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The map label for this gene is toxA [H]

Identifier: 187933118

GI number: 187933118

Start: 3370438

End: 3371922

Strand: Reverse

Name: toxA [H]

Synonym: CLL_A3227

Alternate gene names: 187933118

Gene position: 3371922-3370438 (Counterclockwise)

Preceding gene: 187935395

Following gene: 187933855

Centisome position: 88.73

GC content: 31.58

Gene sequence:

>1485_bases
ATGATAAAAAGAATTAAGAAAATAATGGCATTAGTGCTTGTTGCAACTTCTGTAGTAGCTATAGCACCTAGAGAAATGTT
TAAAGGAAATGTTACTGCTTATGCAGCGACAACAAAAGAAGGGATGCCTACAGAACAAGAAATAATAGGTGCATTACAAG
AGGAGCTAAAAAAAGAGTATTTAGGATGTTTAGCAGTTAAAGTAATTCCAGAACCAGTAAAAACTTTAAATATAACATTA
ACTACTAGTGAAGCAACTAAAATAGCAACTCCAATTGCGGAAAAGAAGGCAAAACAAATAGTTGAAGCAAAAGGATTGCA
TGATGGTGATCCTGGATATGATGATGCAGTTAAAGCTACAACTAAGGTAATACTTACACAACTTGTACCAGTATTGCAAG
CTGCGTGTAAAAACATTCCAATATATAAATATGCAGCAATAGGAACTGATGGACAAACAGTTATTGGTAAGGGGTTTGTT
GTTGGAGGAGGCGTAGAAGCATTATTACTTCAAACAGGAAAATCACCTATATATGTAGATGCAACTAATTTAGATAATAC
TATTGTAAATGAATTAATAGATAAGATAAAAGGTGCAATAGGTAATATTAGTAGTACTATTACTGACGCTTTAGATGATA
TAGCTCATTCTGTGGATAAAATTTCAAATTCTATAACTGATTTATTTGATGATTTAGATGACAGTACTGATGATTTCTTT
GATAAAATAAATAAAGATGAAGGCTGGGATAAGCATGACGGATATGTTTATTACTATGATGAAGATGGTATTAAGTATAG
AGGCGTTCATGAAATAAAAGGAAAGAATTATTATTTTAATAGAGTTGATGGAGCCATGGAAACAGGATGGCAAATTGTTG
ATGGAAAGAGATGCTATTTTTCCCCTAAAAAAGGATATCAACTTTATAGTCAATGGATAAAAGATGGAGATAAGATATAT
TGTCTTGATGAAAAAGGTGAAGTTAGAAAATCACAATGGGCTCAAGATGGAGCGAATTCATGTTACTTAAAAGCTGATGG
AACAGTAGCTAAAGGATGGTATTCTGTAAATAGAGATGAAAGATATTACTTTAATGAAACTACTGGATATATAGAAACAT
CAAAGTGGATATATGATGATCAAGAATGGTACTATTTAAAAGATAGTGGAGTAGCAGCAACTGATTGGGAATGTGTTAAT
GGAAAATGGTATTGCTTTAAATCAACTGGTAAATTGTATTCAGGTTGGTTTAGAAATGAAGGTAGCTGGTATTATTCGGA
TTCTACTGGAGCTATGCAAACAGGTTGGGTATATCATAAAAATAAGTGGTTTTATTTAGATGATAGTGGAAAAATGAAAA
AGAATGAGTGGTTATCAGTAAATGGCAAATGGTATTACTTTAATTTAAATGGAGAAATGATTACTAGTTCAAGATATATA
GATGGAACAAAATATCACTTTAATTCAGACGGAAGTTTACAATAA

Upstream 100 bases:

>100_bases
AATAAATGAACTTGTAAATATTGAAGTCTAATATAGTACATAAAACTAGAATTTATTATAGTGAATTTTTTGATTTTAAA
GTTATCAAGGGGGAAGAACG

Downstream 100 bases:

>100_bases
TAGTATTTACTATTTGGTGGCAGTTATTTTATAGTATAACTGCCACTTGTTTTATATTCAAATGATATTGTAACAGTAAT
TTTTGTGTTTCTAATTTGGA

Product: collagenolytic protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MIKRIKKIMALVLVATSVVAIAPREMFKGNVTAYAATTKEGMPTEQEIIGALQEELKKEYLGCLAVKVIPEPVKTLNITL
TTSEATKIATPIAEKKAKQIVEAKGLHDGDPGYDDAVKATTKVILTQLVPVLQAACKNIPIYKYAAIGTDGQTVIGKGFV
VGGGVEALLLQTGKSPIYVDATNLDNTIVNELIDKIKGAIGNISSTITDALDDIAHSVDKISNSITDLFDDLDDSTDDFF
DKINKDEGWDKHDGYVYYYDEDGIKYRGVHEIKGKNYYFNRVDGAMETGWQIVDGKRCYFSPKKGYQLYSQWIKDGDKIY
CLDEKGEVRKSQWAQDGANSCYLKADGTVAKGWYSVNRDERYYFNETTGYIETSKWIYDDQEWYYLKDSGVAATDWECVN
GKWYCFKSTGKLYSGWFRNEGSWYYSDSTGAMQTGWVYHKNKWFYLDDSGKMKKNEWLSVNGKWYYFNLNGEMITSSRYI
DGTKYHFNSDGSLQ

Sequences:

>Translated_494_residues
MIKRIKKIMALVLVATSVVAIAPREMFKGNVTAYAATTKEGMPTEQEIIGALQEELKKEYLGCLAVKVIPEPVKTLNITL
TTSEATKIATPIAEKKAKQIVEAKGLHDGDPGYDDAVKATTKVILTQLVPVLQAACKNIPIYKYAAIGTDGQTVIGKGFV
VGGGVEALLLQTGKSPIYVDATNLDNTIVNELIDKIKGAIGNISSTITDALDDIAHSVDKISNSITDLFDDLDDSTDDFF
DKINKDEGWDKHDGYVYYYDEDGIKYRGVHEIKGKNYYFNRVDGAMETGWQIVDGKRCYFSPKKGYQLYSQWIKDGDKIY
CLDEKGEVRKSQWAQDGANSCYLKADGTVAKGWYSVNRDERYYFNETTGYIETSKWIYDDQEWYYLKDSGVAATDWECVN
GKWYCFKSTGKLYSGWFRNEGSWYYSDSTGAMQTGWVYHKNKWFYLDDSGKMKKNEWLSVNGKWYYFNLNGEMITSSRYI
DGTKYHFNSDGSLQ
>Mature_494_residues
MIKRIKKIMALVLVATSVVAIAPREMFKGNVTAYAATTKEGMPTEQEIIGALQEELKKEYLGCLAVKVIPEPVKTLNITL
TTSEATKIATPIAEKKAKQIVEAKGLHDGDPGYDDAVKATTKVILTQLVPVLQAACKNIPIYKYAAIGTDGQTVIGKGFV
VGGGVEALLLQTGKSPIYVDATNLDNTIVNELIDKIKGAIGNISSTITDALDDIAHSVDKISNSITDLFDDLDDSTDDFF
DKINKDEGWDKHDGYVYYYDEDGIKYRGVHEIKGKNYYFNRVDGAMETGWQIVDGKRCYFSPKKGYQLYSQWIKDGDKIY
CLDEKGEVRKSQWAQDGANSCYLKADGTVAKGWYSVNRDERYYFNETTGYIETSKWIYDDQEWYYLKDSGVAATDWECVN
GKWYCFKSTGKLYSGWFRNEGSWYYSDSTGAMQTGWVYHKNKWFYLDDSGKMKKNEWLSVNGKWYYFNLNGEMITSSRYI
DGTKYHFNSDGSLQ

Specific function: Only after the enteral delivery of the enterotoxin A may the characteristic disease called pseudomembranous colitis be induced [H]

COG id: COG5263

COG function: function code R; FOG: Glucan-binding domain (YG repeat)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 32 cell wall-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018337
- InterPro:   IPR007577
- InterPro:   IPR020974 [H]

Pfam domain/function: PF01473 CW_binding_1; PF04488 Gly_transf_sug; PF11713 Peptidase_C80 [H]

EC number: NA

Molecular weight: Translated: 55797; Mature: 55797

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKRIKKIMALVLVATSVVAIAPREMFKGNVTAYAATTKEGMPTEQEIIGALQEELKKEY
CHHHHHHHHHHHHHHHHHHHHCCHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
LGCLAVKVIPEPVKTLNITLTTSEATKIATPIAEKKAKQIVEAKGLHDGDPGYDDAVKAT
HHEEEEEECCCCCEEEEEEEEECCCHHHHCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
TKVILTQLVPVLQAACKNIPIYKYAAIGTDGQTVIGKGFVVGGGVEALLLQTGKSPIYVD
HHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEECCEEECCCCEEEEEECCCCCEEEE
ATNLDNTIVNELIDKIKGAIGNISSTITDALDDIAHSVDKISNSITDLFDDLDDSTDDFF
CCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
DKINKDEGWDKHDGYVYYYDEDGIKYRGVHEIKGKNYYFNRVDGAMETGWQIVDGKRCYF
HHCCCCCCCCCCCCEEEEECCCCCEECCEEEECCCCEEEECCCCHHHCCCEEECCCEEEE
SPKKGYQLYSQWIKDGDKIYCLDEKGEVRKSQWAQDGANSCYLKADGTVAKGWYSVNRDE
CCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCCCEEEEEECCCEEECEEECCCCC
RYYFNETTGYIETSKWIYDDQEWYYLKDSGVAATDWECVNGKWYCFKSTGKLYSGWFRNE
EEEEECCCCEEEECCEEECCCCEEEEECCCCEECCCEEECCEEEEECCCCCEEECEECCC
GSWYYSDSTGAMQTGWVYHKNKWFYLDDSGKMKKNEWLSVNGKWYYFNLNGEMITSSRYI
CCEEEECCCCCEEECEEEECCEEEEECCCCCCCCCCEEEECCEEEEEEECCEEEECCEEE
DGTKYHFNSDGSLQ
CCCEEEECCCCCCC
>Mature Secondary Structure
MIKRIKKIMALVLVATSVVAIAPREMFKGNVTAYAATTKEGMPTEQEIIGALQEELKKEY
CHHHHHHHHHHHHHHHHHHHHCCHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
LGCLAVKVIPEPVKTLNITLTTSEATKIATPIAEKKAKQIVEAKGLHDGDPGYDDAVKAT
HHEEEEEECCCCCEEEEEEEEECCCHHHHCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
TKVILTQLVPVLQAACKNIPIYKYAAIGTDGQTVIGKGFVVGGGVEALLLQTGKSPIYVD
HHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEECCEEECCCCEEEEEECCCCCEEEE
ATNLDNTIVNELIDKIKGAIGNISSTITDALDDIAHSVDKISNSITDLFDDLDDSTDDFF
CCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
DKINKDEGWDKHDGYVYYYDEDGIKYRGVHEIKGKNYYFNRVDGAMETGWQIVDGKRCYF
HHCCCCCCCCCCCCEEEEECCCCCEECCEEEECCCCEEEECCCCHHHCCCEEECCCEEEE
SPKKGYQLYSQWIKDGDKIYCLDEKGEVRKSQWAQDGANSCYLKADGTVAKGWYSVNRDE
CCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCCCEEEEEECCCEEECEEECCCCC
RYYFNETTGYIETSKWIYDDQEWYYLKDSGVAATDWECVNGKWYCFKSTGKLYSGWFRNE
EEEEECCCCEEEECCEEECCCCEEEEECCCCEECCCEEECCEEEEECCCCCEEECEECCC
GSWYYSDSTGAMQTGWVYHKNKWFYLDDSGKMKKNEWLSVNGKWYYFNLNGEMITSSRYI
CCEEEECCCCCEEECEEEECCEEEEECCCCCCCCCCEEEECCEEEEEEECCEEEECCEEE
DGTKYHFNSDGSLQ
CCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2109310; 2105276 [H]