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The map label for this gene is fba [H]

Identifier: 187735227

GI number: 187735227

Start: 850692

End: 851723

Strand: Direct

Name: fba [H]

Synonym: Amuc_0721

Alternate gene names: 187735227

Gene position: 850692-851723 (Clockwise)

Preceding gene: 187735226

Following gene: 187735229

Centisome position: 31.93

GC content: 57.36

Gene sequence:

>1032_bases
ATGCCAATAGCCACACCAGAACAATACATTACCATGCTTGAAACGGCCAAAAAGGAAGGCTACGCCTATCCGGCCGTTAA
CGTGACCACGATCGAAGTCATCAACGGCGCTCTCCGCGCTTTTTCCGAAGCCAAAAGCGACGGTATCATTCAGGTTTCCA
TCGGTGGCGGCAAATTCGCCTCCGGCAGCTCCGTAGGCAATTCCGCCCTTGGCGCCATTGTTCTGGCGGAAGCAACGCGT
CGTCTGGCTGAAAAGCACAACGTTCTCGTAGCCCTTCACACGGACCACTGCCAGCCCGAACACGTGGATACTTTCCTGCG
TCCTCTGATTGCCGAATCCCGCCGCCGCGTGGAACGCGGTGAAGCCCCCCTCTTCAATTCCCACATGCTGGATGCCTCCA
CGCTTCCCATGGCGGAAAACCTCAAGCTTTCCCGGGAACTGCTGAAGGAATGCGCCGAACTGGGCATCGTTCTTGAAATC
GAAATCGGCGTTGTGGGCGGAGAAGAAGACGGAGTGGACAACTCCGGCCATCCCGCCGACAAGCTTTACACTTCTCCGGA
AGATATGCTGATGACGTATGAAGCCCTCGCGCCCCTCGGCAAATTCATGCTGGCCGCCACTTTCGGCAACGTGCACGGCG
TGTACAAGCCCGGCCACGTCAAACTGAAACCCAGCATCCTGCGGGACGGTCAGGAAGCCGTGGTAGCCAAACACGGAGAA
GCGGCTCGCATGCCCCTCGTCTTCCATGGCGGTTCCGGTTCCGAACTTTCCGATATCCGCGAAGCCGTTTCCTACGGCGT
CGTCAAGATGAACATCGACACCGACACGCAATACGCCTTCACCCGCCCGATCGTCTCCCACATGTGCGAACACATCAACG
GAGTGCTCAAGATTGATGGCGAAGTGGGCAACAAGAAGGATTACGATCCCCGTTCCTATCTTGCCAAGGGTGAAAAGGGA
GTCGCCGCCCGCCTTCAGGAAGCCGCCGACAACCTTATGTCCGCCGGCAAGACCCTCTTTGGCAAAATCTAA

Upstream 100 bases:

>100_bases
GATTCGAACATGAACATGTCCCGCAAGAGCGCTGCAACCCCGGCGTGCGCCTGAGTTCAGCCTTGCCCTCCTGAAAAAAA
ACACCTATCATATCCCCGTT

Downstream 100 bases:

>100_bases
AAAGAGTTCCCTCAACGAGTTTAATGCCATGCCCGGTTTCTTAAAAGAAACCGGGCATTTTTTCTGGAAAAACCCGCCAA
CAGGGTAAGGCGGGAAACGC

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MPIATPEQYITMLETAKKEGYAYPAVNVTTIEVINGALRAFSEAKSDGIIQVSIGGGKFASGSSVGNSALGAIVLAEATR
RLAEKHNVLVALHTDHCQPEHVDTFLRPLIAESRRRVERGEAPLFNSHMLDASTLPMAENLKLSRELLKECAELGIVLEI
EIGVVGGEEDGVDNSGHPADKLYTSPEDMLMTYEALAPLGKFMLAATFGNVHGVYKPGHVKLKPSILRDGQEAVVAKHGE
AARMPLVFHGGSGSELSDIREAVSYGVVKMNIDTDTQYAFTRPIVSHMCEHINGVLKIDGEVGNKKDYDPRSYLAKGEKG
VAARLQEAADNLMSAGKTLFGKI

Sequences:

>Translated_343_residues
MPIATPEQYITMLETAKKEGYAYPAVNVTTIEVINGALRAFSEAKSDGIIQVSIGGGKFASGSSVGNSALGAIVLAEATR
RLAEKHNVLVALHTDHCQPEHVDTFLRPLIAESRRRVERGEAPLFNSHMLDASTLPMAENLKLSRELLKECAELGIVLEI
EIGVVGGEEDGVDNSGHPADKLYTSPEDMLMTYEALAPLGKFMLAATFGNVHGVYKPGHVKLKPSILRDGQEAVVAKHGE
AARMPLVFHGGSGSELSDIREAVSYGVVKMNIDTDTQYAFTRPIVSHMCEHINGVLKIDGEVGNKKDYDPRSYLAKGEKG
VAARLQEAADNLMSAGKTLFGKI
>Mature_342_residues
PIATPEQYITMLETAKKEGYAYPAVNVTTIEVINGALRAFSEAKSDGIIQVSIGGGKFASGSSVGNSALGAIVLAEATRR
LAEKHNVLVALHTDHCQPEHVDTFLRPLIAESRRRVERGEAPLFNSHMLDASTLPMAENLKLSRELLKECAELGIVLEIE
IGVVGGEEDGVDNSGHPADKLYTSPEDMLMTYEALAPLGKFMLAATFGNVHGVYKPGHVKLKPSILRDGQEAVVAKHGEA
ARMPLVFHGGSGSELSDIREAVSYGVVKMNIDTDTQYAFTRPIVSHMCEHINGVLKIDGEVGNKKDYDPRSYLAKGEKGV
AARLQEAADNLMSAGKTLFGKI

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789293, Length=337, Percent_Identity=41.2462908011869, Blast_Score=244, Evalue=7e-66,
Organism=Escherichia coli, GI87082041, Length=310, Percent_Identity=27.4193548387097, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1789526, Length=306, Percent_Identity=29.0849673202614, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788072, Length=263, Percent_Identity=31.1787072243346, Blast_Score=82, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6322790, Length=337, Percent_Identity=36.7952522255193, Blast_Score=201, Evalue=1e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006411
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 36924; Mature: 36792

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIATPEQYITMLETAKKEGYAYPAVNVTTIEVINGALRAFSEAKSDGIIQVSIGGGKFA
CCCCCHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
SGSSVGNSALGAIVLAEATRRLAEKHNVLVALHTDHCQPEHVDTFLRPLIAESRRRVERG
CCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHC
EAPLFNSHMLDASTLPMAENLKLSRELLKECAELGIVLEIEIGVVGGEEDGVDNSGHPAD
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCCCCHH
KLYTSPEDMLMTYEALAPLGKFMLAATFGNVHGVYKPGHVKLKPSILRDGQEAVVAKHGE
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECHHHHCCCCHHHHCCCCC
AARMPLVFHGGSGSELSDIREAVSYGVVKMNIDTDTQYAFTRPIVSHMCEHINGVLKIDG
CCCCCEEEECCCCCHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEECC
EVGNKKDYDPRSYLAKGEKGVAARLQEAADNLMSAGKTLFGKI
CCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHCCC
>Mature Secondary Structure 
PIATPEQYITMLETAKKEGYAYPAVNVTTIEVINGALRAFSEAKSDGIIQVSIGGGKFA
CCCCHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
SGSSVGNSALGAIVLAEATRRLAEKHNVLVALHTDHCQPEHVDTFLRPLIAESRRRVERG
CCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHC
EAPLFNSHMLDASTLPMAENLKLSRELLKECAELGIVLEIEIGVVGGEEDGVDNSGHPAD
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCCCCHH
KLYTSPEDMLMTYEALAPLGKFMLAATFGNVHGVYKPGHVKLKPSILRDGQEAVVAKHGE
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECHHHHCCCCHHHHCCCCC
AARMPLVFHGGSGSELSDIREAVSYGVVKMNIDTDTQYAFTRPIVSHMCEHINGVLKIDG
CCCCCEEEECCCCCHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEECC
EVGNKKDYDPRSYLAKGEKGVAARLQEAADNLMSAGKTLFGKI
CCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2615658; 12948626 [H]