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The map label for this gene is acsA1 [H]

Identifier: 187927751

GI number: 187927751

Start: 693591

End: 695645

Strand: Reverse

Name: acsA1 [H]

Synonym: Rpic_0655

Alternate gene names: 187927751

Gene position: 695645-693591 (Counterclockwise)

Preceding gene: 187927752

Following gene: 187927750

Centisome position: 17.64

GC content: 66.42

Gene sequence:

>2055_bases
ATGAGCACCATCCAGGAAGGCGCCCTCCTATGGACGCCATCGGCTGACTTCATCGCGCGCTCGCGCCTGACGCATTACCT
CGACTGGCTCGCGCGCGAACGCGGGCTGCGCTTTTCGGCGACCACGCCCGAGGGCTACGCACGACTCTGGGAATGGTCGA
CCACTGAACTCGAGGCGTTCTGGACGTCCGTCTGGGACTACCTTGACCTGCGCGCCTCGACACCGTTCTCGCAGATGCTG
GGCGACCGCACCATGCCCGGCGCGCAATGGCTGGTCGGCGCGAAGCTCAATTACGTCGATCAGGTCATGCGCCATGTGGA
AGAAGGCGGCAGCCCCGACCGCACCGCCATCCGATACGCCAGCGAGACCAAGCCGCTCGCCGACTTGTCATGGCGCGAAC
TGCGCCAACGCGTTGCCTCGCTGGCGGATGCGCTGCGCAAGATGGGCGTGGTGCCGGGCGACCGCGTCGCCGCATATCTG
TCGAACACGCCGGACGCGATCGTGGCGTTTCTCGCCACGGCCAGCGTCGGGGCCATCTGGTCTGTCTGTGCGCCCGACAT
GGGCCAGGTGGCCGTGACCGACCGCTTCCGGCAGATCGAGCCCAAAGTGCTGATCGCGTTGGACGGCTATCACTACGGCG
GCCGCGCGTTCGACCGCACCGACATCGTCGCAGAGATGGTCGCCGCACTGCCAACTGTCGAACACCTCGTGCTCGTGCCG
CAGTTGCTTGGCGAGGTCAACCGCGCGCGCTTCCCGGAGGCCCGCGACTGGTGCGACCTGACTGCGAACGACGTACCACT
CGTCGTCACACCCGTCGCCGCCGACCACCCGCTGTGGATTCTCTATTCGTCCGGCACCACCGGCATGCCCAAGCCGATCG
TGCACGGCCATGGCGGCCTGCTGCTGGTGCAGACGATGATGGGCGCGCTGCATCTCGACCTTGGCCCCGACGACGTCTAC
CACTGGTACAGCAGCACCGGCTGGGTCATGTGGAATTCGCAAGCGAGCGGCTTACTCGGCGGCGTCACGCTCGCCATCTA
CGACGGCAACCCCGGCACGCCCGATCTCAATACGCTGTGGCGCTTCGCACAGGATGCGGGCGTGACCTTCTTTGGCGCCG
GCGCGGCGTTCTTCGCCAATTGCCTGAAGGCCGGCATCGAGCCCGGGCGCGATTTCGACCTGTCGAGACTGCGTGCGGTC
GGCTCGACCGGCTCGCCGCTCTCGGCCGAGGCGTACGACTGGATCTACCGCCACGTAAAAGCCGACGTCTGGCTCAACCC
CATTTCCGGCGGCACCGACTTCGCTGGCTGCTTCGTGGGCGGCGTCGCAACACTGCCCGTCTATGCGGGTGAGATGCAAT
GCCGCAACCTCGGCTCGCGTGTGGAAGCACTGGACGAGGCTGGCCGACCGCTCATCGACGCGGTAGGCGAGCTGGTCTGC
ACCGCGCCCATTCCGTCGATGCCGCTCTTCTTCTGGGGCGACAGCGACGGCAGCCGCTACCGCGACAGCTACTTCGACAT
GTACCCCGGCCAGTGGCGCCACGGCGACTGGATCAAGATCACGCCACGCGGCGGCGCCATCATCTACGGCCGGTCGGATG
CCACGATCAACCGCCACGGTATCCGCATGGGCACAGCCGAGCTGTACCGCGTAGTGGAAGATCTGCCGGAAGTGCTCGAC
AGCCTTGTCGTCGATCTGGAATTCCTCGGCCGCGAATCGTTCATGCCACTGTTCGTCGTGCTGCGCGAAGGTGCGACGCT
CGACGACACGCTGCGCAGCACGATCAATGCACGCATCAAGGCAGGGCTGTCGGCCCGGCATGTGCCCAACGTGGTCGTAC
AGGCACCCGGCGTGCCGCGCACGCTGTCGGGCAAGAAGATGGAAGTGCCCATCAAGAAACTGCTGCTTGGCGCACCAATC
GAGCGCGTCGCCAACCCCGATGCAATGGCAAACCCGGAGGTGCTTGCGTGGTACGCGACCTACGCCGGGTCGCTGGCCCG
GCAAAGCAGCGCGCACGGCGAGCCCGCGCCCGCATTGGAATCGTGGCGGAGCTAG

Upstream 100 bases:

>100_bases
TGTGCATGGGCGGCATCTGAACCGTCGCCCCCTCTCGGCCGACCCGCCACAACGATAGAGCGGGCGGCCTTTCCCCTTGC
CTGACCGGCGGAGGAGACAC

Downstream 100 bases:

>100_bases
ACCGATCGTTGGTCTCTGGTTTCACAATCTCCGCCAATCGAACGATGGCAGGGACCGGGTGTGATGACTAACGTACAGCT
TGCACCGGCACATCAAGATG

Product: acetoacetyl-CoA synthetase

Products: NA

Alternate protein names: Acetoacetate--CoA ligase 1; Acyl-activating enzyme 1 [H]

Number of amino acids: Translated: 684; Mature: 683

Protein sequence:

>684_residues
MSTIQEGALLWTPSADFIARSRLTHYLDWLARERGLRFSATTPEGYARLWEWSTTELEAFWTSVWDYLDLRASTPFSQML
GDRTMPGAQWLVGAKLNYVDQVMRHVEEGGSPDRTAIRYASETKPLADLSWRELRQRVASLADALRKMGVVPGDRVAAYL
SNTPDAIVAFLATASVGAIWSVCAPDMGQVAVTDRFRQIEPKVLIALDGYHYGGRAFDRTDIVAEMVAALPTVEHLVLVP
QLLGEVNRARFPEARDWCDLTANDVPLVVTPVAADHPLWILYSSGTTGMPKPIVHGHGGLLLVQTMMGALHLDLGPDDVY
HWYSSTGWVMWNSQASGLLGGVTLAIYDGNPGTPDLNTLWRFAQDAGVTFFGAGAAFFANCLKAGIEPGRDFDLSRLRAV
GSTGSPLSAEAYDWIYRHVKADVWLNPISGGTDFAGCFVGGVATLPVYAGEMQCRNLGSRVEALDEAGRPLIDAVGELVC
TAPIPSMPLFFWGDSDGSRYRDSYFDMYPGQWRHGDWIKITPRGGAIIYGRSDATINRHGIRMGTAELYRVVEDLPEVLD
SLVVDLEFLGRESFMPLFVVLREGATLDDTLRSTINARIKAGLSARHVPNVVVQAPGVPRTLSGKKMEVPIKKLLLGAPI
ERVANPDAMANPEVLAWYATYAGSLARQSSAHGEPAPALESWRS

Sequences:

>Translated_684_residues
MSTIQEGALLWTPSADFIARSRLTHYLDWLARERGLRFSATTPEGYARLWEWSTTELEAFWTSVWDYLDLRASTPFSQML
GDRTMPGAQWLVGAKLNYVDQVMRHVEEGGSPDRTAIRYASETKPLADLSWRELRQRVASLADALRKMGVVPGDRVAAYL
SNTPDAIVAFLATASVGAIWSVCAPDMGQVAVTDRFRQIEPKVLIALDGYHYGGRAFDRTDIVAEMVAALPTVEHLVLVP
QLLGEVNRARFPEARDWCDLTANDVPLVVTPVAADHPLWILYSSGTTGMPKPIVHGHGGLLLVQTMMGALHLDLGPDDVY
HWYSSTGWVMWNSQASGLLGGVTLAIYDGNPGTPDLNTLWRFAQDAGVTFFGAGAAFFANCLKAGIEPGRDFDLSRLRAV
GSTGSPLSAEAYDWIYRHVKADVWLNPISGGTDFAGCFVGGVATLPVYAGEMQCRNLGSRVEALDEAGRPLIDAVGELVC
TAPIPSMPLFFWGDSDGSRYRDSYFDMYPGQWRHGDWIKITPRGGAIIYGRSDATINRHGIRMGTAELYRVVEDLPEVLD
SLVVDLEFLGRESFMPLFVVLREGATLDDTLRSTINARIKAGLSARHVPNVVVQAPGVPRTLSGKKMEVPIKKLLLGAPI
ERVANPDAMANPEVLAWYATYAGSLARQSSAHGEPAPALESWRS
>Mature_683_residues
STIQEGALLWTPSADFIARSRLTHYLDWLARERGLRFSATTPEGYARLWEWSTTELEAFWTSVWDYLDLRASTPFSQMLG
DRTMPGAQWLVGAKLNYVDQVMRHVEEGGSPDRTAIRYASETKPLADLSWRELRQRVASLADALRKMGVVPGDRVAAYLS
NTPDAIVAFLATASVGAIWSVCAPDMGQVAVTDRFRQIEPKVLIALDGYHYGGRAFDRTDIVAEMVAALPTVEHLVLVPQ
LLGEVNRARFPEARDWCDLTANDVPLVVTPVAADHPLWILYSSGTTGMPKPIVHGHGGLLLVQTMMGALHLDLGPDDVYH
WYSSTGWVMWNSQASGLLGGVTLAIYDGNPGTPDLNTLWRFAQDAGVTFFGAGAAFFANCLKAGIEPGRDFDLSRLRAVG
STGSPLSAEAYDWIYRHVKADVWLNPISGGTDFAGCFVGGVATLPVYAGEMQCRNLGSRVEALDEAGRPLIDAVGELVCT
APIPSMPLFFWGDSDGSRYRDSYFDMYPGQWRHGDWIKITPRGGAIIYGRSDATINRHGIRMGTAELYRVVEDLPEVLDS
LVVDLEFLGRESFMPLFVVLREGATLDDTLRSTINARIKAGLSARHVPNVVVQAPGVPRTLSGKKMEVPIKKLLLGAPIE
RVANPDAMANPEVLAWYATYAGSLARQSSAHGEPAPALESWRS

Specific function: Involved in poly-3-hydroxybutyrate degradation. Activates acetoacetate to acetoacetyl-CoA [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI31982927, Length=668, Percent_Identity=37.125748502994, Blast_Score=460, Evalue=1e-129,
Organism=Homo sapiens, GI28416953, Length=653, Percent_Identity=27.5650842266462, Blast_Score=212, Evalue=8e-55,
Organism=Homo sapiens, GI8923896, Length=638, Percent_Identity=25.3918495297806, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI253970489, Length=651, Percent_Identity=25.0384024577573, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI13375727, Length=615, Percent_Identity=27.3170731707317, Blast_Score=162, Evalue=1e-39,
Organism=Escherichia coli, GI1790505, Length=646, Percent_Identity=26.4705882352941, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1786529, Length=610, Percent_Identity=25.7377049180328, Blast_Score=143, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17569507, Length=630, Percent_Identity=33.8095238095238, Blast_Score=389, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI71983001, Length=626, Percent_Identity=25.8785942492013, Blast_Score=152, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI71982997, Length=626, Percent_Identity=25.8785942492013, Blast_Score=152, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6323182, Length=650, Percent_Identity=28.3076923076923, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6319264, Length=642, Percent_Identity=26.3239875389408, Blast_Score=187, Evalue=6e-48,
Organism=Drosophila melanogaster, GI24667955, Length=641, Percent_Identity=25.1170046801872, Blast_Score=186, Evalue=5e-47,
Organism=Drosophila melanogaster, GI62472339, Length=547, Percent_Identity=26.3254113345521, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24667959, Length=508, Percent_Identity=25.7874015748031, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI21355225, Length=632, Percent_Identity=25.7911392405063, Blast_Score=157, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005914
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.16 [H]

Molecular weight: Translated: 74927; Mature: 74796

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTIQEGALLWTPSADFIARSRLTHYLDWLARERGLRFSATTPEGYARLWEWSTTELEAF
CCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHCCCCHHHHHH
WTSVWDYLDLRASTPFSQMLGDRTMPGAQWLVGAKLNYVDQVMRHVEEGGSPDRTAIRYA
HHHHHHHHHCCCCCCHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCCHHHEEEC
SETKPLADLSWRELRQRVASLADALRKMGVVPGDRVAAYLSNTPDAIVAFLATASVGAIW
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHH
SVCAPDMGQVAVTDRFRQIEPKVLIALDGYHYGGRAFDRTDIVAEMVAALPTVEHLVLVP
HHCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHH
QLLGEVNRARFPEARDWCDLTANDVPLVVTPVAADHPLWILYSSGTTGMPKPIVHGHGGL
HHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCEEECCCCH
LLVQTMMGALHLDLGPDDVYHWYSSTGWVMWNSQASGLLGGVTLAIYDGNPGTPDLNTLW
HHHHHHHHHEEECCCCHHHHHHHCCCCEEEECCCCCCCCCCEEEEEECCCCCCCCHHHHH
RFAQDAGVTFFGAGAAFFANCLKAGIEPGRDFDLSRLRAVGSTGSPLSAEAYDWIYRHVK
HHHHHCCCEEEECHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHH
ADVWLNPISGGTDFAGCFVGGVATLPVYAGEMQCRNLGSRVEALDEAGRPLIDAVGELVC
HCEEEECCCCCCCHHHHHHCCHHHHCEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHEE
TAPIPSMPLFFWGDSDGSRYRDSYFDMYPGQWRHGDWIKITPRGGAIIYGRSDATINRHG
CCCCCCCCEEEEECCCCCHHHHHHHCCCCCCCCCCCEEEEECCCCEEEECCCCCEEECCC
IRMGTAELYRVVEDLPEVLDSLVVDLEFLGRESFMPLFVVLREGATLDDTLRSTINARIK
CEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHH
AGLSARHVPNVVVQAPGVPRTLSGKKMEVPIKKLLLGAPIERVANPDAMANPEVLAWYAT
CCCCCCCCCCEEEECCCCCCCCCCCEEECCHHHHHHCCCHHHHCCCCCCCCCCEEEEHHH
YAGSLARQSSAHGEPAPALESWRS
HHHHHHHHCCCCCCCCCHHHHCCC
>Mature Secondary Structure 
STIQEGALLWTPSADFIARSRLTHYLDWLARERGLRFSATTPEGYARLWEWSTTELEAF
CCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHCCCCHHHHHH
WTSVWDYLDLRASTPFSQMLGDRTMPGAQWLVGAKLNYVDQVMRHVEEGGSPDRTAIRYA
HHHHHHHHHCCCCCCHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCCHHHEEEC
SETKPLADLSWRELRQRVASLADALRKMGVVPGDRVAAYLSNTPDAIVAFLATASVGAIW
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHH
SVCAPDMGQVAVTDRFRQIEPKVLIALDGYHYGGRAFDRTDIVAEMVAALPTVEHLVLVP
HHCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHH
QLLGEVNRARFPEARDWCDLTANDVPLVVTPVAADHPLWILYSSGTTGMPKPIVHGHGGL
HHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCEEECCCCH
LLVQTMMGALHLDLGPDDVYHWYSSTGWVMWNSQASGLLGGVTLAIYDGNPGTPDLNTLW
HHHHHHHHHEEECCCCHHHHHHHCCCCEEEECCCCCCCCCCEEEEEECCCCCCCCHHHHH
RFAQDAGVTFFGAGAAFFANCLKAGIEPGRDFDLSRLRAVGSTGSPLSAEAYDWIYRHVK
HHHHHCCCEEEECHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHH
ADVWLNPISGGTDFAGCFVGGVATLPVYAGEMQCRNLGSRVEALDEAGRPLIDAVGELVC
HCEEEECCCCCCCHHHHHHCCHHHHCEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHEE
TAPIPSMPLFFWGDSDGSRYRDSYFDMYPGQWRHGDWIKITPRGGAIIYGRSDATINRHG
CCCCCCCCEEEEECCCCCHHHHHHHCCCCCCCCCCCEEEEECCCCEEEECCCCCEEECCC
IRMGTAELYRVVEDLPEVLDSLVVDLEFLGRESFMPLFVVLREGATLDDTLRSTINARIK
CEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHH
AGLSARHVPNVVVQAPGVPRTLSGKKMEVPIKKLLLGAPIERVANPDAMANPEVLAWYAT
CCCCCCCCCCEEEECCCCCCCCCCCEEECCHHHHHHCCCHHHHCCCCCCCCCCEEEEHHH
YAGSLARQSSAHGEPAPALESWRS
HHHHHHHHCCCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10735852; 11481430 [H]