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The map label for this gene is ggtA [H]

Identifier: 183221297

GI number: 183221297

Start: 2003747

End: 2005519

Strand: Reverse

Name: ggtA [H]

Synonym: LEPBI_I1914

Alternate gene names: 183221297

Gene position: 2005519-2003747 (Counterclockwise)

Preceding gene: 183221298

Following gene: 183221296

Centisome position: 55.71

GC content: 42.53

Gene sequence:

>1773_bases
TTGATCGGGACAAAAAGAAGGGCTTTTCTTTTTTGTTTTTTCTTTCTTCTGCCTTTACTCGTTGGTAGTTGTGAAACGAT
TCACACACTTTTCGATCCAAAAGAGAGATCCTTTGTTTCAGAACCAATTTTCCCTCAAGTCCAAGGATCAGTTGAAAAAC
GAGATCGATACGAACTCGTAGGCCGAGAATTTATGATCGCCACCGATCACCCTTTGGCTTCCCAAGCGGGAGTGGAAGTT
TGGAAGAAGGGTGGGAACGTAGTGGATGTGTTTTCCGCTGCCAGTTTTGCCATCTCTGTCTTACGACCTCATTCCACAGG
TTTATTTGGAGGTGGATTTGCGGTTCTTTATTTTCCTAAAAAAGGAAAGTGGGCTTATGATTTTCGCGAGCGATCCCCAA
AAAAAGGGACTGCCTCCTTTTATTTAAAACCGGATGGAAGTGCAAACTCTGAAAAAATTCTGAAAGGACCATATAGCGTA
GCGGTTCCAGGGAATGTCCAAGGGATTCTAAAAATTCAAAAACAACATGGAAAACTTCCATTGGAAGAGGTATTAGCGCC
TGCAATGCGTTATGCGAAAAATGGGTTTTCCGTTTACGCAGATTTAGCGAATGCCGTAACCAAAGTTTGGCCTAATATGA
ATCCAGAGATGCAAAAAGTGTTTGGGATCGATAACCGTCCCATCCGTGAAGGGGAACTTCTTGTCCAAGAGGATTTATTC
CAAACCTTCACTCGAATTTTAGACCAGGAAGAGAAGGAATGGATTGATGGGGAGACAGTCAAACTTGTTTCCCAATATTA
CGAAGGATATGATGGTTTTATCAGTGAAGCGGATTGGAAAGAATACCAAGTAAAACAATTGGACCCGTTGGTAAGTTCGG
TATGGGGTCATCAAATTCTCACAATGCCTCCGCCGAGTTCTGGAGTCCATTTGGTGACCATGATGCATTTGTATGCAGAA
ATGATGAAACGGAAATCGTTTCCCAAAGGGATCGTAGGAGAATCCATTCAAATCACAGAAGCGATGCGGGTGGCTTTTCG
AGACCGAGCAGTCCTTGGAGGAGATCCCAAATTTACAGAGATCCCAGTTACCAAACTGAACTCACAGGCATACATCCAAG
AAGAAGTAAACCAAATCGAAAAAAAAGTGGTCTCTGGCAGTTGGCAAGAAATCCAAAAACCTGTTGAACCAAAAGATTCC
TATAACACGACTCATATTTCTGTTTTAGACAAGGAAGGAAACGCAGTTTCTTCCACACAATCCATCAACGGGATTTTTGG
AGCAGGGCAAATGGTTCCTGGCACTGGACTTGTTTTGAATAATACCATGGACGATTTTTCCATCGCACCCGGGATTCCCA
ATTTATACGGACTTGTCGGTTCCAAGGCCAATGCCATTGCACCAGGAAAAACCCCTCTTTCCAGCATGAGTCCTTCCATT
CTTTTGGATCCGAATGGGAACACCAAACTTGTCATAGGAGCTCCAGGTGGATCCCAAATCCCTACTAGTATTTTCAATAC
CTTGTATCATTATTTGATCCAAAAACGAAGTCTATATGAAAGTGTTTCCTTTCCTAGGATCCACCACCAATACAACCCTG
ATACATTATTTTTAGATCCAGAACTAAAAGGATATTTTCCTGAATCGGAATTACCATTTTACCAAGTCCAATATGGTAGG
CACCGAGCAAAAGTATTCGTAGTGTCAAAAGAAGGAGACAAACTGATAGGAGTGTCGGATCCGAAAGGGGAAGGAGTTCC
TTTAGGTTTTTAG

Upstream 100 bases:

>100_bases
ATGGAATTTCGGAAATCATTGTCCATGTGGTTTGGAACCCCAAATGGGATCCGCGTCAGATGGCAAGCGAAGAAGCAAAA
ATGCAAATGGGGATTTTCGA

Downstream 100 bases:

>100_bases
TCGATGAAAGGAAAATTATTAAAACCGAAACAAAAAAATTCAACAGTCGCCTTATTTGCAAATGAATATAAAGACTGTCT
CCTCAGCGCCAAACATGGAT

Product: gamma-glutamyltranspeptidase small subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 590; Mature: 590

Protein sequence:

>590_residues
MIGTKRRAFLFCFFFLLPLLVGSCETIHTLFDPKERSFVSEPIFPQVQGSVEKRDRYELVGREFMIATDHPLASQAGVEV
WKKGGNVVDVFSAASFAISVLRPHSTGLFGGGFAVLYFPKKGKWAYDFRERSPKKGTASFYLKPDGSANSEKILKGPYSV
AVPGNVQGILKIQKQHGKLPLEEVLAPAMRYAKNGFSVYADLANAVTKVWPNMNPEMQKVFGIDNRPIREGELLVQEDLF
QTFTRILDQEEKEWIDGETVKLVSQYYEGYDGFISEADWKEYQVKQLDPLVSSVWGHQILTMPPPSSGVHLVTMMHLYAE
MMKRKSFPKGIVGESIQITEAMRVAFRDRAVLGGDPKFTEIPVTKLNSQAYIQEEVNQIEKKVVSGSWQEIQKPVEPKDS
YNTTHISVLDKEGNAVSSTQSINGIFGAGQMVPGTGLVLNNTMDDFSIAPGIPNLYGLVGSKANAIAPGKTPLSSMSPSI
LLDPNGNTKLVIGAPGGSQIPTSIFNTLYHYLIQKRSLYESVSFPRIHHQYNPDTLFLDPELKGYFPESELPFYQVQYGR
HRAKVFVVSKEGDKLIGVSDPKGEGVPLGF

Sequences:

>Translated_590_residues
MIGTKRRAFLFCFFFLLPLLVGSCETIHTLFDPKERSFVSEPIFPQVQGSVEKRDRYELVGREFMIATDHPLASQAGVEV
WKKGGNVVDVFSAASFAISVLRPHSTGLFGGGFAVLYFPKKGKWAYDFRERSPKKGTASFYLKPDGSANSEKILKGPYSV
AVPGNVQGILKIQKQHGKLPLEEVLAPAMRYAKNGFSVYADLANAVTKVWPNMNPEMQKVFGIDNRPIREGELLVQEDLF
QTFTRILDQEEKEWIDGETVKLVSQYYEGYDGFISEADWKEYQVKQLDPLVSSVWGHQILTMPPPSSGVHLVTMMHLYAE
MMKRKSFPKGIVGESIQITEAMRVAFRDRAVLGGDPKFTEIPVTKLNSQAYIQEEVNQIEKKVVSGSWQEIQKPVEPKDS
YNTTHISVLDKEGNAVSSTQSINGIFGAGQMVPGTGLVLNNTMDDFSIAPGIPNLYGLVGSKANAIAPGKTPLSSMSPSI
LLDPNGNTKLVIGAPGGSQIPTSIFNTLYHYLIQKRSLYESVSFPRIHHQYNPDTLFLDPELKGYFPESELPFYQVQYGR
HRAKVFVVSKEGDKLIGVSDPKGEGVPLGF
>Mature_590_residues
MIGTKRRAFLFCFFFLLPLLVGSCETIHTLFDPKERSFVSEPIFPQVQGSVEKRDRYELVGREFMIATDHPLASQAGVEV
WKKGGNVVDVFSAASFAISVLRPHSTGLFGGGFAVLYFPKKGKWAYDFRERSPKKGTASFYLKPDGSANSEKILKGPYSV
AVPGNVQGILKIQKQHGKLPLEEVLAPAMRYAKNGFSVYADLANAVTKVWPNMNPEMQKVFGIDNRPIREGELLVQEDLF
QTFTRILDQEEKEWIDGETVKLVSQYYEGYDGFISEADWKEYQVKQLDPLVSSVWGHQILTMPPPSSGVHLVTMMHLYAE
MMKRKSFPKGIVGESIQITEAMRVAFRDRAVLGGDPKFTEIPVTKLNSQAYIQEEVNQIEKKVVSGSWQEIQKPVEPKDS
YNTTHISVLDKEGNAVSSTQSINGIFGAGQMVPGTGLVLNNTMDDFSIAPGIPNLYGLVGSKANAIAPGKTPLSSMSPSI
LLDPNGNTKLVIGAPGGSQIPTSIFNTLYHYLIQKRSLYESVSFPRIHHQYNPDTLFLDPELKGYFPESELPFYQVQYGR
HRAKVFVVSKEGDKLIGVSDPKGEGVPLGF

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=490, Percent_Identity=30.6122448979592, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI73915090, Length=490, Percent_Identity=30.6122448979592, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI73915096, Length=490, Percent_Identity=30.6122448979592, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI73915094, Length=490, Percent_Identity=30.6122448979592, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI113429324, Length=488, Percent_Identity=28.8934426229508, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI113429326, Length=493, Percent_Identity=28.6004056795132, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI109148539, Length=540, Percent_Identity=26.8518518518519, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI153266885, Length=554, Percent_Identity=24.187725631769, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI153266901, Length=555, Percent_Identity=24.1441441441441, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI153266907, Length=553, Percent_Identity=22.7848101265823, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI30581157, Length=136, Percent_Identity=41.1764705882353, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI30581155, Length=136, Percent_Identity=41.1764705882353, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI218505805, Length=132, Percent_Identity=37.8787878787879, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI310124095, Length=136, Percent_Identity=33.8235294117647, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1789856, Length=581, Percent_Identity=32.8743545611015, Blast_Score=308, Evalue=8e-85,
Organism=Caenorhabditis elegans, GI212646519, Length=533, Percent_Identity=30.2063789868668, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI72000294, Length=532, Percent_Identity=29.8872180451128, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI193208247, Length=493, Percent_Identity=28.1947261663286, Blast_Score=186, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI193208245, Length=493, Percent_Identity=28.1947261663286, Blast_Score=186, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17542894, Length=599, Percent_Identity=26.7111853088481, Blast_Score=178, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17506189, Length=516, Percent_Identity=28.8759689922481, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI72001495, Length=231, Percent_Identity=25.974025974026, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI72001497, Length=231, Percent_Identity=25.974025974026, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6323330, Length=523, Percent_Identity=24.0917782026769, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI18859893, Length=482, Percent_Identity=31.1203319502075, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI161077496, Length=502, Percent_Identity=28.0876494023904, Blast_Score=181, Evalue=2e-45,
Organism=Drosophila melanogaster, GI161077878, Length=483, Percent_Identity=28.7784679089027, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24642670, Length=483, Percent_Identity=28.7784679089027, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24642666, Length=483, Percent_Identity=28.7784679089027, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI161077880, Length=483, Percent_Identity=28.7784679089027, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI45551474, Length=483, Percent_Identity=28.7784679089027, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI18859741, Length=508, Percent_Identity=26.1811023622047, Blast_Score=139, Evalue=8e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 65566; Mature: 65566

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGTKRRAFLFCFFFLLPLLVGSCETIHTLFDPKERSFVSEPIFPQVQGSVEKRDRYELV
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHCCCCCHHHCCCHHHHHHHHHC
GREFMIATDHPLASQAGVEVWKKGGNVVDVFSAASFAISVLRPHSTGLFGGGFAVLYFPK
CCEEEEEECCCCCHHHHHHHHHCCCCEEEEHHHHHHHHEEECCCCCCEECCCEEEEEECC
KGKWAYDFRERSPKKGTASFYLKPDGSANSEKILKGPYSVAVPGNVQGILKIQKQHGKLP
CCCEEECHHHCCCCCCCEEEEECCCCCCCCCCEECCCEEEECCCCCHHHEEEEHHCCCCC
LEEVLAPAMRYAKNGFSVYADLANAVTKVWPNMNPEMQKVFGIDNRPIREGELLVQEDLF
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHH
QTFTRILDQEEKEWIDGETVKLVSQYYEGYDGFISEADWKEYQVKQLDPLVSSVWGHQIL
HHHHHHHCCHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEE
TMPPPSSGVHLVTMMHLYAEMMKRKSFPKGIVGESIQITEAMRVAFRDRAVLGGDPKFTE
ECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCEEECCCCCCEE
IPVTKLNSQAYIQEEVNQIEKKVVSGSWQEIQKPVEPKDSYNTTHISVLDKEGNAVSSTQ
CCHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCH
SINGIFGAGQMVPGTGLVLNNTMDDFSIAPGIPNLYGLVGSKANAIAPGKTPLSSMSPSI
HCCCEECCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHCCCCE
LLDPNGNTKLVIGAPGGSQIPTSIFNTLYHYLIQKRSLYESVSFPRIHHQYNPDTLFLDP
EECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCEEEECC
ELKGYFPESELPFYQVQYGRHRAKVFVVSKEGDKLIGVSDPKGEGVPLGF
CCCCCCCCCCCCEEEEECCCCEEEEEEEECCCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MIGTKRRAFLFCFFFLLPLLVGSCETIHTLFDPKERSFVSEPIFPQVQGSVEKRDRYELV
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHCCCCCHHHCCCHHHHHHHHHC
GREFMIATDHPLASQAGVEVWKKGGNVVDVFSAASFAISVLRPHSTGLFGGGFAVLYFPK
CCEEEEEECCCCCHHHHHHHHHCCCCEEEEHHHHHHHHEEECCCCCCEECCCEEEEEECC
KGKWAYDFRERSPKKGTASFYLKPDGSANSEKILKGPYSVAVPGNVQGILKIQKQHGKLP
CCCEEECHHHCCCCCCCEEEEECCCCCCCCCCEECCCEEEECCCCCHHHEEEEHHCCCCC
LEEVLAPAMRYAKNGFSVYADLANAVTKVWPNMNPEMQKVFGIDNRPIREGELLVQEDLF
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHH
QTFTRILDQEEKEWIDGETVKLVSQYYEGYDGFISEADWKEYQVKQLDPLVSSVWGHQIL
HHHHHHHCCHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEE
TMPPPSSGVHLVTMMHLYAEMMKRKSFPKGIVGESIQITEAMRVAFRDRAVLGGDPKFTE
ECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCEEECCCCCCEE
IPVTKLNSQAYIQEEVNQIEKKVVSGSWQEIQKPVEPKDSYNTTHISVLDKEGNAVSSTQ
CCHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCH
SINGIFGAGQMVPGTGLVLNNTMDDFSIAPGIPNLYGLVGSKANAIAPGKTPLSSMSPSI
HCCCEECCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHCCCCE
LLDPNGNTKLVIGAPGGSQIPTSIFNTLYHYLIQKRSLYESVSFPRIHHQYNPDTLFLDP
EECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCEEEECC
ELKGYFPESELPFYQVQYGRHRAKVFVVSKEGDKLIGVSDPKGEGVPLGF
CCCCCCCCCCCCEEEEECCCCEEEEEEEECCCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]