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The map label for this gene is clpC [H]

Identifier: 183221935

GI number: 183221935

Start: 2660602

End: 2663151

Strand: Reverse

Name: clpC [H]

Synonym: LEPBI_I2574

Alternate gene names: 183221935

Gene position: 2663151-2660602 (Counterclockwise)

Preceding gene: 183221936

Following gene: 183221934

Centisome position: 73.98

GC content: 42.31

Gene sequence:

>2550_bases
ATGTTGGAATTCACCAAAAGAGCAAAAAGAGTCATCAACGAAATCGCCCAAGATGAGGCTAAACGTTTAGGTTCCGATTT
TATCGGTCCTGAACACATTCTACTTGGGCTTCTCCGGGAGGAGGACTCTGTCGCGATTAAGATTCTCACGAATCTAAACA
TCAATTTAAACGAACTCCGTAAAGAAGTGGAGAAACGTACCCGCGAGGGTTCGGGTGCTTTGTTACTCGATGTCAGCCAA
GGGCAAGACAAGTACCAAAAAATGATCGAAGTTTCCAAAGAAGAGGCAAAACGCCTCAAACATAACTATGTGGGAACCGA
GCACATTCTCCTCGCATTACTTCGTGATAATAATAATATAGCGGGAGGATCTTTATCTTCCTTTAGCGTAAATTATAATG
TCATCAAATCGGAAATTTTACGTCTGTTAGGCGCACCTCCTTCAGGAGCTGTGGGTGGTTCCACTGGGACCCAGTCCACA
GGCCAAAGCCAATCACAAACGGCAGCACCAAGACAAGAAAAAAGTAAAACTCCGATCCTTGATGAATTTGCACGAGACCT
CACACAATTGGCACGTGAGAAAAAATTGGACCCAGTCATTGGGCGCTCAAAAGAAATCGAACGTGTGATCCAAATTTTAT
CGAGAAAAACCAAAAACAACCCGGTTCTCGTCGGAGAATCAGGTGTTGGGAAAACGGCGATCGTGGAAGGCCTTGCGCAA
GCTGTGATCGAAAAATTGGTCCCAGATTTACTTTTCGATAAACGAGTGTTATCTTTAGATTTGGCAAGCCTCATTGCAGG
TACCAAATACCGTGGTGAGTTTGAAGAACGATTGAAAAAAATCATGAAAGAAATCGTCACTTCCCAAAACATCATCATCT
TCATTGATGAGTTGCACACTCTGATTGGGGCTGGGGCCGCAGAAGGGGCAGTGGATGCCGCAAACATTTTAAAACCGGCA
CTCGCACGTGGCGAACTCCAATGCATTGGAGCAACAACGAATAACGAATATCGTAAATACATCGAAAAAGATTCTGCATT
GGAACGAAGGTTCCAAATGGTGAAGGTACTCGAACCTTCCGTTGACGATGCGGTTCTTATTTTGGATGGATTGAAAAAAG
CATACGAATCCCACCATAAGGTGCGTTATTCGGAAAAAGCCATCGAACAGGCAGTCAAACTTTCACACCGTTATATCAAC
GACAGGTTTTTACCAGACAAAGCAATTGATATCATCGATGAAGCAGGAGCCAAAGCAAGACTTGCCAATTGCCAACGACC
AAATGAAATCAAAGAGATCGAAGAAGAGATCAAATCGTTATCTCTGAAAAAAGAAGATTTGGTTCGTAGCCAAGAGTATG
AAAAAGCGGCCGCTGTTCGCGATGAAGTGAATCGTAAAAAAGGTGAATTGGAAGAAAAAACCAAACAATGGCAAGAGAGA
ATGGAAGGGTATGCCGTTTCCATCGAGGAAGAAGACATCCTTTCTGTTGTCAGTCTTTGGACGGGAATTCCATTGAAAAA
AATGGAACAATCCGAAAACACAAAACTTCTTAATTTGGAAGAAGACATCAAATCTCGAATTGTTGGGCAAACCGAAGCGA
TTGAAAAAGTGGCACGTGCCGTCAGACGCTCTCGCACTGGTCTCAAAAGTGAAAAACGACCTACTGGATCGTTTATTTTC
CTTGGACCAACTGGTGTGGGAAAAACGGAACTTGCAAAAGCCCTCGCGGAACAATTGTTCGGTTCGGAAGACAATATGCT
TCGTATCGATATGTCGGAATACATGGAGCCACATGCGGTATCAAGACTGATTGGAGCTCCTCCTGGTTATGTAGGGTATG
ATGATGGTGGCCAACTCACAGAATTTGTGAGAAGAAAACCATACAGTTTGGTTTTACTTGATGAGATCGAAAAAGCCCAC
CATGATTTGTTTAATATCCTTTTGCAAATTATGGAAGAGGGGAATTTAACCGATACGAAAGGTCGTAAGGTCAACTTCCG
AGATACCATCATCATCATGACATCCAATATTGCCGCGAAGGAAATATCCAAAGGTGGAAGATTGGGTTTTGAAGATTTTG
CAGACGAAAGGGAAGCTTATAAGGCTGAACAGGCAAGAGAACAACTTAAAAAACATTTTAATCCTGAGTTTTTAAACCGT
GTGGATGAAGTGGTTTACTTTGCTCCTCTCAAAAAAGAAGAAATCGTTAGCATTGTGGATATCATGTTAAAAGATTTTAA
CAAACGTTTGACGGAGAAAAAAGTATTCGTGGAACTCACATTCGCTGCAAAAGAACATTTTGCTACGATTGGATACGACC
AAAACTACGGAGCCCGACCACTCCGACGTGTGTTCCAAAGAGAATTGGAAGATTATATGGCGGTTCAGTCTCTCAAAGGT
GTTTATGAAAACCCTACTAAAATTTTGGTAGATATGGCAGAAGGAAAACTTGTGTATTCCGAATCAGCTTGGGAAGATTA
CAAAGAAGTTCCTAAAAAAGACGATGGATCTTCGCCAAACACTGAGGAAAAAGACTTAGCCCTCGTATAA

Upstream 100 bases:

>100_bases
TCAGTTTTACAAAATTCTTGGTTTACGAGGCTCCCTTTGACCCAGTACGGTCAAGATGGGAACAAGGACGTTCGTCTAAT
TACTAAAGGCAGGGTGCGGC

Downstream 100 bases:

>100_bases
GGGTTTTTAGGAAGGCGAAAGGAAATGGCAATTCTCATTCCCCTCGTCTTCCTATTTTCTTATTTTTTCATCCGTAAAAT
ATGGTTCCAACTTCGTAAAA

Product: ATPase ClpC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 849; Mature: 849

Protein sequence:

>849_residues
MLEFTKRAKRVINEIAQDEAKRLGSDFIGPEHILLGLLREEDSVAIKILTNLNINLNELRKEVEKRTREGSGALLLDVSQ
GQDKYQKMIEVSKEEAKRLKHNYVGTEHILLALLRDNNNIAGGSLSSFSVNYNVIKSEILRLLGAPPSGAVGGSTGTQST
GQSQSQTAAPRQEKSKTPILDEFARDLTQLAREKKLDPVIGRSKEIERVIQILSRKTKNNPVLVGESGVGKTAIVEGLAQ
AVIEKLVPDLLFDKRVLSLDLASLIAGTKYRGEFEERLKKIMKEIVTSQNIIIFIDELHTLIGAGAAEGAVDAANILKPA
LARGELQCIGATTNNEYRKYIEKDSALERRFQMVKVLEPSVDDAVLILDGLKKAYESHHKVRYSEKAIEQAVKLSHRYIN
DRFLPDKAIDIIDEAGAKARLANCQRPNEIKEIEEEIKSLSLKKEDLVRSQEYEKAAAVRDEVNRKKGELEEKTKQWQER
MEGYAVSIEEEDILSVVSLWTGIPLKKMEQSENTKLLNLEEDIKSRIVGQTEAIEKVARAVRRSRTGLKSEKRPTGSFIF
LGPTGVGKTELAKALAEQLFGSEDNMLRIDMSEYMEPHAVSRLIGAPPGYVGYDDGGQLTEFVRRKPYSLVLLDEIEKAH
HDLFNILLQIMEEGNLTDTKGRKVNFRDTIIIMTSNIAAKEISKGGRLGFEDFADEREAYKAEQAREQLKKHFNPEFLNR
VDEVVYFAPLKKEEIVSIVDIMLKDFNKRLTEKKVFVELTFAAKEHFATIGYDQNYGARPLRRVFQRELEDYMAVQSLKG
VYENPTKILVDMAEGKLVYSESAWEDYKEVPKKDDGSSPNTEEKDLALV

Sequences:

>Translated_849_residues
MLEFTKRAKRVINEIAQDEAKRLGSDFIGPEHILLGLLREEDSVAIKILTNLNINLNELRKEVEKRTREGSGALLLDVSQ
GQDKYQKMIEVSKEEAKRLKHNYVGTEHILLALLRDNNNIAGGSLSSFSVNYNVIKSEILRLLGAPPSGAVGGSTGTQST
GQSQSQTAAPRQEKSKTPILDEFARDLTQLAREKKLDPVIGRSKEIERVIQILSRKTKNNPVLVGESGVGKTAIVEGLAQ
AVIEKLVPDLLFDKRVLSLDLASLIAGTKYRGEFEERLKKIMKEIVTSQNIIIFIDELHTLIGAGAAEGAVDAANILKPA
LARGELQCIGATTNNEYRKYIEKDSALERRFQMVKVLEPSVDDAVLILDGLKKAYESHHKVRYSEKAIEQAVKLSHRYIN
DRFLPDKAIDIIDEAGAKARLANCQRPNEIKEIEEEIKSLSLKKEDLVRSQEYEKAAAVRDEVNRKKGELEEKTKQWQER
MEGYAVSIEEEDILSVVSLWTGIPLKKMEQSENTKLLNLEEDIKSRIVGQTEAIEKVARAVRRSRTGLKSEKRPTGSFIF
LGPTGVGKTELAKALAEQLFGSEDNMLRIDMSEYMEPHAVSRLIGAPPGYVGYDDGGQLTEFVRRKPYSLVLLDEIEKAH
HDLFNILLQIMEEGNLTDTKGRKVNFRDTIIIMTSNIAAKEISKGGRLGFEDFADEREAYKAEQAREQLKKHFNPEFLNR
VDEVVYFAPLKKEEIVSIVDIMLKDFNKRLTEKKVFVELTFAAKEHFATIGYDQNYGARPLRRVFQRELEDYMAVQSLKG
VYENPTKILVDMAEGKLVYSESAWEDYKEVPKKDDGSSPNTEEKDLALV
>Mature_849_residues
MLEFTKRAKRVINEIAQDEAKRLGSDFIGPEHILLGLLREEDSVAIKILTNLNINLNELRKEVEKRTREGSGALLLDVSQ
GQDKYQKMIEVSKEEAKRLKHNYVGTEHILLALLRDNNNIAGGSLSSFSVNYNVIKSEILRLLGAPPSGAVGGSTGTQST
GQSQSQTAAPRQEKSKTPILDEFARDLTQLAREKKLDPVIGRSKEIERVIQILSRKTKNNPVLVGESGVGKTAIVEGLAQ
AVIEKLVPDLLFDKRVLSLDLASLIAGTKYRGEFEERLKKIMKEIVTSQNIIIFIDELHTLIGAGAAEGAVDAANILKPA
LARGELQCIGATTNNEYRKYIEKDSALERRFQMVKVLEPSVDDAVLILDGLKKAYESHHKVRYSEKAIEQAVKLSHRYIN
DRFLPDKAIDIIDEAGAKARLANCQRPNEIKEIEEEIKSLSLKKEDLVRSQEYEKAAAVRDEVNRKKGELEEKTKQWQER
MEGYAVSIEEEDILSVVSLWTGIPLKKMEQSENTKLLNLEEDIKSRIVGQTEAIEKVARAVRRSRTGLKSEKRPTGSFIF
LGPTGVGKTELAKALAEQLFGSEDNMLRIDMSEYMEPHAVSRLIGAPPGYVGYDDGGQLTEFVRRKPYSLVLLDEIEKAH
HDLFNILLQIMEEGNLTDTKGRKVNFRDTIIIMTSNIAAKEISKGGRLGFEDFADEREAYKAEQAREQLKKHFNPEFLNR
VDEVVYFAPLKKEEIVSIVDIMLKDFNKRLTEKKVFVELTFAAKEHFATIGYDQNYGARPLRRVFQRELEDYMAVQSLKG
VYENPTKILVDMAEGKLVYSESAWEDYKEVPKKDDGSSPNTEEKDLALV

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=348, Percent_Identity=34.4827586206897, Blast_Score=199, Evalue=1e-50,
Organism=Escherichia coli, GI1788943, Length=857, Percent_Identity=43.4072345390898, Blast_Score=657, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=814, Percent_Identity=38.8206388206388, Blast_Score=504, Evalue=1e-144,
Organism=Saccharomyces cerevisiae, GI6320464, Length=738, Percent_Identity=45.7994579945799, Blast_Score=595, Evalue=1e-171,
Organism=Saccharomyces cerevisiae, GI6323002, Length=908, Percent_Identity=35.7929515418502, Blast_Score=504, Evalue=1e-143,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- InterPro:   IPR001943 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 95648; Mature: 95648

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS50151 UVR ; PS00870 CLPAB_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEFTKRAKRVINEIAQDEAKRLGSDFIGPEHILLGLLREEDSVAIKILTNLNINLNELR
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHH
KEVEKRTREGSGALLLDVSQGQDKYQKMIEVSKEEAKRLKHNYVGTEHILLALLRDNNNI
HHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
AGGSLSSFSVNYNVIKSEILRLLGAPPSGAVGGSTGTQSTGQSQSQTAAPRQEKSKTPIL
CCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHCCCCCHH
DEFARDLTQLAREKKLDPVIGRSKEIERVIQILSRKTKNNPVLVGESGVGKTAIVEGLAQ
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHH
AVIEKLVPDLLFDKRVLSLDLASLIAGTKYRGEFEERLKKIMKEIVTSQNIIIFIDELHT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHH
LIGAGAAEGAVDAANILKPALARGELQCIGATTNNEYRKYIEKDSALERRFQMVKVLEPS
HHCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
VDDAVLILDGLKKAYESHHKVRYSEKAIEQAVKLSHRYINDRFLPDKAIDIIDEAGAKAR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHH
LANCQRPNEIKEIEEEIKSLSLKKEDLVRSQEYEKAAAVRDEVNRKKGELEEKTKQWQER
HHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
MEGYAVSIEEEDILSVVSLWTGIPLKKMEQSENTKLLNLEEDIKSRIVGQTEAIEKVARA
HCCEEEEECHHHHHHHHHHHHCCCHHHHHCCCCCEEECHHHHHHHHHCCCHHHHHHHHHH
VRRSRTGLKSEKRPTGSFIFLGPTGVGKTELAKALAEQLFGSEDNMLRIDMSEYMEPHAV
HHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEHHHHCCHHHH
SRLIGAPPGYVGYDDGGQLTEFVRRKPYSLVLLDEIEKAHHDLFNILLQIMEEGNLTDTK
HHHHCCCCCCCCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GRKVNFRDTIIIMTSNIAAKEISKGGRLGFEDFADEREAYKAEQAREQLKKHFNPEFLNR
CCEEECCCEEEEEECCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
VDEVVYFAPLKKEEIVSIVDIMLKDFNKRLTEKKVFVELTFAAKEHFATIGYDQNYGARP
HHHHHEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHEECCCCCCCCCHH
LRRVFQRELEDYMAVQSLKGVYENPTKILVDMAEGKLVYSESAWEDYKEVPKKDDGSSPN
HHHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCCEEECCHHHHHHHHCCCCCCCCCCC
TEEKDLALV
CCCCCCCCC
>Mature Secondary Structure
MLEFTKRAKRVINEIAQDEAKRLGSDFIGPEHILLGLLREEDSVAIKILTNLNINLNELR
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHH
KEVEKRTREGSGALLLDVSQGQDKYQKMIEVSKEEAKRLKHNYVGTEHILLALLRDNNNI
HHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
AGGSLSSFSVNYNVIKSEILRLLGAPPSGAVGGSTGTQSTGQSQSQTAAPRQEKSKTPIL
CCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHCCCCCHH
DEFARDLTQLAREKKLDPVIGRSKEIERVIQILSRKTKNNPVLVGESGVGKTAIVEGLAQ
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHH
AVIEKLVPDLLFDKRVLSLDLASLIAGTKYRGEFEERLKKIMKEIVTSQNIIIFIDELHT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHH
LIGAGAAEGAVDAANILKPALARGELQCIGATTNNEYRKYIEKDSALERRFQMVKVLEPS
HHCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
VDDAVLILDGLKKAYESHHKVRYSEKAIEQAVKLSHRYINDRFLPDKAIDIIDEAGAKAR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHH
LANCQRPNEIKEIEEEIKSLSLKKEDLVRSQEYEKAAAVRDEVNRKKGELEEKTKQWQER
HHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
MEGYAVSIEEEDILSVVSLWTGIPLKKMEQSENTKLLNLEEDIKSRIVGQTEAIEKVARA
HCCEEEEECHHHHHHHHHHHHCCCHHHHHCCCCCEEECHHHHHHHHHCCCHHHHHHHHHH
VRRSRTGLKSEKRPTGSFIFLGPTGVGKTELAKALAEQLFGSEDNMLRIDMSEYMEPHAV
HHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEHHHHCCHHHH
SRLIGAPPGYVGYDDGGQLTEFVRRKPYSLVLLDEIEKAHHDLFNILLQIMEEGNLTDTK
HHHHCCCCCCCCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GRKVNFRDTIIIMTSNIAAKEISKGGRLGFEDFADEREAYKAEQAREQLKKHFNPEFLNR
CCEEECCCEEEEEECCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
VDEVVYFAPLKKEEIVSIVDIMLKDFNKRLTEKKVFVELTFAAKEHFATIGYDQNYGARP
HHHHHEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHEECCCCCCCCCHH
LRRVFQRELEDYMAVQSLKGVYENPTKILVDMAEGKLVYSESAWEDYKEVPKKDDGSSPN
HHHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCCEEECCHHHHHHHHCCCCCCCCCCC
TEEKDLALV
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]