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The map label for this gene is murC [H]

Identifier: 183221142

GI number: 183221142

Start: 1833867

End: 1835276

Strand: Reverse

Name: murC [H]

Synonym: LEPBI_I1756

Alternate gene names: 183221142

Gene position: 1835276-1833867 (Counterclockwise)

Preceding gene: 183221143

Following gene: 183221138

Centisome position: 50.98

GC content: 38.16

Gene sequence:

>1410_bases
ATGAAAGGTCCTATACTATTTTTAGGCATTGGTGGGAGTGGGATGTCAAGCCTTGCTCATATGGCCATCGATTTACAAAT
TCCAGTCGTCGGTTATGATAAAAAAAAATCAGATATCACAGACTACTTAGTCGAACGTGGTGTAAAACTCTATCATTCGA
TTGGAGAAATTCCTTTGGATGGTATCCAAATGGTAGTCTACAGTTCTGCCATCAATGACAAACACAAAGATGTGTTTAAT
CGTATTCAAAATTTAAACATTCCTTTGAAACATCGATCGGAATTTATGCACCTTCTTGTTTCCAATCAGAAATCAATTTC
TGTTGCGGGTAGCCATGGTAAAACTTCGACCACAACTATGGTCTCACAGATTTTAACGGAAGTTGGACTTGATCCAACCA
TCATGATTGGAGGGGATACCAGTTTATTACAAAAACGTGGTGGTAAGATGGGAAAGGGTGACTATGCAGTTTACGAATCA
GACGAATCTGACGGAACCTTTCTTCGCCATAAAGCCAACATTAGATTATTGACGAATATCGATAACGACCATCTAGATTA
CTACCGAACGCGAGAAAGGTTAGAAGAAGCTTTCTTAGACTATATGGGTTTTGGATCTCCTGGTGAAGTTGTATTATTTG
TTGGTGATCCAGGGATAAAATCAGTATTAGAAATTCATTATCGTAACCTTACGTTTCATAATGAGTTACACCTGAACTTA
CTTGTCACAAAATCACATACAAATGAAGAATGGTTTTCCTATTTTTTATCCCAGTTTCAGAAACAAATCACTGTGGTTCT
TTATGAAGTGAAAGAAAATCAACTTTATTTCCAACTGGAAAACCAGTCCTATACATTAGAATTACCGTATCCCGGTGTCC
ATTACCTTACCAATGGATTAGTGGCTCTCACTTGTGCATATAGAATTGGAATCAGTCCCTCTCAGTCTTCTCAAATTCTC
TCTCGTTATATCGGTGTGAAACGAAGGCAAGAAATTTTGGGAGTTTGGAATGAGGTGACAGTGATCGATGACTATGGCCA
CCACCCAACTGAAATCAAAATGGTGATTCAATCTTTGAAAGATAAAATCAAAAACAAAGGAAAACTCCATGTGATTTTCC
AACCTCATCGATACACTCGCACAAAGTTATTGTTAGAAGATCTAGCGAAATCACTTCTCGGTGCAGATTTTGTATTTTTA
CTTCCCATCTATTCCGCTGGGGAAAACCCAATGGAAGGGATTACTTCGAATCGCTTTTTACCGTATCTGACTGGAAGCCA
AACTACAATGTTAGATGGTAATATTAGGGAAGACTTGGAGCAAATCAAATCTCATCTGAACAAAGGAGACCTTTTATTGT
GTTTGGGAGCTGGAAATGTGAGGGATTGGGGAATGGAACTTGTTTCTTAA

Upstream 100 bases:

>100_bases
CGTGAAATGGGCCATATCAGTTTGGCGTTATCGAATGTAAATGCAGCCTACCAAACCGTTTCTTATTTTTTTTCAGACTC
AAACTAGGATTAAAACGTAA

Downstream 100 bases:

>100_bases
ATCTAATGATTAAAAAATTTTAGAGGTCATGAAAGAGGGGGTTTACTTCCTCTAAACTTCCTTTAAAATTCAAATGTCCC
ATTTTTCTTCCTGGTTTTGC

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MKGPILFLGIGGSGMSSLAHMAIDLQIPVVGYDKKKSDITDYLVERGVKLYHSIGEIPLDGIQMVVYSSAINDKHKDVFN
RIQNLNIPLKHRSEFMHLLVSNQKSISVAGSHGKTSTTTMVSQILTEVGLDPTIMIGGDTSLLQKRGGKMGKGDYAVYES
DESDGTFLRHKANIRLLTNIDNDHLDYYRTRERLEEAFLDYMGFGSPGEVVLFVGDPGIKSVLEIHYRNLTFHNELHLNL
LVTKSHTNEEWFSYFLSQFQKQITVVLYEVKENQLYFQLENQSYTLELPYPGVHYLTNGLVALTCAYRIGISPSQSSQIL
SRYIGVKRRQEILGVWNEVTVIDDYGHHPTEIKMVIQSLKDKIKNKGKLHVIFQPHRYTRTKLLLEDLAKSLLGADFVFL
LPIYSAGENPMEGITSNRFLPYLTGSQTTMLDGNIREDLEQIKSHLNKGDLLLCLGAGNVRDWGMELVS

Sequences:

>Translated_469_residues
MKGPILFLGIGGSGMSSLAHMAIDLQIPVVGYDKKKSDITDYLVERGVKLYHSIGEIPLDGIQMVVYSSAINDKHKDVFN
RIQNLNIPLKHRSEFMHLLVSNQKSISVAGSHGKTSTTTMVSQILTEVGLDPTIMIGGDTSLLQKRGGKMGKGDYAVYES
DESDGTFLRHKANIRLLTNIDNDHLDYYRTRERLEEAFLDYMGFGSPGEVVLFVGDPGIKSVLEIHYRNLTFHNELHLNL
LVTKSHTNEEWFSYFLSQFQKQITVVLYEVKENQLYFQLENQSYTLELPYPGVHYLTNGLVALTCAYRIGISPSQSSQIL
SRYIGVKRRQEILGVWNEVTVIDDYGHHPTEIKMVIQSLKDKIKNKGKLHVIFQPHRYTRTKLLLEDLAKSLLGADFVFL
LPIYSAGENPMEGITSNRFLPYLTGSQTTMLDGNIREDLEQIKSHLNKGDLLLCLGAGNVRDWGMELVS
>Mature_469_residues
MKGPILFLGIGGSGMSSLAHMAIDLQIPVVGYDKKKSDITDYLVERGVKLYHSIGEIPLDGIQMVVYSSAINDKHKDVFN
RIQNLNIPLKHRSEFMHLLVSNQKSISVAGSHGKTSTTTMVSQILTEVGLDPTIMIGGDTSLLQKRGGKMGKGDYAVYES
DESDGTFLRHKANIRLLTNIDNDHLDYYRTRERLEEAFLDYMGFGSPGEVVLFVGDPGIKSVLEIHYRNLTFHNELHLNL
LVTKSHTNEEWFSYFLSQFQKQITVVLYEVKENQLYFQLENQSYTLELPYPGVHYLTNGLVALTCAYRIGISPSQSSQIL
SRYIGVKRRQEILGVWNEVTVIDDYGHHPTEIKMVIQSLKDKIKNKGKLHVIFQPHRYTRTKLLLEDLAKSLLGADFVFL
LPIYSAGENPMEGITSNRFLPYLTGSQTTMLDGNIREDLEQIKSHLNKGDLLLCLGAGNVRDWGMELVS

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=392, Percent_Identity=31.3775510204082, Blast_Score=165, Evalue=7e-42,
Organism=Escherichia coli, GI1790680, Length=408, Percent_Identity=25.7352941176471, Blast_Score=128, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 52947; Mature: 52947

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGPILFLGIGGSGMSSLAHMAIDLQIPVVGYDKKKSDITDYLVERGVKLYHSIGEIPLD
CCCCEEEEEECCCCHHHHHHEEEEEEEEEEECCCCHHHHHHHHHHCCHHHHHHHCCCCCC
GIQMVVYSSAINDKHKDVFNRIQNLNIPLKHRSEFMHLLVSNQKSISVAGSHGKTSTTTM
HHHEEEEHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHH
VSQILTEVGLDPTIMIGGDTSLLQKRGGKMGKGDYAVYESDESDGTFLRHKANIRLLTNI
HHHHHHHHCCCCEEEECCCHHHHHHCCCCCCCCCEEEEECCCCCCCEEEEECCEEEEECC
DNDHLDYYRTRERLEEAFLDYMGFGSPGEVVLFVGDPGIKSVLEIHYRNLTFHNELHLNL
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHCCEEECEEEEEE
LVTKSHTNEEWFSYFLSQFQKQITVVLYEVKENQLYFQLENQSYTLELPYPGVHYLTNGL
EEEECCCCHHHHHHHHHHHHHHEEEEEEEEECCEEEEEECCCEEEEECCCCCHHHHHCCC
VALTCAYRIGISPSQSSQILSRYIGVKRRQEILGVWNEVTVIDDYGHHPTEIKMVIQSLK
EEEEEHHHCCCCCCHHHHHHHHHHCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHH
DKIKNKGKLHVIFQPHRYTRTKLLLEDLAKSLLGADFVFLLPIYSAGENPMEGITSNRFL
HHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEEHHCCCCCCHHCCCCCCEE
PYLTGSQTTMLDGNIREDLEQIKSHLNKGDLLLCLGAGNVRDWGMELVS
EEEECCCEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCC
>Mature Secondary Structure
MKGPILFLGIGGSGMSSLAHMAIDLQIPVVGYDKKKSDITDYLVERGVKLYHSIGEIPLD
CCCCEEEEEECCCCHHHHHHEEEEEEEEEEECCCCHHHHHHHHHHCCHHHHHHHCCCCCC
GIQMVVYSSAINDKHKDVFNRIQNLNIPLKHRSEFMHLLVSNQKSISVAGSHGKTSTTTM
HHHEEEEHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHH
VSQILTEVGLDPTIMIGGDTSLLQKRGGKMGKGDYAVYESDESDGTFLRHKANIRLLTNI
HHHHHHHHCCCCEEEECCCHHHHHHCCCCCCCCCEEEEECCCCCCCEEEEECCEEEEECC
DNDHLDYYRTRERLEEAFLDYMGFGSPGEVVLFVGDPGIKSVLEIHYRNLTFHNELHLNL
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHCCEEECEEEEEE
LVTKSHTNEEWFSYFLSQFQKQITVVLYEVKENQLYFQLENQSYTLELPYPGVHYLTNGL
EEEECCCCHHHHHHHHHHHHHHEEEEEEEEECCEEEEEECCCEEEEECCCCCHHHHHCCC
VALTCAYRIGISPSQSSQILSRYIGVKRRQEILGVWNEVTVIDDYGHHPTEIKMVIQSLK
EEEEEHHHCCCCCCHHHHHHHHHHCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHH
DKIKNKGKLHVIFQPHRYTRTKLLLEDLAKSLLGADFVFLLPIYSAGENPMEGITSNRFL
HHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEEHHCCCCCCHHCCCCCCEE
PYLTGSQTTMLDGNIREDLEQIKSHLNKGDLLLCLGAGNVRDWGMELVS
EEEECCCEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA