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The map label for this gene is rfbD

Identifier: 187730759

GI number: 187730759

Start: 1099506

End: 1100405

Strand: Direct

Name: rfbD

Synonym: SbBS512_E1193

Alternate gene names: 187730759

Gene position: 1099506-1100405 (Clockwise)

Preceding gene: 187730265

Following gene: 187731110

Centisome position: 23.82

GC content: 46.56

Gene sequence:

>900_bases
ATGAATATCCTCCTTTTTGGCAAAACAGGGCAGGTAGGTTGGGAACTACAGCGTGCTCTGGCACCTCTGGGTAATTTGAT
TGCTCTTGATGTTCACTCCACTGATTACTGTGGTGATTTTAGTAATCCTGAAGGTGTAGCTGAAACCGTAAGAAGCATTC
GGCCTGAGATTATTGTCAACGCAGCCGCTCACACCGCAGTAGACAAAGCAGAATCAGAACCGGAGTTTGCACAATTAATT
AACGCAACAAGTGTCGAAGCGATTGCGAAAGCAGCAAATGAAGTTGGAGCTTGGGTTATCCATTACTCGACTGATTACGT
CTTCCCTGGAAATGGCGATATGCCATGGCTGGAGACGGATGCAACCGCACCACTAAATGTTTACGGTGAAACAAAGTTAG
CTGGAGAAAAAGCGTTACAGGAATATTGCGCGAAGCATCTTATTTTCCGGACCAGCTGGGTCTATGCAGGAAAAGGAAAT
AACTTCGCCAAAACGATGTTACGTCTGGCAAAAGAGCGTGAAGAATTAGCGGTTATTAACGATCAGTTTGGTGCGCCAAC
AGGTGCTGAACTGCTGGCTGATTGTACAGCACATGCCATTCGTGTCGCACTGAATAAACCGGATGTCGCAGGCTTGTACC
ATTTGGTAGCCAGTGGTACCACAACCTGGTACGATTATGCTGCGCTGGTTTTTGAAGAGGCGCGCAAAGCAGGCATTCCC
CTTGCACTCAACAAGCTTAACGCAGTACCAACAACTGCCTATCCTACACCAGCTCGGCGTCCACATAACTCTCGCCTTAA
TACAGAAAAATTTCAGCAGAATTTTGCGCTTGTCTTGCCTGACTGGCAGGTTGGTGTGAAACGCATGTTCAACGAATTAT
TTACGACTACAGCAATTTAA

Upstream 100 bases:

>100_bases
AAACGGTGGAATGGTACCTGTCCAATACAAAATGGGTTGATAATGTGAAAAGTGGTGCCTATCAATCGTGGATTGAACAG
AACTATGAGGGCCGCCAGTA

Downstream 100 bases:

>100_bases
TAGTTTTTGCATCTTGTTCGTGATGATGGAGCAAGATGAATTAAAAGGAATGATGAAATGAAAACGCGTAAGGGTATTAT
TTTAGCGGGTGGTTCTGGTA

Product: dTDP-4-dehydrorhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MNILLFGKTGQVGWELQRALAPLGNLIALDVHSTDYCGDFSNPEGVAETVRSIRPEIIVNAAAHTAVDKAESEPEFAQLI
NATSVEAIAKAANEVGAWVIHYSTDYVFPGNGDMPWLETDATAPLNVYGETKLAGEKALQEYCAKHLIFRTSWVYAGKGN
NFAKTMLRLAKEREELAVINDQFGAPTGAELLADCTAHAIRVALNKPDVAGLYHLVASGTTTWYDYAALVFEEARKAGIP
LALNKLNAVPTTAYPTPARRPHNSRLNTEKFQQNFALVLPDWQVGVKRMFNELFTTTAI

Sequences:

>Translated_299_residues
MNILLFGKTGQVGWELQRALAPLGNLIALDVHSTDYCGDFSNPEGVAETVRSIRPEIIVNAAAHTAVDKAESEPEFAQLI
NATSVEAIAKAANEVGAWVIHYSTDYVFPGNGDMPWLETDATAPLNVYGETKLAGEKALQEYCAKHLIFRTSWVYAGKGN
NFAKTMLRLAKEREELAVINDQFGAPTGAELLADCTAHAIRVALNKPDVAGLYHLVASGTTTWYDYAALVFEEARKAGIP
LALNKLNAVPTTAYPTPARRPHNSRLNTEKFQQNFALVLPDWQVGVKRMFNELFTTTAI
>Mature_299_residues
MNILLFGKTGQVGWELQRALAPLGNLIALDVHSTDYCGDFSNPEGVAETVRSIRPEIIVNAAAHTAVDKAESEPEFAQLI
NATSVEAIAKAANEVGAWVIHYSTDYVFPGNGDMPWLETDATAPLNVYGETKLAGEKALQEYCAKHLIFRTSWVYAGKGN
NFAKTMLRLAKEREELAVINDQFGAPTGAELLADCTAHAIRVALNKPDVAGLYHLVASGTTTWYDYAALVFEEARKAGIP
LALNKLNAVPTTAYPTPARRPHNSRLNTEKFQQNFALVLPDWQVGVKRMFNELFTTTAI

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI11034825, Length=233, Percent_Identity=27.4678111587983, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI33519455, Length=233, Percent_Identity=27.4678111587983, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1788352, Length=299, Percent_Identity=98.9966555183946, Blast_Score=612, Evalue=1e-177,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 32708; Mature: 32708

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILLFGKTGQVGWELQRALAPLGNLIALDVHSTDYCGDFSNPEGVAETVRSIRPEIIVN
CEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCEEEE
AAAHTAVDKAESEPEFAQLINATSVEAIAKAANEVGAWVIHYSTDYVFPGNGDMPWLETD
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCEEECCCCCCCEEECC
ATAPLNVYGETKLAGEKALQEYCAKHLIFRTSWVYAGKGNNFAKTMLRLAKEREELAVIN
CCCCEEECCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHEEEC
DQFGAPTGAELLADCTAHAIRVALNKPDVAGLYHLVASGTTTWYDYAALVFEEARKAGIP
CCCCCCCHHHHHHHHHHHHHEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
LALNKLNAVPTTAYPTPARRPHNSRLNTEKFQQNFALVLPDWQVGVKRMFNELFTTTAI
EEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEECCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNILLFGKTGQVGWELQRALAPLGNLIALDVHSTDYCGDFSNPEGVAETVRSIRPEIIVN
CEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCEEEE
AAAHTAVDKAESEPEFAQLINATSVEAIAKAANEVGAWVIHYSTDYVFPGNGDMPWLETD
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCEEECCCCCCCEEECC
ATAPLNVYGETKLAGEKALQEYCAKHLIFRTSWVYAGKGNNFAKTMLRLAKEREELAVIN
CCCCEEECCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHEEEC
DQFGAPTGAELLADCTAHAIRVALNKPDVAGLYHLVASGTTTWYDYAALVFEEARKAGIP
CCCCCCCHHHHHHHHHHHHHEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
LALNKLNAVPTTAYPTPARRPHNSRLNTEKFQQNFALVLPDWQVGVKRMFNELFTTTAI
EEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEECCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7559340 [H]