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The map label for this gene is pcoR [H]

Identifier: 183222106

GI number: 183222106

Start: 2838470

End: 2839720

Strand: Reverse

Name: pcoR [H]

Synonym: LEPBI_I2748

Alternate gene names: 183222106

Gene position: 2839720-2838470 (Counterclockwise)

Preceding gene: 183222107

Following gene: 183222103

Centisome position: 78.89

GC content: 33.49

Gene sequence:

>1251_bases
TTGAAAGAGAAACGGATATTAGTTGCTGAAGATGATGGTGTTTTAGGTTTTTATTTAAAACAACAACTCTCGGAACTTGG
TTACCAAGTCGTACTTGCCAAAGATGGCAAATCAGCATTGGCTTCTTATTTAGAAAAACCGTTTCCTGTTGTCATCACAG
ATTATGAAATGCCTGGACTCAATGGTGATGAGCTCATCTCCAGTTTAAAAATCGGAGATGTAGAACCTGTGATTATGATG
ATCACAGGAAATTCTGATCCCAAACTCATTGTCAAAGTCATGAAAATGGGTGCCTTTGATTATATCATCAAACCGATCCA
GAATTTTGAAATTGCCTTAAAGGTAAAACGTGCTTTTGAATTTTATGAGATGAAACGGATTGAAACCATTTCTCGTAAAG
AGCACCAATTACGATTGGAAGGTCAATTGGAATGGATACAATGGAAAGAAAAAATGAATTCCATTGGGAAATTGAAAAGG
CAAAATCAAAATCTCTTTGAAAGTTTAAAACATAGTTTTTGCCAAGGAGCAGGATTTGGAGCTTTGGTCTCCATCTTAAA
AATGGTAAATGATACTTCTGAATTTGATGGAAAGTATTATAAGATTGAATCTGAACTCATGGAACTCATCCAAACGAATG
CAGATATGGCAGAAAAATCATTAAATGCTTTTGCAGAAATTGACTCTTTGATCACAACACAACCATCATTTGAAAAGTTA
ACCATGTTTGAATTGTACCTAGAGATGAAAGGTTGGATCGATGAAATGTCTCATATTTTGGAAATTCAAAAACATAAAAT
CGTAATCAGCGATATTCACAATCATCATTCAACTCAGAATCTCCTTATCAACAAATCATGCTTTAAAAAATCATTTACTG
AAATCATTACAAACGCCTGTAAATTTTCATTTCCTGATACAACTATCACCATCATCATAAAAATGGAAAATGAATGGTTC
AAATGTGCAATCTATAATGAACCAACAGCTAATTTTGATGGATCTGTTGGGATTCCAATTCAATTTGAAAATTTGATATT
TGAGCCCTTCTATCGTTTGTCGAAAAGTGTATTTGAATCATATGGTACTTTAGATTTTGGATTGGGATTGAGTTATGTAG
ACACTTGCATCAAAAAACATAATGGAAAAATCTCCATTTTTAATGTGAAAGACCATTTCGATTGGAATGGAGCTCCCAAA
ACAAAAGTAGCCTTTCAAATTTCGCTTCCGATTCAAAACGAAACGAAGTAA

Upstream 100 bases:

>100_bases
TTTCTACTGATCGATTCAGGAGATAGAAGGAAGGATCAAAGTGATTTCAAAAATCTGAAACTTGTTTAGTTTGAGTTTAC
AGTGATTCAAAGGATCATTT

Downstream 100 bases:

>100_bases
ATCACTTACTCTTTCCTTGTTTGCATCCGTTTCTTTTTGAGTTTTAGGATGACTAGAAACGTAGTTAGTAATATTGGGAA
CATAAAAACAAACAGTACAT

Product: putative two-component signal transduction system

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MKEKRILVAEDDGVLGFYLKQQLSELGYQVVLAKDGKSALASYLEKPFPVVITDYEMPGLNGDELISSLKIGDVEPVIMM
ITGNSDPKLIVKVMKMGAFDYIIKPIQNFEIALKVKRAFEFYEMKRIETISRKEHQLRLEGQLEWIQWKEKMNSIGKLKR
QNQNLFESLKHSFCQGAGFGALVSILKMVNDTSEFDGKYYKIESELMELIQTNADMAEKSLNAFAEIDSLITTQPSFEKL
TMFELYLEMKGWIDEMSHILEIQKHKIVISDIHNHHSTQNLLINKSCFKKSFTEIITNACKFSFPDTTITIIIKMENEWF
KCAIYNEPTANFDGSVGIPIQFENLIFEPFYRLSKSVFESYGTLDFGLGLSYVDTCIKKHNGKISIFNVKDHFDWNGAPK
TKVAFQISLPIQNETK

Sequences:

>Translated_416_residues
MKEKRILVAEDDGVLGFYLKQQLSELGYQVVLAKDGKSALASYLEKPFPVVITDYEMPGLNGDELISSLKIGDVEPVIMM
ITGNSDPKLIVKVMKMGAFDYIIKPIQNFEIALKVKRAFEFYEMKRIETISRKEHQLRLEGQLEWIQWKEKMNSIGKLKR
QNQNLFESLKHSFCQGAGFGALVSILKMVNDTSEFDGKYYKIESELMELIQTNADMAEKSLNAFAEIDSLITTQPSFEKL
TMFELYLEMKGWIDEMSHILEIQKHKIVISDIHNHHSTQNLLINKSCFKKSFTEIITNACKFSFPDTTITIIIKMENEWF
KCAIYNEPTANFDGSVGIPIQFENLIFEPFYRLSKSVFESYGTLDFGLGLSYVDTCIKKHNGKISIFNVKDHFDWNGAPK
TKVAFQISLPIQNETK
>Mature_416_residues
MKEKRILVAEDDGVLGFYLKQQLSELGYQVVLAKDGKSALASYLEKPFPVVITDYEMPGLNGDELISSLKIGDVEPVIMM
ITGNSDPKLIVKVMKMGAFDYIIKPIQNFEIALKVKRAFEFYEMKRIETISRKEHQLRLEGQLEWIQWKEKMNSIGKLKR
QNQNLFESLKHSFCQGAGFGALVSILKMVNDTSEFDGKYYKIESELMELIQTNADMAEKSLNAFAEIDSLITTQPSFEKL
TMFELYLEMKGWIDEMSHILEIQKHKIVISDIHNHHSTQNLLINKSCFKKSFTEIITNACKFSFPDTTITIIIKMENEWF
KCAIYNEPTANFDGSVGIPIQFENLIFEPFYRLSKSVFESYGTLDFGLGLSYVDTCIKKHNGKISIFNVKDHFDWNGAPK
TKVAFQISLPIQNETK

Specific function: Probable member of a two-component regulatory system pcoS/pcoR. May be involved in the activation of copper resistance gene operon pcoABCD by binding to a specific site on the cop operon promoter (copper box) [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=122, Percent_Identity=27.0491803278689, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 47758; Mature: 47758

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEKRILVAEDDGVLGFYLKQQLSELGYQVVLAKDGKSALASYLEKPFPVVITDYEMPGL
CCCCEEEEECCCCEEHHHHHHHHHHCCEEEEEECCCHHHHHHHHCCCCCEEEECCCCCCC
NGDELISSLKIGDVEPVIMMITGNSDPKLIVKVMKMGAFDYIIKPIQNFEIALKVKRAFE
CHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHCCHHHHHHHHCCCEEEEEHHHHHH
FYEMKRIETISRKEHQLRLEGQLEWIQWKEKMNSIGKLKRQNQNLFESLKHSFCQGAGFG
HHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHH
ALVSILKMVNDTSEFDGKYYKIESELMELIQTNADMAEKSLNAFAEIDSLITTQPSFEKL
HHHHHHHHHCCCHHHCCEEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHH
TMFELYLEMKGWIDEMSHILEIQKHKIVISDIHNHHSTQNLLINKSCFKKSFTEIITNAC
HHHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHCCCCCHHEEEEHHHHHHHHHHHHHHHH
KFSFPDTTITIIIKMENEWFKCAIYNEPTANFDGSVGIPIQFENLIFEPFYRLSKSVFES
CCCCCCCEEEEEEEECCCEEEEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHH
YGTLDFGLGLSYVDTCIKKHNGKISIFNVKDHFDWNGAPKTKVAFQISLPIQNETK
CCCEEECCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEEEEECCCCCCC
>Mature Secondary Structure
MKEKRILVAEDDGVLGFYLKQQLSELGYQVVLAKDGKSALASYLEKPFPVVITDYEMPGL
CCCCEEEEECCCCEEHHHHHHHHHHCCEEEEEECCCHHHHHHHHCCCCCEEEECCCCCCC
NGDELISSLKIGDVEPVIMMITGNSDPKLIVKVMKMGAFDYIIKPIQNFEIALKVKRAFE
CHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHCCHHHHHHHHCCCEEEEEHHHHHH
FYEMKRIETISRKEHQLRLEGQLEWIQWKEKMNSIGKLKRQNQNLFESLKHSFCQGAGFG
HHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHH
ALVSILKMVNDTSEFDGKYYKIESELMELIQTNADMAEKSLNAFAEIDSLITTQPSFEKL
HHHHHHHHHCCCHHHCCEEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHH
TMFELYLEMKGWIDEMSHILEIQKHKIVISDIHNHHSTQNLLINKSCFKKSFTEIITNAC
HHHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHCCCCCHHEEEEHHHHHHHHHHHHHHHH
KFSFPDTTITIIIKMENEWFKCAIYNEPTANFDGSVGIPIQFENLIFEPFYRLSKSVFES
CCCCCCCEEEEEEEECCCEEEEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHH
YGTLDFGLGLSYVDTCIKKHNGKISIFNVKDHFDWNGAPKTKVAFQISLPIQNETK
CCCEEECCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334; 9141682 [H]