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The map label for this gene is upp

Identifier: 186476817

GI number: 186476817

Start: 2314737

End: 2315387

Strand: Direct

Name: upp

Synonym: Bphy_2063

Alternate gene names: 186476817

Gene position: 2314737-2315387 (Clockwise)

Preceding gene: 186476802

Following gene: 186476818

Centisome position: 66.53

GC content: 61.9

Gene sequence:

>651_bases
ATGACCCAGGACAGCCGTTTTCCCAATCTTTTCATCCTCGATCACCCGCTGATCCAGCACAAGCTGTCGCACATGCGCGA
CCGCGACACGTCAACGCGGACGTTCCGCGAACTGCTGCGCGAGATCACGTTGCTGATGGGCTATGAAATCACCCGCAACC
TGCCGATGACGACGCGTCGCGTGAGCACGCCGCTCGTCGATATCGACGCGCCCGTAATCGCCGGCAAGAAGCTCGCGATC
GTGCCTGTGCTGCGGGCGGGCGTCGGCATGTCGGACGGGCTGCTCGAACTGATTCCGTCGGCGCGGGTCGGCCATATCGG
GGTGTATCGCGACGACGATCATCGGCCGGTGGAATATCTGGTGCGCCTGCCGGATCTCGAGGACCGGATTTTCATCCTGT
GCGATCCGATGGTCGCGACGGGGTATTCCGCCGTGCATGCGATCGATGTGCTCAAGCGCCGCGGCGTCGCGGGCGAGAAC
ATCTCGTTTTTGGCGCTCGTGGCCGCGCCTGAGGGGGTGCAAGTGTTTCAGGACGCACATCCCGACGTGAAGCTGTACGT
CGCTTCGCTCGATTCGCATCTGAATGAGCATGCGTACATTATTCCCGGGCTCGGCGATGCCGGGGACCGGTTGTTTGGGA
CCAAGAATTAA

Upstream 100 bases:

>100_bases
ACCGCCGCCCGTCGGGCTCCGGGAGCGCCGCGCCACAGAATCGCCAGAACGTCGACAGACCATCATCAGCCAGCCCAACC
TCGCCGCGAGGCGCCCCGTC

Downstream 100 bases:

>100_bases
GGTTTGCACCATCGGGACGCGGGCGTTGCCGTTTTTTTGGGGGGCGTTGCGGGCGTCGCAAACAAAAAACCAAGCCCGCG
CCCCGAAGGCGCCCCACCCC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MTQDSRFPNLFILDHPLIQHKLSHMRDRDTSTRTFRELLREITLLMGYEITRNLPMTTRRVSTPLVDIDAPVIAGKKLAI
VPVLRAGVGMSDGLLELIPSARVGHIGVYRDDDHRPVEYLVRLPDLEDRIFILCDPMVATGYSAVHAIDVLKRRGVAGEN
ISFLALVAAPEGVQVFQDAHPDVKLYVASLDSHLNEHAYIIPGLGDAGDRLFGTKN

Sequences:

>Translated_216_residues
MTQDSRFPNLFILDHPLIQHKLSHMRDRDTSTRTFRELLREITLLMGYEITRNLPMTTRRVSTPLVDIDAPVIAGKKLAI
VPVLRAGVGMSDGLLELIPSARVGHIGVYRDDDHRPVEYLVRLPDLEDRIFILCDPMVATGYSAVHAIDVLKRRGVAGEN
ISFLALVAAPEGVQVFQDAHPDVKLYVASLDSHLNEHAYIIPGLGDAGDRLFGTKN
>Mature_215_residues
TQDSRFPNLFILDHPLIQHKLSHMRDRDTSTRTFRELLREITLLMGYEITRNLPMTTRRVSTPLVDIDAPVIAGKKLAIV
PVLRAGVGMSDGLLELIPSARVGHIGVYRDDDHRPVEYLVRLPDLEDRIFILCDPMVATGYSAVHAIDVLKRRGVAGENI
SFLALVAAPEGVQVFQDAHPDVKLYVASLDSHLNEHAYIIPGLGDAGDRLFGTKN

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=193, Percent_Identity=33.160621761658, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI57863312, Length=193, Percent_Identity=33.160621761658, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=50, Blast_Score=202, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17539894, Length=226, Percent_Identity=28.7610619469027, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17539892, Length=226, Percent_Identity=28.7610619469027, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321920, Length=190, Percent_Identity=35.7894736842105, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI45550449, Length=222, Percent_Identity=34.2342342342342, Blast_Score=97, Evalue=7e-21,
Organism=Drosophila melanogaster, GI28573516, Length=222, Percent_Identity=34.2342342342342, Blast_Score=97, Evalue=8e-21,
Organism=Drosophila melanogaster, GI28573514, Length=222, Percent_Identity=34.2342342342342, Blast_Score=97, Evalue=8e-21,
Organism=Drosophila melanogaster, GI28573512, Length=222, Percent_Identity=34.2342342342342, Blast_Score=97, Evalue=8e-21,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_BURP8 (B2JE33)

Other databases:

- EMBL:   CP001043
- RefSeq:   YP_001858287.1
- ProteinModelPortal:   B2JE33
- SMR:   B2JE33
- GeneID:   6243551
- GenomeReviews:   CP001043_GR
- KEGG:   bph:Bphy_2063
- HOGENOM:   HBG326432
- OMA:   IQHKLSH
- ProtClustDB:   PRK00129
- HAMAP:   MF_01218_B
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: NA

EC number: =2.4.2.9

Molecular weight: Translated: 24039; Mature: 23908

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: BINDING 85-85 BINDING 110-110 BINDING 200-200 BINDING 206-206

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQDSRFPNLFILDHPLIQHKLSHMRDRDTSTRTFRELLREITLLMGYEITRNLPMTTRR
CCCCCCCCEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCHHHHCCCCCCHHH
VSTPLVDIDAPVIAGKKLAIVPVLRAGVGMSDGLLELIPSARVGHIGVYRDDDHRPVEYL
HCCCEEECCCCEECCCCEEEEEHHHHCCCCCCCHHHHCCCCCCCEEEEEECCCCCHHHHH
VRLPDLEDRIFILCDPMVATGYSAVHAIDVLKRRGVAGENISFLALVAAPEGVQVFQDAH
EECCCCCCCEEEEECCHHHCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHCCC
PDVKLYVASLDSHLNEHAYIIPGLGDAGDRLFGTKN
CCEEEEEEEHHHCCCCCEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
TQDSRFPNLFILDHPLIQHKLSHMRDRDTSTRTFRELLREITLLMGYEITRNLPMTTRR
CCCCCCCEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCHHHHCCCCCCHHH
VSTPLVDIDAPVIAGKKLAIVPVLRAGVGMSDGLLELIPSARVGHIGVYRDDDHRPVEYL
HCCCEEECCCCEECCCCEEEEEHHHHCCCCCCCHHHHCCCCCCCEEEEEECCCCCHHHHH
VRLPDLEDRIFILCDPMVATGYSAVHAIDVLKRRGVAGENISFLALVAAPEGVQVFQDAH
EECCCCCCCEEEEECCHHHCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHCCC
PDVKLYVASLDSHLNEHAYIIPGLGDAGDRLFGTKN
CCEEEEEEEHHHCCCCCEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA