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The map label for this gene is moeB [H]

Identifier: 187927315

GI number: 187927315

Start: 224786

End: 225535

Strand: Reverse

Name: moeB [H]

Synonym: Rpic_0207

Alternate gene names: 187927315

Gene position: 225535-224786 (Counterclockwise)

Preceding gene: 187927316

Following gene: 187927304

Centisome position: 5.72

GC content: 67.33

Gene sequence:

>750_bases
ATGAACGACGATCAACTGCTGCGCTACTCGCGCCATATCCTGCTCGACGAAATCGGCATCGAGGGGCAGACGCGCCTGCT
TGAAAGCCATGCGCTTGTCATCGGCGCGGGCGGGCTGGGCGCTGCGGCCCTGCCGTATCTGGCGGCGGCGGGCATAGGCA
CGCTCACCATCGTCGACGACGACACGGTGGACCTGACCAACCTGCAGCGCCAGATCATCCACACAACGGAATCGGTCGGG
CAGCCGAAGGTGGCATCCGCGCAGGCGGCCATCGCCCGGCTGAATCCCGACGTGCGCGTGCATGCCGTGCAGCGCCGGCT
CGATACGGATGCCATCGGCGCACGCCTTGATGGCGTGAGCGTGGTACTGGACTGCTCCGATAACTTCGGCACTCGCCAGG
CCACCAACCTTGCCTGCGTGCGGGCTGGCGTGCCGCTGGTGTCGGGCGCAGCCATCCGTTTCGACGGACAGATCAGCGTG
TTCGACAGCCGCGCCGGCGGCCCCTGCTACGCCTGCCTGTTCCCACCCGACGAGCCCGCGCCCGACGTGGCGTGCGCAAC
GATGGGCGTGTTCTCGCCGCTGGTGGGCATGGTGGGTACGGTGCAGGCCGCCGAGGCACTCAAGCTGATCGCCGGCATCG
GCAGTTCGCTTGCCGGCCGCCTTCTGATGCTCGACGGTTTAACGATGGAATGGACGACGATGCGCATCGCTCGACAGCCG
TCCTGTCCGGTCTGCGGGGGCATGCACTGA

Upstream 100 bases:

>100_bases
GCCTGCGCCGGAGCCCACCGGCGCACGATAAGACACCTGCCGGCAAACACTGGCAAACTTACGAGGCCGTGCACTGCACG
GCCTTTTTCATTGCACCACC

Downstream 100 bases:

>100_bases
CGCGCCGGTACACGCACGACAAAAAAGGAGGCCGAGGCCTCCTTCTTTTTTGCGGCTGACGAGCCTTATTCGCCCTCAGG
CTCCATCTGCGATTGCAGGT

Product: UBA/THIF-type NAD/FAD binding protein

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase [H]

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MNDDQLLRYSRHILLDEIGIEGQTRLLESHALVIGAGGLGAAALPYLAAAGIGTLTIVDDDTVDLTNLQRQIIHTTESVG
QPKVASAQAAIARLNPDVRVHAVQRRLDTDAIGARLDGVSVVLDCSDNFGTRQATNLACVRAGVPLVSGAAIRFDGQISV
FDSRAGGPCYACLFPPDEPAPDVACATMGVFSPLVGMVGTVQAAEALKLIAGIGSSLAGRLLMLDGLTMEWTTMRIARQP
SCPVCGGMH

Sequences:

>Translated_249_residues
MNDDQLLRYSRHILLDEIGIEGQTRLLESHALVIGAGGLGAAALPYLAAAGIGTLTIVDDDTVDLTNLQRQIIHTTESVG
QPKVASAQAAIARLNPDVRVHAVQRRLDTDAIGARLDGVSVVLDCSDNFGTRQATNLACVRAGVPLVSGAAIRFDGQISV
FDSRAGGPCYACLFPPDEPAPDVACATMGVFSPLVGMVGTVQAAEALKLIAGIGSSLAGRLLMLDGLTMEWTTMRIARQP
SCPVCGGMH
>Mature_249_residues
MNDDQLLRYSRHILLDEIGIEGQTRLLESHALVIGAGGLGAAALPYLAAAGIGTLTIVDDDTVDLTNLQRQIIHTTESVG
QPKVASAQAAIARLNPDVRVHAVQRRLDTDAIGARLDGVSVVLDCSDNFGTRQATNLACVRAGVPLVSGAAIRFDGQISV
FDSRAGGPCYACLFPPDEPAPDVACATMGVFSPLVGMVGTVQAAEALKLIAGIGSSLAGRLLMLDGLTMEWTTMRIARQP
SCPVCGGMH

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=228, Percent_Identity=45.6140350877193, Blast_Score=174, Evalue=5e-44,
Organism=Homo sapiens, GI4885649, Length=146, Percent_Identity=28.0821917808219, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI38045948, Length=151, Percent_Identity=33.112582781457, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1787048, Length=249, Percent_Identity=44.9799196787149, Blast_Score=228, Evalue=4e-61,
Organism=Escherichia coli, GI87082356, Length=249, Percent_Identity=46.9879518072289, Blast_Score=218, Evalue=3e-58,
Organism=Escherichia coli, GI1789177, Length=139, Percent_Identity=35.2517985611511, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17540406, Length=257, Percent_Identity=41.2451361867704, Blast_Score=202, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI193203301, Length=198, Percent_Identity=28.7878787878788, Blast_Score=87, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6321903, Length=250, Percent_Identity=37.2, Blast_Score=171, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6320598, Length=140, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24582879, Length=249, Percent_Identity=41.7670682730924, Blast_Score=197, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24660640, Length=151, Percent_Identity=32.4503311258278, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28573937, Length=185, Percent_Identity=28.6486486486486, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24641311, Length=258, Percent_Identity=29.0697674418605, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR012730
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 25986; Mature: 25986

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDDQLLRYSRHILLDEIGIEGQTRLLESHALVIGAGGLGAAALPYLAAAGIGTLTIVDD
CCCHHHHHHHHHHHHHHCCCCCHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEEC
DTVDLTNLQRQIIHTTESVGQPKVASAQAAIARLNPDVRVHAVQRRLDTDAIGARLDGVS
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEHHHHHHHCHHHHCCEECCEE
VVLDCSDNFGTRQATNLACVRAGVPLVSGAAIRFDGQISVFDSRAGGPCYACLFPPDEPA
EEEECCCCCCCCCCCCEEEEECCCCEECCEEEEECCEEEEEECCCCCCEEEEECCCCCCC
PDVACATMGVFSPLVGMVGTVQAAEALKLIAGIGSSLAGRLLMLDGLTMEWTTMRIARQP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCEEEEECCCEEEEEEEEEECCC
SCPVCGGMH
CCCCCCCCC
>Mature Secondary Structure
MNDDQLLRYSRHILLDEIGIEGQTRLLESHALVIGAGGLGAAALPYLAAAGIGTLTIVDD
CCCHHHHHHHHHHHHHHCCCCCHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEEC
DTVDLTNLQRQIIHTTESVGQPKVASAQAAIARLNPDVRVHAVQRRLDTDAIGARLDGVS
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEHHHHHHHCHHHHCCEECCEE
VVLDCSDNFGTRQATNLACVRAGVPLVSGAAIRFDGQISVFDSRAGGPCYACLFPPDEPA
EEEECCCCCCCCCCCCEEEEECCCCEECCEEEEECCEEEEEECCCCCCEEEEECCCCCCC
PDVACATMGVFSPLVGMVGTVQAAEALKLIAGIGSSLAGRLLMLDGLTMEWTTMRIARQP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCEEEEECCCEEEEEEEEEECCC
SCPVCGGMH
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503 [H]