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The map label for this gene is strD [H]

Identifier: 187927490

GI number: 187927490

Start: 412105

End: 412797

Strand: Reverse

Name: strD [H]

Synonym: Rpic_0387

Alternate gene names: 187927490

Gene position: 412797-412105 (Counterclockwise)

Preceding gene: 187927491

Following gene: 187927488

Centisome position: 10.47

GC content: 68.98

Gene sequence:

>693_bases
ATGATTTTTGCGGCGGGCCGCGGCGACCGCATGCGTCCGCTGACGGACCACACGCCCAAGCCGCTGCTCACCGTGGGCGG
CAAACCGCTGATCGTCTGGCAGATCGAGCGCCTGGCTGCGGCCGGCGTGCGCGACATCGTCATCAACCACGCATGGCTGG
GCGCGCAGATCGAAGCCGCGCTGGGAGATGGCAGTGCGTGGGGCGTGCGCCTCGCGTATTCGCCGGAAGGGCAGGCACTG
GAAACGGCAGGCGGGGTCGCGCAGGCCATGTCGCTGCTGCATGCCGGCGAGGGCCACAGCGTATTCATCGCCGTCAGCGG
CGATGTGTTCTGCGATTACGACTACGCCTTGCTGCGTGACCGGGCGCCCGCAATGGCCGCGCAAGCGGCACCCAGCATGC
ACCTGGTGATGGTGCCGAACCCGCCGTACCACCTGCGCGGCGATTTCGCGCTGGATAACGAAGGCGTGCTCCACGCCGAC
GGCACCGAGCGGCTCACGTTCGGCAACATCGGCTTGTACGACACGCGCCTGTTTGCCAGCATCGCGCCCGGCACGCGGCT
GGCGATGACGCCGCTGTACCACCAGGCCATCGCCGAAGGCCGCGCTACGGGCGAGCGCTTCGACGGTCGCTGGGAAAACG
TCGGAACGCCGGCCCAGCTGGCCGCACTCGACGCAGAACTCGCGGTGCGCTAG

Upstream 100 bases:

>100_bases
TCGCACGGGTGACGAAGAGCGCGATGTGGACCATCGTCGGCGGCATGGCTGTGCTGCTGATTCTCATGAAGGTGATGGCT
TGAATTCGACCACGCGCGCC

Downstream 100 bases:

>100_bases
GCGCTTACGCCATCGCGGCGGACAACGATTCCGCCGTCATCGGGCGGCCCAGCAGGTAGCCCTGCAGCGAGTGACAACCG
AGCCGCGTGAGAAACGCCTG

Product: Nucleotidyl transferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MIFAAGRGDRMRPLTDHTPKPLLTVGGKPLIVWQIERLAAAGVRDIVINHAWLGAQIEAALGDGSAWGVRLAYSPEGQAL
ETAGGVAQAMSLLHAGEGHSVFIAVSGDVFCDYDYALLRDRAPAMAAQAAPSMHLVMVPNPPYHLRGDFALDNEGVLHAD
GTERLTFGNIGLYDTRLFASIAPGTRLAMTPLYHQAIAEGRATGERFDGRWENVGTPAQLAALDAELAVR

Sequences:

>Translated_230_residues
MIFAAGRGDRMRPLTDHTPKPLLTVGGKPLIVWQIERLAAAGVRDIVINHAWLGAQIEAALGDGSAWGVRLAYSPEGQAL
ETAGGVAQAMSLLHAGEGHSVFIAVSGDVFCDYDYALLRDRAPAMAAQAAPSMHLVMVPNPPYHLRGDFALDNEGVLHAD
GTERLTFGNIGLYDTRLFASIAPGTRLAMTPLYHQAIAEGRATGERFDGRWENVGTPAQLAALDAELAVR
>Mature_230_residues
MIFAAGRGDRMRPLTDHTPKPLLTVGGKPLIVWQIERLAAAGVRDIVINHAWLGAQIEAALGDGSAWGVRLAYSPEGQAL
ETAGGVAQAMSLLHAGEGHSVFIAVSGDVFCDYDYALLRDRAPAMAAQAAPSMHLVMVPNPPYHLRGDFALDNEGVLHAD
GTERLTFGNIGLYDTRLFASIAPGTRLAMTPLYHQAIAEGRATGERFDGRWENVGTPAQLAALDAELAVR

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=116, Percent_Identity=36.2068965517241, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI11761619, Length=116, Percent_Identity=36.2068965517241, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI133931050, Length=116, Percent_Identity=36.2068965517241, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320148, Length=121, Percent_Identity=37.1900826446281, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355443, Length=119, Percent_Identity=36.1344537815126, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24644084, Length=119, Percent_Identity=36.1344537815126, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 24534; Mature: 24534

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFAAGRGDRMRPLTDHTPKPLLTVGGKPLIVWQIERLAAAGVRDIVINHAWLGAQIEAA
CEEECCCCCCCCCCCCCCCCCEEEECCCEEEEEEEHHHHHCCHHHEEEECEEECEEEEEE
LGDGSAWGVRLAYSPEGQALETAGGVAQAMSLLHAGEGHSVFIAVSGDVFCDYDYALLRD
ECCCCCCEEEEEECCCCCEEHHHCCHHHHHHHHHCCCCCEEEEEECCCEEECCCHHHHHC
RAPAMAAQAAPSMHLVMVPNPPYHLRGDFALDNEGVLHADGTERLTFGNIGLYDTRLFAS
CCCHHHHHCCCCEEEEEECCCCCEEECCEEECCCCEEECCCCCEEEECCCCCCHHHEEEE
IAPGTRLAMTPLYHQAIAEGRATGERFDGRWENVGTPAQLAALDAELAVR
ECCCCEEEECHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHEEECCEEECC
>Mature Secondary Structure
MIFAAGRGDRMRPLTDHTPKPLLTVGGKPLIVWQIERLAAAGVRDIVINHAWLGAQIEAA
CEEECCCCCCCCCCCCCCCCCEEEECCCEEEEEEEHHHHHCCHHHEEEECEEECEEEEEE
LGDGSAWGVRLAYSPEGQALETAGGVAQAMSLLHAGEGHSVFIAVSGDVFCDYDYALLRD
ECCCCCCEEEEEECCCCCEEHHHCCHHHHHHHHHCCCCCEEEEEECCCEEECCCHHHHHC
RAPAMAAQAAPSMHLVMVPNPPYHLRGDFALDNEGVLHADGTERLTFGNIGLYDTRLFAS
CCCHHHHHCCCCEEEEEECCCCCEEECCEEECCCCEEECCCCCEEEECCCCCCHHHEEEE
IAPGTRLAMTPLYHQAIAEGRATGERFDGRWENVGTPAQLAALDAELAVR
ECCCCEEEECHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHEEECCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]