Click here to switch to the map view.

The map label for this gene is merR [H]

Identifier: 183221570

GI number: 183221570

Start: 2276203

End: 2276586

Strand: Direct

Name: merR [H]

Synonym: LEPBI_I2191

Alternate gene names: 183221570

Gene position: 2276203-2276586 (Clockwise)

Preceding gene: 183221568

Following gene: 183221571

Centisome position: 63.23

GC content: 28.39

Gene sequence:

>384_bases
ATGCATATCGGAGAGTTTTCAAGAATTTGCAAAATATCAAAGGAATCCATTCGATACTATGAAAAAGAAGGACTTTTGAA
AGGGTCTAGAAAGGAGAATAATTATCGAGTTTACTCTAAAAAAGATATACGCGTAGTCGAATTGATCAATTCTCTTAAAA
ATTCTGGATTTACACTTTTTGAAATTAGAAGTTTTTTAAATTTATATGACTCGGATTCCAAATGCAAAGAAGTTCAAATT
AAACTAGAAAACAAATTACTTATCATAAAAGACAGAATTTCTGAACTTATTTCTATTCAGGAAAAGCTTAATAAATCTAT
CCTAGAATGTGAAGACAATCCCAATAAAAAATTCTGCAATATTGTCTCAAGTTCCCATTTATAG

Upstream 100 bases:

>100_bases
AATTCTCCCGAATATATTTTCCTTGCTATATATATGTGACAACATTCTAGTTTACTAGAAGGCTTACATTTTTTTATTAT
TCTCAAAAAAAGGTAATTTT

Downstream 100 bases:

>100_bases
CAAATTGAATTAAATTTACATTATTTAATTTTAAAATAATATGTTAGAATCTTGAAAACGTCGCATAACATCGGCTAAAC
ACTGCGCTTCGGGTCTACGC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 127; Mature: 127

Protein sequence:

>127_residues
MHIGEFSRICKISKESIRYYEKEGLLKGSRKENNYRVYSKKDIRVVELINSLKNSGFTLFEIRSFLNLYDSDSKCKEVQI
KLENKLLIIKDRISELISIQEKLNKSILECEDNPNKKFCNIVSSSHL

Sequences:

>Translated_127_residues
MHIGEFSRICKISKESIRYYEKEGLLKGSRKENNYRVYSKKDIRVVELINSLKNSGFTLFEIRSFLNLYDSDSKCKEVQI
KLENKLLIIKDRISELISIQEKLNKSILECEDNPNKKFCNIVSSSHL
>Mature_127_residues
MHIGEFSRICKISKESIRYYEKEGLLKGSRKENNYRVYSKKDIRVVELINSLKNSGFTLFEIRSFLNLYDSDSKCKEVQI
KLENKLLIIKDRISELISIQEKLNKSILECEDNPNKKFCNIVSSSHL

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=128, Percent_Identity=27.34375, Blast_Score=63, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 14908; Mature: 14908

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIGEFSRICKISKESIRYYEKEGLLKGSRKENNYRVYSKKDIRVVELINSLKNSGFTLF
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCHHH
EIRSFLNLYDSDSKCKEVQIKLENKLLIIKDRISELISIQEKLNKSILECEDNPNKKFCN
HHHHHHHHCCCCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
IVSSSHL
HHHCCCC
>Mature Secondary Structure
MHIGEFSRICKISKESIRYYEKEGLLKGSRKENNYRVYSKKDIRVVELINSLKNSGFTLF
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCHHH
EIRSFLNLYDSDSKCKEVQIKLENKLLIIKDRISELISIQEKLNKSILECEDNPNKKFCN
HHHHHHHHCCCCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
IVSSSHL
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3037534 [H]