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The map label for this gene is murC [H]

Identifier: 187735166

GI number: 187735166

Start: 775858

End: 778155

Strand: Direct

Name: murC [H]

Synonym: Amuc_0660

Alternate gene names: 187735166

Gene position: 775858-778155 (Clockwise)

Preceding gene: 187735165

Following gene: 187735167

Centisome position: 29.12

GC content: 60.92

Gene sequence:

>2298_bases
ATGATTGAAACCTTACGCAAAAGACTGACAGACAGGGAACACCCGGCACGCCTACATCTCATCGGGGTAGCCGGGTCAGG
CATGTCCGGCCTGGCGCTCATGCTGATGGAAATGGGGCACCGGGTGAGCGGCTGCGACCGGGTGACCAGCGCAGAGACCG
AACGGCTTCAAAGCCTGGGGCTGTCTTTCTCCTGCCCGCATTCCGCAGACGCCGTTTCCGATGCGGAAATTGTCATTTAT
TCCAGTGCCATCCGGGCGGACAATCCGGCCCTGGCGGCAGCACGCAAGCTGAATATTCCCTGCATGCGCCGCGCGGAATG
CCTGGCAGCCATCCTGAACGGGAAGAAAGGGGTCGTGGTCTCCGGTACGCATGGAAAAACCACTACTTCAGCCCTCTGCG
CGCACCTGATGAGGGAAGGCCGCATGCGTCCGTGCCACTACGTGGGGGCGGAAATCCCCGTGCTGGGAACCAACGCCCAC
TGGAATGAAGACAGCGAATACCTGGTGGCGGAAGGGGATGAAAGCGACGGCACGCTGGTAAATTACATTCCGGAGCACAG
CATCGTCCTCAACATTGAACCGGAACACCTGGACCACTACAAGGATCTGGATGAAATCAAGGCCGTGTTCGACCGGCTTT
GCTCCCAGACGCGCGGCAAGATTATTTATTGCCGCGCGCATCCCGGCGCTGAGGATGTCTGCGCCAAGTACCCCAATTCC
GTTTCCTACGGCTGGTCCGATGCGGACTACACCGCTACGGACGTGCTGGAACGCCGCGGACGCACCCTGTTCACCGTGTT
GAAGGGGAAAGAGGAACTGGGCCGCGTGGAGCTGGGCATACCCGGACGCCACAATGTCCTGAATTCCCTGGCCGCGATTG
CTCTGGCAACGGAACTGGGCGTGGATTTCCCGGCGGTGACGCGGGGCCTGGCCTCCTTTGCGGGAGCCAAACGGCGCTTT
GAAACCAAATACCTTTCCTCCTCCATCCGGATTGTGGACGACTACGGCCACCACCCAACGGAAATAGCCGCCACGCTCCA
AACTGCCCGTTCCCTCCAGCCGAACCGCCTGGTAGTTTACTTCCAGCCGCACCGCTACACGCGCACGCAGCTTCTGGCGG
ATGACTTCGGCAAGGTGCTCCAGGAGGCGGACCTCGTTTTCGTAGCGGACGTGTATCCCGCCAGCGAACTGCCTATTGAA
GGGGTAAGCGGGCAGACGATCATCAACGCCATGCACAGGCACGGCCCCGTGGAAACCCGTTACCTTCCCGACCTGGGCAT
AGCCCACCACACCATCGGCAACGCGCTGAAACCCGGAGACCTGTTCCTGACGCTGGGAGCCGGGAACGTCCATGAATGCG
GCATGCGCATCGCGCGCGACCTGGCCCTGCTGGAGGATCTGGAACGCACTGCGGGCGGTTCTCTGGAAGGCAAGCTGTAC
GAACCCATGTCACGCCATACGACCATGGGAGTAGGCGGATGCGCCCAGTACTGGCTGGAGCCTTCCACCTTTTCCGGAAT
GCAGGCGGCCGTCAACTATTGCCGGGACAGGAATATCCCCGTACACGTCATTGGCCGCGGTTCCAACATCATTGTCAGGG
ACGGCGGACTGCGCGGCGCCGTCATCCACCCCTCTGGGGGAGAATTCGATGTGCTGGAAATCCAGGGGAACCGCCTCACC
GCCGGAGCGGGCGTGCGGTTGAAAAAACTGGTTTCCACCGCCGTCCAGAACGGCCTTGGCGGCCTGGAATGGATGGACGG
CATTCCCGGCAATGTGGGAGGAAGCCTCCGCATGAACGCCGGAGCCATGGGCATGGATATGGTCAAAAACCTCGTTTCCG
TCACCTGTCTGGATGAAGACGGGGAAATCCGCAGCCATACAAGGGAAGAATTGAACGCCCAGTACCGTTCCATTCCGGAC
CTGGTCCACAATTTTGTGCTTCAGGCCGTGTTTGAGGCGCAGCCCGCCCCTGCGGAAGAAATGGAGCGTCTTCTGGAGGC
GGCACGGGCCAGGCGGAAGCTTTCCCAGCCCGTCGGAGCCAGCGCCGGCTGCATCTTCAAAAACCCGCCGGAAATCCCGG
CAGGCAGGCTCATTGACGAACTGGGGCTGAAAGGCGCCTGCGTGGGAGACGCCTGCGTATCAGACGTGCACGCCAATTTT
ATCATCAACCGGGGTCATGCCAGAGCGAGGGACATCACCATCCTGATCGACATGATCCGCAAGGAGGCCAAGGAAAACCG
CGGCATCGACCTGAAATCGGAAGCCCAGGTCATCGGAGACCGGGACCCCCAGTTTTAA

Upstream 100 bases:

>100_bases
CTGCTGGCCTCCATGAATGAATGTGCTTTACGTCTGGACATGCCTGATGCAGTATCCCGCATCGCCAATGTCATTGAACA
TACGGACCATGCAGCCTCCC

Downstream 100 bases:

>100_bases
CCCATTCATTATTTATTCCAATATGAACACTCTCAAGCGCGACCTCAAAATCGCCCTCCTGCTCGGAGGTCCCGGGGCAG
AACGGGAAGTATCCCTTGTT

Product: UDP-N-acetylmuramate/alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 765; Mature: 765

Protein sequence:

>765_residues
MIETLRKRLTDREHPARLHLIGVAGSGMSGLALMLMEMGHRVSGCDRVTSAETERLQSLGLSFSCPHSADAVSDAEIVIY
SSAIRADNPALAAARKLNIPCMRRAECLAAILNGKKGVVVSGTHGKTTTSALCAHLMREGRMRPCHYVGAEIPVLGTNAH
WNEDSEYLVAEGDESDGTLVNYIPEHSIVLNIEPEHLDHYKDLDEIKAVFDRLCSQTRGKIIYCRAHPGAEDVCAKYPNS
VSYGWSDADYTATDVLERRGRTLFTVLKGKEELGRVELGIPGRHNVLNSLAAIALATELGVDFPAVTRGLASFAGAKRRF
ETKYLSSSIRIVDDYGHHPTEIAATLQTARSLQPNRLVVYFQPHRYTRTQLLADDFGKVLQEADLVFVADVYPASELPIE
GVSGQTIINAMHRHGPVETRYLPDLGIAHHTIGNALKPGDLFLTLGAGNVHECGMRIARDLALLEDLERTAGGSLEGKLY
EPMSRHTTMGVGGCAQYWLEPSTFSGMQAAVNYCRDRNIPVHVIGRGSNIIVRDGGLRGAVIHPSGGEFDVLEIQGNRLT
AGAGVRLKKLVSTAVQNGLGGLEWMDGIPGNVGGSLRMNAGAMGMDMVKNLVSVTCLDEDGEIRSHTREELNAQYRSIPD
LVHNFVLQAVFEAQPAPAEEMERLLEAARARRKLSQPVGASAGCIFKNPPEIPAGRLIDELGLKGACVGDACVSDVHANF
IINRGHARARDITILIDMIRKEAKENRGIDLKSEAQVIGDRDPQF

Sequences:

>Translated_765_residues
MIETLRKRLTDREHPARLHLIGVAGSGMSGLALMLMEMGHRVSGCDRVTSAETERLQSLGLSFSCPHSADAVSDAEIVIY
SSAIRADNPALAAARKLNIPCMRRAECLAAILNGKKGVVVSGTHGKTTTSALCAHLMREGRMRPCHYVGAEIPVLGTNAH
WNEDSEYLVAEGDESDGTLVNYIPEHSIVLNIEPEHLDHYKDLDEIKAVFDRLCSQTRGKIIYCRAHPGAEDVCAKYPNS
VSYGWSDADYTATDVLERRGRTLFTVLKGKEELGRVELGIPGRHNVLNSLAAIALATELGVDFPAVTRGLASFAGAKRRF
ETKYLSSSIRIVDDYGHHPTEIAATLQTARSLQPNRLVVYFQPHRYTRTQLLADDFGKVLQEADLVFVADVYPASELPIE
GVSGQTIINAMHRHGPVETRYLPDLGIAHHTIGNALKPGDLFLTLGAGNVHECGMRIARDLALLEDLERTAGGSLEGKLY
EPMSRHTTMGVGGCAQYWLEPSTFSGMQAAVNYCRDRNIPVHVIGRGSNIIVRDGGLRGAVIHPSGGEFDVLEIQGNRLT
AGAGVRLKKLVSTAVQNGLGGLEWMDGIPGNVGGSLRMNAGAMGMDMVKNLVSVTCLDEDGEIRSHTREELNAQYRSIPD
LVHNFVLQAVFEAQPAPAEEMERLLEAARARRKLSQPVGASAGCIFKNPPEIPAGRLIDELGLKGACVGDACVSDVHANF
IINRGHARARDITILIDMIRKEAKENRGIDLKSEAQVIGDRDPQF
>Mature_765_residues
MIETLRKRLTDREHPARLHLIGVAGSGMSGLALMLMEMGHRVSGCDRVTSAETERLQSLGLSFSCPHSADAVSDAEIVIY
SSAIRADNPALAAARKLNIPCMRRAECLAAILNGKKGVVVSGTHGKTTTSALCAHLMREGRMRPCHYVGAEIPVLGTNAH
WNEDSEYLVAEGDESDGTLVNYIPEHSIVLNIEPEHLDHYKDLDEIKAVFDRLCSQTRGKIIYCRAHPGAEDVCAKYPNS
VSYGWSDADYTATDVLERRGRTLFTVLKGKEELGRVELGIPGRHNVLNSLAAIALATELGVDFPAVTRGLASFAGAKRRF
ETKYLSSSIRIVDDYGHHPTEIAATLQTARSLQPNRLVVYFQPHRYTRTQLLADDFGKVLQEADLVFVADVYPASELPIE
GVSGQTIINAMHRHGPVETRYLPDLGIAHHTIGNALKPGDLFLTLGAGNVHECGMRIARDLALLEDLERTAGGSLEGKLY
EPMSRHTTMGVGGCAQYWLEPSTFSGMQAAVNYCRDRNIPVHVIGRGSNIIVRDGGLRGAVIHPSGGEFDVLEIQGNRLT
AGAGVRLKKLVSTAVQNGLGGLEWMDGIPGNVGGSLRMNAGAMGMDMVKNLVSVTCLDEDGEIRSHTREELNAQYRSIPD
LVHNFVLQAVFEAQPAPAEEMERLLEAARARRKLSQPVGASAGCIFKNPPEIPAGRLIDELGLKGACVGDACVSDVHANF
IINRGHARARDITILIDMIRKEAKENRGIDLKSEAQVIGDRDPQF

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=460, Percent_Identity=37.3913043478261, Blast_Score=247, Evalue=2e-66,
Organism=Escherichia coli, GI1790680, Length=467, Percent_Identity=28.6937901498929, Blast_Score=154, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 83166; Mature: 83166

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIETLRKRLTDREHPARLHLIGVAGSGMSGLALMLMEMGHRVSGCDRVTSAETERLQSLG
CHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCC
LSFSCPHSADAVSDAEIVIYSSAIRADNPALAAARKLNIPCMRRAECLAAILNGKKGVVV
CCCCCCCCCCCCCCCEEEEEECHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEE
SGTHGKTTTSALCAHLMREGRMRPCHYVGAEIPVLGTNAHWNEDSEYLVAEGDESDGTLV
ECCCCCCHHHHHHHHHHHCCCCCCCEECCCCCEEECCCCCCCCCCCEEEEECCCCCCCEE
NYIPEHSIVLNIEPEHLDHYKDLDEIKAVFDRLCSQTRGKIIYCRAHPGAEDVCAKYPNS
EECCCCCEEEEECHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCC
VSYGWSDADYTATDVLERRGRTLFTVLKGKEELGRVELGIPGRHNVLNSLAAIALATELG
CCCCCCCCCCHHHHHHHHCCCEEEEEECCHHHHCEEEECCCCHHHHHHHHHHHHHHHHHC
VDFPAVTRGLASFAGAKRRFETKYLSSSIRIVDDYGHHPTEIAATLQTARSLQPNRLVVY
CCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEE
FQPHRYTRTQLLADDFGKVLQEADLVFVADVYPASELPIEGVSGQTIINAMHRHGPVETR
ECCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
YLPDLGIAHHTIGNALKPGDLFLTLGAGNVHECGMRIARDLALLEDLERTAGGSLEGKLY
CCCCCCHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
EPMSRHTTMGVGGCAQYWLEPSTFSGMQAAVNYCRDRNIPVHVIGRGSNIIVRDGGLRGA
CCHHHHCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCEEE
VIHPSGGEFDVLEIQGNRLTAGAGVRLKKLVSTAVQNGLGGLEWMDGIPGNVGGSLRMNA
EECCCCCCEEEEEEECCEEECCCCHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCEEECC
GAMGMDMVKNLVSVTCLDEDGEIRSHTREELNAQYRSIPDLVHNFVLQAVFEAQPAPAEE
CCCCHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
MERLLEAARARRKLSQPVGASAGCIFKNPPEIPAGRLIDELGLKGACVGDACVSDVHANF
HHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCE
IINRGHARARDITILIDMIRKEAKENRGIDLKSEAQVIGDRDPQF
EEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCC
>Mature Secondary Structure
MIETLRKRLTDREHPARLHLIGVAGSGMSGLALMLMEMGHRVSGCDRVTSAETERLQSLG
CHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCC
LSFSCPHSADAVSDAEIVIYSSAIRADNPALAAARKLNIPCMRRAECLAAILNGKKGVVV
CCCCCCCCCCCCCCCEEEEEECHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEE
SGTHGKTTTSALCAHLMREGRMRPCHYVGAEIPVLGTNAHWNEDSEYLVAEGDESDGTLV
ECCCCCCHHHHHHHHHHHCCCCCCCEECCCCCEEECCCCCCCCCCCEEEEECCCCCCCEE
NYIPEHSIVLNIEPEHLDHYKDLDEIKAVFDRLCSQTRGKIIYCRAHPGAEDVCAKYPNS
EECCCCCEEEEECHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCC
VSYGWSDADYTATDVLERRGRTLFTVLKGKEELGRVELGIPGRHNVLNSLAAIALATELG
CCCCCCCCCCHHHHHHHHCCCEEEEEECCHHHHCEEEECCCCHHHHHHHHHHHHHHHHHC
VDFPAVTRGLASFAGAKRRFETKYLSSSIRIVDDYGHHPTEIAATLQTARSLQPNRLVVY
CCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEE
FQPHRYTRTQLLADDFGKVLQEADLVFVADVYPASELPIEGVSGQTIINAMHRHGPVETR
ECCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
YLPDLGIAHHTIGNALKPGDLFLTLGAGNVHECGMRIARDLALLEDLERTAGGSLEGKLY
CCCCCCHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
EPMSRHTTMGVGGCAQYWLEPSTFSGMQAAVNYCRDRNIPVHVIGRGSNIIVRDGGLRGA
CCHHHHCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCEEE
VIHPSGGEFDVLEIQGNRLTAGAGVRLKKLVSTAVQNGLGGLEWMDGIPGNVGGSLRMNA
EECCCCCCEEEEEEECCEEECCCCHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCEEECC
GAMGMDMVKNLVSVTCLDEDGEIRSHTREELNAQYRSIPDLVHNFVLQAVFEAQPAPAEE
CCCCHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
MERLLEAARARRKLSQPVGASAGCIFKNPPEIPAGRLIDELGLKGACVGDACVSDVHANF
HHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCE
IINRGHARARDITILIDMIRKEAKENRGIDLKSEAQVIGDRDPQF
EEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA