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The map label for this gene is adk [H]

Identifier: 187918282

GI number: 187918282

Start: 431162

End: 431794

Strand: Direct

Name: adk [H]

Synonym: BH0417

Alternate gene names: 187918282

Gene position: 431162-431794 (Clockwise)

Preceding gene: 187918281

Following gene: 187918283

Centisome position: 46.75

GC content: 30.81

Gene sequence:

>633_bases
ATGAAGCTTGTTTTTTTAGGGCCCCCGGGTTCTGGAAAAGGTACAATTGCCAAGATCCTCTCAAATAAATTAAATTACTA
TCATATCTCAACAGGGGATTTATTTAGAGAAAATATATCAAATGCTACACCTCTTGGTAAGGAAATCAAACAAATAGTTG
AGAATGGACAATTAGTCCCCGACTCAATCACAATTAAAATTGTTGAAGATAAAATCAATACCCTTGAAAATAAGGATAAT
TTTATTCTTGATGGATTTCCCAGAAACATCAATCAAGCCAAAGCTCTAGATAAGTTCTTGAAAAATATTCAAATAATAAA
TTTTTTACTCGATGAAGAAATACTAATAAAAAGGCTTTCTGGCAGAAGAATATGCAAGTCTTGCGGAGGAATATTTAACA
TATACACACTTCCTACAAAAGAAAAGGAAATTTGTGATCTTTGTAAAGGTATCCTTTACCAACGAAAAGATGATACAGAG
GGGTCTTTAAAAGTTAGACTTCAAGAATATCACTTACAAACAAAACCACTAACAGATTTTTACTCAAAAAGCAACAGGCT
TAATAATATTAATGCATCAAAGGATATTGATGAAGTGGAAAAAAGCTTAATGGAAATAATATCAAAAAGTTAA

Upstream 100 bases:

>100_bases
CATTGGGTCTGCAATTGGAACAATTGTTGGATTTCAATTCTTGTTAAATATTTTTAGCTAAATACCAAAAAGAAAAATAA
AAATATACAGGAGTCACATT

Downstream 100 bases:

>100_bases
ATATTAATTTAAAATAATGCCAAATAATTTATTTTTTTTAAAAAAAAAGGTACAATACAGAAAATATGGAAGGAGATTTT
ATTACAGCAAGAATTTATAT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MKLVFLGPPGSGKGTIAKILSNKLNYYHISTGDLFRENISNATPLGKEIKQIVENGQLVPDSITIKIVEDKINTLENKDN
FILDGFPRNINQAKALDKFLKNIQIINFLLDEEILIKRLSGRRICKSCGGIFNIYTLPTKEKEICDLCKGILYQRKDDTE
GSLKVRLQEYHLQTKPLTDFYSKSNRLNNINASKDIDEVEKSLMEIISKS

Sequences:

>Translated_210_residues
MKLVFLGPPGSGKGTIAKILSNKLNYYHISTGDLFRENISNATPLGKEIKQIVENGQLVPDSITIKIVEDKINTLENKDN
FILDGFPRNINQAKALDKFLKNIQIINFLLDEEILIKRLSGRRICKSCGGIFNIYTLPTKEKEICDLCKGILYQRKDDTE
GSLKVRLQEYHLQTKPLTDFYSKSNRLNNINASKDIDEVEKSLMEIISKS
>Mature_210_residues
MKLVFLGPPGSGKGTIAKILSNKLNYYHISTGDLFRENISNATPLGKEIKQIVENGQLVPDSITIKIVEDKINTLENKDN
FILDGFPRNINQAKALDKFLKNIQIINFLLDEEILIKRLSGRRICKSCGGIFNIYTLPTKEKEICDLCKGILYQRKDDTE
GSLKVRLQEYHLQTKPLTDFYSKSNRLNNINASKDIDEVEKSLMEIISKS

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=215, Percent_Identity=36.2790697674419, Blast_Score=151, Evalue=5e-37,
Organism=Homo sapiens, GI4502013, Length=215, Percent_Identity=36.2790697674419, Blast_Score=150, Evalue=5e-37,
Organism=Homo sapiens, GI19923437, Length=194, Percent_Identity=33.5051546391753, Blast_Score=128, Evalue=4e-30,
Organism=Homo sapiens, GI310110345, Length=196, Percent_Identity=33.6734693877551, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI53832003, Length=196, Percent_Identity=33.6734693877551, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI8051579, Length=196, Percent_Identity=33.6734693877551, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI53832001, Length=196, Percent_Identity=33.6734693877551, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI4502011, Length=204, Percent_Identity=29.9019607843137, Blast_Score=101, Evalue=5e-22,
Organism=Homo sapiens, GI7706497, Length=217, Percent_Identity=30.8755760368664, Blast_Score=94, Evalue=7e-20,
Organism=Homo sapiens, GI28144897, Length=206, Percent_Identity=27.6699029126214, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI28144899, Length=206, Percent_Identity=27.6699029126214, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI22749187, Length=189, Percent_Identity=26.4550264550265, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1786680, Length=214, Percent_Identity=34.5794392523364, Blast_Score=143, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17552384, Length=214, Percent_Identity=34.5794392523364, Blast_Score=147, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17533833, Length=200, Percent_Identity=31, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17567503, Length=197, Percent_Identity=28.4263959390863, Blast_Score=97, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17550688, Length=214, Percent_Identity=29.4392523364486, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17537943, Length=188, Percent_Identity=28.7234042553192, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320432, Length=215, Percent_Identity=37.6744186046512, Blast_Score=153, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6321018, Length=195, Percent_Identity=30.7692307692308, Blast_Score=105, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6322828, Length=212, Percent_Identity=26.4150943396226, Blast_Score=86, Evalue=5e-18,
Organism=Drosophila melanogaster, GI22026816, Length=211, Percent_Identity=36.0189573459716, Blast_Score=150, Evalue=6e-37,
Organism=Drosophila melanogaster, GI17737899, Length=183, Percent_Identity=37.1584699453552, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24645822, Length=183, Percent_Identity=37.1584699453552, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI221459597, Length=215, Percent_Identity=28.3720930232558, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21356893, Length=215, Percent_Identity=28.3720930232558, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17647141, Length=207, Percent_Identity=22.2222222222222, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24663208, Length=207, Percent_Identity=22.2222222222222, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23850; Mature: 23850

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVFLGPPGSGKGTIAKILSNKLNYYHISTGDLFRENISNATPLGKEIKQIVENGQLVP
CEEEEECCCCCCCHHHHHHHHCCCCEEEECCHHHHHHHCCCCCCCHHHHHHHHHCCCCCC
DSITIKIVEDKINTLENKDNFILDGFPRNINQAKALDKFLKNIQIINFLLDEEILIKRLS
CCEEEEEEHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GRRICKSCGGIFNIYTLPTKEKEICDLCKGILYQRKDDTEGSLKVRLQEYHLQTKPLTDF
CHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHCCCCCHHHH
YSKSNRLNNINASKDIDEVEKSLMEIISKS
HHHCCCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLVFLGPPGSGKGTIAKILSNKLNYYHISTGDLFRENISNATPLGKEIKQIVENGQLVP
CEEEEECCCCCCCHHHHHHHHCCCCEEEECCHHHHHHHCCCCCCCHHHHHHHHHCCCCCC
DSITIKIVEDKINTLENKDNFILDGFPRNINQAKALDKFLKNIQIINFLLDEEILIKRLS
CCEEEEEEHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GRRICKSCGGIFNIYTLPTKEKEICDLCKGILYQRKDDTEGSLKVRLQEYHLQTKPLTDF
CHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHCCCCCHHHH
YSKSNRLNNINASKDIDEVEKSLMEIISKS
HHHCCCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA