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The map label for this gene is hisD

Identifier: 183221211

GI number: 183221211

Start: 1910606

End: 1911898

Strand: Reverse

Name: hisD

Synonym: LEPBI_I1825

Alternate gene names: 183221211

Gene position: 1911898-1910606 (Counterclockwise)

Preceding gene: 183221212

Following gene: 183221210

Centisome position: 53.11

GC content: 43.54

Gene sequence:

>1293_bases
ATGCCAATTCCCATCTTACATTGTGATCGAAATTCCAAAGAATTGTACTCACGGTTTCTTCAGGGAGCAAGGGAAGACTT
AACGACGGCAACAGACCGCATTTTACCCATTTTGGAATCAGTTCGCACCCAAGGGGATCAGGCACTTTTTTCCTACACCG
AAATGTTTGATGGGATCAAACTTTCACAACTTACCATAGATCCTAAAAAAATTAAAACGAATGTTGACGAGAAAACAAAA
GAAGCATTCCTCAGGGCCAAATCCAATATCGAAGCCTTCCACATGGAACAAAAACGAGAGTCTTGGTCCAAGGTCATTGA
TGGGAATCGATTGGGTGTCAAATACACACCGATTCCTTCCCTGGCAGTATATGCTCCTGGTGGAAAAGCATTGTACCCTT
CTAGTGTCCTTATGGGCATCATTCCAGCAAAAATTGCAGGAGTTCCTTCCATACAACTCATCACACCTCCACAAAAAGAT
GGCATCCCTGAAATTTTGGTATGGTTGGCTCAGATTATGGATATTGATCGGATTGTCACAGTGGGAGGTGCCCAAGGAAT
CGCCGCTGCTGCTTACGGAACCGAATCGGTACCCAAGTCAGAGTTCATTGTAGGTCCTGGGAATGCGTATGTAGCCGCCG
CCAAATCGTATTTAAGTGGGCAAGGTCTGATTGGGATCGAGAGCCCCGCTGGCCCCAGTGAAGTTTGTATCATTGCCGAC
GAAAATGCTAACCCAAAATGGATCGCCTGTGATATGTTATCCCAAGCGGAGCACGGTGAAGATTCCTCAGCAATCCTTCT
TACAACAGATTTAACTCTTGCCAAACGAGTCAGTGAAGAATTAGAAATTGCATTTTCAGAAAGGCCAAAACGATTGCAGA
TGAAGCAGACTGCAATTTACGAAAACTCAAGTATCCTTGTTTTTCCTACCTTGGATGATTGTATTTGGTTTTCCAATGAA
CTTGCCCCGGAACACTTAGAAATCCAAACGAAGGACTATGAATCGGTGTTTGCAAAAATCGAACATGCTGGCAGTGTATT
CCTCGGTCCTTATTCACCAGTTGCGATGGGAGATTATATCTCAGGAACCAATCATATTTTGCCAACAGCAAGAGGCAGTC
GTATTTATTCATCTTTAGGAGTTGATACATTTCTGAAACGTGTCACATTCCAAGAAGTCACAAAAGAATCCCTCGAGAAC
TTGTATCCATTTGTCAAACTCATGTCTGAATTGGAAGGACTTGACGAAGAACATGGAACTAGTGTGAAAGTCCGAACGAG
GCAATTCCAATGA

Upstream 100 bases:

>100_bases
AAATCAGGACTCGAACTCGGCCCACGTTACCAAATCGAAATCTCTTCTCGTTTTTGACAAAAAGCTTGTTTAGGAAGGCA
CTTCCTTCCAAGCTGAATTT

Downstream 100 bases:

>100_bases
TCGTTGTATCAGAGATTGCAGATCTAAAAACGATCATTTCCGAATGGAAACAAAATCAGGAAACCATTGGGTTTTGTCCG
ACAATGGGTACCCTTCATGA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MPIPILHCDRNSKELYSRFLQGAREDLTTATDRILPILESVRTQGDQALFSYTEMFDGIKLSQLTIDPKKIKTNVDEKTK
EAFLRAKSNIEAFHMEQKRESWSKVIDGNRLGVKYTPIPSLAVYAPGGKALYPSSVLMGIIPAKIAGVPSIQLITPPQKD
GIPEILVWLAQIMDIDRIVTVGGAQGIAAAAYGTESVPKSEFIVGPGNAYVAAAKSYLSGQGLIGIESPAGPSEVCIIAD
ENANPKWIACDMLSQAEHGEDSSAILLTTDLTLAKRVSEELEIAFSERPKRLQMKQTAIYENSSILVFPTLDDCIWFSNE
LAPEHLEIQTKDYESVFAKIEHAGSVFLGPYSPVAMGDYISGTNHILPTARGSRIYSSLGVDTFLKRVTFQEVTKESLEN
LYPFVKLMSELEGLDEEHGTSVKVRTRQFQ

Sequences:

>Translated_430_residues
MPIPILHCDRNSKELYSRFLQGAREDLTTATDRILPILESVRTQGDQALFSYTEMFDGIKLSQLTIDPKKIKTNVDEKTK
EAFLRAKSNIEAFHMEQKRESWSKVIDGNRLGVKYTPIPSLAVYAPGGKALYPSSVLMGIIPAKIAGVPSIQLITPPQKD
GIPEILVWLAQIMDIDRIVTVGGAQGIAAAAYGTESVPKSEFIVGPGNAYVAAAKSYLSGQGLIGIESPAGPSEVCIIAD
ENANPKWIACDMLSQAEHGEDSSAILLTTDLTLAKRVSEELEIAFSERPKRLQMKQTAIYENSSILVFPTLDDCIWFSNE
LAPEHLEIQTKDYESVFAKIEHAGSVFLGPYSPVAMGDYISGTNHILPTARGSRIYSSLGVDTFLKRVTFQEVTKESLEN
LYPFVKLMSELEGLDEEHGTSVKVRTRQFQ
>Mature_429_residues
PIPILHCDRNSKELYSRFLQGAREDLTTATDRILPILESVRTQGDQALFSYTEMFDGIKLSQLTIDPKKIKTNVDEKTKE
AFLRAKSNIEAFHMEQKRESWSKVIDGNRLGVKYTPIPSLAVYAPGGKALYPSSVLMGIIPAKIAGVPSIQLITPPQKDG
IPEILVWLAQIMDIDRIVTVGGAQGIAAAAYGTESVPKSEFIVGPGNAYVAAAKSYLSGQGLIGIESPAGPSEVCIIADE
NANPKWIACDMLSQAEHGEDSSAILLTTDLTLAKRVSEELEIAFSERPKRLQMKQTAIYENSSILVFPTLDDCIWFSNEL
APEHLEIQTKDYESVFAKIEHAGSVFLGPYSPVAMGDYISGTNHILPTARGSRIYSSLGVDTFLKRVTFQEVTKESLENL
YPFVKLMSELEGLDEEHGTSVKVRTRQFQ

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=424, Percent_Identity=39.622641509434, Blast_Score=272, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6319819, Length=408, Percent_Identity=39.9509803921569, Blast_Score=267, Evalue=2e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_LEPBA (B0S9F2)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001962857.1
- GeneID:   6387233
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_1772
- HOGENOM:   HBG329596
- OMA:   TEWEVEK
- ProtClustDB:   PRK00877
- BioCyc:   LBIF355278:LBF_1772-MONOMER
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 47348; Mature: 47216

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 324-324 ACT_SITE 325-325 BINDING 124-124 BINDING 185-185 BINDING 208-208 BINDING 233-233 BINDING 255-255 BINDING 258-258 BINDING 325-325 BINDING 358-358 BINDING 412-412 BINDING 418-418

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIPILHCDRNSKELYSRFLQGAREDLTTATDRILPILESVRTQGDQALFSYTEMFDGIK
CCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCE
LSQLTIDPKKIKTNVDEKTKEAFLRAKSNIEAFHMEQKRESWSKVIDGNRLGVKYTPIPS
EEEEEECHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCC
LAVYAPGGKALYPSSVLMGIIPAKIAGVPSIQLITPPQKDGIPEILVWLAQIMDIDRIVT
EEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCHHHEEE
VGGAQGIAAAAYGTESVPKSEFIVGPGNAYVAAAKSYLSGQGLIGIESPAGPSEVCIIAD
ECCCCCCEEECCCCCCCCCCCEEECCCCHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEC
ENANPKWIACDMLSQAEHGEDSSAILLTTDLTLAKRVSEELEIAFSERPKRLQMKQTAIY
CCCCCCEEEEEHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHEE
ENSSILVFPTLDDCIWFSNELAPEHLEIQTKDYESVFAKIEHAGSVFLGPYSPVAMGDYI
CCCCEEEEECHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHCCCEEECCCCCCCCCCCC
SGTNHILPTARGSRIYSSLGVDTFLKRVTFQEVTKESLENLYPFVKLMSELEGLDEEHGT
CCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCC
SVKVRTRQFQ
EEEEEECCCC
>Mature Secondary Structure 
PIPILHCDRNSKELYSRFLQGAREDLTTATDRILPILESVRTQGDQALFSYTEMFDGIK
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCE
LSQLTIDPKKIKTNVDEKTKEAFLRAKSNIEAFHMEQKRESWSKVIDGNRLGVKYTPIPS
EEEEEECHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCC
LAVYAPGGKALYPSSVLMGIIPAKIAGVPSIQLITPPQKDGIPEILVWLAQIMDIDRIVT
EEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCHHHEEE
VGGAQGIAAAAYGTESVPKSEFIVGPGNAYVAAAKSYLSGQGLIGIESPAGPSEVCIIAD
ECCCCCCEEECCCCCCCCCCCEEECCCCHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEC
ENANPKWIACDMLSQAEHGEDSSAILLTTDLTLAKRVSEELEIAFSERPKRLQMKQTAIY
CCCCCCEEEEEHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHEE
ENSSILVFPTLDDCIWFSNELAPEHLEIQTKDYESVFAKIEHAGSVFLGPYSPVAMGDYI
CCCCEEEEECHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHCCCEEECCCCCCCCCCCC
SGTNHILPTARGSRIYSSLGVDTFLKRVTFQEVTKESLENLYPFVKLMSELEGLDEEHGT
CCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCC
SVKVRTRQFQ
EEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA