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The map label for this gene is norM [H]

Identifier: 187934221

GI number: 187934221

Start: 2722326

End: 2723654

Strand: Reverse

Name: norM [H]

Synonym: CLL_A2613

Alternate gene names: 187934221

Gene position: 2723654-2722326 (Counterclockwise)

Preceding gene: 187933218

Following gene: 187933549

Centisome position: 71.67

GC content: 27.09

Gene sequence:

>1329_bases
ATGAAAAAAGTTGATTTAACTGAAGGAAAAGTAGCAAAAGTAATATTAACATTAGCAATCCCTATAATGGGAAGTTCATT
ATTGCAGTTTGCATATAATTTAATAGATATGATATGGGTTGGCGGACTTGGAAGTAATGCAGTAGCAAGTATAGGATCTT
CAAGTTTTTTTATAGGACTAGGATATTCTATAAATGCTCTAGTGGTAATTGGAGCAGGAATAAAAGTATCACATGCAATA
GGAGAAAAAGATGAAAAATCAATTAAAGGATATATAAATTCAGGGATTTTGATAAATTTAATTTTAGGAATTATATATGC
TTTGATTTTAGTTTTTTTAGGAAAACATTTTATAGGATTTTTACACTTGAACAATTCAGACGTTGAGAGTAAAGCATATT
GGTATCTTGCAATTAGTGCTCCTATGATGTTTTTTACATTTTTTAATATTTTCTATACTAGAATACTAAATAGTTTTGGA
AACAATAAAAGTGCATTAAAAATAAATGCTTTAGGAATAGTAATAAATTTAATATTAGATCCTATTCTTATATATGTTTT
TAAACTAGGTGTAATAGGAGCAGCAGTAGCAACATTAGTTTCAAATTTTGTAATGTTTATAGTATTTAAAATTAATGGTA
GGGATATATTTAAATTTGACTTTAATATTGGAATAGAAAAAGAAAAAGTATTAGAAATAATAAGATTAGGATTTCCAATG
TCTTTTCAAAGAATCTTATTCACATTAGTAAATATAGTACTTGCAAGAATTATAGCTATCTTTGGATCAGATGCTATTGC
AGCTCAAAAGATAGGACTTCAAATAGAATCTATAACTTTTATGGTTATAGGTGGGTTGAATGGTGCTATTGCAAGTTTTG
CAGGACAAAATTATGGGGCTAAAAAATTTAATAGGATTATTAAAGGGTATAGAAGTTCATTGAAAATAGGGATTATATAT
TCGATATTAACAGCAATAGCATTTGCTTTTATGCCAAGTGTTTTAGTAAAAATATTCATTAGAGATGAATCTACTATTTT
AATAGCCAGTGGGTATTTACAAATAATAGCTGTTTCACAGATATTTAGTACTATTGAAATGGTATCTAATGGATTGTTTA
CAGGTATAGGAAAACCTAAAATACCAGCATATATTAGTATAGGTTTTACTATTTTACGAATTCCTATGGCTTTAGTGCTT
ACTAAATTTATGGGGGTAAATGGTATTTGGTGGAGTATAGCTTTATCAAGTATTTTTAAAGGCGTCATTTCTTATATCTT
ATATATATTACAAGTACGAAAGGAGTATAGATATGTTGGGAAATTTTAA

Upstream 100 bases:

>100_bases
GTACAGTGGCATCCGGAAGAAATGAGAGGAAATCAATTTAATATGAGTGATTTATTTAAAGAATTTATAAGTAAAACTTA
GAAAAGAATATGGAGATAAT

Downstream 100 bases:

>100_bases
ACTGTTATTTAAATTTAATTCATTATTTTTAGAAAAAGATAGTTTATTTAAGAGAGAATTCTAACGTAAGTACAGGTGGA
GATAATATAGATTATACTAA

Product: mate efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MKKVDLTEGKVAKVILTLAIPIMGSSLLQFAYNLIDMIWVGGLGSNAVASIGSSSFFIGLGYSINALVVIGAGIKVSHAI
GEKDEKSIKGYINSGILINLILGIIYALILVFLGKHFIGFLHLNNSDVESKAYWYLAISAPMMFFTFFNIFYTRILNSFG
NNKSALKINALGIVINLILDPILIYVFKLGVIGAAVATLVSNFVMFIVFKINGRDIFKFDFNIGIEKEKVLEIIRLGFPM
SFQRILFTLVNIVLARIIAIFGSDAIAAQKIGLQIESITFMVIGGLNGAIASFAGQNYGAKKFNRIIKGYRSSLKIGIIY
SILTAIAFAFMPSVLVKIFIRDESTILIASGYLQIIAVSQIFSTIEMVSNGLFTGIGKPKIPAYISIGFTILRIPMALVL
TKFMGVNGIWWSIALSSIFKGVISYILYILQVRKEYRYVGKF

Sequences:

>Translated_442_residues
MKKVDLTEGKVAKVILTLAIPIMGSSLLQFAYNLIDMIWVGGLGSNAVASIGSSSFFIGLGYSINALVVIGAGIKVSHAI
GEKDEKSIKGYINSGILINLILGIIYALILVFLGKHFIGFLHLNNSDVESKAYWYLAISAPMMFFTFFNIFYTRILNSFG
NNKSALKINALGIVINLILDPILIYVFKLGVIGAAVATLVSNFVMFIVFKINGRDIFKFDFNIGIEKEKVLEIIRLGFPM
SFQRILFTLVNIVLARIIAIFGSDAIAAQKIGLQIESITFMVIGGLNGAIASFAGQNYGAKKFNRIIKGYRSSLKIGIIY
SILTAIAFAFMPSVLVKIFIRDESTILIASGYLQIIAVSQIFSTIEMVSNGLFTGIGKPKIPAYISIGFTILRIPMALVL
TKFMGVNGIWWSIALSSIFKGVISYILYILQVRKEYRYVGKF
>Mature_442_residues
MKKVDLTEGKVAKVILTLAIPIMGSSLLQFAYNLIDMIWVGGLGSNAVASIGSSSFFIGLGYSINALVVIGAGIKVSHAI
GEKDEKSIKGYINSGILINLILGIIYALILVFLGKHFIGFLHLNNSDVESKAYWYLAISAPMMFFTFFNIFYTRILNSFG
NNKSALKINALGIVINLILDPILIYVFKLGVIGAAVATLVSNFVMFIVFKINGRDIFKFDFNIGIEKEKVLEIIRLGFPM
SFQRILFTLVNIVLARIIAIFGSDAIAAQKIGLQIESITFMVIGGLNGAIASFAGQNYGAKKFNRIIKGYRSSLKIGIIY
SILTAIAFAFMPSVLVKIFIRDESTILIASGYLQIIAVSQIFSTIEMVSNGLFTGIGKPKIPAYISIGFTILRIPMALVL
TKFMGVNGIWWSIALSSIFKGVISYILYILQVRKEYRYVGKF

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=435, Percent_Identity=22.7586206896552, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI48994890, Length=421, Percent_Identity=21.3776722090261, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48549; Mature: 48549

Theoretical pI: Translated: 10.37; Mature: 10.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVDLTEGKVAKVILTLAIPIMGSSLLQFAYNLIDMIWVGGLGSNAVASIGSSSFFIGL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCEEEEE
GYSINALVVIGAGIKVSHAIGEKDEKSIKGYINSGILINLILGIIYALILVFLGKHFIGF
CCCCCEEEEEECCCEEEHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEEE
LHLNNSDVESKAYWYLAISAPMMFFTFFNIFYTRILNSFGNNKSALKINALGIVINLILD
EEECCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHH
PILIYVFKLGVIGAAVATLVSNFVMFIVFKINGRDIFKFDFNIGIEKEKVLEIIRLGFPM
HHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCEEEEEECCCCCCHHHHHHHHHHCCCH
SFQRILFTLVNIVLARIIAIFGSDAIAAQKIGLQIESITFMVIGGLNGAIASFAGQNYGA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCEEEEEEEEEEEECCCHHHHHHCCCCCCH
KKFNRIIKGYRSSLKIGIIYSILTAIAFAFMPSVLVKIFIRDESTILIASGYLQIIAVSQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEECCHHHHHHHHH
IFSTIEMVSNGLFTGIGKPKIPAYISIGFTILRIPMALVLTKFMGVNGIWWSIALSSIFK
HHHHHHHHHCCCEECCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
GVISYILYILQVRKEYRYVGKF
HHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKKVDLTEGKVAKVILTLAIPIMGSSLLQFAYNLIDMIWVGGLGSNAVASIGSSSFFIGL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCEEEEE
GYSINALVVIGAGIKVSHAIGEKDEKSIKGYINSGILINLILGIIYALILVFLGKHFIGF
CCCCCEEEEEECCCEEEHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEEE
LHLNNSDVESKAYWYLAISAPMMFFTFFNIFYTRILNSFGNNKSALKINALGIVINLILD
EEECCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHH
PILIYVFKLGVIGAAVATLVSNFVMFIVFKINGRDIFKFDFNIGIEKEKVLEIIRLGFPM
HHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCEEEEEECCCCCCHHHHHHHHHHCCCH
SFQRILFTLVNIVLARIIAIFGSDAIAAQKIGLQIESITFMVIGGLNGAIASFAGQNYGA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCEEEEEEEEEEEECCCHHHHHHCCCCCCH
KKFNRIIKGYRSSLKIGIIYSILTAIAFAFMPSVLVKIFIRDESTILIASGYLQIIAVSQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEECCHHHHHHHHH
IFSTIEMVSNGLFTGIGKPKIPAYISIGFTILRIPMALVLTKFMGVNGIWWSIALSSIFK
HHHHHHHHHCCCEECCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
GVISYILYILQVRKEYRYVGKF
HHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]