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The map label for this gene is hpt [H]

Identifier: 187736419

GI number: 187736419

Start: 2350039

End: 2350581

Strand: Reverse

Name: hpt [H]

Synonym: Amuc_1937

Alternate gene names: 187736419

Gene position: 2350581-2350039 (Counterclockwise)

Preceding gene: 187736421

Following gene: 187736418

Centisome position: 88.23

GC content: 53.22

Gene sequence:

>543_bases
ATGACTTACACCATCACTCCTTTGATTGCAGAGGATGCCATCTGCGCGCGCGTCAGGGAACTGGCCGCATCCATTGACAG
GGCCATGGCAGGAAAACCCTATATTTTATTGCTGCTGCTGAACGGCGCTCTTCCTTTCGCTGCGATGTTGGAGAAGCATT
TGAAATCCCGGCCTGCGGTGAAAGCCGTCAAGATTTCCAGTTATGCCGGAATGAGAAATTCCGGTTCCGTGGCGTGGGAG
GGGGATTGCGGGGATTTCCAGCCCGATGTGCCTGTTCTGGTGGTGGATGACGTTCTGGATACGGGCGCTACGCTGGATGA
AGTTTGCCGGGAATTGAAAAGAAGAGGGGCGAAGGAAGTCCTCACTGCTGTAGCCGTGGACAAGCACTGTTGCCGGAAAG
TGCCTTTTGAGGCTGATTACGTGGCTTTTACGCAGGGAAACGATTTCCTGGTGGGGTTTGGAATGGACCTGGATGGGAAT
TACCGGGAACTCCCGTACATTGGGAAAGTGGTCATGGCTGACACAGTTGAGAATTCAGATTGA

Upstream 100 bases:

>100_bases
TTGTAAAATTTGCTGGAGCCCGGCCGGGAATGTTTTGTCTCCGTTCATTCTCCTTTAAGGATTGATTTTCTTACAGGAAA
CATTATCATGCCCCGTTTCC

Downstream 100 bases:

>100_bases
ACAACCTGTTGAAAAAAAGTGTCCAAAACAATTGGAGCGGCAGAATTATCCGCCGTCCTGCTTAACAAGGGAAACCGGAA
AGGAGAACCAAGACATGAAA

Product: phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MTYTITPLIAEDAICARVRELAASIDRAMAGKPYILLLLLNGALPFAAMLEKHLKSRPAVKAVKISSYAGMRNSGSVAWE
GDCGDFQPDVPVLVVDDVLDTGATLDEVCRELKRRGAKEVLTAVAVDKHCCRKVPFEADYVAFTQGNDFLVGFGMDLDGN
YRELPYIGKVVMADTVENSD

Sequences:

>Translated_180_residues
MTYTITPLIAEDAICARVRELAASIDRAMAGKPYILLLLLNGALPFAAMLEKHLKSRPAVKAVKISSYAGMRNSGSVAWE
GDCGDFQPDVPVLVVDDVLDTGATLDEVCRELKRRGAKEVLTAVAVDKHCCRKVPFEADYVAFTQGNDFLVGFGMDLDGN
YRELPYIGKVVMADTVENSD
>Mature_179_residues
TYTITPLIAEDAICARVRELAASIDRAMAGKPYILLLLLNGALPFAAMLEKHLKSRPAVKAVKISSYAGMRNSGSVAWEG
DCGDFQPDVPVLVVDDVLDTGATLDEVCRELKRRGAKEVLTAVAVDKHCCRKVPFEADYVAFTQGNDFLVGFGMDLDGNY
RELPYIGKVVMADTVENSD

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI87081689, Length=177, Percent_Identity=32.7683615819209, Blast_Score=89, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17510817, Length=168, Percent_Identity=32.1428571428571, Blast_Score=80, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 19589; Mature: 19458

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYTITPLIAEDAICARVRELAASIDRAMAGKPYILLLLLNGALPFAAMLEKHLKSRPAV
CCEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCE
KAVKISSYAGMRNSGSVAWEGDCGDFQPDVPVLVVDDVLDTGATLDEVCRELKRRGAKEV
EEEEEHHHCCCCCCCCEEECCCCCCCCCCCCEEEECCHHCCCCCHHHHHHHHHHCCHHHH
LTAVAVDKHCCRKVPFEADYVAFTQGNDFLVGFGMDLDGNYRELPYIGKVVMADTVENSD
HHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCHHHHEEEEECCCCCC
>Mature Secondary Structure 
TYTITPLIAEDAICARVRELAASIDRAMAGKPYILLLLLNGALPFAAMLEKHLKSRPAV
CEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCE
KAVKISSYAGMRNSGSVAWEGDCGDFQPDVPVLVVDDVLDTGATLDEVCRELKRRGAKEV
EEEEEHHHCCCCCCCCEEECCCCCCCCCCCCEEEECCHHCCCCCHHHHHHHHHHCCHHHH
LTAVAVDKHCCRKVPFEADYVAFTQGNDFLVGFGMDLDGNYRELPYIGKVVMADTVENSD
HHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCHHHHEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]