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The map label for this gene is panC

Identifier: 183221210

GI number: 183221210

Start: 1909758

End: 1910609

Strand: Reverse

Name: panC

Synonym: LEPBI_I1824

Alternate gene names: 183221210

Gene position: 1910609-1909758 (Counterclockwise)

Preceding gene: 183221211

Following gene: 183221209

Centisome position: 53.08

GC content: 37.56

Gene sequence:

>852_bases
ATGATCGTTGTATCAGAGATTGCAGATCTAAAAACGATCATTTCCGAATGGAAACAAAATCAGGAAACCATTGGGTTTTG
TCCGACAATGGGTACCCTTCATGACGGGCATATGGATTTGGTTAAAACTTCGAAAGGACAATGTACTAAAACAATTGTCT
CCATCTTTATCAATCCAACACAATTCAATGATCCAAAAGACTTTGATGCGTATCCCAAAAATACAGAATCGGATTTAAAG
TTATGCGAAGAACATGGAGTGGATTTGGTTTTTTTACCAAGTGTGGAAGTGATCTATCCAAAATCACAAACTCCCATCCA
AATGAGTATTCCCAGCTTACAGACAACTCTCTGTGGACGAACAAGGCCAGGTCACTTTGAAGGTGTATTACAAATTGTTT
CAAAACTTTTCCATCTAACAGAACCTAATTATGGATTTTTTGGACTCAAAGACTACCAACAGTATCGAATCATTTCCGCC
ATGGTAGAAGAACTGAATTTTCCTATCAAAATTCTCGGAGTTCCCACAAAAAGGGAATCGGATGGACTGGCGATGAGTTC
GAGAAATCTTAGGCTTTCACCAAAAGATAGAGAAACGGCATCTCTTATTCCAAGAATGTTCCAACTTGCCAAAAAAACAT
TATTAGGTGGGGAAAAGAACCTGATTGTTTGGAAAGAAATTCTAACTGACTTCCTTTTGACTGGATCCAATGTGAAAATT
GATTATTTAGAAATTGTCGATCCTATCACTTTACAACCTCTCTCAAATTTAAATGGAGAACTTTTACTGGCTACTGCCGT
ATTTGTTGGTGAGGTTCGTCTCATTGACAATGAAGTTTTAGTCTCTCCCTAA

Upstream 100 bases:

>100_bases
CCCTCGAGAACTTGTATCCATTTGTCAAACTCATGTCTGAATTGGAAGGACTTGACGAAGAACATGGAACTAGTGTGAAA
GTCCGAACGAGGCAATTCCA

Downstream 100 bases:

>100_bases
TTCCATCCAATGACAAAAGACATTCAAATTAGACCCTTCCAAGCAAAAGACGTTTTTAAAGAAGCTAAAGAAACACTCGT
AAACCTTAGTGGGATTCCAG

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MIVVSEIADLKTIISEWKQNQETIGFCPTMGTLHDGHMDLVKTSKGQCTKTIVSIFINPTQFNDPKDFDAYPKNTESDLK
LCEEHGVDLVFLPSVEVIYPKSQTPIQMSIPSLQTTLCGRTRPGHFEGVLQIVSKLFHLTEPNYGFFGLKDYQQYRIISA
MVEELNFPIKILGVPTKRESDGLAMSSRNLRLSPKDRETASLIPRMFQLAKKTLLGGEKNLIVWKEILTDFLLTGSNVKI
DYLEIVDPITLQPLSNLNGELLLATAVFVGEVRLIDNEVLVSP

Sequences:

>Translated_283_residues
MIVVSEIADLKTIISEWKQNQETIGFCPTMGTLHDGHMDLVKTSKGQCTKTIVSIFINPTQFNDPKDFDAYPKNTESDLK
LCEEHGVDLVFLPSVEVIYPKSQTPIQMSIPSLQTTLCGRTRPGHFEGVLQIVSKLFHLTEPNYGFFGLKDYQQYRIISA
MVEELNFPIKILGVPTKRESDGLAMSSRNLRLSPKDRETASLIPRMFQLAKKTLLGGEKNLIVWKEILTDFLLTGSNVKI
DYLEIVDPITLQPLSNLNGELLLATAVFVGEVRLIDNEVLVSP
>Mature_283_residues
MIVVSEIADLKTIISEWKQNQETIGFCPTMGTLHDGHMDLVKTSKGQCTKTIVSIFINPTQFNDPKDFDAYPKNTESDLK
LCEEHGVDLVFLPSVEVIYPKSQTPIQMSIPSLQTTLCGRTRPGHFEGVLQIVSKLFHLTEPNYGFFGLKDYQQYRIISA
MVEELNFPIKILGVPTKRESDGLAMSSRNLRLSPKDRETASLIPRMFQLAKKTLLGGEKNLIVWKEILTDFLLTGSNVKI
DYLEIVDPITLQPLSNLNGELLLATAVFVGEVRLIDNEVLVSP

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=283, Percent_Identity=38.5159010600707, Blast_Score=203, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6322046, Length=303, Percent_Identity=33.993399339934, Blast_Score=163, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_LEPBA (B0S9F1)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001962856.1
- ProteinModelPortal:   B0S9F1
- SMR:   B0S9F1
- GeneID:   6387603
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_1771
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- ProtClustDB:   PRK00380
- BioCyc:   LBIF355278:LBF_1771-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31740; Mature: 31740

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 154-154

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVVSEIADLKTIISEWKQNQETIGFCPTMGTLHDGHMDLVKTSKGQCTKTIVSIFINPT
CEEHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHCCCCHHHHHHHHHEECCC
QFNDPKDFDAYPKNTESDLKLCEEHGVDLVFLPSVEVIYPKSQTPIQMSIPSLQTTLCGR
CCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCEEEEECCCCCCEEEECCCHHHHHCCC
TRPGHFEGVLQIVSKLFHLTEPNYGFFGLKDYQQYRIISAMVEELNFPIKILGVPTKRES
CCCCHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
DGLAMSSRNLRLSPKDRETASLIPRMFQLAKKTLLGGEKNLIVWKEILTDFLLTGSNVKI
CCCEECCCCCEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCCCEE
DYLEIVDPITLQPLSNLNGELLLATAVFVGEVRLIDNEVLVSP
EEEECCCCCEECHHCCCCCCEEEEEHHHHHEEEEECCEEEECC
>Mature Secondary Structure
MIVVSEIADLKTIISEWKQNQETIGFCPTMGTLHDGHMDLVKTSKGQCTKTIVSIFINPT
CEEHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHCCCCHHHHHHHHHEECCC
QFNDPKDFDAYPKNTESDLKLCEEHGVDLVFLPSVEVIYPKSQTPIQMSIPSLQTTLCGR
CCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCEEEEECCCCCCEEEECCCHHHHHCCC
TRPGHFEGVLQIVSKLFHLTEPNYGFFGLKDYQQYRIISAMVEELNFPIKILGVPTKRES
CCCCHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
DGLAMSSRNLRLSPKDRETASLIPRMFQLAKKTLLGGEKNLIVWKEILTDFLLTGSNVKI
CCCEECCCCCEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCCCEE
DYLEIVDPITLQPLSNLNGELLLATAVFVGEVRLIDNEVLVSP
EEEECCCCCEECHHCCCCCCEEEEEHHHHHEEEEECCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA