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The map label for this gene is mutL [H]

Identifier: 187918084

GI number: 187918084

Start: 214488

End: 216326

Strand: Direct

Name: mutL [H]

Synonym: BH0211

Alternate gene names: 187918084

Gene position: 214488-216326 (Clockwise)

Preceding gene: 187918083

Following gene: 187918085

Centisome position: 23.26

GC content: 29.04

Gene sequence:

>1839_bases
ATGAACAAAATAAAATTTTTAGACAAAAGTCTAGTACAAAAAATAGCAGCAGGAGAAGCCATAGACAGGCCTTGTTCTAT
TTTAAGAGAATTACTTGACAATGCAATAGATTCTGGAGCGGATAAAATCGAAGTTTTTATTGAAGAAGGTGGTATTCGAA
GAATACTAATAACAGATAATGGTAGCGGAATAAGCAGAGAAGACTTAAAAATATGTTACCTACCCCACACTACTTCAAAA
ATAAATGAAGAACAAGACCTTGAAAAAATCCAAACACTAGGATTTAGAGGAGAAGCTCTCTCAAGCATTGCCATTTGTTC
AAATCTCACAATAACAAGTTCAACTACAGGAGAAGACAGCTACCAAATTGAAGTTGAAAATGGAACTGAAAAGTATTTTA
AAAAACAATCCGCAATAAATGGAACAATAGTAGATGTTACAAATTTATTTCACAATTTTCCAGCAAGAAAAAGATTCTTA
AAAAAAGACTCTATCGAGACAAAAATGTGTTTAAAAGTTTTTGAAGAAAAGGCTGTCACTCATCCTGGTATTGACTTTAA
ATTAAATATAAACAATGAATTGAGAAAAGTTTACTTTAAAGAAAGCTTAATAGATAGGGTTCAAAGTGTATATGGAGAAA
TAATAGATAACAATAAATTTGGAAAAATAGAAGCAGAATATGAAAATATACAAATGAAGATCTTTTTTGCTCCACCCAAC
TTCTCAAGGAAAGACAAACGAAACATAAAAATCTTCGTCAATAGAAGACCTGTTGAAGAGAAAAACCTATCTGAAGCAAT
AATTGATGGACATAGCAGAATACTAACTAATAGAAATTTTCCAGTATGTTACCTATTCTTAGAAATAGATCCCAGATACA
TCGATTTCAATATACACCCTCAAAAAAAAGAAGTAAGATTTTTTAACTTGCCATTTCTTCCTAAACAAATTGCAAGCAAT
ATTAATGAATTCTTTGACAGAGGGCAAAAAGAAATTTTACAAGACTACCATAACATAATAATCAAAAGGCAACTAACAAA
TGATGATCATCTATTACACACTGAGGATGATCCAACAAACTCAGATTTTCAAGCTTATAAAATCACACAAAACGAAGCAT
TAACTTTAGACAAGCCTCAAAACAATAAAATAACAAACATAATAGAAGACAAGGTAAAATTTGAAAGTCAACCCCCAACT
CAAAAAGATAAACCATCATTCAAAAACTACATACAAAATATTTTTCTAAAAACTTCCACAATGCTAAATGATTTACAAAA
ACCAATAGAAAAACATGAATTTAAATACATAGGACAACTATTTTCGGAATTTTTAATAGTAGAAAGCGATAATGAAGTTT
ACTTCATAGATCAACACGCACTTCATGAAAAAATTATATATCAAATCCTAATAAAATCAGAAAAAATTATTCAAAAACTT
CTAGTACCAATTGAGTTTCAAGTAGACTGTGAAGATAAAGATAAAATACTAGCAAGCGAATTGGAAGAATATAAAAAAAT
AGATATTACAGTTAACAAAATAAAGGAGCAAACTTATCAACTCGAATCAATTCCCAATATCTGTAACAAGTATGAAAGTG
TTATCATTCAATTTCTAAAGACAAGAAAAAGCAAAACAATTGATTCTCTAGAAGCCGACTTATATGCAACTATTGCATGT
AGACAAGCCATTAAACGCAATGATACAATAAGTTCTGAATTTAGTCAATTTTTAATAAACGAATTTTTCAATCTCAAGCT
AAAACATTGTCCACATGGAAGAAAAATTTACCATAAAATCTCTAAATTTGAGCTTGAAAAAAATGTTAACAGAAAATAA

Upstream 100 bases:

>100_bases
TAGAATATAATGATAATGGAAGTGACAAAATACTTAAAGAAGTGATTAACAAATTTCCTAATTACAAACAAAATAAAACA
ATAATGAAAATAATAGGCAA

Downstream 100 bases:

>100_bases
AATAAACATGGAAGCCGGTAATGATAAAAACTCTTAAATCGAAAATTAAAAAACTAATACCACAAAGAGATAAAAAATTA
GTTGAACTTGGGAAGGCGCT

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 612; Mature: 612

Protein sequence:

>612_residues
MNKIKFLDKSLVQKIAAGEAIDRPCSILRELLDNAIDSGADKIEVFIEEGGIRRILITDNGSGISREDLKICYLPHTTSK
INEEQDLEKIQTLGFRGEALSSIAICSNLTITSSTTGEDSYQIEVENGTEKYFKKQSAINGTIVDVTNLFHNFPARKRFL
KKDSIETKMCLKVFEEKAVTHPGIDFKLNINNELRKVYFKESLIDRVQSVYGEIIDNNKFGKIEAEYENIQMKIFFAPPN
FSRKDKRNIKIFVNRRPVEEKNLSEAIIDGHSRILTNRNFPVCYLFLEIDPRYIDFNIHPQKKEVRFFNLPFLPKQIASN
INEFFDRGQKEILQDYHNIIIKRQLTNDDHLLHTEDDPTNSDFQAYKITQNEALTLDKPQNNKITNIIEDKVKFESQPPT
QKDKPSFKNYIQNIFLKTSTMLNDLQKPIEKHEFKYIGQLFSEFLIVESDNEVYFIDQHALHEKIIYQILIKSEKIIQKL
LVPIEFQVDCEDKDKILASELEEYKKIDITVNKIKEQTYQLESIPNICNKYESVIIQFLKTRKSKTIDSLEADLYATIAC
RQAIKRNDTISSEFSQFLINEFFNLKLKHCPHGRKIYHKISKFELEKNVNRK

Sequences:

>Translated_612_residues
MNKIKFLDKSLVQKIAAGEAIDRPCSILRELLDNAIDSGADKIEVFIEEGGIRRILITDNGSGISREDLKICYLPHTTSK
INEEQDLEKIQTLGFRGEALSSIAICSNLTITSSTTGEDSYQIEVENGTEKYFKKQSAINGTIVDVTNLFHNFPARKRFL
KKDSIETKMCLKVFEEKAVTHPGIDFKLNINNELRKVYFKESLIDRVQSVYGEIIDNNKFGKIEAEYENIQMKIFFAPPN
FSRKDKRNIKIFVNRRPVEEKNLSEAIIDGHSRILTNRNFPVCYLFLEIDPRYIDFNIHPQKKEVRFFNLPFLPKQIASN
INEFFDRGQKEILQDYHNIIIKRQLTNDDHLLHTEDDPTNSDFQAYKITQNEALTLDKPQNNKITNIIEDKVKFESQPPT
QKDKPSFKNYIQNIFLKTSTMLNDLQKPIEKHEFKYIGQLFSEFLIVESDNEVYFIDQHALHEKIIYQILIKSEKIIQKL
LVPIEFQVDCEDKDKILASELEEYKKIDITVNKIKEQTYQLESIPNICNKYESVIIQFLKTRKSKTIDSLEADLYATIAC
RQAIKRNDTISSEFSQFLINEFFNLKLKHCPHGRKIYHKISKFELEKNVNRK
>Mature_612_residues
MNKIKFLDKSLVQKIAAGEAIDRPCSILRELLDNAIDSGADKIEVFIEEGGIRRILITDNGSGISREDLKICYLPHTTSK
INEEQDLEKIQTLGFRGEALSSIAICSNLTITSSTTGEDSYQIEVENGTEKYFKKQSAINGTIVDVTNLFHNFPARKRFL
KKDSIETKMCLKVFEEKAVTHPGIDFKLNINNELRKVYFKESLIDRVQSVYGEIIDNNKFGKIEAEYENIQMKIFFAPPN
FSRKDKRNIKIFVNRRPVEEKNLSEAIIDGHSRILTNRNFPVCYLFLEIDPRYIDFNIHPQKKEVRFFNLPFLPKQIASN
INEFFDRGQKEILQDYHNIIIKRQLTNDDHLLHTEDDPTNSDFQAYKITQNEALTLDKPQNNKITNIIEDKVKFESQPPT
QKDKPSFKNYIQNIFLKTSTMLNDLQKPIEKHEFKYIGQLFSEFLIVESDNEVYFIDQHALHEKIIYQILIKSEKIIQKL
LVPIEFQVDCEDKDKILASELEEYKKIDITVNKIKEQTYQLESIPNICNKYESVIIQFLKTRKSKTIDSLEADLYATIAC
RQAIKRNDTISSEFSQFLINEFFNLKLKHCPHGRKIYHKISKFELEKNVNRK

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=313, Percent_Identity=35.7827476038339, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI4505911, Length=324, Percent_Identity=29.0123456790123, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI189458898, Length=324, Percent_Identity=29.0123456790123, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI189458896, Length=315, Percent_Identity=28.2539682539683, Blast_Score=109, Evalue=1e-23,
Organism=Homo sapiens, GI310128478, Length=360, Percent_Identity=23.8888888888889, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI4505913, Length=339, Percent_Identity=24.4837758112094, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI263191589, Length=219, Percent_Identity=31.5068493150685, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI310128480, Length=292, Percent_Identity=23.972602739726, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI91992162, Length=274, Percent_Identity=27.007299270073, Blast_Score=67, Evalue=6e-11,
Organism=Homo sapiens, GI91992160, Length=274, Percent_Identity=27.007299270073, Blast_Score=67, Evalue=7e-11,
Organism=Escherichia coli, GI1790612, Length=515, Percent_Identity=26.4077669902913, Blast_Score=176, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI71991825, Length=326, Percent_Identity=29.7546012269939, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17562796, Length=340, Percent_Identity=25, Blast_Score=113, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6323819, Length=331, Percent_Identity=35.3474320241692, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6324247, Length=360, Percent_Identity=29.4444444444444, Blast_Score=136, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6325093, Length=289, Percent_Identity=25.2595155709343, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323063, Length=327, Percent_Identity=28.7461773700306, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17136968, Length=318, Percent_Identity=33.6477987421384, Blast_Score=165, Evalue=1e-40,
Organism=Drosophila melanogaster, GI17136970, Length=174, Percent_Identity=36.2068965517241, Blast_Score=101, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 71441; Mature: 71441

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1 ; PS00659 GLYCOSYL_HYDROL_F5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIKFLDKSLVQKIAAGEAIDRPCSILRELLDNAIDSGADKIEVFIEEGGIRRILITDN
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEEECC
GSGISREDLKICYLPHTTSKINEEQDLEKIQTLGFRGEALSSIAICSNLTITSSTTGEDS
CCCCCCCCCEEEEECCCCHHCCCHHHHHHHHHCCCCCHHHHHHHHHCCCEEECCCCCCCC
YQIEVENGTEKYFKKQSAINGTIVDVTNLFHNFPARKRFLKKDSIETKMCLKVFEEKAVT
EEEEECCCHHHHHHHHHCCCCEEEEHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHCCC
HPGIDFKLNINNELRKVYFKESLIDRVQSVYGEIIDNNKFGKIEAEYENIQMKIFFAPPN
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCEEEEEEECCCC
FSRKDKRNIKIFVNRRPVEEKNLSEAIIDGHSRILTNRNFPVCYLFLEIDPRYIDFNIHP
CCCCCCCCEEEEEECCCCCCCCHHHHHHCCCHHEEECCCCCEEEEEEEECCEEEEEEECC
QKKEVRFFNLPFLPKQIASNINEFFDRGQKEILQDYHNIIIKRQLTNDDHLLHTEDDPTN
CCCCEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHEEEEEECCCCCEEECCCCCCC
SDFQAYKITQNEALTLDKPQNNKITNIIEDKVKFESQPPTQKDKPSFKNYIQNIFLKTST
CCCEEEEEECCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
MLNDLQKPIEKHEFKYIGQLFSEFLIVESDNEVYFIDQHALHEKIIYQILIKSEKIIQKL
HHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHH
LVPIEFQVDCEDKDKILASELEEYKKIDITVNKIKEQTYQLESIPNICNKYESVIIQFLK
HCCCEEEECCCCHHHHHHHHHHHHHEECEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRKSKTIDSLEADLYATIACRQAIKRNDTISSEFSQFLINEFFNLKLKHCPHGRKIYHKI
HHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEECCCCCHHHHHHH
SKFELEKNVNRK
HHHHHHHCCCCC
>Mature Secondary Structure
MNKIKFLDKSLVQKIAAGEAIDRPCSILRELLDNAIDSGADKIEVFIEEGGIRRILITDN
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEEECC
GSGISREDLKICYLPHTTSKINEEQDLEKIQTLGFRGEALSSIAICSNLTITSSTTGEDS
CCCCCCCCCEEEEECCCCHHCCCHHHHHHHHHCCCCCHHHHHHHHHCCCEEECCCCCCCC
YQIEVENGTEKYFKKQSAINGTIVDVTNLFHNFPARKRFLKKDSIETKMCLKVFEEKAVT
EEEEECCCHHHHHHHHHCCCCEEEEHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHCCC
HPGIDFKLNINNELRKVYFKESLIDRVQSVYGEIIDNNKFGKIEAEYENIQMKIFFAPPN
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCEEEEEEECCCC
FSRKDKRNIKIFVNRRPVEEKNLSEAIIDGHSRILTNRNFPVCYLFLEIDPRYIDFNIHP
CCCCCCCCEEEEEECCCCCCCCHHHHHHCCCHHEEECCCCCEEEEEEEECCEEEEEEECC
QKKEVRFFNLPFLPKQIASNINEFFDRGQKEILQDYHNIIIKRQLTNDDHLLHTEDDPTN
CCCCEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHEEEEEECCCCCEEECCCCCCC
SDFQAYKITQNEALTLDKPQNNKITNIIEDKVKFESQPPTQKDKPSFKNYIQNIFLKTST
CCCEEEEEECCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
MLNDLQKPIEKHEFKYIGQLFSEFLIVESDNEVYFIDQHALHEKIIYQILIKSEKIIQKL
HHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHH
LVPIEFQVDCEDKDKILASELEEYKKIDITVNKIKEQTYQLESIPNICNKYESVIIQFLK
HCCCEEEECCCCHHHHHHHHHHHHHEECEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRKSKTIDSLEADLYATIACRQAIKRNDTISSEFSQFLINEFFNLKLKHCPHGRKIYHKI
HHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEECCCCCHHHHHHH
SKFELEKNVNRK
HHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA