)

Preceding gene: 188527028

Following gene: 188527030

Centisome position: 13.52

GC content: 40.66

Gene sequence:

>1038_bases
ATGCAAGCGAATGAAAGCATGGGATCTCAACACCAAAAAACCGATGAAAGAGTGATTTACTTGGCTGGGGGGTGCTTTTG
GGGGCTAGAGGCGTATATGGAGAGGATTTATGGCGTCATAGACGCAAGCTCTGGTTACGCTAACGGCAAGACTTCAAGCA
CGAATTATGAAAAGTTGCATGAAAGCGATCATGCTGAAAGCGTGAAAGTGGTTTATGATCCTAAAAAAATCAGTTTGGAC
AAGTTGTTGCGTTATTATTTTAAGGTGATTGATCCGGTGAGCGTGAATAAGCAGGGTAATGATGTGGGCAGGCAGTATCG
CACGGGGATTTATTATGTCAATAGCGCGGATAAAGAAGTGATAGATCACGCCTTAAAAGCGTTACAAAAAGAAGTGAAAG
GCAAAATCGCTATTGAGGTAGAGCCTTTAAAAAATTATGTGAGGGCTGAAGAATATCACCAAGATTATTTGAAAAAACAC
CCTGGTGGCTATTGCCATATTGATTTGAAAAAGGCGGATGAAGTGATTGTAGATAGCGATAAATACACCAAACCAAGCGA
TGAAGTTTTAAAGAAAAAACTCACCAAACTCCAGTATGAAGTGACGCAAAACAAACACACTGAGAAACCCTTTGAAAATG
AGTATTACAATAAAGAAGAAGAGGGTATTTATGTGGATATTACCACAGGCGAGCCGTTATTTTCTTCAGCGGATAAATAC
GACTCCGGTTGCGGGTGGCCAAGCTTTTCTAAGCCTATCAATAAAGATGTGGTGAAATACGAAGACGATGAGAGCCTTAA
TAGGAAACGCATTGAAGTGTTGAGCCGTATTGGTAAGGCGCATTTAGGGCATGTGTTTAACGATGGGCCTAAAGAATTAG
GGGGCTTAAGGTATTGCATTAATAGCGCGGCTTTAAGGTTTATCCCCTTAAAAGACATGGAAAAAGAGGGTTATGGCGAG
TTCATCCCCTATATCAAAAAGGGTGAATTGAAAAAATACATCCAGGATAAAAAAAACGCATTAAGGGGTAATGACTAG

Upstream 100 bases:

>100_bases
TTTAGCTTATAATTGCTATCATTATTGAAATAAAGGTTATTTAATGAAAGTATTATCTTACTTGAAACATTTTTATCTTT
TTCTACTAATAGGAGCGTTT

Downstream 100 bases:

>100_bases
CACCCCCTAATGGGGGTAAAATGGGGGGTTAAAGCGTTATCTTAAAAACGCTAAAAACCGCTCGCTGATTTATTTTCAAC
TATTCTTATTCAAAAAACAA

Product: bifunctional methionine sulfoxide reductase A/B protein

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MQANESMGSQHQKTDERVIYLAGGCFWGLEAYMERIYGVIDASSGYANGKTSSTNYEKLHESDHAESVKVVYDPKKISLD
KLLRYYFKVIDPVSVNKQGNDVGRQYRTGIYYVNSADKEVIDHALKALQKEVKGKIAIEVEPLKNYVRAEEYHQDYLKKH
PGGYCHIDLKKADEVIVDSDKYTKPSDEVLKKKLTKLQYEVTQNKHTEKPFENEYYNKEEEGIYVDITTGEPLFSSADKY
DSGCGWPSFSKPINKDVVKYEDDESLNRKRIEVLSRIGKAHLGHVFNDGPKELGGLRYCINSAALRFIPLKDMEKEGYGE
FIPYIKKGELKKYIQDKKNALRGND

Sequences:

>Translated_345_residues
MQANESMGSQHQKTDERVIYLAGGCFWGLEAYMERIYGVIDASSGYANGKTSSTNYEKLHESDHAESVKVVYDPKKISLD
KLLRYYFKVIDPVSVNKQGNDVGRQYRTGIYYVNSADKEVIDHALKALQKEVKGKIAIEVEPLKNYVRAEEYHQDYLKKH
PGGYCHIDLKKADEVIVDSDKYTKPSDEVLKKKLTKLQYEVTQNKHTEKPFENEYYNKEEEGIYVDITTGEPLFSSADKY
DSGCGWPSFSKPINKDVVKYEDDESLNRKRIEVLSRIGKAHLGHVFNDGPKELGGLRYCINSAALRFIPLKDMEKEGYGE
FIPYIKKGELKKYIQDKKNALRGND
>Mature_345_residues
MQANESMGSQHQKTDERVIYLAGGCFWGLEAYMERIYGVIDASSGYANGKTSSTNYEKLHESDHAESVKVVYDPKKISLD
KLLRYYFKVIDPVSVNKQGNDVGRQYRTGIYYVNSADKEVIDHALKALQKEVKGKIAIEVEPLKNYVRAEEYHQDYLKKH
PGGYCHIDLKKADEVIVDSDKYTKPSDEVLKKKLTKLQYEVTQNKHTEKPFENEYYNKEEEGIYVDITTGEPLFSSADKY
DSGCGWPSFSKPINKDVVKYEDDESLNRKRIEVLSRIGKAHLGHVFNDGPKELGGLRYCINSAALRFIPLKDMEKEGYGE
FIPYIKKGELKKYIQDKKNALRGND

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI301336164, Length=124, Percent_Identity=50.8064516129032, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI301336162, Length=124, Percent_Identity=50.8064516129032, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI73089054, Length=124, Percent_Identity=50.8064516129032, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI37620216, Length=124, Percent_Identity=50.8064516129032, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI117606353, Length=128, Percent_Identity=46.09375, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI6912516, Length=150, Percent_Identity=36, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI208609995, Length=150, Percent_Identity=36, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI208609993, Length=116, Percent_Identity=35.3448275862069, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1788077, Length=125, Percent_Identity=48.8, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1790665, Length=151, Percent_Identity=33.7748344370861, Blast_Score=96, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17553450, Length=111, Percent_Identity=44.1441441441441, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI115532676, Length=111, Percent_Identity=44.1441441441441, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17533973, Length=137, Percent_Identity=35.036496350365, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320881, Length=160, Percent_Identity=40.625, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319816, Length=135, Percent_Identity=37.037037037037, Blast_Score=90, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24645799, Length=122, Percent_Identity=48.3606557377049, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45553335, Length=122, Percent_Identity=48.3606557377049, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21356369, Length=122, Percent_Identity=48.3606557377049, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24645801, Length=133, Percent_Identity=44.3609022556391, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24645804, Length=133, Percent_Identity=44.3609022556391, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI221378664, Length=122, Percent_Identity=45.9016393442623, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI221378662, Length=129, Percent_Identity=44.1860465116279, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24664627, Length=140, Percent_Identity=32.1428571428571, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45553131, Length=145, Percent_Identity=32.4137931034483, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 39561; Mature: 39561

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: PS00191 CYTOCHROME_B5_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQANESMGSQHQKTDERVIYLAGGCFWGLEAYMERIYGVIDASSGYANGKTSSTNYEKLH
CCCCCCCCCHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
ESDHAESVKVVYDPKKISLDKLLRYYFKVIDPVSVNKQGNDVGRQYRTGIYYVNSADKEV
CCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCEEEECCCCHHH
IDHALKALQKEVKGKIAIEVEPLKNYVRAEEYHQDYLKKHPGGYCHIDLKKADEVIVDSD
HHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCC
KYTKPSDEVLKKKLTKLQYEVTQNKHTEKPFENEYYNKEEEGIYVDITTGEPLFSSADKY
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHCCCCCC
DSGCGWPSFSKPINKDVVKYEDDESLNRKRIEVLSRIGKAHLGHVFNDGPKELGGLRYCI
CCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCHHHCCCHHHHHHHHHHH
NSAALRFIPLKDMEKEGYGEFIPYIKKGELKKYIQDKKNALRGND
HHHHEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQANESMGSQHQKTDERVIYLAGGCFWGLEAYMERIYGVIDASSGYANGKTSSTNYEKLH
CCCCCCCCCHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
ESDHAESVKVVYDPKKISLDKLLRYYFKVIDPVSVNKQGNDVGRQYRTGIYYVNSADKEV
CCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCEEEECCCCHHH
IDHALKALQKEVKGKIAIEVEPLKNYVRAEEYHQDYLKKHPGGYCHIDLKKADEVIVDSD
HHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCC
KYTKPSDEVLKKKLTKLQYEVTQNKHTEKPFENEYYNKEEEGIYVDITTGEPLFSSADKY
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHCCCCCC
DSGCGWPSFSKPINKDVVKYEDDESLNRKRIEVLSRIGKAHLGHVFNDGPKELGGLRYCI
CCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCHHHCCCHHHHHHHHHHH
NSAALRFIPLKDMEKEGYGEFIPYIKKGELKKYIQDKKNALRGND
HHHHEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]