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The map label for this gene is fadH [H]

Identifier: 183221849

GI number: 183221849

Start: 2562902

End: 2564896

Strand: Reverse

Name: fadH [H]

Synonym: LEPBI_I2481

Alternate gene names: 183221849

Gene position: 2564896-2562902 (Counterclockwise)

Preceding gene: 183221851

Following gene: 183221848

Centisome position: 71.25

GC content: 40.3

Gene sequence:

>1995_bases
ATGAACCAAGCCTTTACCCCGATCAAAATTGGAAATTTGACCCTACCGAATCGATTTTTGATGGGATCCATGCATTTAGG
AGTGGAAGGTGAAACTGGTGTAGCAGATCGTATGGCGACTTTTTATCGGAAACGCTTTGAAGGTGGAGTCGGAATGATTG
TGACAGGTGGGATCAGTGTGAATGAAGAGGGAAAAGGTTCCAAATCGTTTTTCCAATTTTTAGATCCCACCCACGCTAAC
GAACTGAAATTGATGAACCAATCATTACAAGGGAAAGGTATCATGTGTGCTCAGTTATTCCATGCAGGTCGTTATGCATT
TGATAGAAATTGTGTTGCACCGTCTGCTATTAGAGCACCAATCAATCGTTATGTGCCAAGAGAATTGTCGGAAGAAGAAT
GTTGGAAGACCATTGAAGATTTTGGACGATCAGCTAAAATTGCATATGAAGTTGGATTTGGGGCAGTGGAGATTATGGGA
AGTGAAGGTTATCTTCTCAATCAATTTTTTTCACCAGTGACCAACCATCGGAATGATTATTTTGGAGGTGATGCCAAACG
TCGTATGAATTTTTCAATCGAAGTCCTCCGATCAGTGAAAAAAAATCTGCCAGAAGGATTTCCCATTATCTTTCGGATGT
CAGGGATCGATTTAATTCCAGGGAATCCAAGCTTTGAAGAAGTAATCGGTTTATCCAATGTTCTGCGTGATGAAAACGTT
TCCGCTTTAAATATTGGAATTGGATGGCATGAATCACGTGTTCCAACGATTAGCCAATTGGTTCCAAGAGGGGCTTGGGT
TCCAATTGCTCGTCGTATCAAAGAACATACCAAAGGCATTCCCATCATTGCATCCAATCGAGTGAACGATGGGGAAACGA
TAGAAAAGGTATTTTTAGAACAAAGTGTGGATCTCATATCGATGGCAAGGCCATTTCTCGCAGATCCATTCATCGTCAAA
AAATTACAATCAAATGAATCACACCGAATCAATACCTGCGTTGCTTGTAACCAAGCTTGTTTAGACCATGCGTTCCAAGA
AAAACATGTTTCCTGTATTGTGAATCCTATGGCGATGAATGAAGGAAAATACAGTCAGAACAAAACCACCAATCCCAAAA
AAGTATTGGTCATCGGAACGGGTCCCGCTGGTTTAGAAGCAGCACGTGCTGCCAAAGAATTAGGGCATGATGTGACAATT
TTTGAAAAAAGAGATCAAATTGGAGGACAGTTCCAACTTGCTTCTCACATTCCAGGTAAATCTGAATTCAATGAAACCAT
TCGGTATTTTAAGAATGAATTGGAAACAATTGGTGTTAATATCCAATTGAATACGGAAGCAAATATCCAAAACATCAAAT
CTGAAAACGCAGATGTTGTGATTTTTGCCTGTGGAGTGATCCCAAGAGGATTTCAATTGAAAGGTTTGGAACGATTGCCA
AATGGAAGTTATGCGGATTATCTCACCGGAAAATTTGTGCCAGGAAAACAAGTGGCAGTGATTGGAGGAGGAGGGATTGG
CGTTGACGTTGCCCATCGGTTGACAGAAGAACATGATCCAACCCTAGAGTCCTATCAGAAAAAATATAATATATCTTCGT
TTACCAATGCGGTCGTACAAACTGAAGTCGCACATCGTAAGGTAGCCGTGTTTCGAAGGAATGGCAAACATGGTGCTGGT
CTTGGTCCTACTACTTTTTGGGCACTCAAACAAGAGTTAGAATCAGTTGGCGTTCAATTTTACCAAGGATTAAGTTATAA
AGAGGTAACAAAAGAAGGCCTGGTGGTAGTATTTAAAAATGGAGAGGAATTTTTGTATCCTTGTGATTCTATTGTTTTGT
GTGTTGGGCAAGAAAAAGAAGACTCATTATACGAAGAGTATACGAAACAATTTCCAAACCAAAAAACCATATTGATCGGT
GGTGCAAAGGATGCAAAAAACATCGACGCCAAACGAGCATTTTTCGAAGGACTAGAAGCAGCATACAGTATTTAA

Upstream 100 bases:

>100_bases
CGTTTGGCTAGCAGATATTTACCGTTGGTAAATTATTGCTTGTTGGTGATTTCAAATATATTACCAATGGTAAATTATTT
CATTTTAGCAGGAAATTGAT

Downstream 100 bases:

>100_bases
GGAGATAAATATGATCGCTAATAATTATTTTTCAGATGATAAGGACTTACAGTTAATCTACAACCAATTGATCGATTGGA
AATCAATCGTTAAAGAAGCG

Product: 2,4-dienoyl-CoA reductase (NADPH)

Products: NA

Alternate protein names: 2,4-dienoyl coenzyme A reductase [H]

Number of amino acids: Translated: 664; Mature: 664

Protein sequence:

>664_residues
MNQAFTPIKIGNLTLPNRFLMGSMHLGVEGETGVADRMATFYRKRFEGGVGMIVTGGISVNEEGKGSKSFFQFLDPTHAN
ELKLMNQSLQGKGIMCAQLFHAGRYAFDRNCVAPSAIRAPINRYVPRELSEEECWKTIEDFGRSAKIAYEVGFGAVEIMG
SEGYLLNQFFSPVTNHRNDYFGGDAKRRMNFSIEVLRSVKKNLPEGFPIIFRMSGIDLIPGNPSFEEVIGLSNVLRDENV
SALNIGIGWHESRVPTISQLVPRGAWVPIARRIKEHTKGIPIIASNRVNDGETIEKVFLEQSVDLISMARPFLADPFIVK
KLQSNESHRINTCVACNQACLDHAFQEKHVSCIVNPMAMNEGKYSQNKTTNPKKVLVIGTGPAGLEAARAAKELGHDVTI
FEKRDQIGGQFQLASHIPGKSEFNETIRYFKNELETIGVNIQLNTEANIQNIKSENADVVIFACGVIPRGFQLKGLERLP
NGSYADYLTGKFVPGKQVAVIGGGGIGVDVAHRLTEEHDPTLESYQKKYNISSFTNAVVQTEVAHRKVAVFRRNGKHGAG
LGPTTFWALKQELESVGVQFYQGLSYKEVTKEGLVVVFKNGEEFLYPCDSIVLCVGQEKEDSLYEEYTKQFPNQKTILIG
GAKDAKNIDAKRAFFEGLEAAYSI

Sequences:

>Translated_664_residues
MNQAFTPIKIGNLTLPNRFLMGSMHLGVEGETGVADRMATFYRKRFEGGVGMIVTGGISVNEEGKGSKSFFQFLDPTHAN
ELKLMNQSLQGKGIMCAQLFHAGRYAFDRNCVAPSAIRAPINRYVPRELSEEECWKTIEDFGRSAKIAYEVGFGAVEIMG
SEGYLLNQFFSPVTNHRNDYFGGDAKRRMNFSIEVLRSVKKNLPEGFPIIFRMSGIDLIPGNPSFEEVIGLSNVLRDENV
SALNIGIGWHESRVPTISQLVPRGAWVPIARRIKEHTKGIPIIASNRVNDGETIEKVFLEQSVDLISMARPFLADPFIVK
KLQSNESHRINTCVACNQACLDHAFQEKHVSCIVNPMAMNEGKYSQNKTTNPKKVLVIGTGPAGLEAARAAKELGHDVTI
FEKRDQIGGQFQLASHIPGKSEFNETIRYFKNELETIGVNIQLNTEANIQNIKSENADVVIFACGVIPRGFQLKGLERLP
NGSYADYLTGKFVPGKQVAVIGGGGIGVDVAHRLTEEHDPTLESYQKKYNISSFTNAVVQTEVAHRKVAVFRRNGKHGAG
LGPTTFWALKQELESVGVQFYQGLSYKEVTKEGLVVVFKNGEEFLYPCDSIVLCVGQEKEDSLYEEYTKQFPNQKTILIG
GAKDAKNIDAKRAFFEGLEAAYSI
>Mature_664_residues
MNQAFTPIKIGNLTLPNRFLMGSMHLGVEGETGVADRMATFYRKRFEGGVGMIVTGGISVNEEGKGSKSFFQFLDPTHAN
ELKLMNQSLQGKGIMCAQLFHAGRYAFDRNCVAPSAIRAPINRYVPRELSEEECWKTIEDFGRSAKIAYEVGFGAVEIMG
SEGYLLNQFFSPVTNHRNDYFGGDAKRRMNFSIEVLRSVKKNLPEGFPIIFRMSGIDLIPGNPSFEEVIGLSNVLRDENV
SALNIGIGWHESRVPTISQLVPRGAWVPIARRIKEHTKGIPIIASNRVNDGETIEKVFLEQSVDLISMARPFLADPFIVK
KLQSNESHRINTCVACNQACLDHAFQEKHVSCIVNPMAMNEGKYSQNKTTNPKKVLVIGTGPAGLEAARAAKELGHDVTI
FEKRDQIGGQFQLASHIPGKSEFNETIRYFKNELETIGVNIQLNTEANIQNIKSENADVVIFACGVIPRGFQLKGLERLP
NGSYADYLTGKFVPGKQVAVIGGGGIGVDVAHRLTEEHDPTLESYQKKYNISSFTNAVVQTEVAHRKVAVFRRNGKHGAG
LGPTTFWALKQELESVGVQFYQGLSYKEVTKEGLVVVFKNGEEFLYPCDSIVLCVGQEKEDSLYEEYTKQFPNQKTILIG
GAKDAKNIDAKRAFFEGLEAAYSI

Specific function: Catalyzes the NADP-dependent reduction of 2,4-dienoyl- CoA to yield trans-2- enoyl-CoA [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789463, Length=673, Percent_Identity=39.2273402674591, Blast_Score=493, Evalue=1e-140,
Organism=Escherichia coli, GI1787939, Length=215, Percent_Identity=29.3023255813954, Blast_Score=93, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17559804, Length=238, Percent_Identity=30.2521008403361, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17565138, Length=340, Percent_Identity=25, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17540738, Length=231, Percent_Identity=30.3030303030303, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17559802, Length=304, Percent_Identity=24.6710526315789, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17564188, Length=237, Percent_Identity=28.2700421940928, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17566914, Length=242, Percent_Identity=25.6198347107438, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI72001454, Length=188, Percent_Identity=29.2553191489362, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR001155 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF07992 Pyr_redox_2 [H]

EC number: =1.3.1.34 [H]

Molecular weight: Translated: 73554; Mature: 73554

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQAFTPIKIGNLTLPNRFLMGSMHLGVEGETGVADRMATFYRKRFEGGVGMIVTGGISV
CCCCCCCEEECCEECCCHHEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCEEE
NEEGKGSKSFFQFLDPTHANELKLMNQSLQGKGIMCAQLFHAGRYAFDRNCVAPSAIRAP
CCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCHHCCCCCCCCHHHHHH
INRYVPRELSEEECWKTIEDFGRSAKIAYEVGFGAVEIMGSEGYLLNQFFSPVTNHRNDY
HHHCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHCCCCCC
FGGDAKRRMNFSIEVLRSVKKNLPEGFPIIFRMSGIDLIPGNPSFEEVIGLSNVLRDENV
CCCCCHHHCCHHHHHHHHHHHHCCCCCCEEEEECCEEECCCCCCHHHHHHHHHHHHCCCC
SALNIGIGWHESRVPTISQLVPRGAWVPIARRIKEHTKGIPIIASNRVNDGETIEKVFLE
CEEEEECCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHH
QSVDLISMARPFLADPFIVKKLQSNESHRINTCVACNQACLDHAFQEKHVSCIVNPMAMN
HHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCC
EGKYSQNKTTNPKKVLVIGTGPAGLEAARAAKELGHDVTIFEKRDQIGGQFQLASHIPGK
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCCH
SEFNETIRYFKNELETIGVNIQLNTEANIQNIKSENADVVIFACGVIPRGFQLKGLERLP
HHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHCCCCCCEEEEECCCCCCCCEECCHHHCC
NGSYADYLTGKFVPGKQVAVIGGGGIGVDVAHRLTEEHDPTLESYQKKYNISSFTNAVVQ
CCCCCHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHH
TEVAHRKVAVFRRNGKHGAGLGPTTFWALKQELESVGVQFYQGLSYKEVTKEGLVVVFKN
HHHHHHHEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEEEC
GEEFLYPCDSIVLCVGQEKEDSLYEEYTKQFPNQKTILIGGAKDAKNIDAKRAFFEGLEA
CCCEEECCCEEEEEECCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHH
AYSI
HHCC
>Mature Secondary Structure
MNQAFTPIKIGNLTLPNRFLMGSMHLGVEGETGVADRMATFYRKRFEGGVGMIVTGGISV
CCCCCCCEEECCEECCCHHEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCEEE
NEEGKGSKSFFQFLDPTHANELKLMNQSLQGKGIMCAQLFHAGRYAFDRNCVAPSAIRAP
CCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCHHCCCCCCCCHHHHHH
INRYVPRELSEEECWKTIEDFGRSAKIAYEVGFGAVEIMGSEGYLLNQFFSPVTNHRNDY
HHHCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHCCCCCC
FGGDAKRRMNFSIEVLRSVKKNLPEGFPIIFRMSGIDLIPGNPSFEEVIGLSNVLRDENV
CCCCCHHHCCHHHHHHHHHHHHCCCCCCEEEEECCEEECCCCCCHHHHHHHHHHHHCCCC
SALNIGIGWHESRVPTISQLVPRGAWVPIARRIKEHTKGIPIIASNRVNDGETIEKVFLE
CEEEEECCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHH
QSVDLISMARPFLADPFIVKKLQSNESHRINTCVACNQACLDHAFQEKHVSCIVNPMAMN
HHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCC
EGKYSQNKTTNPKKVLVIGTGPAGLEAARAAKELGHDVTIFEKRDQIGGQFQLASHIPGK
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCCH
SEFNETIRYFKNELETIGVNIQLNTEANIQNIKSENADVVIFACGVIPRGFQLKGLERLP
HHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHCCCCCCEEEEECCCCCCCCEECCHHHCC
NGSYADYLTGKFVPGKQVAVIGGGGIGVDVAHRLTEEHDPTLESYQKKYNISSFTNAVVQ
CCCCCHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHH
TEVAHRKVAVFRRNGKHGAGLGPTTFWALKQELESVGVQFYQGLSYKEVTKEGLVVVFKN
HHHHHHHEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEEEC
GEEFLYPCDSIVLCVGQEKEDSLYEEYTKQFPNQKTILIGGAKDAKNIDAKRAFFEGLEA
CCCEEECCCEEEEEECCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHH
AYSI
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9346310; 9278503 [H]