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The map label for this gene is zraS [C]

Identifier: 187927139

GI number: 187927139

Start: 40695

End: 42893

Strand: Reverse

Name: zraS [C]

Synonym: Rpic_0029

Alternate gene names: 187927139

Gene position: 42893-40695 (Counterclockwise)

Preceding gene: 187927141

Following gene: 187927138

Centisome position: 1.09

GC content: 66.98

Gene sequence:

>2199_bases
ATGCCGTTTCTCGCGCATCACCATGACTGCCTCGGCTGGAACGGTGAGATGGCGCAGCGCGTGCTGGCATTCGATTGGGC
CTCCACTGAACTGGGCCCGATCCAGGACTGGTCACCCAGCCTGCGTGCCGCCGTGCACATGGTGCTGGCGTGTCCGGTGC
CGCTGGTCATGCTGTGGGGCCGCCACGGCTACATGGTCTACAACGATGCCTACGCCGTGTTTGCCGGCGGGCGTCATCCC
TATCTGCTGGGTTGCCCCGTTGAACTGGGCTGGCCCGAAGTGGCCGACTTCAACCGCCATGTCATGGACGTCTGCCTCGG
TGGCGGCACGCTGTCGTACCGCGACAAGGAACTTGTCCTGCTGCGCAACGGCCGCCCCGAAGACGTGTGGATGGATCTTT
ACTACAGCCCGCTGCCCGATGACACCGGCCGCCCGGCGGGTGTGCTGGCCATCGTGGTGGAAACCACCGAGCGCGTGCAG
ACCGAGCGCGAACGGCAGGCTGCCGAACAGGCCCTGCGCCAGTTGACCGAAACGCTGGAGCAACGCGTGGCCGATGCGCT
GTCTGCCCGCGCCGAAGTGGAAGCGCAATTGCGCCAGGCCCAGAAGATGGAAGCCATCGGCAACCTGACCGGCGGCGTGG
CCCACGACTTCAACAACGTGCTCCAGGTGATTGCCGGCAATCTGCAGATGCTCTCGGTGGAGGCGCCGAACAACACGCGC
GTGCAGCATCGGATTGCCGCCGCCACGCGTGCCGTGCAGCGCGGTGCCACGCTGGCGGCGCAGCTGCTCGCCTTTGCGCG
CCGCCAGCAGCTCTCGCCGGCGGTCGTCAACCCGACGCGGCTGGTCCAAGGCATGAGCGAGATGCTGCACCGCGCACTGG
GCGAAGCCATCAAGGTGGAAACGCACCTGGCCGCCGACTTGTGGAACGTCCAGGCCGACCGCAACCAGCTCGAGAACGCG
CTGCTGAACCTCGCCATCAACGCACGCGATGCTATGCGCGGCGGCGGCATGCTCACCATTGCCGCCAACAACGTCACGCT
CGACAACACACAGGCGGACGTGCGTGATCAGCTTACCCCCGGCGACTACCTTGTCTTCTCCGTCACCGATACCGGCGTGG
GCATGCCGCCCGAAGTGGTCGAACACGCTTTCGAGCCCTTCTTTACCACCAAGCCCGACGGCCACGGCACGGGCCTGGGG
CTCAGCATGGTGTTCGGCTTCGTCAAGCAGAGCGGCGGGCACATCGCCATCGACAGTACAGTCGGACAAGGCACCACGGT
GCAGCTCTACTTCCCGCGCTGCACGGAGGCGGCCCCGGACGATGCCGTCGAGCTGCGCGACACCATCGTTACGCCCATGG
GCGGGCGCGAGACCATCCTCGTGGTGGAGGACGATACCGACGTGCGCCTGACCGCCGTCGACATGCTGACCCAACTCGGT
TACCGCGTGCTCACGGCCGCCAACGGCCAGGCCGCGCTCGACCTCATGAACAGCGGCACGTCCATCGACCTGCTGTTTAC
CGACGTGATCATGCCAGGCCCCATCAAGGGCAGCGAACTGTCGATACGCGCCGCGCAGCGCGTGCCGCCACTGCCGGTGC
TGCTCGTCTCGGGCTATCCGCGTGACGAGGTGCAGCACGACGGCAGGCTGCCGCCGGGTGTGACACTGCTCGGCAAGCCC
TACCGGCGTGATGACCTGGCGCGCATGGTGCGCAACGTGCTCACCGCCAGCCGCACCGCGCAGGCACAGGCGCAATCGGC
ATCGCCATCGGCGGGCCCTGCCGTGGCTACAGACGCTTCACAACCGCCTGCGGTGCTGCTGGTGGAAGACGACACCGCCT
CGCGCGAAGCCATGCAGGAGGTGCTCACCACCTTCGGCCTGCAATGCGTGGCCGCCGTCAATGCCGAAGACGCCCTTGCA
CTGGCCCGCACGCGCTCCGTTCAGGTGCTGCTGACCGACCTCACCCTGCCCGGCCAATCCGGCGCGAACCTCGCCCGCAC
GCTGCTGCGCATGCAACCGCAACTGCAGGTGCTGCTGATGTCCGGCTATGGCACGGAAGCCGAGATTGGCGAGCCCATTG
CCGGCGCACGCCTGCTCGGCAAACCGATCGACCTGATGACGCTGCAGCAGGCGCTGGCGCCGTGGCTCGGCGCAACCGTA
AGGGCTGCCGATACGCAGAATGTGACGAACGCCGCATAA

Upstream 100 bases:

>100_bases
ATGGCTTTGAGCCGTCTGTTGCCGACACCGGCCGGCCTCCCGATTTTCTAGAATGACCACAACTCGGGTGCACTGTGCTG
CCCGCCGGACAGGAGACCTT

Downstream 100 bases:

>100_bases
CCGAAGCACCCGGTCACAAACGATCTCGCCCGCCCGTCTAGGGAGCATCATCCCCGGACGACACGCCCGCCATGACCAAG
CCCAGCCCCGACCGCACCAC

Product: PAS/PAC sensor hybrid histidine kinase

Products: NA

Alternate protein names: Blue-light-activated histidine kinase; Response regulator [H]

Number of amino acids: Translated: 732; Mature: 731

Protein sequence:

>732_residues
MPFLAHHHDCLGWNGEMAQRVLAFDWASTELGPIQDWSPSLRAAVHMVLACPVPLVMLWGRHGYMVYNDAYAVFAGGRHP
YLLGCPVELGWPEVADFNRHVMDVCLGGGTLSYRDKELVLLRNGRPEDVWMDLYYSPLPDDTGRPAGVLAIVVETTERVQ
TERERQAAEQALRQLTETLEQRVADALSARAEVEAQLRQAQKMEAIGNLTGGVAHDFNNVLQVIAGNLQMLSVEAPNNTR
VQHRIAAATRAVQRGATLAAQLLAFARRQQLSPAVVNPTRLVQGMSEMLHRALGEAIKVETHLAADLWNVQADRNQLENA
LLNLAINARDAMRGGGMLTIAANNVTLDNTQADVRDQLTPGDYLVFSVTDTGVGMPPEVVEHAFEPFFTTKPDGHGTGLG
LSMVFGFVKQSGGHIAIDSTVGQGTTVQLYFPRCTEAAPDDAVELRDTIVTPMGGRETILVVEDDTDVRLTAVDMLTQLG
YRVLTAANGQAALDLMNSGTSIDLLFTDVIMPGPIKGSELSIRAAQRVPPLPVLLVSGYPRDEVQHDGRLPPGVTLLGKP
YRRDDLARMVRNVLTASRTAQAQAQSASPSAGPAVATDASQPPAVLLVEDDTASREAMQEVLTTFGLQCVAAVNAEDALA
LARTRSVQVLLTDLTLPGQSGANLARTLLRMQPQLQVLLMSGYGTEAEIGEPIAGARLLGKPIDLMTLQQALAPWLGATV
RAADTQNVTNAA

Sequences:

>Translated_732_residues
MPFLAHHHDCLGWNGEMAQRVLAFDWASTELGPIQDWSPSLRAAVHMVLACPVPLVMLWGRHGYMVYNDAYAVFAGGRHP
YLLGCPVELGWPEVADFNRHVMDVCLGGGTLSYRDKELVLLRNGRPEDVWMDLYYSPLPDDTGRPAGVLAIVVETTERVQ
TERERQAAEQALRQLTETLEQRVADALSARAEVEAQLRQAQKMEAIGNLTGGVAHDFNNVLQVIAGNLQMLSVEAPNNTR
VQHRIAAATRAVQRGATLAAQLLAFARRQQLSPAVVNPTRLVQGMSEMLHRALGEAIKVETHLAADLWNVQADRNQLENA
LLNLAINARDAMRGGGMLTIAANNVTLDNTQADVRDQLTPGDYLVFSVTDTGVGMPPEVVEHAFEPFFTTKPDGHGTGLG
LSMVFGFVKQSGGHIAIDSTVGQGTTVQLYFPRCTEAAPDDAVELRDTIVTPMGGRETILVVEDDTDVRLTAVDMLTQLG
YRVLTAANGQAALDLMNSGTSIDLLFTDVIMPGPIKGSELSIRAAQRVPPLPVLLVSGYPRDEVQHDGRLPPGVTLLGKP
YRRDDLARMVRNVLTASRTAQAQAQSASPSAGPAVATDASQPPAVLLVEDDTASREAMQEVLTTFGLQCVAAVNAEDALA
LARTRSVQVLLTDLTLPGQSGANLARTLLRMQPQLQVLLMSGYGTEAEIGEPIAGARLLGKPIDLMTLQQALAPWLGATV
RAADTQNVTNAA
>Mature_731_residues
PFLAHHHDCLGWNGEMAQRVLAFDWASTELGPIQDWSPSLRAAVHMVLACPVPLVMLWGRHGYMVYNDAYAVFAGGRHPY
LLGCPVELGWPEVADFNRHVMDVCLGGGTLSYRDKELVLLRNGRPEDVWMDLYYSPLPDDTGRPAGVLAIVVETTERVQT
ERERQAAEQALRQLTETLEQRVADALSARAEVEAQLRQAQKMEAIGNLTGGVAHDFNNVLQVIAGNLQMLSVEAPNNTRV
QHRIAAATRAVQRGATLAAQLLAFARRQQLSPAVVNPTRLVQGMSEMLHRALGEAIKVETHLAADLWNVQADRNQLENAL
LNLAINARDAMRGGGMLTIAANNVTLDNTQADVRDQLTPGDYLVFSVTDTGVGMPPEVVEHAFEPFFTTKPDGHGTGLGL
SMVFGFVKQSGGHIAIDSTVGQGTTVQLYFPRCTEAAPDDAVELRDTIVTPMGGRETILVVEDDTDVRLTAVDMLTQLGY
RVLTAANGQAALDLMNSGTSIDLLFTDVIMPGPIKGSELSIRAAQRVPPLPVLLVSGYPRDEVQHDGRLPPGVTLLGKPY
RRDDLARMVRNVLTASRTAQAQAQSASPSAGPAVATDASQPPAVLLVEDDTASREAMQEVLTTFGLQCVAAVNAEDALAL
ARTRSVQVLLTDLTLPGQSGANLARTLLRMQPQLQVLLMSGYGTEAEIGEPIAGARLLGKPIDLMTLQQALAPWLGATVR
AADTQNVTNAA

Specific function: Photosensitive kinase and response regulator that is involved in increased bacterial virulence upon exposure to light [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=247, Percent_Identity=27.9352226720648, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1788549, Length=247, Percent_Identity=29.1497975708502, Blast_Score=90, Evalue=6e-19,
Organism=Escherichia coli, GI145693157, Length=564, Percent_Identity=21.8085106382979, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI48994928, Length=258, Percent_Identity=27.906976744186, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87081816, Length=427, Percent_Identity=23.4192037470726, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 78889; Mature: 78758

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFLAHHHDCLGWNGEMAQRVLAFDWASTELGPIQDWSPSLRAAVHMVLACPVPLVMLWG
CCCCCCCCCCCCCCHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHC
RHGYMVYNDAYAVFAGGRHPYLLGCPVELGWPEVADFNRHVMDVCLGGGTLSYRDKELVL
CCCEEEEECCEEEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCEECCCCCEEEE
LRNGRPEDVWMDLYYSPLPDDTGRPAGVLAIVVETTERVQTERERQAAEQALRQLTETLE
EECCCCCCEEEEEEECCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
QRVADALSARAEVEAQLRQAQKMEAIGNLTGGVAHDFNNVLQVIAGNLQMLSVEAPNNTR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCH
VQHRIAAATRAVQRGATLAAQLLAFARRQQLSPAVVNPTRLVQGMSEMLHRALGEAIKVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEH
THLAADLWNVQADRNQLENALLNLAINARDAMRGGGMLTIAANNVTLDNTQADVRDQLTP
HHHHHHHHHCHHHHHHHHHHHHHEEECCHHHHCCCCEEEEEECCEEECCCCHHHHHCCCC
GDYLVFSVTDTGVGMPPEVVEHAFEPFFTTKPDGHGTGLGLSMVFGFVKQSGGHIAIDST
CCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECC
VGQGTTVQLYFPRCTEAAPDDAVELRDTIVTPMGGRETILVVEDDTDVRLTAVDMLTQLG
CCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCEEHHHHHHHHCC
YRVLTAANGQAALDLMNSGTSIDLLFTDVIMPGPIKGSELSIRAAQRVPPLPVLLVSGYP
CEEEEECCCCEEEHHHCCCCEEEEEEEEEECCCCCCCCCEEEEHHHCCCCCCEEEECCCC
RDEVQHDGRLPPGVTLLGKPYRRDDLARMVRNVLTASRTAQAQAQSASPSAGPAVATDAS
HHHHCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCC
QPPAVLLVEDDTASREAMQEVLTTFGLQCVAAVNAEDALALARTRSVQVLLTDLTLPGQS
CCCEEEEEECCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCEEEEEEEEECCCCC
GANLARTLLRMQPQLQVLLMSGYGTEAEIGEPIAGARLLGKPIDLMTLQQALAPWLGATV
CHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHCCEE
RAADTQNVTNAA
EECCCCCCCCCC
>Mature Secondary Structure 
PFLAHHHDCLGWNGEMAQRVLAFDWASTELGPIQDWSPSLRAAVHMVLACPVPLVMLWG
CCCCCCCCCCCCCHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHC
RHGYMVYNDAYAVFAGGRHPYLLGCPVELGWPEVADFNRHVMDVCLGGGTLSYRDKELVL
CCCEEEEECCEEEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCEECCCCCEEEE
LRNGRPEDVWMDLYYSPLPDDTGRPAGVLAIVVETTERVQTERERQAAEQALRQLTETLE
EECCCCCCEEEEEEECCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
QRVADALSARAEVEAQLRQAQKMEAIGNLTGGVAHDFNNVLQVIAGNLQMLSVEAPNNTR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCH
VQHRIAAATRAVQRGATLAAQLLAFARRQQLSPAVVNPTRLVQGMSEMLHRALGEAIKVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEH
THLAADLWNVQADRNQLENALLNLAINARDAMRGGGMLTIAANNVTLDNTQADVRDQLTP
HHHHHHHHHCHHHHHHHHHHHHHEEECCHHHHCCCCEEEEEECCEEECCCCHHHHHCCCC
GDYLVFSVTDTGVGMPPEVVEHAFEPFFTTKPDGHGTGLGLSMVFGFVKQSGGHIAIDST
CCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECC
VGQGTTVQLYFPRCTEAAPDDAVELRDTIVTPMGGRETILVVEDDTDVRLTAVDMLTQLG
CCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCEEHHHHHHHHCC
YRVLTAANGQAALDLMNSGTSIDLLFTDVIMPGPIKGSELSIRAAQRVPPLPVLLVSGYP
CEEEEECCCCEEEHHHCCCCEEEEEEEEEECCCCCCCCCEEEEHHHCCCCCCEEEECCCC
RDEVQHDGRLPPGVTLLGKPYRRDDLARMVRNVLTASRTAQAQAQSASPSAGPAVATDAS
HHHHCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCC
QPPAVLLVEDDTASREAMQEVLTTFGLQCVAAVNAEDALALARTRSVQVLLTDLTLPGQS
CCCEEEEEECCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCEEEEEEEEECCCCC
GANLARTLLRMQPQLQVLLMSGYGTEAEIGEPIAGARLLGKPIDLMTLQQALAPWLGATV
CHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHCCEE
RAADTQNVTNAA
EECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA