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The map label for this gene is purC [H]

Identifier: 183221308

GI number: 183221308

Start: 2013372

End: 2014229

Strand: Reverse

Name: purC [H]

Synonym: LEPBI_I1925

Alternate gene names: 183221308

Gene position: 2014229-2013372 (Counterclockwise)

Preceding gene: 183221309

Following gene: 183221307

Centisome position: 55.96

GC content: 41.49

Gene sequence:

>858_bases
ATGATACCAAATCCGCATTATAAAGGTAAGGTGAGAGATGTTTATGATTTAGGGGATAAACTTTTGCTTGTTGCTACCGA
TCGGATCTCAGCCTTTGATGTTGTATTTTCTGAACCGGTCGAAGACAAAGGAAAAATCCTCACTCGAATCTCTACAAATT
GGTTCCGGTATTTTTCAAATATTCCGAATCATTTGGTCACCGACGACCCCAATCTTTTTCCAAAACCGTATCAGAACGAA
CCAAGTTTACTTGGACGTTCTGTCCTAGTCAAAAAAGCAAAACGAATTGATTTTGAATGTGTGGTACGGGGGTATCTGAC
TGGTTCTGCTTGGAAAGAATACTTACAATCGGGCACAATTGCAGAAACTCCTTATCCGAAAGGGATCCAAGAGTCTTTCC
AATTTCCTTCTCCCATTTTCACTCCCGCGAGGAAAAATGATTCGGGTCATGATGAAAATGTGAGCGAAGAAACCATGGAA
AGGGAAGTTGGGTCAGTTCTCTTCCAAAAGGTAAAACAAATATCCCTACGACTTTATGAAGAAGCCCATGATTTGATGGC
AAAACAAGGGATCCTACTGTGTGATACCAAATTTGAATTTGGACTCATAGGCGACGAACCCATCCTCATTGATGAAATTT
TGACCCCAGACTCTTCGCGGTATTGGGACAAATCGACGTATTCCCTGGGAAAAACTCCCGCCAGTTTCGACAAACAAATC
CTTCGAAATTGGCTCGAAACGACTCCTTGGGACAAAAATCCGCCACCACCACAACTCCCCGAATCCTTGATTCAGGAACT
ACGTAAAAAATACTTGGAATTGGAAGAGAAAATCAACTTATGTTTGTCGCAAAAATAA

Upstream 100 bases:

>100_bases
TATCTGGAGGGGATATCCTTCCCACTGTTCAAAATAAAATTTTAGAGTTTTGTGGGGTTTCTACTCCTAGTGATGATATG
GCAATGGTGTGTATCCAATT

Downstream 100 bases:

>100_bases
ATGTCACCCTCAAAGAATCGGTCCTTGACCCACAAGGACAAACCGTTCTCCGTACCCTTCACGACCAAGGGAAACTACAA
ATCCAAGACTTACGCGTTGG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MIPNPHYKGKVRDVYDLGDKLLLVATDRISAFDVVFSEPVEDKGKILTRISTNWFRYFSNIPNHLVTDDPNLFPKPYQNE
PSLLGRSVLVKKAKRIDFECVVRGYLTGSAWKEYLQSGTIAETPYPKGIQESFQFPSPIFTPARKNDSGHDENVSEETME
REVGSVLFQKVKQISLRLYEEAHDLMAKQGILLCDTKFEFGLIGDEPILIDEILTPDSSRYWDKSTYSLGKTPASFDKQI
LRNWLETTPWDKNPPPPQLPESLIQELRKKYLELEEKINLCLSQK

Sequences:

>Translated_285_residues
MIPNPHYKGKVRDVYDLGDKLLLVATDRISAFDVVFSEPVEDKGKILTRISTNWFRYFSNIPNHLVTDDPNLFPKPYQNE
PSLLGRSVLVKKAKRIDFECVVRGYLTGSAWKEYLQSGTIAETPYPKGIQESFQFPSPIFTPARKNDSGHDENVSEETME
REVGSVLFQKVKQISLRLYEEAHDLMAKQGILLCDTKFEFGLIGDEPILIDEILTPDSSRYWDKSTYSLGKTPASFDKQI
LRNWLETTPWDKNPPPPQLPESLIQELRKKYLELEEKINLCLSQK
>Mature_285_residues
MIPNPHYKGKVRDVYDLGDKLLLVATDRISAFDVVFSEPVEDKGKILTRISTNWFRYFSNIPNHLVTDDPNLFPKPYQNE
PSLLGRSVLVKKAKRIDFECVVRGYLTGSAWKEYLQSGTIAETPYPKGIQESFQFPSPIFTPARKNDSGHDENVSEETME
REVGSVLFQKVKQISLRLYEEAHDLMAKQGILLCDTKFEFGLIGDEPILIDEILTPDSSRYWDKSTYSLGKTPASFDKQI
LRNWLETTPWDKNPPPPQLPESLIQELRKKYLELEEKINLCLSQK

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Escherichia coli, GI1788820, Length=224, Percent_Identity=32.5892857142857, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319326, Length=285, Percent_Identity=42.4561403508772, Blast_Score=226, Evalue=2e-60,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 32789; Mature: 32789

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPNPHYKGKVRDVYDLGDKLLLVATDRISAFDVVFSEPVEDKGKILTRISTNWFRYFSN
CCCCCCCCCCCHHHHHCCCCEEEEEECCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHC
IPNHLVTDDPNLFPKPYQNEPSLLGRSVLVKKAKRIDFECVVRGYLTGSAWKEYLQSGTI
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHCCCC
AETPYPKGIQESFQFPSPIFTPARKNDSGHDENVSEETMEREVGSVLFQKVKQISLRLYE
CCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EAHDLMAKQGILLCDTKFEFGLIGDEPILIDEILTPDSSRYWDKSTYSLGKTPASFDKQI
HHHHHHHHCCCEEEECCCCEEECCCCCEEHHHHCCCCCCCCCCCCHHCCCCCCHHHHHHH
LRNWLETTPWDKNPPPPQLPESLIQELRKKYLELEEKINLCLSQK
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIPNPHYKGKVRDVYDLGDKLLLVATDRISAFDVVFSEPVEDKGKILTRISTNWFRYFSN
CCCCCCCCCCCHHHHHCCCCEEEEEECCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHC
IPNHLVTDDPNLFPKPYQNEPSLLGRSVLVKKAKRIDFECVVRGYLTGSAWKEYLQSGTI
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHCCCC
AETPYPKGIQESFQFPSPIFTPARKNDSGHDENVSEETMEREVGSVLFQKVKQISLRLYE
CCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EAHDLMAKQGILLCDTKFEFGLIGDEPILIDEILTPDSSRYWDKSTYSLGKTPASFDKQI
HHHHHHHHCCCEEEECCCCEEECCCCCEEHHHHCCCCCCCCCCCCHHCCCCCCHHHHHHH
LRNWLETTPWDKNPPPPQLPESLIQELRKKYLELEEKINLCLSQK
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA