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The map label for this gene is groL

Identifier: 187735900

GI number: 187735900

Start: 1683318

End: 1684970

Strand: Direct

Name: groL

Synonym: Amuc_1408

Alternate gene names: 187735900

Gene position: 1683318-1684970 (Clockwise)

Preceding gene: 187735899

Following gene: 187735901

Centisome position: 63.19

GC content: 59.1

Gene sequence:

>1653_bases
ATGGCTAAACAAATCCAATTTGACGAAACCGCCCGCCAGGCTCTGCTCCGCGGCGTGGAACAGATTGCCAAGGCTGTCAA
GAGCACGCTGGGCCCTGCCGGCCGCAACGTAGTGATTGACAAAAAATTCGGTTCCCCCCTCATCACCAAGGACGGCGTAA
CCGTGGCCAAGGAAATTGAACTGGAAGACCCGTTTGAAAACATGGGCGCCCAGCTTGTCCGGGAAGTATCTTCCAAAACC
AATGACGTGGCCGGCGACGGCACCACTACCGCTACCGTGCTGGCTGAAAGCATTTACCGCGAAGGCCTGCGCAACGTTAC
TGCCGGGGCCAACCCCATCTCCCTCCAGAGGGGCATCATGAAGGCTGCGGATTCCGTTGTGGAAGAACTCAAGAAGATCA
GCAAGCCTGTCGACTCCAGCAAGGAAGTGGCCCAGGTCGCTACCGTCTCCGCCAACTGGGACGCTGAAATCGGCAACATC
ATCGCGGAAGCCATGGACAAGGTGGGCAAGGACGGCACCATCACCGTGGAAGAAGCCAAGGGCATTGAAACTACGCTGGA
CGTGGTGGAAGGCATGCAGTTTGACAAGGGATACCTGTCCCCCTACTTCGTGACGAACGCGGAAACGATGGAAGCGGTGC
TGGAAAACCCCTACATCCTCATCCACGAAAAGAAAATCAACAACCTGAAGGACTTTCTTCCGCTGCTTGAAAAAGTGGCC
AAGAGCGGCCGTCCCTTCCTGGTAATCGCGGAAGACATTGAAGGCGAAGCCCTCGCCACCCTGGTAGTCAACCGTCTGCG
CGGCGTGCTGAACATCTGCGCGGTCAAGGCTCCCGGCTTCGGCGACCGCCGCAAGGCCATGATGGAAGACATCGCCATCC
TTACCGGCGGCAAGTGCATCACGGAAGACCTGGGCATCAAGCTGGAAAACGTGGGCATCGAAGACCTCGGCCAGGCCAAG
CGCGTGGTTGTTTCCAAGGATGAAACCGTTATCGTGGAAGGTTCCGCCAAATCTTCCGATATTGAAGCCCGCATTTCCCA
GATTCGCCGCCAGATCAAGGACACCACGTCCGACTACGACCGCGAAAAACTCCAGGAACGCCTGGCCAAGCTGGCCGGCG
GTGTGGCCGTCATCCATGTGGGTGCCGCTACGGAAACGGAAATGAAGGAAAAGAAGGCCCGTGTGGACGACGCCCTGCAC
GCTACCCGCGCTGCGGTGGAAGAAGGCATCGTTCCCGGCGGCGGCGTGGCGCTGATTCGCGCCCAGAAAGCCATTGACAC
CCTCAAACTGGAAGGTGATGAAGCAACCGGCGCCCAGATCGTTTATCGCGCTGTGGAAGCCCCGCTCCGCCAGCTGGCCT
GCAATGCCGGCCGCGAAGGAGCCCTCATCGTCGCCAACGTGAAAGGCATGAAGAATACTGCCGAAGGTTACAACGTGGCC
ACGGACAAGTATGAAGACCTGCTTTCCGCCGGCGTGGTGGATCCGACCAAGGTGACCCGTTCCGCTCTGCAGAATGCGGC
CTCCATCGCCGGCCTGCTGCTTACCACGGAATGCGTCATTGCCGACAAGCCCGAGAAGAAGAGCTGCAGCTGCGGCTCCG
GAGCTTCCGACATGGGCGGCATGGGAGGAATGGGCGGCATGGGCATGATGTAA

Upstream 100 bases:

>100_bases
CGGGGAAGACTACCTTATCCTGTCTGAAAACGATATTCTGGCCATCATCGGCTAAATGGCACCACACACACATTCAACAT
CATTTTAAATATTTAACATT

Downstream 100 bases:

>100_bases
GCCCCGTCCGTTTCTTCGAGACCAAGGCAATCGGCTTCAAGGCTCCCCGGAAAAACCGGGGAGCCTTTTTTAATATGCTT
CATCAGGAGCCGGTTTCGGG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60

Number of amino acids: Translated: 550; Mature: 549

Protein sequence:

>550_residues
MAKQIQFDETARQALLRGVEQIAKAVKSTLGPAGRNVVIDKKFGSPLITKDGVTVAKEIELEDPFENMGAQLVREVSSKT
NDVAGDGTTTATVLAESIYREGLRNVTAGANPISLQRGIMKAADSVVEELKKISKPVDSSKEVAQVATVSANWDAEIGNI
IAEAMDKVGKDGTITVEEAKGIETTLDVVEGMQFDKGYLSPYFVTNAETMEAVLENPYILIHEKKINNLKDFLPLLEKVA
KSGRPFLVIAEDIEGEALATLVVNRLRGVLNICAVKAPGFGDRRKAMMEDIAILTGGKCITEDLGIKLENVGIEDLGQAK
RVVVSKDETVIVEGSAKSSDIEARISQIRRQIKDTTSDYDREKLQERLAKLAGGVAVIHVGAATETEMKEKKARVDDALH
ATRAAVEEGIVPGGGVALIRAQKAIDTLKLEGDEATGAQIVYRAVEAPLRQLACNAGREGALIVANVKGMKNTAEGYNVA
TDKYEDLLSAGVVDPTKVTRSALQNAASIAGLLLTTECVIADKPEKKSCSCGSGASDMGGMGGMGGMGMM

Sequences:

>Translated_550_residues
MAKQIQFDETARQALLRGVEQIAKAVKSTLGPAGRNVVIDKKFGSPLITKDGVTVAKEIELEDPFENMGAQLVREVSSKT
NDVAGDGTTTATVLAESIYREGLRNVTAGANPISLQRGIMKAADSVVEELKKISKPVDSSKEVAQVATVSANWDAEIGNI
IAEAMDKVGKDGTITVEEAKGIETTLDVVEGMQFDKGYLSPYFVTNAETMEAVLENPYILIHEKKINNLKDFLPLLEKVA
KSGRPFLVIAEDIEGEALATLVVNRLRGVLNICAVKAPGFGDRRKAMMEDIAILTGGKCITEDLGIKLENVGIEDLGQAK
RVVVSKDETVIVEGSAKSSDIEARISQIRRQIKDTTSDYDREKLQERLAKLAGGVAVIHVGAATETEMKEKKARVDDALH
ATRAAVEEGIVPGGGVALIRAQKAIDTLKLEGDEATGAQIVYRAVEAPLRQLACNAGREGALIVANVKGMKNTAEGYNVA
TDKYEDLLSAGVVDPTKVTRSALQNAASIAGLLLTTECVIADKPEKKSCSCGSGASDMGGMGGMGGMGMM
>Mature_549_residues
AKQIQFDETARQALLRGVEQIAKAVKSTLGPAGRNVVIDKKFGSPLITKDGVTVAKEIELEDPFENMGAQLVREVSSKTN
DVAGDGTTTATVLAESIYREGLRNVTAGANPISLQRGIMKAADSVVEELKKISKPVDSSKEVAQVATVSANWDAEIGNII
AEAMDKVGKDGTITVEEAKGIETTLDVVEGMQFDKGYLSPYFVTNAETMEAVLENPYILIHEKKINNLKDFLPLLEKVAK
SGRPFLVIAEDIEGEALATLVVNRLRGVLNICAVKAPGFGDRRKAMMEDIAILTGGKCITEDLGIKLENVGIEDLGQAKR
VVVSKDETVIVEGSAKSSDIEARISQIRRQIKDTTSDYDREKLQERLAKLAGGVAVIHVGAATETEMKEKKARVDDALHA
TRAAVEEGIVPGGGVALIRAQKAIDTLKLEGDEATGAQIVYRAVEAPLRQLACNAGREGALIVANVKGMKNTAEGYNVAT
DKYEDLLSAGVVDPTKVTRSALQNAASIAGLLLTTECVIADKPEKKSCSCGSGASDMGGMGGMGGMGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=529, Percent_Identity=48.7712665406427, Blast_Score=506, Evalue=1e-143,
Organism=Homo sapiens, GI31542947, Length=529, Percent_Identity=48.7712665406427, Blast_Score=506, Evalue=1e-143,
Organism=Homo sapiens, GI24307939, Length=352, Percent_Identity=22.7272727272727, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=61.8147448015123, Blast_Score=660, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=48.8679245283019, Blast_Score=516, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=47.8672985781991, Blast_Score=198, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=50.9541984732824, Blast_Score=533, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24641193, Length=532, Percent_Identity=49.6240601503759, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24641191, Length=532, Percent_Identity=49.6240601503759, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI45550936, Length=525, Percent_Identity=46.6666666666667, Blast_Score=495, Evalue=1e-140,
Organism=Drosophila melanogaster, GI45550132, Length=525, Percent_Identity=46.6666666666667, Blast_Score=495, Evalue=1e-140,
Organism=Drosophila melanogaster, GI45550935, Length=525, Percent_Identity=46.6666666666667, Blast_Score=495, Evalue=1e-140,
Organism=Drosophila melanogaster, GI17864606, Length=556, Percent_Identity=44.7841726618705, Blast_Score=456, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24584129, Length=549, Percent_Identity=37.1584699453552, Blast_Score=323, Evalue=1e-88,
Organism=Drosophila melanogaster, GI19921262, Length=549, Percent_Identity=37.1584699453552, Blast_Score=323, Evalue=1e-88,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH60_AKKM8 (B2UKV8)

Other databases:

- EMBL:   CP001071
- RefSeq:   YP_001878012.1
- ProteinModelPortal:   B2UKV8
- SMR:   B2UKV8
- GeneID:   6275718
- GenomeReviews:   CP001071_GR
- KEGG:   amu:Amuc_1408
- HOGENOM:   HBG625289
- OMA:   ATDKYED
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 58445; Mature: 58314

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQIQFDETARQALLRGVEQIAKAVKSTLGPAGRNVVIDKKFGSPLITKDGVTVAKEIE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEECCCCCEEEECC
LEDPFENMGAQLVREVSSKTNDVAGDGTTTATVLAESIYREGLRNVTAGANPISLQRGIM
CCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
KAADSVVEELKKISKPVDSSKEVAQVATVSANWDAEIGNIIAEAMDKVGKDGTITVEEAK
HHHHHHHHHHHHHHCCCCCCHHHHHHHEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCC
GIETTLDVVEGMQFDKGYLSPYFVTNAETMEAVLENPYILIHEKKINNLKDFLPLLEKVA
CCHHHHHHHHCCCCCCCCCCCEEEECHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHH
KSGRPFLVIAEDIEGEALATLVVNRLRGVLNICAVKAPGFGDRRKAMMEDIAILTGGKCI
HCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEE
TEDLGIKLENVGIEDLGQAKRVVVSKDETVIVEGSAKSSDIEARISQIRRQIKDTTSDYD
HHHHCCEEECCCHHHHCCHHEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHH
REKLQERLAKLAGGVAVIHVGAATETEMKEKKARVDDALHATRAAVEEGIVPGGGVALIR
HHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
AQKAIDTLKLEGDEATGAQIVYRAVEAPLRQLACNAGREGALIVANVKGMKNTAEGYNVA
HHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCC
TDKYEDLLSAGVVDPTKVTRSALQNAASIAGLLLTTECVIADKPEKKSCSCGSGASDMGG
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
MGGMGGMGMM
CCCCCCCCCC
>Mature Secondary Structure 
AKQIQFDETARQALLRGVEQIAKAVKSTLGPAGRNVVIDKKFGSPLITKDGVTVAKEIE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEECCCCCEEEECC
LEDPFENMGAQLVREVSSKTNDVAGDGTTTATVLAESIYREGLRNVTAGANPISLQRGIM
CCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
KAADSVVEELKKISKPVDSSKEVAQVATVSANWDAEIGNIIAEAMDKVGKDGTITVEEAK
HHHHHHHHHHHHHHCCCCCCHHHHHHHEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCC
GIETTLDVVEGMQFDKGYLSPYFVTNAETMEAVLENPYILIHEKKINNLKDFLPLLEKVA
CCHHHHHHHHCCCCCCCCCCCEEEECHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHH
KSGRPFLVIAEDIEGEALATLVVNRLRGVLNICAVKAPGFGDRRKAMMEDIAILTGGKCI
HCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEE
TEDLGIKLENVGIEDLGQAKRVVVSKDETVIVEGSAKSSDIEARISQIRRQIKDTTSDYD
HHHHCCEEECCCHHHHCCHHEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHH
REKLQERLAKLAGGVAVIHVGAATETEMKEKKARVDDALHATRAAVEEGIVPGGGVALIR
HHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
AQKAIDTLKLEGDEATGAQIVYRAVEAPLRQLACNAGREGALIVANVKGMKNTAEGYNVA
HHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCC
TDKYEDLLSAGVVDPTKVTRSALQNAASIAGLLLTTECVIADKPEKKSCSCGSGASDMGG
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
MGGMGGMGMM
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA