BacMap

Definition	Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)' chromosome chromosome I, complete sequence.
Accession	NC_010602
Length	3,599,677

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The map label for this gene is cyaA [H]

Identifier: 183221786

GI number: 183221786

Start: 2489169

End: 2490401

Strand: Reverse

Name: cyaA [H]

Synonym: LEPBI_I2416

Alternate gene names: 183221786

Gene position: 2490401-2489169 (Counterclockwise)

Preceding gene: 183221787

Following gene: 183221782

Centisome position: 69.18

GC content: 35.69

Gene sequence:

>1233_bases
GTGGATTTAGAAAAAGAAGAAATTGTCCGGGTATTGGTTTTAGAACCGCAGAAAAAATCGTATGATACCATTTCCCAATT
GTTGATCGAGTGGTTTGGCGATTACATTGAATTGACTTGGCGCTCATTGTTTGAAAATGGTGCCGATGAAATTAAAAAAG
TCCAATATGATCTTTTGATTACGGAAATCCAATTTCCAGAATTAGAAGAGTCTTCTGAAGATATCCTGGAAAAAATTATG
GATATGGCAGGTCCTTCGGAGTTGCCTGTTGTTGTGTTCACAAAAGCTGAAGGGAAACAACTTCCGATCCATGCATTCCA
ATTGGGGATCAATGAATACTTCAGCAAACGAAGGTTAAAGAAAAATATCTTAGAACATCGATTCCGAAATTTGTTTCGAG
AAATTTATCGCAAGAAAGTTGTCTCCATTCAAATGGATGATAGTATGAAACGATTTCAAGATCTATACGGTATGAACCAA
TCGGAAATTCAAGATCTGAATACGATGGTTAAAAAGTTTAAAAAGGAACTCGAAAAAGAATACGAAGAAAAATTAAACTT
AGAAAATGAAAAAAAGAAAATGCAGAACGTTTTTGGGATGTACGTCGATCCTATCATTGTTGAAAGTTTAATGAATAATT
CTTTATCTTTGGACCAAAAAGGAAAGGAACAGGAAGTATCAGTTTTGTTTTCAGATATTCGGGGATATACATCTTTATCT
GAAAAAATGAAACCTGAACAAGTCATTTCTTTTTTAAATGAGTACTTTACTGCAATGACTGAAGTAATTCTCGGATATGG
TGGAATGATCGATAAATACATTGGAGATTCCATCATGTGTTTGTTTGGTGCTCCAGTCTTCCAAGATGATCATAGGCAGA
ATGCATTGGACTGTGCATTGGAAATGGTACAAGTATTTGAATTATGGCAACCGAAGTGGAACCAAATTTATGGATTCACT
CCGCAACTTGGAATTGGAGTTGCTTCAGGTAAAGTCATTGTGGGTAATGTTGGTTCCTTCCAAAAACTATCGTATACTGC
AGTGGGAGACACAGTCAATATGGCAAGTCGATTAGAATCGATGGCAAAACCAATGCATGTTTATGTTTCCGAAGGACTTT
ATAATCACCTTCCAGAAGAGTATTCCAAAAAATACCGATATGAGGAATTGGAGCCTGTGAAAATCAAAGGCAAAGAAGGT
CTACATCGTATTTTGAGTGTAAAACCAATTTAA

Upstream 100 bases:

>100_bases
CAGATGTCATTTTGCAAGGTTTCCGGTTACTCATCGGAAGATTTTCCTTCCAATTCCAAGAGGCGCTTCACAAATTTTTA
GAGAGTGAAAAATAAGGCCC

Downstream 100 bases:

>100_bases
CATTTTTTATAATGTGCTACAGAACTGATACAATTCATTCGTTTTCAGTTTTTCATCTTTAGCGGCAAGATAAGATTTTA
CATCTTCAATTTCGAATCCC

Product: putative adenylate or guanylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1; AC 1 [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MDLEKEEIVRVLVLEPQKKSYDTISQLLIEWFGDYIELTWRSLFENGADEIKKVQYDLLITEIQFPELEESSEDILEKIM
DMAGPSELPVVVFTKAEGKQLPIHAFQLGINEYFSKRRLKKNILEHRFRNLFREIYRKKVVSIQMDDSMKRFQDLYGMNQ
SEIQDLNTMVKKFKKELEKEYEEKLNLENEKKKMQNVFGMYVDPIIVESLMNNSLSLDQKGKEQEVSVLFSDIRGYTSLS
EKMKPEQVISFLNEYFTAMTEVILGYGGMIDKYIGDSIMCLFGAPVFQDDHRQNALDCALEMVQVFELWQPKWNQIYGFT
PQLGIGVASGKVIVGNVGSFQKLSYTAVGDTVNMASRLESMAKPMHVYVSEGLYNHLPEEYSKKYRYEELEPVKIKGKEG
LHRILSVKPI

Sequences:

>Translated_410_residues
MDLEKEEIVRVLVLEPQKKSYDTISQLLIEWFGDYIELTWRSLFENGADEIKKVQYDLLITEIQFPELEESSEDILEKIM
DMAGPSELPVVVFTKAEGKQLPIHAFQLGINEYFSKRRLKKNILEHRFRNLFREIYRKKVVSIQMDDSMKRFQDLYGMNQ
SEIQDLNTMVKKFKKELEKEYEEKLNLENEKKKMQNVFGMYVDPIIVESLMNNSLSLDQKGKEQEVSVLFSDIRGYTSLS
EKMKPEQVISFLNEYFTAMTEVILGYGGMIDKYIGDSIMCLFGAPVFQDDHRQNALDCALEMVQVFELWQPKWNQIYGFT
PQLGIGVASGKVIVGNVGSFQKLSYTAVGDTVNMASRLESMAKPMHVYVSEGLYNHLPEEYSKKYRYEELEPVKIKGKEG
LHRILSVKPI
>Mature_410_residues
MDLEKEEIVRVLVLEPQKKSYDTISQLLIEWFGDYIELTWRSLFENGADEIKKVQYDLLITEIQFPELEESSEDILEKIM
DMAGPSELPVVVFTKAEGKQLPIHAFQLGINEYFSKRRLKKNILEHRFRNLFREIYRKKVVSIQMDDSMKRFQDLYGMNQ
SEIQDLNTMVKKFKKELEKEYEEKLNLENEKKKMQNVFGMYVDPIIVESLMNNSLSLDQKGKEQEVSVLFSDIRGYTSLS
EKMKPEQVISFLNEYFTAMTEVILGYGGMIDKYIGDSIMCLFGAPVFQDDHRQNALDCALEMVQVFELWQPKWNQIYGFT
PQLGIGVASGKVIVGNVGSFQKLSYTAVGDTVNMASRLESMAKPMHVYVSEGLYNHLPEEYSKKYRYEELEPVKIKGKEG
LHRILSVKPI

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate cyclase domain [H]

Homologues:

Organism=Homo sapiens, GI4557255, Length=170, Percent_Identity=30, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI167830411, Length=219, Percent_Identity=29.2237442922374, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI4580422, Length=261, Percent_Identity=27.5862068965517, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI134152694, Length=243, Percent_Identity=27.9835390946502, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI24497587, Length=171, Percent_Identity=29.8245614035088, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI115387102, Length=235, Percent_Identity=25.9574468085106, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI148536830, Length=218, Percent_Identity=25.2293577981651, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI222080083, Length=219, Percent_Identity=27.8538812785388, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI4557257, Length=218, Percent_Identity=22.0183486238532, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI34486092, Length=171, Percent_Identity=25.1461988304094, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI4504211, Length=229, Percent_Identity=31.0043668122271, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI10947061, Length=171, Percent_Identity=23.9766081871345, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI10181096, Length=171, Percent_Identity=23.9766081871345, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI194595474, Length=243, Percent_Identity=29.2181069958848, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI194595476, Length=243, Percent_Identity=29.2181069958848, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI194595472, Length=243, Percent_Identity=29.2181069958848, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI67763816, Length=243, Percent_Identity=29.2181069958848, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI194595478, Length=243, Percent_Identity=29.2181069958848, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI194595482, Length=221, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI4504215, Length=223, Percent_Identity=26.457399103139, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI4504217, Length=313, Percent_Identity=25.5591054313099, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71989822, Length=266, Percent_Identity=30.0751879699248, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71989805, Length=266, Percent_Identity=30.0751879699248, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17534657, Length=231, Percent_Identity=29.004329004329, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI193207841, Length=235, Percent_Identity=30.2127659574468, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI212645052, Length=248, Percent_Identity=29.0322580645161, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17534665, Length=245, Percent_Identity=27.7551020408163, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17534653, Length=257, Percent_Identity=29.5719844357977, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17534655, Length=242, Percent_Identity=28.5123966942149, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17508769, Length=174, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71995899, Length=194, Percent_Identity=29.3814432989691, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71995895, Length=242, Percent_Identity=25.6198347107438, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71995893, Length=194, Percent_Identity=29.3814432989691, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71982300, Length=240, Percent_Identity=28.75, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI86564713, Length=250, Percent_Identity=28.8, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17561802, Length=231, Percent_Identity=28.1385281385281, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17568383, Length=166, Percent_Identity=34.9397590361446, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17534649, Length=179, Percent_Identity=30.7262569832402, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI212645647, Length=218, Percent_Identity=27.5229357798165, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71995305, Length=254, Percent_Identity=30.7086614173228, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17534651, Length=183, Percent_Identity=31.6939890710383, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17561800, Length=231, Percent_Identity=27.7056277056277, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17534659, Length=253, Percent_Identity=26.0869565217391, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193206632, Length=241, Percent_Identity=26.5560165975104, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI212659371, Length=231, Percent_Identity=26.8398268398268, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71985505, Length=226, Percent_Identity=28.7610619469027, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI115535133, Length=223, Percent_Identity=27.3542600896861, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17561804, Length=284, Percent_Identity=23.943661971831, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71983004, Length=243, Percent_Identity=23.4567901234568, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71995300, Length=219, Percent_Identity=30.5936073059361, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71990146, Length=253, Percent_Identity=27.2727272727273, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI193208534, Length=160, Percent_Identity=25, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17561810, Length=264, Percent_Identity=22.7272727272727, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24663843, Length=246, Percent_Identity=28.8617886178862, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24663839, Length=246, Percent_Identity=29.2682926829268, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI161076872, Length=243, Percent_Identity=30.4526748971193, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28574512, Length=243, Percent_Identity=30.4526748971193, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI161078020, Length=251, Percent_Identity=28.6852589641434, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI62484477, Length=196, Percent_Identity=30.1020408163265, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI62484298, Length=196, Percent_Identity=30.1020408163265, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281366459, Length=255, Percent_Identity=29.4117647058824, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281366457, Length=255, Percent_Identity=29.4117647058824, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281366455, Length=255, Percent_Identity=29.4117647058824, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI56292422, Length=255, Percent_Identity=29.4117647058824, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI56292424, Length=255, Percent_Identity=29.4117647058824, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24666940, Length=255, Percent_Identity=29.4117647058824, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI116008008, Length=196, Percent_Identity=30.1020408163265, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221330470, Length=244, Percent_Identity=27.8688524590164, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221330468, Length=248, Percent_Identity=28.2258064516129, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI85725044, Length=291, Percent_Identity=25.7731958762887, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281366320, Length=160, Percent_Identity=26.25, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24642014, Length=206, Percent_Identity=25.2427184466019, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24647268, Length=178, Percent_Identity=28.6516853932584, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24585694, Length=189, Percent_Identity=26.4550264550265, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161084260, Length=160, Percent_Identity=26.25, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI62473752, Length=158, Percent_Identity=25.9493670886076, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17137448, Length=158, Percent_Identity=25.9493670886076, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24583978, Length=161, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054 [H]

Pfam domain/function: PF00211 Guanylate_cyc [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 47662; Mature: 47662

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLEKEEIVRVLVLEPQKKSYDTISQLLIEWFGDYIELTWRSLFENGADEIKKVQYDLLI
CCCCHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHE
TEIQFPELEESSEDILEKIMDMAGPSELPVVVFTKAEGKQLPIHAFQLGINEYFSKRRLK
EECCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
KNILEHRFRNLFREIYRKKVVSIQMDDSMKRFQDLYGMNQSEIQDLNTMVKKFKKELEKE
HHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
YEEKLNLENEKKKMQNVFGMYVDPIIVESLMNNSLSLDQKGKEQEVSVLFSDIRGYTSLS
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
EKMKPEQVISFLNEYFTAMTEVILGYGGMIDKYIGDSIMCLFGAPVFQDDHRQNALDCAL
HHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHH
EMVQVFELWQPKWNQIYGFTPQLGIGVASGKVIVGNVGSFQKLSYTAVGDTVNMASRLES
HHHHHHHHHCCCHHCCCCCCCCCCCEEECCCEEEECCCCCHHCEEHHCCCHHHHHHHHHH
MAKPMHVYVSEGLYNHLPEEYSKKYRYEELEPVKIKGKEGLHRILSVKPI
HHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCEEECCHHHHHHHHHCCCC
>Mature Secondary Structure
MDLEKEEIVRVLVLEPQKKSYDTISQLLIEWFGDYIELTWRSLFENGADEIKKVQYDLLI
CCCCHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHE
TEIQFPELEESSEDILEKIMDMAGPSELPVVVFTKAEGKQLPIHAFQLGINEYFSKRRLK
EECCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
KNILEHRFRNLFREIYRKKVVSIQMDDSMKRFQDLYGMNQSEIQDLNTMVKKFKKELEKE
HHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
YEEKLNLENEKKKMQNVFGMYVDPIIVESLMNNSLSLDQKGKEQEVSVLFSDIRGYTSLS
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
EKMKPEQVISFLNEYFTAMTEVILGYGGMIDKYIGDSIMCLFGAPVFQDDHRQNALDCAL
HHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHH
EMVQVFELWQPKWNQIYGFTPQLGIGVASGKVIVGNVGSFQKLSYTAVGDTVNMASRLES
HHHHHHHHHCCCHHCCCCCCCCCCCEEECCCEEEECCCCCHHCEEHHCCCHHHHHHHHHH
MAKPMHVYVSEGLYNHLPEEYSKKYRYEELEPVKIKGKEGLHRILSVKPI
HHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCEEECCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]