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The map label for this gene is uvrB [H]

Identifier: 187736045

GI number: 187736045

Start: 1866924

End: 1869071

Strand: Direct

Name: uvrB [H]

Synonym: Amuc_1555

Alternate gene names: 187736045

Gene position: 1866924-1869071 (Clockwise)

Preceding gene: 187736043

Following gene: 187736046

Centisome position: 70.08

GC content: 54.61

Gene sequence:

>2148_bases
ATGTCGTCTTTTGAGTTGAATTCCTCCTTCAAGCCTTCCGGAGACCAGGAGCAGGCCATCGGCAAACTGCTCAAGTCTCT
GGAGGCGGGTAACAAGCACCAGGGGCTCCTGGGAGTGACCGGGAGCGGCAAGACATTCACCATGGCGAATTTGATTGCCC
GGATGAACAGGCCCACGCTGGTGATTTCCCACAACAAGACGCTTGCCGCACAGCTTCATTCGGAGCTGAAGAGTTTTTTC
CCGAATAACGCGGTGGATTACTACGTTTCCTATTTCGATTATTACCAGCCGGAGGCGTATATCGCCAGTTCCGACACCTA
CATTGAAAAGGATTCCGCCATTAATGACGAGTTGGACCGCCTGAGCCTGAATGCCATGAATTCCCTGATGACACGGAGGG
ATGTGATTGTGGTGGCATCCGTTTCCTGCATTTACGGCCTGTCCACTCCGGAGGATTACAGGAACCTGACGCTGCGCATG
CGCGAGGGGGATGTCATGGACCGGGACGTGTTTTTGAAGCATCTGGTGGAACGCCTGTTCGAGCGGCAGGATTTTGATTT
TACCCGCGGCACGTTCCGCGTGCGCGGTGAGGTGGTGGAGGTGTTTCCCGCTTATTCGGAAGGTGAAGCAATCCGCGTAG
AGTTTTTCGGCGACGAGGTGGAACGGGTTTCTTTGATTGACTCCGCCACCGGGCGTGTGAGGGAACGGCTTGGGAGCTAC
ACTTTTTTCCCGGCCAAGCAGTATGTGGCCGCTCCGGAGAAACGGGCGGCGGCGTTAAAGGCTATCCGGGAAGAGCTGGA
GGACCGCGTAGGCTGGTTTGAGAAGCATGGGCGCCTGCTGGAAGCGCAGCGGCTTAAATTGCGCACGGATTATGATTTGG
AACTGATTGAAGAGCTGGGTTTCTGCAAGGGGATTGAAAATTATTCCCGCCATTTGTCCGGCCGCCTGCCCGGAAGCGCC
CCATCCACCCTGCTGGATTTCTTTCCCAAGGATTCATTGACCCTGATTGATGAAAGTCATGTGGCGGTGCCGCAGCTGGG
AGGCATGTACGAGGGGGACCGAAGCCGCAAAAATATTCTGGTGGAGCATGGGTTCCGCCTGCCCAGCGCTCTGGATAACA
GGCCTTTGAAATTCCATGAGTTTATGGAAAGGCAGAACCAGATTGTGTATGCTTCCGCTACTCCGGGGCCATTTGAACTG
GTAAATTGCCGTGCGGATAATAAGACGTATATTCCCGTGCGCCGTGCCGCCAGATCCGGAGAAAAGGCTCCGGAAGGGTT
CAAAGGAATTTTGTTTACCTCTCCCAAGGACATTCGCGTTGCTCCCAGCCCATCCACGGAACCGGTAGAAAAATTTGACC
CAACCAGGCGTTCTACACCCCTGATTGTAGAGCAGATTATCCGGCCTACCGGGCTGCTGGAGCCGAAGATTACCATCCGT
CCATTGAAAGGGCAGATTGACGAGACGATCGCCATGTGCAATGAACGCGTTGCCAAAAATGAACGCGTGCTGGTCACGAC
GCTGACCAAGAAGACGGCGGAAGATTTGACGGAGTACCTGAAAGGGGTAGGATTGAAGGTGTCCTACATTCACGCGGATG
TGGATGCGATTGAGCGTGTGGAGATTTTACGTGCTTTGAGAGCCAGGAAGATAGACGTTCTGGTAGGCATTAACCTGCTT
AGGGAAGGGCTGGATTTGCCGGAGGTTTCCCTGGTGTGCATTCTGGATGCGGACAAGGAGGGGTTTTTGCGCAATGAGAC
ATCCCTGGTGCAGACGGCGGGCCGCGCCGCGCGGCATTTGAATGGAGAGTGCGTCTTGTTTGCGGATGTGATGACGGATT
CCATCAAACGGCTGGTTGAGCTGACGGATTACCGTCGGGGTATTCAGGAAAAATACAACCGGGAACACGGTATTGTCCCC
CAGACGGTGAGCCGTTCCGAACAGGGGCAGTTGAAGTTGTACGCAGAGGATGATGAAGAGTCCTTCCGCGTAGCGGAGGA
TGAAGCCGGGTATGGTCTGGAAGAGCGCATTGCCAGGCTGGAGACGGAAATGAAGGAGGCTGCTTCCCATTTGGAATTTG
AACGCGCCGCCTTGATTCGGGATGAAATCAGGCAGATGCGCGGAGAATATGGAAAAGGCAGGGGATAA

Upstream 100 bases:

>100_bases
GTGGGAATGTACATGCCGCATATACTGGGTCAGGAGGGGAAAATTGTCAAACATTGTCCTAGCCCGGCGGGGCGGGAGCA
ATATACTGACGGCATTGCGT

Downstream 100 bases:

>100_bases
TATCCGGCGTGATGAATTGGGGATGAGCTTTCTGGTAGGATGGCATGCTGTTTTTTCGTGATATTTGTCCATCTTATTCT
TGGCCGTCATTTGACGGTGA

Product: excinuclease ABC, B subunit

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 715; Mature: 714

Protein sequence:

>715_residues
MSSFELNSSFKPSGDQEQAIGKLLKSLEAGNKHQGLLGVTGSGKTFTMANLIARMNRPTLVISHNKTLAAQLHSELKSFF
PNNAVDYYVSYFDYYQPEAYIASSDTYIEKDSAINDELDRLSLNAMNSLMTRRDVIVVASVSCIYGLSTPEDYRNLTLRM
REGDVMDRDVFLKHLVERLFERQDFDFTRGTFRVRGEVVEVFPAYSEGEAIRVEFFGDEVERVSLIDSATGRVRERLGSY
TFFPAKQYVAAPEKRAAALKAIREELEDRVGWFEKHGRLLEAQRLKLRTDYDLELIEELGFCKGIENYSRHLSGRLPGSA
PSTLLDFFPKDSLTLIDESHVAVPQLGGMYEGDRSRKNILVEHGFRLPSALDNRPLKFHEFMERQNQIVYASATPGPFEL
VNCRADNKTYIPVRRAARSGEKAPEGFKGILFTSPKDIRVAPSPSTEPVEKFDPTRRSTPLIVEQIIRPTGLLEPKITIR
PLKGQIDETIAMCNERVAKNERVLVTTLTKKTAEDLTEYLKGVGLKVSYIHADVDAIERVEILRALRARKIDVLVGINLL
REGLDLPEVSLVCILDADKEGFLRNETSLVQTAGRAARHLNGECVLFADVMTDSIKRLVELTDYRRGIQEKYNREHGIVP
QTVSRSEQGQLKLYAEDDEESFRVAEDEAGYGLEERIARLETEMKEAASHLEFERAALIRDEIRQMRGEYGKGRG

Sequences:

>Translated_715_residues
MSSFELNSSFKPSGDQEQAIGKLLKSLEAGNKHQGLLGVTGSGKTFTMANLIARMNRPTLVISHNKTLAAQLHSELKSFF
PNNAVDYYVSYFDYYQPEAYIASSDTYIEKDSAINDELDRLSLNAMNSLMTRRDVIVVASVSCIYGLSTPEDYRNLTLRM
REGDVMDRDVFLKHLVERLFERQDFDFTRGTFRVRGEVVEVFPAYSEGEAIRVEFFGDEVERVSLIDSATGRVRERLGSY
TFFPAKQYVAAPEKRAAALKAIREELEDRVGWFEKHGRLLEAQRLKLRTDYDLELIEELGFCKGIENYSRHLSGRLPGSA
PSTLLDFFPKDSLTLIDESHVAVPQLGGMYEGDRSRKNILVEHGFRLPSALDNRPLKFHEFMERQNQIVYASATPGPFEL
VNCRADNKTYIPVRRAARSGEKAPEGFKGILFTSPKDIRVAPSPSTEPVEKFDPTRRSTPLIVEQIIRPTGLLEPKITIR
PLKGQIDETIAMCNERVAKNERVLVTTLTKKTAEDLTEYLKGVGLKVSYIHADVDAIERVEILRALRARKIDVLVGINLL
REGLDLPEVSLVCILDADKEGFLRNETSLVQTAGRAARHLNGECVLFADVMTDSIKRLVELTDYRRGIQEKYNREHGIVP
QTVSRSEQGQLKLYAEDDEESFRVAEDEAGYGLEERIARLETEMKEAASHLEFERAALIRDEIRQMRGEYGKGRG
>Mature_714_residues
SSFELNSSFKPSGDQEQAIGKLLKSLEAGNKHQGLLGVTGSGKTFTMANLIARMNRPTLVISHNKTLAAQLHSELKSFFP
NNAVDYYVSYFDYYQPEAYIASSDTYIEKDSAINDELDRLSLNAMNSLMTRRDVIVVASVSCIYGLSTPEDYRNLTLRMR
EGDVMDRDVFLKHLVERLFERQDFDFTRGTFRVRGEVVEVFPAYSEGEAIRVEFFGDEVERVSLIDSATGRVRERLGSYT
FFPAKQYVAAPEKRAAALKAIREELEDRVGWFEKHGRLLEAQRLKLRTDYDLELIEELGFCKGIENYSRHLSGRLPGSAP
STLLDFFPKDSLTLIDESHVAVPQLGGMYEGDRSRKNILVEHGFRLPSALDNRPLKFHEFMERQNQIVYASATPGPFELV
NCRADNKTYIPVRRAARSGEKAPEGFKGILFTSPKDIRVAPSPSTEPVEKFDPTRRSTPLIVEQIIRPTGLLEPKITIRP
LKGQIDETIAMCNERVAKNERVLVTTLTKKTAEDLTEYLKGVGLKVSYIHADVDAIERVEILRALRARKIDVLVGINLLR
EGLDLPEVSLVCILDADKEGFLRNETSLVQTAGRAARHLNGECVLFADVMTDSIKRLVELTDYRRGIQEKYNREHGIVPQ
TVSRSEQGQLKLYAEDDEESFRVAEDEAGYGLEERIARLETEMKEAASHLEFERAALIRDEIRQMRGEYGKGRG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=717, Percent_Identity=48.5355648535565, Blast_Score=651, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 80958; Mature: 80827

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSFELNSSFKPSGDQEQAIGKLLKSLEAGNKHQGLLGVTGSGKTFTMANLIARMNRPTL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHCCCCEE
VISHNKTLAAQLHSELKSFFPNNAVDYYVSYFDYYQPEAYIASSDTYIEKDSAINDELDR
EEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCEECCCCCCCHHHHH
LSLNAMNSLMTRRDVIVVASVSCIYGLSTPEDYRNLTLRMREGDVMDRDVFLKHLVERLF
HHHHHHHHHHHHCCEEEEEEHHHHCCCCCCHHHHCEEEEEECCCCCCHHHHHHHHHHHHH
ERQDFDFTRGTFRVRGEVVEVFPAYSEGEAIRVEFFGDEVERVSLIDSATGRVRERLGSY
CCCCCCCCCCEEEECCEEEEEECCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCC
TFFPAKQYVAAPEKRAAALKAIREELEDRVGWFEKHGRLLEAQRLKLRTDYDLELIEELG
EECCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHH
FCKGIENYSRHLSGRLPGSAPSTLLDFFPKDSLTLIDESHVAVPQLGGMYEGDRSRKNIL
HHCCHHHHHHHHCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEE
VEHGFRLPSALDNRPLKFHEFMERQNQIVYASATPGPFELVNCRADNKTYIPVRRAARSG
HCCCCCCCHHHCCCCCHHHHHHHHCCCEEEEECCCCCEEEEEEECCCCEECHHHHHHCCC
EKAPEGFKGILFTSPKDIRVAPSPSTEPVEKFDPTRRSTPLIVEQIIRPTGLLEPKITIR
CCCCCCCCEEEEECCCCCEECCCCCCCCHHHCCCCCCCCHHHHHHHHCCCCCCCCCEEEE
PLKGQIDETIAMCNERVAKNERVLVTTLTKKTAEDLTEYLKGVGLKVSYIHADVDAIERV
ECCCHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHH
EILRALRARKIDVLVGINLLREGLDLPEVSLVCILDADKEGFLRNETSLVQTAGRAARHL
HHHHHHHHCCHHHHEEHHHHHCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHC
NGECVLFADVMTDSIKRLVELTDYRRGIQEKYNREHGIVPQTVSRSEQGQLKLYAEDDEE
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEEEECCCCC
SFRVAEDEAGYGLEERIARLETEMKEAASHLEFERAALIRDEIRQMRGEYGKGRG
CCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SSFELNSSFKPSGDQEQAIGKLLKSLEAGNKHQGLLGVTGSGKTFTMANLIARMNRPTL
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHCCCCEE
VISHNKTLAAQLHSELKSFFPNNAVDYYVSYFDYYQPEAYIASSDTYIEKDSAINDELDR
EEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCEECCCCCCCHHHHH
LSLNAMNSLMTRRDVIVVASVSCIYGLSTPEDYRNLTLRMREGDVMDRDVFLKHLVERLF
HHHHHHHHHHHHCCEEEEEEHHHHCCCCCCHHHHCEEEEEECCCCCCHHHHHHHHHHHHH
ERQDFDFTRGTFRVRGEVVEVFPAYSEGEAIRVEFFGDEVERVSLIDSATGRVRERLGSY
CCCCCCCCCCEEEECCEEEEEECCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCC
TFFPAKQYVAAPEKRAAALKAIREELEDRVGWFEKHGRLLEAQRLKLRTDYDLELIEELG
EECCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHH
FCKGIENYSRHLSGRLPGSAPSTLLDFFPKDSLTLIDESHVAVPQLGGMYEGDRSRKNIL
HHCCHHHHHHHHCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEE
VEHGFRLPSALDNRPLKFHEFMERQNQIVYASATPGPFELVNCRADNKTYIPVRRAARSG
HCCCCCCCHHHCCCCCHHHHHHHHCCCEEEEECCCCCEEEEEEECCCCEECHHHHHHCCC
EKAPEGFKGILFTSPKDIRVAPSPSTEPVEKFDPTRRSTPLIVEQIIRPTGLLEPKITIR
CCCCCCCCEEEEECCCCCEECCCCCCCCHHHCCCCCCCCHHHHHHHHCCCCCCCCCEEEE
PLKGQIDETIAMCNERVAKNERVLVTTLTKKTAEDLTEYLKGVGLKVSYIHADVDAIERV
ECCCHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHH
EILRALRARKIDVLVGINLLREGLDLPEVSLVCILDADKEGFLRNETSLVQTAGRAARHL
HHHHHHHHCCHHHHEEHHHHHCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHC
NGECVLFADVMTDSIKRLVELTDYRRGIQEKYNREHGIVPQTVSRSEQGQLKLYAEDDEE
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEEEECCCCC
SFRVAEDEAGYGLEERIARLETEMKEAASHLEFERAALIRDEIRQMRGEYGKGRG
CCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]