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The map label for this gene is zraR [H]

Identifier: 187927700

GI number: 187927700

Start: 639628

End: 641007

Strand: Reverse

Name: zraR [H]

Synonym: Rpic_0604

Alternate gene names: 187927700

Gene position: 641007-639628 (Counterclockwise)

Preceding gene: 187927701

Following gene: 187927699

Centisome position: 16.26

GC content: 63.48

Gene sequence:

>1380_bases
ATGAACGCGTACATCAACCGCCCGTTGCTTTATGTTTCACTGCGTCACGATGCAACGCGTTGCCGCTACCTGGCTCAACA
GGGCTGGCAACTGCTCTTCGCCAACAACCGCCGCGACCTTGAAGCGCTGAACCTGTGCGAAGAGTCCGTCCTGGGCGGTC
TGCTGGATCTGGATTGCGGTTACTCCGACACCGAATTGGAAGAACTGGAACCTTGGCTTGCCCGGCAGAACATTGGCTGG
ATCGGAGTGGTTGGCAACGGTGACATGTTGTCTGACCCGATGCGCAAGCTGCTCGGCCTGTACTTTGTCGACTACTACAA
CATCCCGTGCGACAGCGCCGAATTGGCACACGCACTGGGGCACGCCGTCGGCATGGCACACCTGCGCCCGGCGGCAACGC
TCACACGCGATACGCTGCGCCCCGATGGCATGATCGGCAACTGCCTCGCCATGCAGGGCCTGTTCCGCGGCATCGAGAAG
GTCTCGAAATGGGATACGCCCGTGTTGGTCTCGGGCGAATCCGGCACCGGAAAAGAACTCGCGGCACGCGCAATCCACTG
CGCCTCGCGCCGCGCCGGCCAGCCATTCATCGCCGTCAATTGCGCGGCCATTCCCCCCACGCTGCTGATGTCCGAACTGT
TCGGCTATGAGCGTGGCGCCTTCACCGGCGCCGTCAAGCGCAAGCCCGGCCGCATCGAAATGGCGCACGGCGGCACCCTC
TTCCTGGATGAAATCGGCGACATGCCGCTAGAAAGCCAGACCAGCCTGCTGCGCTTTCTCGAAACCGGCTGCATCGAACG
GCTGGGCGGCACGGAGTCGGTTGCCGTCGACGTGCGCGTCATCTCAGCCACCCATGTCGACCTGGAAGCGGCCATTGCGG
CGGAACGCTTTCGCGGCGATCTCTATCACCGCCTCTGCGTGCTGCGCGTCAAGCAACCCGCACTGCGCGAGCGCGACACC
GACATCCTGCTACTGGCCGAACATATCCTCAACAGCGTGCGCAGCCATTCGCCCGAGCACATCAAGGGGTTCTCACCGAC
GGCCCTGCGTGCGCTCAGCGTGCACACATGGCCGGGCAATGTGCGGGAGCTGATCAACCGCATCCGGCACGCCGCGGCCA
TGTGCGAAGACGGCATCATCAAGCCGGCCGATCTCGACCTGCAGCCACCCGTCGAGCCGTCGCGCCCGCCTACCCTGGCC
GAGGCCCGGGAAGCAGCAGAGCGCTGTGCCGTCAAAGAAGCCCTGCAACGCAATCATGAACGGCTCATCGACGTGGCCGA
AGAACTTGGCATCTCACGCGTCACGCTGTTCCGGATGATGCGCGAGCACAAGCTGCAGATCCGCAAGGGCGAACTTGGGA
TGGTGTGTGTGCAGGGGTAA

Upstream 100 bases:

>100_bases
GGACGGACGGCTTTCCGCCCTTGTCCGACGGTTGACTTGGCAGTCCATTGGTGGCCGCAACAGCAGTGCGCGGCCCCATA
GAAAAACGTTGGGGGAAAAC

Downstream 100 bases:

>100_bases
AGGCAAGGGGAATGGCGGGGACAGAACAAAAAACAGGGGCGGACCATGTCAGTCAGCCAGCAGGGGACGGCGCGGGTTGA
CCCAGCGCCGAAATCGAGGG

Product: Fis family sigma54 specific transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MNAYINRPLLYVSLRHDATRCRYLAQQGWQLLFANNRRDLEALNLCEESVLGGLLDLDCGYSDTELEELEPWLARQNIGW
IGVVGNGDMLSDPMRKLLGLYFVDYYNIPCDSAELAHALGHAVGMAHLRPAATLTRDTLRPDGMIGNCLAMQGLFRGIEK
VSKWDTPVLVSGESGTGKELAARAIHCASRRAGQPFIAVNCAAIPPTLLMSELFGYERGAFTGAVKRKPGRIEMAHGGTL
FLDEIGDMPLESQTSLLRFLETGCIERLGGTESVAVDVRVISATHVDLEAAIAAERFRGDLYHRLCVLRVKQPALRERDT
DILLLAEHILNSVRSHSPEHIKGFSPTALRALSVHTWPGNVRELINRIRHAAAMCEDGIIKPADLDLQPPVEPSRPPTLA
EAREAAERCAVKEALQRNHERLIDVAEELGISRVTLFRMMREHKLQIRKGELGMVCVQG

Sequences:

>Translated_459_residues
MNAYINRPLLYVSLRHDATRCRYLAQQGWQLLFANNRRDLEALNLCEESVLGGLLDLDCGYSDTELEELEPWLARQNIGW
IGVVGNGDMLSDPMRKLLGLYFVDYYNIPCDSAELAHALGHAVGMAHLRPAATLTRDTLRPDGMIGNCLAMQGLFRGIEK
VSKWDTPVLVSGESGTGKELAARAIHCASRRAGQPFIAVNCAAIPPTLLMSELFGYERGAFTGAVKRKPGRIEMAHGGTL
FLDEIGDMPLESQTSLLRFLETGCIERLGGTESVAVDVRVISATHVDLEAAIAAERFRGDLYHRLCVLRVKQPALRERDT
DILLLAEHILNSVRSHSPEHIKGFSPTALRALSVHTWPGNVRELINRIRHAAAMCEDGIIKPADLDLQPPVEPSRPPTLA
EAREAAERCAVKEALQRNHERLIDVAEELGISRVTLFRMMREHKLQIRKGELGMVCVQG
>Mature_459_residues
MNAYINRPLLYVSLRHDATRCRYLAQQGWQLLFANNRRDLEALNLCEESVLGGLLDLDCGYSDTELEELEPWLARQNIGW
IGVVGNGDMLSDPMRKLLGLYFVDYYNIPCDSAELAHALGHAVGMAHLRPAATLTRDTLRPDGMIGNCLAMQGLFRGIEK
VSKWDTPVLVSGESGTGKELAARAIHCASRRAGQPFIAVNCAAIPPTLLMSELFGYERGAFTGAVKRKPGRIEMAHGGTL
FLDEIGDMPLESQTSLLRFLETGCIERLGGTESVAVDVRVISATHVDLEAAIAAERFRGDLYHRLCVLRVKQPALRERDT
DILLLAEHILNSVRSHSPEHIKGFSPTALRALSVHTWPGNVRELINRIRHAAAMCEDGIIKPADLDLQPPVEPSRPPTLA
EAREAAERCAVKEALQRNHERLIDVAEELGISRVTLFRMMREHKLQIRKGELGMVCVQG

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=344, Percent_Identity=41.2790697674419, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1788905, Length=341, Percent_Identity=39.8826979472141, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1788550, Length=354, Percent_Identity=40.3954802259887, Blast_Score=231, Evalue=6e-62,
Organism=Escherichia coli, GI87082117, Length=329, Percent_Identity=41.6413373860182, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI1790299, Length=326, Percent_Identity=43.2515337423313, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI1789233, Length=323, Percent_Identity=42.1052631578947, Blast_Score=222, Evalue=5e-59,
Organism=Escherichia coli, GI1789087, Length=314, Percent_Identity=41.4012738853503, Blast_Score=215, Evalue=5e-57,
Organism=Escherichia coli, GI87082152, Length=329, Percent_Identity=39.5136778115502, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1786524, Length=331, Percent_Identity=42.2960725075529, Blast_Score=204, Evalue=7e-54,
Organism=Escherichia coli, GI87081872, Length=322, Percent_Identity=38.1987577639752, Blast_Score=202, Evalue=2e-53,
Organism=Escherichia coli, GI1787583, Length=309, Percent_Identity=35.2750809061489, Blast_Score=168, Evalue=6e-43,
Organism=Escherichia coli, GI87081858, Length=284, Percent_Identity=34.8591549295775, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1789828, Length=233, Percent_Identity=34.7639484978541, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50858; Mature: 50858

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAYINRPLLYVSLRHDATRCRYLAQQGWQLLFANNRRDLEALNLCEESVLGGLLDLDCG
CCCCCCCCEEEEEECCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCEECCCC
YSDTELEELEPWLARQNIGWIGVVGNGDMLSDPMRKLLGLYFVDYYNIPCDSAELAHALG
CCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
HAVGMAHLRPAATLTRDTLRPDGMIGNCLAMQGLFRGIEKVSKWDTPVLVSGESGTGKEL
HHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHH
AARAIHCASRRAGQPFIAVNCAAIPPTLLMSELFGYERGAFTGAVKRKPGRIEMAHGGTL
HHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCHHCCCCCEEEEECCCEE
FLDEIGDMPLESQTSLLRFLETGCIERLGGTESVAVDVRVISATHVDLEAAIAAERFRGD
EEHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEECCCHHHHHHHHHHHHH
LYHRLCVLRVKQPALRERDTDILLLAEHILNSVRSHSPEHIKGFSPTALRALSVHTWPGN
HHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHCCCCHHCCCCCHHHHHEEEEECCCCH
VRELINRIRHAAAMCEDGIIKPADLDLQPPVEPSRPPTLAEAREAAERCAVKEALQRNHE
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RLIDVAEELGISRVTLFRMMREHKLQIRKGELGMVCVQG
HHHHHHHHHCCHHHHHHHHHHHHHHEEECCCCCEEEECC
>Mature Secondary Structure
MNAYINRPLLYVSLRHDATRCRYLAQQGWQLLFANNRRDLEALNLCEESVLGGLLDLDCG
CCCCCCCCEEEEEECCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCEECCCC
YSDTELEELEPWLARQNIGWIGVVGNGDMLSDPMRKLLGLYFVDYYNIPCDSAELAHALG
CCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
HAVGMAHLRPAATLTRDTLRPDGMIGNCLAMQGLFRGIEKVSKWDTPVLVSGESGTGKEL
HHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHH
AARAIHCASRRAGQPFIAVNCAAIPPTLLMSELFGYERGAFTGAVKRKPGRIEMAHGGTL
HHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCHHCCCCCEEEEECCCEE
FLDEIGDMPLESQTSLLRFLETGCIERLGGTESVAVDVRVISATHVDLEAAIAAERFRGD
EEHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEECCCHHHHHHHHHHHHH
LYHRLCVLRVKQPALRERDTDILLLAEHILNSVRSHSPEHIKGFSPTALRALSVHTWPGN
HHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHCCCCHHCCCCCHHHHHEEEEECCCCH
VRELINRIRHAAAMCEDGIIKPADLDLQPPVEPSRPPTLAEAREAAERCAVKEALQRNHE
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RLIDVAEELGISRVTLFRMMREHKLQIRKGELGMVCVQG
HHHHHHHHHCCHHHHHHHHHHHHHHEEECCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]