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The map label for this gene is hoxA [H]

Identifier: 183221429

GI number: 183221429

Start: 2129122

End: 2129538

Strand: Direct

Name: hoxA [H]

Synonym: LEPBI_I2047

Alternate gene names: 183221429

Gene position: 2129122-2129538 (Clockwise)

Preceding gene: 183221426

Following gene: 183221432

Centisome position: 59.15

GC content: 37.17

Gene sequence:

>417_bases
GTGGAAATTCTCACGGAGAAAAAAAATGGAAAGAAGGGAATCCTCTTTGTAGATGATGAATCCATCATTTTACTCAGTAT
GAAATCCCAAGTAAAACACCATTTTGGAGAAAAATTTAAGTATCTAACTGCCGAAAATGCAAAAGAAGCATGGGATCTGA
TTTTAGAATTTGAAGAAGAAGGAAATTCAGTTGCTGTCATCATTTCTGATTGGGCCATGCCTGGAATGAATGGGGATGAA
TTTTTACGCAAAGTTCACAAAAGGTTTCCTTCGATTGAAAAAGTCATCATCACTGGATTTGCAGATGAAATATTACTGGA
AGCCTTAGAAAAAGAAATTGGGCTCATCACTTGTTTGAAAAAACCTTGGGACGAAAAGGAACTGATCACCGCCATCTCAC
AGGCCATCGAAGTTTAA

Upstream 100 bases:

>100_bases
TAATGTGGGATATGCTGTCATAAAGACCCAAGTGTAGAAATTCAGGGAATTTGGCAAGATTTACTTGCAATCTAATAAAG
AACGGATATAACTTTGTCCT

Downstream 100 bases:

>100_bases
TTCCCTTTTGGCAAGTAAATCAAAAAAATAGTTTCACCAGGTTTGGAAGTAAGTTCAATCCTTCCCGCATGCCGTTTCAC
AATTTTATTCACAATATCCA

Product: putative response regulator

Products: NADP; 2 glutathione [C]

Alternate protein names: NA

Number of amino acids: Translated: 138; Mature: 138

Protein sequence:

>138_residues
MEILTEKKNGKKGILFVDDESIILLSMKSQVKHHFGEKFKYLTAENAKEAWDLILEFEEEGNSVAVIISDWAMPGMNGDE
FLRKVHKRFPSIEKVIITGFADEILLEALEKEIGLITCLKKPWDEKELITAISQAIEV

Sequences:

>Translated_138_residues
MEILTEKKNGKKGILFVDDESIILLSMKSQVKHHFGEKFKYLTAENAKEAWDLILEFEEEGNSVAVIISDWAMPGMNGDE
FLRKVHKRFPSIEKVIITGFADEILLEALEKEIGLITCLKKPWDEKELITAISQAIEV
>Mature_138_residues
MEILTEKKNGKKGILFVDDESIILLSMKSQVKHHFGEKFKYLTAENAKEAWDLILEFEEEGNSVAVIISDWAMPGMNGDE
FLRKVHKRFPSIEKVIITGFADEILLEALEKEIGLITCLKKPWDEKELITAISQAIEV

Specific function: Probable member of the two-component regulatory system involved in the regulation of the hydrogenase activity. HoxA is probably phosphorylated by a sensory component (which could be hoxX) and then acts in conjunction with sigma-54 as a transcriptional act

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 15735; Mature: 15735

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEILTEKKNGKKGILFVDDESIILLSMKSQVKHHFGEKFKYLTAENAKEAWDLILEFEEE
CCCCCCCCCCCCCEEEECCCCEEEEEHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHCCC
GNSVAVIISDWAMPGMNGDEFLRKVHKRFPSIEKVIITGFADEILLEALEKEIGLITCLK
CCEEEEEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHCCCEECC
KPWDEKELITAISQAIEV
CCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MEILTEKKNGKKGILFVDDESIILLSMKSQVKHHFGEKFKYLTAENAKEAWDLILEFEEE
CCCCCCCCCCCCCEEEECCCCEEEEEHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHCCC
GNSVAVIISDWAMPGMNGDEFLRKVHKRFPSIEKVIITGFADEILLEALEKEIGLITCLK
CCEEEEEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHCCCEECC
KPWDEKELITAISQAIEV
CCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADPH2; oxidized glutathione [C]

Specific reaction: NADPH2 + oxidized glutathione = NADP + 2 glutathione [C]

General reaction: Oxidoreductases; Acting on NADH or NADPH; With a disulfide as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2001989; 12948488 [H]