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The map label for this gene is sdhA [H]

Identifier: 187735483

GI number: 187735483

Start: 1178454

End: 1180412

Strand: Reverse

Name: sdhA [H]

Synonym: Amuc_0985

Alternate gene names: 187735483

Gene position: 1180412-1178454 (Counterclockwise)

Preceding gene: 187735484

Following gene: 187735482

Centisome position: 44.31

GC content: 59.72

Gene sequence:

>1959_bases
ATGATTAATTTTCCCGTAAGCGACTGGATGCCGGATGCCAAAATTCCCTCCGGCCCTATTCAGGACAAATGGTCCAAATA
CAAACTTGAGTCCAAACTGATCAATCCGAACAACAAGCGCAAGTACACGGTACTTGTGGTAGGTTCCGGCCTGGCTGGCG
CCTCCGCTGCCGCCACGCTTGCCGAACTTGGCTACAACGTCAAATGCTTCTGCTACCAGGACAGCCCCCGCCGCGCCCAC
TCCATTGCGGCCCAGGGCGGCATTAACGCGGCCAAGAACTACCAGAACGACGGCGACTCCGTTTACCGCCTGTTTTACGA
CACCGTTAAAGGCGGCGACTTCCGCGCCCGTGAAGCCAATGTCTACCGTCTGGCGGAAGTCTCCTCCAACATCATTGACC
AGTGTGTGGCCCAGGGCGTTCCCTTCGGCCGTGAATACGGCGGCCTGCTGGACAACCGCTCCTTCGGCGGCGCCCAGCTC
AAGCGAACCTTCTACGCACGCGGACAGACGGGCCAGCAGCTCCTGCTGGGTGCCTACCAGGCCCTGGAAAAGGAAGTGGC
CAAGGGACACATTGAAATGTTCTCCCGCCATGAAATGATGGATCTGGTGCTGGTGGACGGCGAAGCCAAGGGCATCGTCA
CCCGCAATCTGGTTACCGGCGAAATCAAATCCTACGCAGGGGATACCGTCCTGCTCTGCACGGGCGGCTACGGCAACGTG
TTCTTCCTGTCCACCAACGCGATGGGTTGCAACGTCACTGCCGCCTACAAAGCCTACAAGCGTGGTGCCTTCTTCGCCAA
CCCCTGCTTCACGCAAATCCACCCCACCTGCATTCCGGTCAAAGGCGACTACCAGTCCAAACTGACGCTGATGTCGGAAT
CCCTCCGCAACAGCGGCCGCATCTGGGTGCCCAAGTCCCGTGAAACCGCAGAAAAAATCCGTAAGAAGGAAATCAAGCCT
TCCGATGTTCCCGAAGAAGAACGGGACTACTACCTGGAACGCAAGTATCCCTCCTTCGGCAACCTGGCTCCGCGCGACAT
TTCCTCCCGCGCCGCCAAGGAAGCCTGCGACGACGGCCGCGGCGTGGCCGTCACCGGCAAGGGCGTCTTCCTGGATTTTG
CGGATGAAATCAAGCGCATGGGCCGCGAATGGATTGACGGCCAATACGGCAATCTGTTTGACATGTACGAAGAAATCACG
GACGACGACCCCCATGAAACGCCCATGATGATCTACCCCGCCTCCCACTACACCATGGGCGGCCTGTGGGTGGACTACAA
CCTCATGTCCAACGTGAAGGGGTTGCACGTCCTCGGTGAAGCCAACTTCTCCGACCACGGCGCCAACCGCCTGGGAGCCT
CCGCCCTGATGCAGGGCCTGTCTGACGGCTACTTCGTCATTCCCGCCACGCTGCCCGCTTACCTGACGACCACCAAGCCC
GGTGCCGTCACCACCGCCGCCCCGGAATTCAAGGCTGCGGAAGACGAAGTGAAGGAACGCATCAACAAGCTCCTGAATGT
GAAGGGCACCAAGACGGTGGACTCCTTCCACCGGGAACTGGGCCTCATCATGTGGGAAGACTGCGGCATGGCCCGCACGG
AAGAAAGCCTGACCCACGCCATTGAACGCATTCCCCAGCTCCGCAAGGAATTCTGGGAAAACGTGCGCGTAACCGGCACG
GCGGACGGCATCAACGCGGAACTGGAAAAAGCCTGCCGCGTGGCCGACTTCCTGGAATTCGCCCAGCTGCTCTGCTATGA
CGCCCTGAACCGCCAGGAATCCTGCGGCGCCCACTTCCGCGTGGAATACCAGCTGCCGGACGGCGAAGCCAAGCGCAACG
ACGATGAATACGCCTATGTAGCCGCCTGGGAATACACTGGCGTGGACAGCCTGCCTGTTCTCCACAAGGAACCGCTGACC
TTCGAGAACGTGCACCTTGCCATCCGCAGCTACAAGTAA

Upstream 100 bases:

>100_bases
CGCCATCGCCTACGGCGCGATTATCTGCCTGGGCTTCATCTCCGTGCCGGTCTCGGTTCTTCTGGGTATCATCAAATAAC
CATCAACTCCTCTCAAAGTC

Downstream 100 bases:

>100_bases
AGATAGCCAATACATTAACACTCAAAAGAAAGATTATAACATGGCTAAAACACTCAATCTCACTCTCAAGGTCTGGCGCC
AGGAAAACCGGGAAGCCAAG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 652; Mature: 652

Protein sequence:

>652_residues
MINFPVSDWMPDAKIPSGPIQDKWSKYKLESKLINPNNKRKYTVLVVGSGLAGASAAATLAELGYNVKCFCYQDSPRRAH
SIAAQGGINAAKNYQNDGDSVYRLFYDTVKGGDFRAREANVYRLAEVSSNIIDQCVAQGVPFGREYGGLLDNRSFGGAQL
KRTFYARGQTGQQLLLGAYQALEKEVAKGHIEMFSRHEMMDLVLVDGEAKGIVTRNLVTGEIKSYAGDTVLLCTGGYGNV
FFLSTNAMGCNVTAAYKAYKRGAFFANPCFTQIHPTCIPVKGDYQSKLTLMSESLRNSGRIWVPKSRETAEKIRKKEIKP
SDVPEEERDYYLERKYPSFGNLAPRDISSRAAKEACDDGRGVAVTGKGVFLDFADEIKRMGREWIDGQYGNLFDMYEEIT
DDDPHETPMMIYPASHYTMGGLWVDYNLMSNVKGLHVLGEANFSDHGANRLGASALMQGLSDGYFVIPATLPAYLTTTKP
GAVTTAAPEFKAAEDEVKERINKLLNVKGTKTVDSFHRELGLIMWEDCGMARTEESLTHAIERIPQLRKEFWENVRVTGT
ADGINAELEKACRVADFLEFAQLLCYDALNRQESCGAHFRVEYQLPDGEAKRNDDEYAYVAAWEYTGVDSLPVLHKEPLT
FENVHLAIRSYK

Sequences:

>Translated_652_residues
MINFPVSDWMPDAKIPSGPIQDKWSKYKLESKLINPNNKRKYTVLVVGSGLAGASAAATLAELGYNVKCFCYQDSPRRAH
SIAAQGGINAAKNYQNDGDSVYRLFYDTVKGGDFRAREANVYRLAEVSSNIIDQCVAQGVPFGREYGGLLDNRSFGGAQL
KRTFYARGQTGQQLLLGAYQALEKEVAKGHIEMFSRHEMMDLVLVDGEAKGIVTRNLVTGEIKSYAGDTVLLCTGGYGNV
FFLSTNAMGCNVTAAYKAYKRGAFFANPCFTQIHPTCIPVKGDYQSKLTLMSESLRNSGRIWVPKSRETAEKIRKKEIKP
SDVPEEERDYYLERKYPSFGNLAPRDISSRAAKEACDDGRGVAVTGKGVFLDFADEIKRMGREWIDGQYGNLFDMYEEIT
DDDPHETPMMIYPASHYTMGGLWVDYNLMSNVKGLHVLGEANFSDHGANRLGASALMQGLSDGYFVIPATLPAYLTTTKP
GAVTTAAPEFKAAEDEVKERINKLLNVKGTKTVDSFHRELGLIMWEDCGMARTEESLTHAIERIPQLRKEFWENVRVTGT
ADGINAELEKACRVADFLEFAQLLCYDALNRQESCGAHFRVEYQLPDGEAKRNDDEYAYVAAWEYTGVDSLPVLHKEPLT
FENVHLAIRSYK
>Mature_652_residues
MINFPVSDWMPDAKIPSGPIQDKWSKYKLESKLINPNNKRKYTVLVVGSGLAGASAAATLAELGYNVKCFCYQDSPRRAH
SIAAQGGINAAKNYQNDGDSVYRLFYDTVKGGDFRAREANVYRLAEVSSNIIDQCVAQGVPFGREYGGLLDNRSFGGAQL
KRTFYARGQTGQQLLLGAYQALEKEVAKGHIEMFSRHEMMDLVLVDGEAKGIVTRNLVTGEIKSYAGDTVLLCTGGYGNV
FFLSTNAMGCNVTAAYKAYKRGAFFANPCFTQIHPTCIPVKGDYQSKLTLMSESLRNSGRIWVPKSRETAEKIRKKEIKP
SDVPEEERDYYLERKYPSFGNLAPRDISSRAAKEACDDGRGVAVTGKGVFLDFADEIKRMGREWIDGQYGNLFDMYEEIT
DDDPHETPMMIYPASHYTMGGLWVDYNLMSNVKGLHVLGEANFSDHGANRLGASALMQGLSDGYFVIPATLPAYLTTTKP
GAVTTAAPEFKAAEDEVKERINKLLNVKGTKTVDSFHRELGLIMWEDCGMARTEESLTHAIERIPQLRKEFWENVRVTGT
ADGINAELEKACRVADFLEFAQLLCYDALNRQESCGAHFRVEYQLPDGEAKRNDDEYAYVAAWEYTGVDSLPVLHKEPLT
FENVHLAIRSYK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=578, Percent_Identity=25.2595155709343, Blast_Score=144, Evalue=4e-34,
Organism=Escherichia coli, GI1790597, Length=541, Percent_Identity=29.2051756007394, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1788928, Length=589, Percent_Identity=25.6366723259762, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI1786942, Length=564, Percent_Identity=25.709219858156, Blast_Score=126, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17505833, Length=550, Percent_Identity=26.9090909090909, Blast_Score=170, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17550100, Length=552, Percent_Identity=26.8115942028986, Blast_Score=149, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6322701, Length=593, Percent_Identity=28.6677908937605, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6322416, Length=606, Percent_Identity=27.5577557755776, Blast_Score=173, Evalue=9e-44,
Organism=Drosophila melanogaster, GI17137288, Length=555, Percent_Identity=26.6666666666667, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24655642, Length=555, Percent_Identity=26.6666666666667, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24655647, Length=555, Percent_Identity=26.6666666666667, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24663005, Length=583, Percent_Identity=24.8713550600343, Blast_Score=133, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 72651; Mature: 72651

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINFPVSDWMPDAKIPSGPIQDKWSKYKLESKLINPNNKRKYTVLVVGSGLAGASAAATL
CCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEEECCCCCHHHHHHH
AELGYNVKCFCYQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTVKGGDFRAREAN
HHCCCCEEEEEECCCCCHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCC
VYRLAEVSSNIIDQCVAQGVPFGREYGGLLDNRSFGGAQLKRTFYARGQTGQQLLLGAYQ
EEEHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCHHHHHHHEECCCCCHHHHHHHHH
ALEKEVAKGHIEMFSRHEMMDLVLVDGEAKGIVTRNLVTGEIKSYAGDTVLLCTGGYGNV
HHHHHHHHHHHHHHHHCCEEEEEEECCCCCCEEEECEEHHHHHHCCCCEEEEEECCCCCE
FFLSTNAMGCNVTAAYKAYKRGAFFANPCFTQIHPTCIPVKGDYQSKLTLMSESLRNSGR
EEEECCCCCCCCHHHHHHHHCCCEECCCCHHCCCCEEEECCCCCHHHHHHHHHHHHCCCC
IWVPKSRETAEKIRKKEIKPSDVPEEERDYYLERKYPSFGNLAPRDISSRAAKEACDDGR
EEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCC
GVAVTGKGVFLDFADEIKRMGREWIDGQYGNLFDMYEEITDDDPHETPMMIYPASHYTMG
CEEEECCCEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCEEEECCCCCEEC
GLWVDYNLMSNVKGLHVLGEANFSDHGANRLGASALMQGLSDGYFVIPATLPAYLTTTKP
CEEEEEHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCEEEEECCC
GAVTTAAPEFKAAEDEVKERINKLLNVKGTKTVDSFHRELGLIMWEDCGMARTEESLTHA
CCEEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCEEEEECCCCCCHHHHHHHH
IERIPQLRKEFWENVRVTGTADGINAELEKACRVADFLEFAQLLCYDALNRQESCGAHFR
HHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
VEYQLPDGEAKRNDDEYAYVAAWEYTGVDSLPVLHKEPLTFENVHLAIRSYK
EEEECCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MINFPVSDWMPDAKIPSGPIQDKWSKYKLESKLINPNNKRKYTVLVVGSGLAGASAAATL
CCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEEECCCCCHHHHHHH
AELGYNVKCFCYQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTVKGGDFRAREAN
HHCCCCEEEEEECCCCCHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCC
VYRLAEVSSNIIDQCVAQGVPFGREYGGLLDNRSFGGAQLKRTFYARGQTGQQLLLGAYQ
EEEHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCHHHHHHHEECCCCCHHHHHHHHH
ALEKEVAKGHIEMFSRHEMMDLVLVDGEAKGIVTRNLVTGEIKSYAGDTVLLCTGGYGNV
HHHHHHHHHHHHHHHHCCEEEEEEECCCCCCEEEECEEHHHHHHCCCCEEEEEECCCCCE
FFLSTNAMGCNVTAAYKAYKRGAFFANPCFTQIHPTCIPVKGDYQSKLTLMSESLRNSGR
EEEECCCCCCCCHHHHHHHHCCCEECCCCHHCCCCEEEECCCCCHHHHHHHHHHHHCCCC
IWVPKSRETAEKIRKKEIKPSDVPEEERDYYLERKYPSFGNLAPRDISSRAAKEACDDGR
EEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCC
GVAVTGKGVFLDFADEIKRMGREWIDGQYGNLFDMYEEITDDDPHETPMMIYPASHYTMG
CEEEECCCEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCEEEECCCCCEEC
GLWVDYNLMSNVKGLHVLGEANFSDHGANRLGASALMQGLSDGYFVIPATLPAYLTTTKP
CEEEEEHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCEEEEECCC
GAVTTAAPEFKAAEDEVKERINKLLNVKGTKTVDSFHRELGLIMWEDCGMARTEESLTHA
CCEEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCEEEEECCCCCCHHHHHHHH
IERIPQLRKEFWENVRVTGTADGINAELEKACRVADFLEFAQLLCYDALNRQESCGAHFR
HHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
VEYQLPDGEAKRNDDEYAYVAAWEYTGVDSLPVLHKEPLTFENVHLAIRSYK
EEEECCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]