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The map label for this gene is yedV [H]

Identifier: 187733083

GI number: 187733083

Start: 853900

End: 855258

Strand: Direct

Name: yedV [H]

Synonym: SbBS512_E0915

Alternate gene names: 187733083

Gene position: 853900-855258 (Clockwise)

Preceding gene: 187732444

Following gene: 187731198

Centisome position: 18.5

GC content: 39.66

Gene sequence:

>1359_bases
ATGAAAAGATTGTCTATAACCGTCCGTTTAACCTTGCTTTTTATATTGCTGCTGTCTGTTGCTGGCGCTGGAATTGTATG
GACTCTCTATAATGGCCTGGCAAGTGAGTTGAAATGGCGCGATGATACAACACTCATTAACCGGACAGCGCAGATCAAGC
AGTTGTTAATTGATGGGGTAAATCCAGATACGTTACCTGTGTACTTTAACCGGATGATGGATGTTAGTCAGGATATCTTG
ATCATTCATGGTGATGGTATCAATAAAATTGTTAACCGGACAAATGTCAGTGATGGCATGTTAAATAACATACCTGCTAG
TGAGACAATCAGCGCAGCTGGCATTTACAGAAGCATTATTAATGACACTGAGATTGATGCTTTACGAATTAATATTGATG
AAGTTTCGCCATCATTAACGGTTACTGTGGCTAAATTGGCTTCAGCCAGACATAACATGCTTGAACAGTATAAAATTAAT
AGCATTATAATTTGCATTGTCGCCATTGTACTTTGCTCAGTATTAAGTCCGCTGTTAATCAGAACGGGATTACGAGAGAT
CAAAAAGTTGAGTGGTGTAACGGAAGCGCTGAATTATAACGATAGCCGGGAGCCTGTTGAGGTTAGCGTATTACCGAGAG
AACTAAAACCTCTTGGGCAGGCGTTGAATAAAATGCATCAAGCCTTAGTCAAAGATTTTGAACGCCTAAGTCAATTTGCT
GACGATCTCGCTCATGAACTTAGAACGCCCATTAATGCATTACTGGGTCAGAATCAGGTTACGCTCAGTCAAACCAGAAG
TATCGCTGAATATCAAAAAACAATTGCCGGTAACATTGAAGAGCTGGAAAATATTTCGCGGTTAACAGAGAACATACTGT
TTCTTGCCCGGGCAGATAAAAACAATGTTTTGGTGAAACTGGACTCGCTTTCTCTCAATAAGGAAGTCGAAAATTTGTTG
GATTATCTTGAATACCTTTCAGACGAGAAAGAGATTTGCTTTAAGGTCGAGTGCAATCAGCAAATCTTTGCGGATAAAAT
TTTACTGCAACGAATGTTATCGAATCTTATTGTTAATGCCATTAGATATTCACCAGAAAAATCGCGTATTCATATAACCA
GTTTTCTTGATACCAACGGCTATCTTAATATTGATGTCGCCAGTCCTGGAACGAAAATTCATGAGCCTGAAAAACTCTTC
CGTAGATTTTGGCGGGGAGATAATTCGCGTCATTCCGTAGGTCAGGGACTTGGTCTTTCTTTAGTCAAAGCGATTGCCGA
ATTACATGGGGGAAGTGCTACGTATCACTATCTCAATAAACATAATGTGTTCCGGATTATGTTACCGCAAAGAAATTAA

Upstream 100 bases:

>100_bases
CCATTCGCAGGCTCCGCGCAAAAGTTGATGATCCTTTTCCTGAAAAGCTAATCGCCACAATACGGGGGATGGGCTATTCA
TTCGTAGCGGTAAAAAAATA

Downstream 100 bases:

>100_bases
CATAGGGCTTCAGTACGCCATAAATCAACCATGAAAAAACGCAGCCACGTCGTGAGTATTAACGTGGCTGCGATTGATTA
TGCGCTTACATTCATACGTA

Product: heavy metal sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MKRLSITVRLTLLFILLLSVAGAGIVWTLYNGLASELKWRDDTTLINRTAQIKQLLIDGVNPDTLPVYFNRMMDVSQDIL
IIHGDGINKIVNRTNVSDGMLNNIPASETISAAGIYRSIINDTEIDALRINIDEVSPSLTVTVAKLASARHNMLEQYKIN
SIIICIVAIVLCSVLSPLLIRTGLREIKKLSGVTEALNYNDSREPVEVSVLPRELKPLGQALNKMHQALVKDFERLSQFA
DDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLSLNKEVENLL
DYLEYLSDEKEICFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDTNGYLNIDVASPGTKIHEPEKLF
RRFWRGDNSRHSVGQGLGLSLVKAIAELHGGSATYHYLNKHNVFRIMLPQRN

Sequences:

>Translated_452_residues
MKRLSITVRLTLLFILLLSVAGAGIVWTLYNGLASELKWRDDTTLINRTAQIKQLLIDGVNPDTLPVYFNRMMDVSQDIL
IIHGDGINKIVNRTNVSDGMLNNIPASETISAAGIYRSIINDTEIDALRINIDEVSPSLTVTVAKLASARHNMLEQYKIN
SIIICIVAIVLCSVLSPLLIRTGLREIKKLSGVTEALNYNDSREPVEVSVLPRELKPLGQALNKMHQALVKDFERLSQFA
DDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLSLNKEVENLL
DYLEYLSDEKEICFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDTNGYLNIDVASPGTKIHEPEKLF
RRFWRGDNSRHSVGQGLGLSLVKAIAELHGGSATYHYLNKHNVFRIMLPQRN
>Mature_452_residues
MKRLSITVRLTLLFILLLSVAGAGIVWTLYNGLASELKWRDDTTLINRTAQIKQLLIDGVNPDTLPVYFNRMMDVSQDIL
IIHGDGINKIVNRTNVSDGMLNNIPASETISAAGIYRSIINDTEIDALRINIDEVSPSLTVTVAKLASARHNMLEQYKIN
SIIICIVAIVLCSVLSPLLIRTGLREIKKLSGVTEALNYNDSREPVEVSVLPRELKPLGQALNKMHQALVKDFERLSQFA
DDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADKNNVLVKLDSLSLNKEVENLL
DYLEYLSDEKEICFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEKSRIHITSFLDTNGYLNIDVASPGTKIHEPEKLF
RRFWRGDNSRHSVGQGLGLSLVKAIAELHGGSATYHYLNKHNVFRIMLPQRN

Specific function: Probable member of a two-component regulatory system yedW/yedV. May activate yedW by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788279, Length=452, Percent_Identity=98.4513274336283, Blast_Score=905, Evalue=0.0,
Organism=Escherichia coli, GI1786783, Length=294, Percent_Identity=33.3333333333333, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1786912, Length=215, Percent_Identity=30.2325581395349, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1789403, Length=445, Percent_Identity=25.8426966292135, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790346, Length=253, Percent_Identity=24.5059288537549, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788393, Length=230, Percent_Identity=26.9565217391304, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790551, Length=292, Percent_Identity=28.4246575342466, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1787894, Length=278, Percent_Identity=28.7769784172662, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1788549, Length=263, Percent_Identity=24.3346007604563, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082128, Length=246, Percent_Identity=26.8292682926829, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789149, Length=212, Percent_Identity=24.5283018867925, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790861, Length=268, Percent_Identity=25.3731343283582, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1786600, Length=257, Percent_Identity=25.6809338521401, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50849; Mature: 50849

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLSITVRLTLLFILLLSVAGAGIVWTLYNGLASELKWRDDTTLINRTAQIKQLLIDGV
CCCEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
NPDTLPVYFNRMMDVSQDILIIHGDGINKIVNRTNVSDGMLNNIPASETISAAGIYRSII
CCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
NDTEIDALRINIDEVSPSLTVTVAKLASARHNMLEQYKINSIIICIVAIVLCSVLSPLLI
CCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTGLREIKKLSGVTEALNYNDSREPVEVSVLPRELKPLGQALNKMHQALVKDFERLSQFA
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADK
HHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEEECC
NNVLVKLDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQQIFADKILLQRMLSNLIVNA
CCEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHH
IRYSPEKSRIHITSFLDTNGYLNIDVASPGTKIHEPEKLFRRFWRGDNSRHSVGQGLGLS
HHCCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHCCCHHH
LVKAIAELHGGSATYHYLNKHNVFRIMLPQRN
HHHHHHHHCCCCEEEEEECCCCEEEEECCCCC
>Mature Secondary Structure
MKRLSITVRLTLLFILLLSVAGAGIVWTLYNGLASELKWRDDTTLINRTAQIKQLLIDGV
CCCEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
NPDTLPVYFNRMMDVSQDILIIHGDGINKIVNRTNVSDGMLNNIPASETISAAGIYRSII
CCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
NDTEIDALRINIDEVSPSLTVTVAKLASARHNMLEQYKINSIIICIVAIVLCSVLSPLLI
CCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTGLREIKKLSGVTEALNYNDSREPVEVSVLPRELKPLGQALNKMHQALVKDFERLSQFA
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNIEELENISRLTENILFLARADK
HHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEEECC
NNVLVKLDSLSLNKEVENLLDYLEYLSDEKEICFKVECNQQIFADKILLQRMLSNLIVNA
CCEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHH
IRYSPEKSRIHITSFLDTNGYLNIDVASPGTKIHEPEKLFRRFWRGDNSRHSVGQGLGLS
HHCCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHCCCHHH
LVKAIAELHGGSATYHYLNKHNVFRIMLPQRN
HHHHHHHHCCCCEEEEEECCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]