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The map label for this gene is cueR [H]

Identifier: 183221636

GI number: 183221636

Start: 2332491

End: 2332883

Strand: Direct

Name: cueR [H]

Synonym: LEPBI_I2260

Alternate gene names: 183221636

Gene position: 2332491-2332883 (Clockwise)

Preceding gene: 183221635

Following gene: 183221637

Centisome position: 64.8

GC content: 28.5

Gene sequence:

>393_bases
ATGTTAATTGGTGAAATTGTTAAAAAAACAGGGATTTCCAGAGATACTATTCGATTCTATGAAAAGGAGGGACTCTTCAA
AAACTGCCTTATTATTCGTAAAGACAACAATTATAAAGAATATTCTTCCGATGTGTTAGAACAACTGCAACTAATTCATA
CACTCAGAAAATTGAATTTTTCTTTATCTGAAATAAACAATTTAACTAGAATCAGAAATCCCAATCTTCTCGACTGTAAT
GATCTTTCAAAGTCCCTTAACAAAAATATAGAAATTATTGATGCACAAATTAATTCTCTTTTAAAACTGAAGGAAGATTT
GATGAAAGTTGAATCAGCTTGTTCACCTAATTGCAATTTTATTGATAAAAAACCTTCATGCTTAAGTTGTTAA

Upstream 100 bases:

>100_bases
AATGGATTCATATTTATGAACATTTTAGACCTCTATCTAATTTTTTATCAGTCTAAACCGTGGAGTTAACTCCATTGTCA
ATAGGGGTTTCGAAAAAAAT

Downstream 100 bases:

>100_bases
ATTCAGAATTATTCCTTATTTACCTAAAACCAACTCTCATTTTCATTTTAGCTGGACTATGCGAAATTGGTGGCGGTTAT
CTAGTTTGGCTTTGGATTCG

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 130; Mature: 130

Protein sequence:

>130_residues
MLIGEIVKKTGISRDTIRFYEKEGLFKNCLIIRKDNNYKEYSSDVLEQLQLIHTLRKLNFSLSEINNLTRIRNPNLLDCN
DLSKSLNKNIEIIDAQINSLLKLKEDLMKVESACSPNCNFIDKKPSCLSC

Sequences:

>Translated_130_residues
MLIGEIVKKTGISRDTIRFYEKEGLFKNCLIIRKDNNYKEYSSDVLEQLQLIHTLRKLNFSLSEINNLTRIRNPNLLDCN
DLSKSLNKNIEIIDAQINSLLKLKEDLMKVESACSPNCNFIDKKPSCLSC
>Mature_130_residues
MLIGEIVKKTGISRDTIRFYEKEGLFKNCLIIRKDNNYKEYSSDVLEQLQLIHTLRKLNFSLSEINNLTRIRNPNLLDCN
DLSKSLNKNIEIIDAQINSLLKLKEDLMKVESACSPNCNFIDKKPSCLSC

Specific function: Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=113, Percent_Identity=29.2035398230088, Blast_Score=64, Evalue=2e-12,
Organism=Escherichia coli, GI1786695, Length=131, Percent_Identity=27.4809160305344, Blast_Score=60, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 14997; Mature: 14997

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
4.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIGEIVKKTGISRDTIRFYEKEGLFKNCLIIRKDNNYKEYSSDVLEQLQLIHTLRKLNF
CCHHHHHHHHCCCHHHHHHHHHCCCHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCC
SLSEINNLTRIRNPNLLDCNDLSKSLNKNIEIIDAQINSLLKLKEDLMKVESACSPNCNF
CHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCC
IDKKPSCLSC
CCCCCCCCCC
>Mature Secondary Structure
MLIGEIVKKTGISRDTIRFYEKEGLFKNCLIIRKDNNYKEYSSDVLEQLQLIHTLRKLNF
CCHHHHHHHHCCCHHHHHHHHHCCCHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCC
SLSEINNLTRIRNPNLLDCNDLSKSLNKNIEIIDAQINSLLKLKEDLMKVESACSPNCNF
CHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCC
IDKKPSCLSC
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]