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The map label for this gene is luxQ [H]

Identifier: 183222624

GI number: 183222624

Start: 3390369

End: 3391979

Strand: Direct

Name: luxQ [H]

Synonym: LEPBI_I3279

Alternate gene names: 183222624

Gene position: 3390369-3391979 (Clockwise)

Preceding gene: 183222623

Following gene: 183222628

Centisome position: 94.19

GC content: 32.34

Gene sequence:

>1611_bases
GTGAGTTTCTTGAATGAAAAACACCTATTAACGATTGTTCAAAAATCTGGAATTGGTATCCTGATTTTAAACGAAAACTT
TAAAATCATATTAACAAATCATTGGTTCCTTAAACGCTCTTTCTTAGATGAACAACACTTAGACAACAAATTAATATTCG
ATGTTTTTCCTGAACTAGTTGGGACACGTACTTTAAAATCAATTGAACAATGCCTTGAATTTTCTCAGTATTCAATCCTG
ACACATACTTTAAATCCCTTCCCATTTCCTTTATTTGATAATGAACAAAAAATAGAAAAAAAAGAAAGGATTTATCAATA
CCTGCATGTCATTCCCATTTCAATCGATGATGAACAAAATCGATTTTGTATGATTCAAATTACAGACGTTTCACAACAAG
TGACCCGAGAAAAATTATTAAGAGAACAAATGGTAGTGGCAAAAGAAAGGGAAGTAGAAGCAAAAAAAGCATCCCAAGCA
AAAACAGATTTTTTAGCTTCCATGAGTCATGAAATCAGAACTCCTCTCAATGCAATTTTAGGAATGGCTGATACCTTAAC
GGAAACAAATCTAACAAATGAACAAATGGAGTATCTAACAGTACTTCGAAACTCCGGTAAGGCATTGTATAACATTATCA
ATGACATTCTAGACTTATCTCGAATTGAATCTGGAAAATTGGAAATTGAACACATTGAATTTTCAATCCGCGATTTACTC
AAAGAAACAATTTCTTTATTTTTAATGAAAGCAAAGTCAAAGGGAATCCAAATTTCTTATTCCGTGAGTGACGATATCGC
AGAACAAATCAAAGGAGATTCCACTCGAATCCAACAAATCTTAATTAACTTGATTGGAAATGCGATGAAATTTACAGAAA
TAGGAAAGATTTATGTAGATGCATCATTAAGTCAGGATCAAAAAAGTTTATGTTTGATTGTTGAAGATACTGGAATTGGA
ATTCCAAATGAAAAATTAAATTCTATTTTTGAAAGTTTTACTCAAGTGGATAGCTCCACAACTCGAAGGTATGGTGGAAC
TGGACTTGGACTTACAATCACAAAAAAGTTAATACTAATGATGAATGGCGAAATATCGGTTCAAAGCCAACTAGGCAAAG
GATCCAAGTTCGTCCTAAATATACCCTACGAAGGTTTGGTTCATAGGGATTCAAACATCCATCAACATTGGTTGGATTTG
GAATTACCAGATGCAGAAAATTTTCCAAAATGTAGAATCTTATTAGCAGAGGATTCAGAAGAAAATGTTTTCATCATCAA
AACATTTTTACGAAAATATCCAATCGAACTTGTGATTGCAAAAAACGGAAAGATTGCATTACAAATGTTTCAATCCGAAA
AATTTGATATCGTTTTAATGGATATGCAAATGCCTGAAATGGATGGATTAGAAGCGACAAAACAAATACGACTGTATGAA
CATAATCAAAACATTGATCCATTGTTTGCAATTCCCATCATCGCAATTTCTGCAAACGTACAAAAAGAAGATATCAGCAA
AAGTTTTATGGCAGGAATCACATCATACATTTCCAAACCAGTGCGTAAGATTGAAATTCTGAAATTGATTTATTTCTATT
TGGCTCTTTAA

Upstream 100 bases:

>100_bases
ATCAATTAAAAGGCAAAGAAATCAAAGGTTACATATTTTTTATTTTAAATTTCGACAGTATCAAAAATCTTTCTCGAGTG
CTCATCGATAAGTTAAAGTA

Downstream 100 bases:

>100_bases
CTGATAAAATTACCTTTTTGATCAGTTTATTTTAATACTTTTTCTACTGCTGTTTCTGGATATGCTTCCAAGACAATTCC
TTCATTGAGTAACTCATTTG

Product: putative two-component sensor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 536; Mature: 535

Protein sequence:

>536_residues
MSFLNEKHLLTIVQKSGIGILILNENFKIILTNHWFLKRSFLDEQHLDNKLIFDVFPELVGTRTLKSIEQCLEFSQYSIL
THTLNPFPFPLFDNEQKIEKKERIYQYLHVIPISIDDEQNRFCMIQITDVSQQVTREKLLREQMVVAKEREVEAKKASQA
KTDFLASMSHEIRTPLNAILGMADTLTETNLTNEQMEYLTVLRNSGKALYNIINDILDLSRIESGKLEIEHIEFSIRDLL
KETISLFLMKAKSKGIQISYSVSDDIAEQIKGDSTRIQQILINLIGNAMKFTEIGKIYVDASLSQDQKSLCLIVEDTGIG
IPNEKLNSIFESFTQVDSSTTRRYGGTGLGLTITKKLILMMNGEISVQSQLGKGSKFVLNIPYEGLVHRDSNIHQHWLDL
ELPDAENFPKCRILLAEDSEENVFIIKTFLRKYPIELVIAKNGKIALQMFQSEKFDIVLMDMQMPEMDGLEATKQIRLYE
HNQNIDPLFAIPIIAISANVQKEDISKSFMAGITSYISKPVRKIEILKLIYFYLAL

Sequences:

>Translated_536_residues
MSFLNEKHLLTIVQKSGIGILILNENFKIILTNHWFLKRSFLDEQHLDNKLIFDVFPELVGTRTLKSIEQCLEFSQYSIL
THTLNPFPFPLFDNEQKIEKKERIYQYLHVIPISIDDEQNRFCMIQITDVSQQVTREKLLREQMVVAKEREVEAKKASQA
KTDFLASMSHEIRTPLNAILGMADTLTETNLTNEQMEYLTVLRNSGKALYNIINDILDLSRIESGKLEIEHIEFSIRDLL
KETISLFLMKAKSKGIQISYSVSDDIAEQIKGDSTRIQQILINLIGNAMKFTEIGKIYVDASLSQDQKSLCLIVEDTGIG
IPNEKLNSIFESFTQVDSSTTRRYGGTGLGLTITKKLILMMNGEISVQSQLGKGSKFVLNIPYEGLVHRDSNIHQHWLDL
ELPDAENFPKCRILLAEDSEENVFIIKTFLRKYPIELVIAKNGKIALQMFQSEKFDIVLMDMQMPEMDGLEATKQIRLYE
HNQNIDPLFAIPIIAISANVQKEDISKSFMAGITSYISKPVRKIEILKLIYFYLAL
>Mature_535_residues
SFLNEKHLLTIVQKSGIGILILNENFKIILTNHWFLKRSFLDEQHLDNKLIFDVFPELVGTRTLKSIEQCLEFSQYSILT
HTLNPFPFPLFDNEQKIEKKERIYQYLHVIPISIDDEQNRFCMIQITDVSQQVTREKLLREQMVVAKEREVEAKKASQAK
TDFLASMSHEIRTPLNAILGMADTLTETNLTNEQMEYLTVLRNSGKALYNIINDILDLSRIESGKLEIEHIEFSIRDLLK
ETISLFLMKAKSKGIQISYSVSDDIAEQIKGDSTRIQQILINLIGNAMKFTEIGKIYVDASLSQDQKSLCLIVEDTGIGI
PNEKLNSIFESFTQVDSSTTRRYGGTGLGLTITKKLILMMNGEISVQSQLGKGSKFVLNIPYEGLVHRDSNIHQHWLDLE
LPDAENFPKCRILLAEDSEENVFIIKTFLRKYPIELVIAKNGKIALQMFQSEKFDIVLMDMQMPEMDGLEATKQIRLYEH
NQNIDPLFAIPIIAISANVQKEDISKSFMAGITSYISKPVRKIEILKLIYFYLAL

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=368, Percent_Identity=35.054347826087, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI87081816, Length=411, Percent_Identity=34.0632603406326, Blast_Score=202, Evalue=5e-53,
Organism=Escherichia coli, GI1789149, Length=257, Percent_Identity=39.6887159533074, Blast_Score=202, Evalue=5e-53,
Organism=Escherichia coli, GI1788713, Length=404, Percent_Identity=31.1881188118812, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI145693157, Length=259, Percent_Identity=40.5405405405405, Blast_Score=178, Evalue=7e-46,
Organism=Escherichia coli, GI1788393, Length=237, Percent_Identity=27.8481012658228, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI1786783, Length=227, Percent_Identity=29.0748898678414, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1790436, Length=234, Percent_Identity=29.4871794871795, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786600, Length=236, Percent_Identity=26.6949152542373, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1786912, Length=247, Percent_Identity=26.3157894736842, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788549, Length=245, Percent_Identity=27.3469387755102, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87082128, Length=227, Percent_Identity=28.1938325991189, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1787894, Length=228, Percent_Identity=27.6315789473684, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790346, Length=241, Percent_Identity=24.4813278008299, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1790861, Length=207, Percent_Identity=24.6376811594203, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790300, Length=286, Percent_Identity=22.7272727272727, Blast_Score=66, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323034, Length=137, Percent_Identity=30.6569343065693, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6322044, Length=100, Percent_Identity=40, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322000, Length=122, Percent_Identity=27.8688524590164, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 61428; Mature: 61297

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFLNEKHLLTIVQKSGIGILILNENFKIILTNHWFLKRSFLDEQHLDNKLIFDVFPELV
CCCCCCCCEEEEEECCCCEEEEECCCEEEEEECCHHHHHHHCCHHHCCCCHHHHHHHHHH
GTRTLKSIEQCLEFSQYSILTHTLNPFPFPLFDNEQKIEKKERIYQYLHVIPISIDDEQN
HHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCC
RFCMIQITDVSQQVTREKLLREQMVVAKEREVEAKKASQAKTDFLASMSHEIRTPLNAIL
CEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
GMADTLTETNLTNEQMEYLTVLRNSGKALYNIINDILDLSRIESGKLEIEHIEFSIRDLL
CCHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHH
KETISLFLMKAKSKGIQISYSVSDDIAEQIKGDSTRIQQILINLIGNAMKFTEIGKIYVD
HHHHHHHHHHCCCCCEEEEEECCHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHCCEEEEE
ASLSQDQKSLCLIVEDTGIGIPNEKLNSIFESFTQVDSSTTRRYGGTGLGLTITKKLILM
CCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHEEEEEE
MNGEISVQSQLGKGSKFVLNIPYEGLVHRDSNIHQHWLDLELPDAENFPKCRILLAEDSE
ECCCEEEEHHCCCCCEEEEECCCCCEEECCCCCCHHEEEEECCCCCCCCCEEEEEEECCC
ENVFIIKTFLRKYPIELVIAKNGKIALQMFQSEKFDIVLMDMQMPEMDGLEATKQIRLYE
CCEEEEEHHHHHCCEEEEEECCCCEEEEEECCCCCCEEEEECCCCCCCCCCHHHEEEEEE
HNQNIDPLFAIPIIAISANVQKEDISKSFMAGITSYISKPVRKIEILKLIYFYLAL
CCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SFLNEKHLLTIVQKSGIGILILNENFKIILTNHWFLKRSFLDEQHLDNKLIFDVFPELV
CCCCCCCEEEEEECCCCEEEEECCCEEEEEECCHHHHHHHCCHHHCCCCHHHHHHHHHH
GTRTLKSIEQCLEFSQYSILTHTLNPFPFPLFDNEQKIEKKERIYQYLHVIPISIDDEQN
HHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCC
RFCMIQITDVSQQVTREKLLREQMVVAKEREVEAKKASQAKTDFLASMSHEIRTPLNAIL
CEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
GMADTLTETNLTNEQMEYLTVLRNSGKALYNIINDILDLSRIESGKLEIEHIEFSIRDLL
CCHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHH
KETISLFLMKAKSKGIQISYSVSDDIAEQIKGDSTRIQQILINLIGNAMKFTEIGKIYVD
HHHHHHHHHHCCCCCEEEEEECCHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHCCEEEEE
ASLSQDQKSLCLIVEDTGIGIPNEKLNSIFESFTQVDSSTTRRYGGTGLGLTITKKLILM
CCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHEEEEEE
MNGEISVQSQLGKGSKFVLNIPYEGLVHRDSNIHQHWLDLELPDAENFPKCRILLAEDSE
ECCCEEEEHHCCCCCEEEEECCCCCEEECCCCCCHHEEEEECCCCCCCCCEEEEEEECCC
ENVFIIKTFLRKYPIELVIAKNGKIALQMFQSEKFDIVLMDMQMPEMDGLEATKQIRLYE
CCEEEEEHHHHHCCEEEEEECCCCEEEEEECCCCCCEEEEECCCCCCCCCCHHHEEEEEE
HNQNIDPLFAIPIIAISANVQKEDISKSFMAGITSYISKPVRKIEILKLIYFYLAL
CCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7984107 [H]