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The map label for this gene is trx [H]

Identifier: 187933486

GI number: 187933486

Start: 2643851

End: 2644165

Strand: Reverse

Name: trx [H]

Synonym: CLL_A2536

Alternate gene names: 187933486

Gene position: 2644165-2643851 (Counterclockwise)

Preceding gene: 187935432

Following gene: 187932748

Centisome position: 69.58

GC content: 25.71

Gene sequence:

>315_bases
ATGATAAAGCACATTAATGATTCGAATTTTGAAAATGAAGTTTTAAATTGTAATGAATTAGTTTTGGTGGATTTTTGGGC
AACTTGGTGTGGACCTTGTAGAATGTTATCTCCAGTATTGGAAGAATTAGACGGGGAATTTAAAAATGTTAAATTTACTA
AAATAGATATTGATGAAAATCCATTATCATCTAGATTTAATGAAATTAGAAGTATTCCAACTATAAAACTATTTAAAAAT
GGCAAACCAATAGAAACATCAATAGGATTTTTACCTAAAGAAGCTTTATCAGACTTAATTAAAGATAATTTATAA

Upstream 100 bases:

>100_bases
AATATAGTAAGCATTTTTTATATGAACAATATTAAAGTAACTGAATATTTTGATATAGAGAGTATTAAATTTAGTAGTGA
AATAATTGAGGAGGAAATTT

Downstream 100 bases:

>100_bases
TTTAGGAGTTTAAATTTATGCAAGAACGATATGATATTGCAATAATAGGAAGTGGACCGGCAGGTCTTTCAGCAGCACTA
AATGCCAAAATAAGAAATAA

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 104; Mature: 104

Protein sequence:

>104_residues
MIKHINDSNFENEVLNCNELVLVDFWATWCGPCRMLSPVLEELDGEFKNVKFTKIDIDENPLSSRFNEIRSIPTIKLFKN
GKPIETSIGFLPKEALSDLIKDNL

Sequences:

>Translated_104_residues
MIKHINDSNFENEVLNCNELVLVDFWATWCGPCRMLSPVLEELDGEFKNVKFTKIDIDENPLSSRFNEIRSIPTIKLFKN
GKPIETSIGFLPKEALSDLIKDNL
>Mature_104_residues
MIKHINDSNFENEVLNCNELVLVDFWATWCGPCRMLSPVLEELDGEFKNVKFTKIDIDENPLSSRFNEIRSIPTIKLFKN
GKPIETSIGFLPKEALSDLIKDNL

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI50592994, Length=86, Percent_Identity=36.046511627907, Blast_Score=70, Evalue=3e-13,
Organism=Homo sapiens, GI21361403, Length=94, Percent_Identity=32.9787234042553, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87082331, Length=104, Percent_Identity=42.3076923076923, Blast_Score=99, Evalue=4e-23,
Organism=Escherichia coli, GI1788936, Length=86, Percent_Identity=44.1860465116279, Blast_Score=75, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17569137, Length=83, Percent_Identity=43.3734939759036, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI32566189, Length=83, Percent_Identity=43.3734939759036, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193209454, Length=83, Percent_Identity=43.3734939759036, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=97, Percent_Identity=39.1752577319588, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17554386, Length=90, Percent_Identity=44.4444444444444, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17507705, Length=89, Percent_Identity=33.7078651685393, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=97, Percent_Identity=35.0515463917526, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=89, Percent_Identity=37.0786516853933, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=89, Percent_Identity=37.0786516853933, Blast_Score=65, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323072, Length=100, Percent_Identity=35, Blast_Score=83, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6321648, Length=97, Percent_Identity=34.020618556701, Blast_Score=81, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319925, Length=100, Percent_Identity=40, Blast_Score=75, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17648013, Length=89, Percent_Identity=44.9438202247191, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583090, Length=89, Percent_Identity=44.9438202247191, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573567, Length=89, Percent_Identity=34.8314606741573, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24664269, Length=66, Percent_Identity=45.4545454545455, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11942; Mature: 11942

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKHINDSNFENEVLNCNELVLVDFWATWCGPCRMLSPVLEELDGEFKNVKFTKIDIDEN
CCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEEECCCC
PLSSRFNEIRSIPTIKLFKNGKPIETSIGFLPKEALSDLIKDNL
CHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MIKHINDSNFENEVLNCNELVLVDFWATWCGPCRMLSPVLEELDGEFKNVKFTKIDIDEN
CCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEEECCCC
PLSSRFNEIRSIPTIKLFKNGKPIETSIGFLPKEALSDLIKDNL
CHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]