Definition Akkermansia muciniphila ATCC BAA-835, complete genome.
Accession NC_010655
Length 2,664,102

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The map label for this gene is sucB [H]

Identifier: 187736179

GI number: 187736179

Start: 2055566

End: 2056657

Strand: Reverse

Name: sucB [H]

Synonym: Amuc_1692

Alternate gene names: 187736179

Gene position: 2056657-2055566 (Counterclockwise)

Preceding gene: 187736180

Following gene: 187736174

Centisome position: 77.2

GC content: 58.42

Gene sequence:

>1092_bases
ATGAGCGACATCCTGACTCCCAACTTTGGAGAATCCATCACCTCCGCCACCGTAGCCGCGTGGCACAAGAATGCCGGCGA
CCCGGTAGCCAAAGGCGACACTCTGGTGACGCTGGAAACGGACAAGGTTTCCACGGATTTGGAGGCGGATGAAAGCGGCG
TGCTGGAAATCCTCGTCCCGGAAGGGGCGGAAGCCCCCATCGGCGCGGTTTTAGGCCGCATTTCCCCCCTTGACGGAAGT
TCCGCCGCACCGCCCTCCGTACCACTGGAAACGCGGGAGAAACCCGCTTCCGGTCCCTCCTCACCTGTGACTGGCGCCCC
GGAACAAAAGCCGGAAAAGAAAACATCCTCACCGGATCAGACAACCTCCGGAAAAAATGGGAAAACAGTAAAGGAGGCTT
CTCCGCGCTTCATCAGAAAACCCATGAGCCCGTTGCGCCGTACCATCGCGGCACGGTTGGTAGAGGCCCAGCACCAGGCG
GCCATCCTGACTACCTTCAACGAATGCGACATGTCCTCCGTGATGGAACTCCGCAAACAATTCAATGCAGCGTACCGGGA
ACGGTACGGAACCAAACTCGGTTTCATGAGCTTCTTTATCAAGGCCGTAGTCAAAGCATTGCAGGAAGTGCCCCAGGTCA
ACGCCAGAATAGACGGTACGGACATCGTGGAAAACCTGTACTATGACATCTCCATAGCCATCGGCACAGATAAGGGTCTC
GTCGTCCCCGTGCTGCGGGACTGCGACCGGAAAACGCTTCCGGAGCTGGAACTGGAACTCGCTTCCCTGACGGAAAAAGC
ACGCAGGGGAAACCTGTCCATGCAGAATCTGCAAGGCGGCTGCTTCACCATCTCCAACGGCGGAACATATGGGTCGCTTC
TTTCCACGCCCATCCTGAACCCGCCCCAGAGCGGCATTCTGGGCATGCATGCCATCCAGGAACGCCCCGTGGTCCGGGAC
GGCCAAATCACCGCCCGGCCCATGATGTACCTGGCCCTTTCCTACGACCACCGCCTGGTGGACGGCAAGCAGGCCGTGCA
ATTCCTCATTACCGTAAAAAATGCCGTGGAAAACCCGGTGTTCGAGCTGTGA

Upstream 100 bases:

>100_bases
CCCTGCGGAGGGGGCCAAAGCGCTGCACGCCGCCGCACAAAAAAGACTCATCGCCGCTGCCTTCGGGCCGCGGGCCCAAT
CCTGAACCCATTTTACTCCC

Downstream 100 bases:

>100_bases
GGAACCGTGGGAAAAAGACTAAAGAAGAAAGACTGAATGCCTTTCCCGCTTTGGAGTATTTTCCCGGAAATCAGTCCTTT
CGGCGCGTTGCCCCGGAAAA

Product: 2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase

Products: NA

Alternate protein names: 2-oxoglutarate dehydrogenase complex component E2; OGDC-E2; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex [H]

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MSDILTPNFGESITSATVAAWHKNAGDPVAKGDTLVTLETDKVSTDLEADESGVLEILVPEGAEAPIGAVLGRISPLDGS
SAAPPSVPLETREKPASGPSSPVTGAPEQKPEKKTSSPDQTTSGKNGKTVKEASPRFIRKPMSPLRRTIAARLVEAQHQA
AILTTFNECDMSSVMELRKQFNAAYRERYGTKLGFMSFFIKAVVKALQEVPQVNARIDGTDIVENLYYDISIAIGTDKGL
VVPVLRDCDRKTLPELELELASLTEKARRGNLSMQNLQGGCFTISNGGTYGSLLSTPILNPPQSGILGMHAIQERPVVRD
GQITARPMMYLALSYDHRLVDGKQAVQFLITVKNAVENPVFEL

Sequences:

>Translated_363_residues
MSDILTPNFGESITSATVAAWHKNAGDPVAKGDTLVTLETDKVSTDLEADESGVLEILVPEGAEAPIGAVLGRISPLDGS
SAAPPSVPLETREKPASGPSSPVTGAPEQKPEKKTSSPDQTTSGKNGKTVKEASPRFIRKPMSPLRRTIAARLVEAQHQA
AILTTFNECDMSSVMELRKQFNAAYRERYGTKLGFMSFFIKAVVKALQEVPQVNARIDGTDIVENLYYDISIAIGTDKGL
VVPVLRDCDRKTLPELELELASLTEKARRGNLSMQNLQGGCFTISNGGTYGSLLSTPILNPPQSGILGMHAIQERPVVRD
GQITARPMMYLALSYDHRLVDGKQAVQFLITVKNAVENPVFEL
>Mature_362_residues
SDILTPNFGESITSATVAAWHKNAGDPVAKGDTLVTLETDKVSTDLEADESGVLEILVPEGAEAPIGAVLGRISPLDGSS
AAPPSVPLETREKPASGPSSPVTGAPEQKPEKKTSSPDQTTSGKNGKTVKEASPRFIRKPMSPLRRTIAARLVEAQHQAA
ILTTFNECDMSSVMELRKQFNAAYRERYGTKLGFMSFFIKAVVKALQEVPQVNARIDGTDIVENLYYDISIAIGTDKGLV
VPVLRDCDRKTLPELELELASLTEKARRGNLSMQNLQGGCFTISNGGTYGSLLSTPILNPPQSGILGMHAIQERPVVRDG
QITARPMMYLALSYDHRLVDGKQAVQFLITVKNAVENPVFEL

Specific function: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components:2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and l

COG id: COG0508

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI19923748, Length=223, Percent_Identity=52.4663677130045, Blast_Score=245, Evalue=4e-65,
Organism=Homo sapiens, GI203098816, Length=231, Percent_Identity=32.9004329004329, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI203098753, Length=231, Percent_Identity=32.9004329004329, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI31711992, Length=229, Percent_Identity=33.6244541484716, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI110671329, Length=416, Percent_Identity=25.4807692307692, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI260898739, Length=166, Percent_Identity=33.7349397590361, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1786946, Length=398, Percent_Identity=41.4572864321608, Blast_Score=317, Evalue=6e-88,
Organism=Escherichia coli, GI1786305, Length=199, Percent_Identity=35.1758793969849, Blast_Score=138, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI25146366, Length=398, Percent_Identity=39.1959798994975, Blast_Score=273, Evalue=7e-74,
Organism=Caenorhabditis elegans, GI17560088, Length=433, Percent_Identity=27.4826789838337, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17537937, Length=407, Percent_Identity=24.3243243243243, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17538894, Length=220, Percent_Identity=31.8181818181818, Blast_Score=108, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6320352, Length=387, Percent_Identity=40.8268733850129, Blast_Score=275, Evalue=7e-75,
Organism=Saccharomyces cerevisiae, GI6324258, Length=227, Percent_Identity=29.0748898678414, Blast_Score=116, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24645909, Length=221, Percent_Identity=55.6561085972851, Blast_Score=262, Evalue=3e-70,
Organism=Drosophila melanogaster, GI24582497, Length=222, Percent_Identity=31.981981981982, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI20129315, Length=222, Percent_Identity=31.981981981982, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI18859875, Length=200, Percent_Identity=34.5, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3096 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR001078
- InterPro:   IPR000089
- InterPro:   IPR023213
- InterPro:   IPR004167
- InterPro:   IPR011053
- InterPro:   IPR006255 [H]

Pfam domain/function: PF00198 2-oxoacid_dh; PF00364 Biotin_lipoyl; PF02817 E3_binding [H]

EC number: =2.3.1.61 [H]

Molecular weight: Translated: 39159; Mature: 39028

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILTPNFGESITSATVAAWHKNAGDPVAKGDTLVTLETDKVSTDLEADESGVLEILVP
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEEC
EGAEAPIGAVLGRISPLDGSSAAPPSVPLETREKPASGPSSPVTGAPEQKPEKKTSSPDQ
CCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TTSGKNGKTVKEASPRFIRKPMSPLRRTIAARLVEAQHQAAILTTFNECDMSSVMELRKQ
CCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHH
FNAAYRERYGTKLGFMSFFIKAVVKALQEVPQVNARIDGTDIVENLYYDISIAIGTDKGL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHEEEEEEEEECCCCE
VVPVLRDCDRKTLPELELELASLTEKARRGNLSMQNLQGGCFTISNGGTYGSLLSTPILN
EEHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCEEEECCCCCCHHHHHCCCCC
PPQSGILGMHAIQERPVVRDGQITARPMMYLALSYDHRLVDGKQAVQFLITVKNAVENPV
CCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCHHCCHHHHHHHHHHHHHHHCCCC
FEL
CCC
>Mature Secondary Structure 
SDILTPNFGESITSATVAAWHKNAGDPVAKGDTLVTLETDKVSTDLEADESGVLEILVP
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEEC
EGAEAPIGAVLGRISPLDGSSAAPPSVPLETREKPASGPSSPVTGAPEQKPEKKTSSPDQ
CCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TTSGKNGKTVKEASPRFIRKPMSPLRRTIAARLVEAQHQAAILTTFNECDMSSVMELRKQ
CCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHH
FNAAYRERYGTKLGFMSFFIKAVVKALQEVPQVNARIDGTDIVENLYYDISIAIGTDKGL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHEEEEEEEEECCCCE
VVPVLRDCDRKTLPELELELASLTEKARRGNLSMQNLQGGCFTISNGGTYGSLLSTPILN
EEHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCEEEECCCCCCHHHHHCCCCC
PPQSGILGMHAIQERPVVRDGQITARPMMYLALSYDHRLVDGKQAVQFLITVKNAVENPV
CCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCHHCCHHHHHHHHHHHHHHHCCCC
FEL
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12874367 [H]