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The map label for this gene is lolC [H]

Identifier: 183221938

GI number: 183221938

Start: 2664673

End: 2666025

Strand: Reverse

Name: lolC [H]

Synonym: LEPBI_I2577

Alternate gene names: 183221938

Gene position: 2666025-2664673 (Counterclockwise)

Preceding gene: 183221941

Following gene: 183221937

Centisome position: 74.06

GC content: 43.75

Gene sequence:

>1353_bases
ATGGGAATCGTCTCTTTAATCACAATCCGTTACATCCGAGGGTCCCGCGTATTGGGTTTCCTCTCTATCAAATCCAGACT
ATCGTTTATCGTGATGGCTGTGGGAGTGGGACTTCTTGTTGTGGTTTTGTCCATTTTTAATGGATTCCAAAAACAAGTGA
AAGAATCCCTTTGGCAGGGTGGGCCTCATATCACAATCGAAAACTCCTATGGATCAGGGGCCATCTACGATTATGAGACT
GTGATCGCCCATTTGAAGTCTGATCCGAAACTTGCTGAATCCTTTGTTTCGGTGGAAGGTAATATCACAAGCCACGGCCT
CATCCAGAGCAATAATAACTTCAACCCTATCATGATCCGAGCTGTGCCCATTGATTCGATTGAAAAATTAGTGGAAAATG
GCCTCCCGAACTTCCCTCGGATCTTACAGTACAACCGAGATGAAATTTCTTCGATCAATTCTAAAAAGATGGTCGTAGTG
GGAAAAGAAATGAGTGCCATTTATGGGTATGGGATTGGTCGGGAGATCACCATGGCAGTGCCTGGTGGACGGTTTACTGT
AGAACGTGGTGTCCAAGTCAATGTGCAATCCTTTCGATTGGTTGGCCTCTTTAAAACTGGTTATTATAATTACGATTCCA
AGTTTGTGTTTTTATCGCTTCCTCAGGCCCAAGAGTTTTTTAAGATGAAAGGTGCTGTGAACCAAATTGCCATCAAGGTT
CGATCGCTCGATGATCTGAAACTCACCAAACATCGAATTTTATCTCGTTTGAATGAGGAGAACTGGAACCAAAAGATCCA
AGATGATACGTCATGGTCAGTGCGAACCATTGCCGAAGAACAAGAGAATTTTCTTGCGGCCCTTCGTTTGGAAAAAACCA
TCATCTCCATCATTGTCTTTTTGTTCATCGTCCTTGCGGCCCTTGGGATGGTAGCAACGGTTCACTCTCTCATTCGTGCC
AAACGTAGGTCGATTGGAACGTTGAAAGCTCTGGGACTTGCTTCCAATGATATCCTCCTTATCTTTACCTTAAACGCGAT
GATTGTCGGAATTTTATCTTCTCTTGTTGGTGGTATGACGGGGATCTTTATCGCCACCAAATTGGAAGTCATCATCAACG
CCATCTCTGAGATCATCAATGGAGTGGGGAGTCTCTTAAATCCTGGAGATTGGGATCCCGTGGAACTGGTTCCCAAAGAC
ATTTATTATTTTGATCATATCCCTGTGGATATTGATATTTCCTTTATCTTTATGGTAACAACTGCTGCTACCATTCTCTC
TGGCCTTGCAGGTTATTTCCCAGCTCGAATGGCCGCCAATCTAAACCCAGTGGATACGATTCGCAATGACTAA

Upstream 100 bases:

>100_bases
GATTGACTTTGACAGAATAATAGTTTGGTGTTTCAGGCATAAGGTTCTTTTTTGACAGTATCCATCTTTCAGAGAAAGCT
GTCAAAAAGATTAGGTCATC

Downstream 100 bases:

>100_bases
TTCTGAAATCAAACCAACAGTCTCCGTAAGGCAGCTTGAAAAGTATTACCAAGTCGTCGACAAAAGGTATCATATCATAT
CAGGGCTCGACTTTGAAGTG

Product: putative lipoprotein releasing system transmembrane protein LolC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MGIVSLITIRYIRGSRVLGFLSIKSRLSFIVMAVGVGLLVVVLSIFNGFQKQVKESLWQGGPHITIENSYGSGAIYDYET
VIAHLKSDPKLAESFVSVEGNITSHGLIQSNNNFNPIMIRAVPIDSIEKLVENGLPNFPRILQYNRDEISSINSKKMVVV
GKEMSAIYGYGIGREITMAVPGGRFTVERGVQVNVQSFRLVGLFKTGYYNYDSKFVFLSLPQAQEFFKMKGAVNQIAIKV
RSLDDLKLTKHRILSRLNEENWNQKIQDDTSWSVRTIAEEQENFLAALRLEKTIISIIVFLFIVLAALGMVATVHSLIRA
KRRSIGTLKALGLASNDILLIFTLNAMIVGILSSLVGGMTGIFIATKLEVIINAISEIINGVGSLLNPGDWDPVELVPKD
IYYFDHIPVDIDISFIFMVTTAATILSGLAGYFPARMAANLNPVDTIRND

Sequences:

>Translated_450_residues
MGIVSLITIRYIRGSRVLGFLSIKSRLSFIVMAVGVGLLVVVLSIFNGFQKQVKESLWQGGPHITIENSYGSGAIYDYET
VIAHLKSDPKLAESFVSVEGNITSHGLIQSNNNFNPIMIRAVPIDSIEKLVENGLPNFPRILQYNRDEISSINSKKMVVV
GKEMSAIYGYGIGREITMAVPGGRFTVERGVQVNVQSFRLVGLFKTGYYNYDSKFVFLSLPQAQEFFKMKGAVNQIAIKV
RSLDDLKLTKHRILSRLNEENWNQKIQDDTSWSVRTIAEEQENFLAALRLEKTIISIIVFLFIVLAALGMVATVHSLIRA
KRRSIGTLKALGLASNDILLIFTLNAMIVGILSSLVGGMTGIFIATKLEVIINAISEIINGVGSLLNPGDWDPVELVPKD
IYYFDHIPVDIDISFIFMVTTAATILSGLAGYFPARMAANLNPVDTIRND
>Mature_449_residues
GIVSLITIRYIRGSRVLGFLSIKSRLSFIVMAVGVGLLVVVLSIFNGFQKQVKESLWQGGPHITIENSYGSGAIYDYETV
IAHLKSDPKLAESFVSVEGNITSHGLIQSNNNFNPIMIRAVPIDSIEKLVENGLPNFPRILQYNRDEISSINSKKMVVVG
KEMSAIYGYGIGREITMAVPGGRFTVERGVQVNVQSFRLVGLFKTGYYNYDSKFVFLSLPQAQEFFKMKGAVNQIAIKVR
SLDDLKLTKHRILSRLNEENWNQKIQDDTSWSVRTIAEEQENFLAALRLEKTIISIIVFLFIVLAALGMVATVHSLIRAK
RRSIGTLKALGLASNDILLIFTLNAMIVGILSSLVGGMTGIFIATKLEVIINAISEIINGVGSLLNPGDWDPVELVPKDI
YYFDHIPVDIDISFIFMVTTAATILSGLAGYFPARMAANLNPVDTIRND

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=439, Percent_Identity=23.9179954441913, Blast_Score=88, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 49741; Mature: 49610

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIVSLITIRYIRGSRVLGFLSIKSRLSFIVMAVGVGLLVVVLSIFNGFQKQVKESLWQG
CCHHHEEHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GPHITIENSYGSGAIYDYETVIAHLKSDPKLAESFVSVEGNITSHGLIQSNNNFNPIMIR
CCEEEEECCCCCCCEEHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEECCCCCCEEEEE
AVPIDSIEKLVENGLPNFPRILQYNRDEISSINSKKMVVVGKEMSAIYGYGIGREITMAV
EECHHHHHHHHHCCCCCCHHHHHCCHHHHHCCCCCEEEEEECHHHHHHCCCCCCEEEEEE
PGGRFTVERGVQVNVQSFRLVGLFKTGYYNYDSKFVFLSLPQAQEFFKMKGAVNQIAIKV
CCCCEEEECCCEEEEEEEEEEEEEECCEEECCCEEEEEECCCHHHHHHHHCCHHHHEEEE
RSLDDLKLTKHRILSRLNEENWNQKIQDDTSWSVRTIAEEQENFLAALRLEKTIISIIVF
ECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFIVLAALGMVATVHSLIRAKRRSIGTLKALGLASNDILLIFTLNAMIVGILSSLVGGMT
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHH
GIFIATKLEVIINAISEIINGVGSLLNPGDWDPVELVPKDIYYFDHIPVDIDISFIFMVT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCEEEECCCCEEECHHHHHHHH
TAATILSGLAGYFPARMAANLNPVDTIRND
HHHHHHHHHHHHHHHHHHCCCCCHHHCCCC
>Mature Secondary Structure 
GIVSLITIRYIRGSRVLGFLSIKSRLSFIVMAVGVGLLVVVLSIFNGFQKQVKESLWQG
CHHHEEHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GPHITIENSYGSGAIYDYETVIAHLKSDPKLAESFVSVEGNITSHGLIQSNNNFNPIMIR
CCEEEEECCCCCCCEEHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEECCCCCCEEEEE
AVPIDSIEKLVENGLPNFPRILQYNRDEISSINSKKMVVVGKEMSAIYGYGIGREITMAV
EECHHHHHHHHHCCCCCCHHHHHCCHHHHHCCCCCEEEEEECHHHHHHCCCCCCEEEEEE
PGGRFTVERGVQVNVQSFRLVGLFKTGYYNYDSKFVFLSLPQAQEFFKMKGAVNQIAIKV
CCCCEEEECCCEEEEEEEEEEEEEECCEEECCCEEEEEECCCHHHHHHHHCCHHHHEEEE
RSLDDLKLTKHRILSRLNEENWNQKIQDDTSWSVRTIAEEQENFLAALRLEKTIISIIVF
ECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFIVLAALGMVATVHSLIRAKRRSIGTLKALGLASNDILLIFTLNAMIVGILSSLVGGMT
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHH
GIFIATKLEVIINAISEIINGVGSLLNPGDWDPVELVPKDIYYFDHIPVDIDISFIFMVT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCEEEECCCCEEECHHHHHHHH
TAATILSGLAGYFPARMAANLNPVDTIRND
HHHHHHHHHHHHHHHHHHCCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]