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The map label for this gene is ycgO [H]

Identifier: 187927441

GI number: 187927441

Start: 358663

End: 360102

Strand: Direct

Name: ycgO [H]

Synonym: Rpic_0338

Alternate gene names: 187927441

Gene position: 358663-360102 (Clockwise)

Preceding gene: 187927440

Following gene: 187927442

Centisome position: 9.1

GC content: 62.36

Gene sequence:

>1440_bases
ATGCTGATCTGGTTTGTCATTGTTTACTGGGTGATTTCGGTCGGGATCGGCCTGTGGGCTGCACTGCGCGTGCGCAGTAC
CGCCGACTTCGCCGTGGCTGGCCGCAGTCTGCCGTTCTACGTCGTGACCGCCACGGTGTTCGCCACCTGGTTCGGCTCCG
AGGCGGTGCTCGGGATTCCCGCGGAATTTCTCAAGGATGGCCTGCACGGTGTGGTGGCCGATCCGTTCGGTTCGTCGCTG
TGCCTGGTGTTGGTGGGTCTGTTCTTTGCCAAGCCGCTGTACCGGATGAACCTGCTCACCATTGGTGACTTCTATCGCAA
CCGCTTTGGCCGCGTGGCCGAAACGCTGACCACCCTGTGCATCGTCGTATCGTACCTGGGCTGGGTGGCAGCGCAGATCA
AGGCGCTGGGGCTGGTGTTCTACACCGTGTCTGACGGCGCGGTTTCGCAAGACCTCGGGATGATGATCGGCGCGGGCAGC
GTGCTGGTCTACACGCTGTTTGGCGGCATGTGGTCGGTGGCGGTGACGGATTTCATCCAGATGATCATCATCGTGATCGG
CATGCTGTACATTGGCTGGGAAGTGTCGGGCCAGGCCGGTGGTGTGGGCGCGGTGGTGGCGCACGCCGCGGCTTCGGGCA
AGTTCTCGTTCTGGCCGGCGTTCAACCCGATCGAGGTCATCGGCTTTGTGACGGCGTGGATCACCATGATGCTCGGCTCG
ATCCCACAGCAGGACGTGTTTCAGCGGGTAACGTCATCGCGCACCGAGCGCATCGCCGGTACGGCGTCGGTGCTGGGCGG
CGTGTTGTACTTCATGTTTGCGTTCGTGCCGATGTTCCTAGCGTATTCGGCCACGCTCATCGACCCGGAGATGGTCGCGA
AATACATCGATACCGATTCGCAGATGATCTTGCCGAACCTGGTGCTGCAGCATGCGCCGATCTTCGCGCAGGTGATGTTC
TTCGGTGCGCTGCTCTCAGCCATCAAGAGCTGCGCGAGCGCGACGCTGCTGGCGCCCTCCGTGACGTTCGCCGAAAATGT
GCTGCGTCCGCTGCTGCCCAACATGGACGACAAGCGTTTCCTGCGCGTGATGCAGGCAGTGGTGCTGACGTTCACGGTCT
TGGTGACGCTCTTTGCGCTGAACTCGCATCTGTCGATCTTCCACATGGTCGAAAGCGCCTACAAGGTGACGCTGGTGGCC
GCGTTCGTGCCCTTGGCCTTTGGCCTGTTCTGGAGGCGCGCGACCAAGCAGGGCGGTCTGTTGGCCATCATCCTGGGCCT
CGCGGCGTGGATCTGGTGCGAAGCGTTCCAGCCGAATGCGATGCTCCCGCCACAATTGGTTGGCCTCCTTGCCAGCTTTG
GCGCGATGGTCCTGGGCTCTCTCGGACCACAGTGGATCGCGAACCGCGCGCCGACCACCAAGGCGGTCACGCAAGCCTGA

Upstream 100 bases:

>100_bases
CCGGCGCGCAGTCCCATCGCTATAATCCGGCCACTTTGCCCGGCACCCCTGGGCCCAAAACCGGGCCACCATGGGTTTTC
CTGCTTCTTTCCGCGCTGCC

Downstream 100 bases:

>100_bases
GCGTCTCGTTGCGGGCGTGCGCGGTGTGCCACTTTGTCGCGCATCGCCATCGGCCGCTCCGAATCTGCGGTCGGGAATTC
CCTCGAAAGGGTTTATAATT

Product: Na+/solute symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MLIWFVIVYWVISVGIGLWAALRVRSTADFAVAGRSLPFYVVTATVFATWFGSEAVLGIPAEFLKDGLHGVVADPFGSSL
CLVLVGLFFAKPLYRMNLLTIGDFYRNRFGRVAETLTTLCIVVSYLGWVAAQIKALGLVFYTVSDGAVSQDLGMMIGAGS
VLVYTLFGGMWSVAVTDFIQMIIIVIGMLYIGWEVSGQAGGVGAVVAHAAASGKFSFWPAFNPIEVIGFVTAWITMMLGS
IPQQDVFQRVTSSRTERIAGTASVLGGVLYFMFAFVPMFLAYSATLIDPEMVAKYIDTDSQMILPNLVLQHAPIFAQVMF
FGALLSAIKSCASATLLAPSVTFAENVLRPLLPNMDDKRFLRVMQAVVLTFTVLVTLFALNSHLSIFHMVESAYKVTLVA
AFVPLAFGLFWRRATKQGGLLAIILGLAAWIWCEAFQPNAMLPPQLVGLLASFGAMVLGSLGPQWIANRAPTTKAVTQA

Sequences:

>Translated_479_residues
MLIWFVIVYWVISVGIGLWAALRVRSTADFAVAGRSLPFYVVTATVFATWFGSEAVLGIPAEFLKDGLHGVVADPFGSSL
CLVLVGLFFAKPLYRMNLLTIGDFYRNRFGRVAETLTTLCIVVSYLGWVAAQIKALGLVFYTVSDGAVSQDLGMMIGAGS
VLVYTLFGGMWSVAVTDFIQMIIIVIGMLYIGWEVSGQAGGVGAVVAHAAASGKFSFWPAFNPIEVIGFVTAWITMMLGS
IPQQDVFQRVTSSRTERIAGTASVLGGVLYFMFAFVPMFLAYSATLIDPEMVAKYIDTDSQMILPNLVLQHAPIFAQVMF
FGALLSAIKSCASATLLAPSVTFAENVLRPLLPNMDDKRFLRVMQAVVLTFTVLVTLFALNSHLSIFHMVESAYKVTLVA
AFVPLAFGLFWRRATKQGGLLAIILGLAAWIWCEAFQPNAMLPPQLVGLLASFGAMVLGSLGPQWIANRAPTTKAVTQA
>Mature_479_residues
MLIWFVIVYWVISVGIGLWAALRVRSTADFAVAGRSLPFYVVTATVFATWFGSEAVLGIPAEFLKDGLHGVVADPFGSSL
CLVLVGLFFAKPLYRMNLLTIGDFYRNRFGRVAETLTTLCIVVSYLGWVAAQIKALGLVFYTVSDGAVSQDLGMMIGAGS
VLVYTLFGGMWSVAVTDFIQMIIIVIGMLYIGWEVSGQAGGVGAVVAHAAASGKFSFWPAFNPIEVIGFVTAWITMMLGS
IPQQDVFQRVTSSRTERIAGTASVLGGVLYFMFAFVPMFLAYSATLIDPEMVAKYIDTDSQMILPNLVLQHAPIFAQVMF
FGALLSAIKSCASATLLAPSVTFAENVLRPLLPNMDDKRFLRVMQAVVLTFTVLVTLFALNSHLSIFHMVESAYKVTLVA
AFVPLAFGLFWRRATKQGGLLAIILGLAAWIWCEAFQPNAMLPPQLVGLLASFGAMVLGSLGPQWIANRAPTTKAVTQA

Specific function: Catalyzes the sodium-dependent uptake of extracellular amino acids [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI11141885, Length=405, Percent_Identity=29.1358024691358, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI4507035, Length=403, Percent_Identity=26.5508684863524, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI14140236, Length=482, Percent_Identity=22.6141078838174, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI157671931, Length=403, Percent_Identity=23.3250620347395, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI256985183, Length=468, Percent_Identity=23.2905982905983, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI109659836, Length=473, Percent_Identity=23.2558139534884, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI4507033, Length=413, Percent_Identity=23.2445520581114, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI87082237, Length=433, Percent_Identity=24.7113163972286, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17539284, Length=454, Percent_Identity=25.9911894273128, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24648033, Length=437, Percent_Identity=26.5446224256293, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21356865, Length=437, Percent_Identity=26.5446224256293, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 51833; Mature: 51833

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIWFVIVYWVISVGIGLWAALRVRSTADFAVAGRSLPFYVVTATVFATWFGSEAVLGIP
CHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCCEECCC
AEFLKDGLHGVVADPFGSSLCLVLVGLFFAKPLYRMNLLTIGDFYRNRFGRVAETLTTLC
HHHHHCCCCEEECCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVVSYLGWVAAQIKALGLVFYTVSDGAVSQDLGMMIGAGSVLVYTLFGGMWSVAVTDFIQ
HHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
MIIIVIGMLYIGWEVSGQAGGVGAVVAHAAASGKFSFWPAFNPIEVIGFVTAWITMMLGS
HHHHHHHHHHHCCEECCCCCCHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHCC
IPQQDVFQRVTSSRTERIAGTASVLGGVLYFMFAFVPMFLAYSATLIDPEMVAKYIDTDS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
QMILPNLVLQHAPIFAQVMFFGALLSAIKSCASATLLAPSVTFAENVLRPLLPNMDDKRF
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHH
LRVMQAVVLTFTVLVTLFALNSHLSIFHMVESAYKVTLVAAFVPLAFGLFWRRATKQGGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
LAIILGLAAWIWCEAFQPNAMLPPQLVGLLASFGAMVLGSLGPQWIANRAPTTKAVTQA
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHCCC
>Mature Secondary Structure
MLIWFVIVYWVISVGIGLWAALRVRSTADFAVAGRSLPFYVVTATVFATWFGSEAVLGIP
CHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCCEECCC
AEFLKDGLHGVVADPFGSSLCLVLVGLFFAKPLYRMNLLTIGDFYRNRFGRVAETLTTLC
HHHHHCCCCEEECCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVVSYLGWVAAQIKALGLVFYTVSDGAVSQDLGMMIGAGSVLVYTLFGGMWSVAVTDFIQ
HHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
MIIIVIGMLYIGWEVSGQAGGVGAVVAHAAASGKFSFWPAFNPIEVIGFVTAWITMMLGS
HHHHHHHHHHHCCEECCCCCCHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHCC
IPQQDVFQRVTSSRTERIAGTASVLGGVLYFMFAFVPMFLAYSATLIDPEMVAKYIDTDS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
QMILPNLVLQHAPIFAQVMFFGALLSAIKSCASATLLAPSVTFAENVLRPLLPNMDDKRF
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHH
LRVMQAVVLTFTVLVTLFALNSHLSIFHMVESAYKVTLVAAFVPLAFGLFWRRATKQGGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
LAIILGLAAWIWCEAFQPNAMLPPQLVGLLASFGAMVLGSLGPQWIANRAPTTKAVTQA
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]