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The map label for this gene is pgsA [H]

Identifier: 183220786

GI number: 183220786

Start: 1456934

End: 1457680

Strand: Direct

Name: pgsA [H]

Synonym: LEPBI_I1397

Alternate gene names: 183220786

Gene position: 1456934-1457680 (Clockwise)

Preceding gene: 183220785

Following gene: 183220787

Centisome position: 40.47

GC content: 40.83

Gene sequence:

>747_bases
GTGGAAGATTGGAAAACCATTGCCAATATCCCAAACCTACTCACGGTTCTTAGGGTTCTTGCCTTACCGTTTTTTATCTT
TGCCTTATTCCAAAAAGAATGGGAATACCAAATTTTTGCCTTTGTGATATTTGCACTCGCTTCCCTTACCGATTTAGTCG
ATGGGTATTTGGCACGGAAATGGAACCAACAAACCGAATTCGGAAAATTCCTCGACCCACTCGCCGATAAGTTTTTGGTC
ATTGGATGTTTTGTTACCTTTTTATTCATCCACGAACCGATTGAAGTTTGGATTGTAGTTCTCATCGTCGGCCGGGATAT
GCTCATCACCTTCCTTCGTTACATTGCCGTTCGCTCAGGCAATAGCCTACGTACTACCATGATGGGAAAAGTCAAAACGG
CTTTCCAGATGGGAGCCATTCTCATCATCCTTGTTGTGTTTATGCTCATCTCAGGAAAACGCCGTGCCATGATCAATGAA
ACCTATGCCTTGGGAAAACTCGCTGGTCTTTCGACTTTGGAGGTGGCTTCCCAAAATGTGTATGAGTTTTATACTTTAGT
GAAAACGTCTGAGACTTTGAGTTTCAAAGATTTTTTTGATTCCATTGCTTCTTTTGTTCCTTATTTTGGAATGTTTTTTA
CCACTTTCATCACTGTGATTTCTGGCCTTCGTTATATCGTGACCAATTACCAACTATTAACCTTTTCCAATCTCAAAAGG
ATTTTTTATGACCGCTCCCACAATTAA

Upstream 100 bases:

>100_bases
TTGTCTATGTCGAAACGAAGGATTTAAAACTGGGCCAATTTGGAAAGGTCAGAGTGGATTCGTTTTATGAACTGGATATG
TCAGGGACTTGGGTGGATTA

Downstream 100 bases:

>100_bases
AGAAATCCTCCACCAAGTGGTGGCGGGACACCATTTGGTGGAAACGCACGCCGAATTCTTTTTGAATGAAGTAATGGATG
GAAACGTCGCAGAACCCGTG

Product: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MEDWKTIANIPNLLTVLRVLALPFFIFALFQKEWEYQIFAFVIFALASLTDLVDGYLARKWNQQTEFGKFLDPLADKFLV
IGCFVTFLFIHEPIEVWIVVLIVGRDMLITFLRYIAVRSGNSLRTTMMGKVKTAFQMGAILIILVVFMLISGKRRAMINE
TYALGKLAGLSTLEVASQNVYEFYTLVKTSETLSFKDFFDSIASFVPYFGMFFTTFITVISGLRYIVTNYQLLTFSNLKR
IFYDRSHN

Sequences:

>Translated_248_residues
MEDWKTIANIPNLLTVLRVLALPFFIFALFQKEWEYQIFAFVIFALASLTDLVDGYLARKWNQQTEFGKFLDPLADKFLV
IGCFVTFLFIHEPIEVWIVVLIVGRDMLITFLRYIAVRSGNSLRTTMMGKVKTAFQMGAILIILVVFMLISGKRRAMINE
TYALGKLAGLSTLEVASQNVYEFYTLVKTSETLSFKDFFDSIASFVPYFGMFFTTFITVISGLRYIVTNYQLLTFSNLKR
IFYDRSHN
>Mature_248_residues
MEDWKTIANIPNLLTVLRVLALPFFIFALFQKEWEYQIFAFVIFALASLTDLVDGYLARKWNQQTEFGKFLDPLADKFLV
IGCFVTFLFIHEPIEVWIVVLIVGRDMLITFLRYIAVRSGNSLRTTMMGKVKTAFQMGAILIILVVFMLISGKRRAMINE
TYALGKLAGLSTLEVASQNVYEFYTLVKTSETLSFKDFFDSIASFVPYFGMFFTTFITVISGLRYIVTNYQLLTFSNLKR
IFYDRSHN

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI188536108, Length=155, Percent_Identity=32.9032258064516, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI10092647, Length=146, Percent_Identity=34.2465753424658, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1788220, Length=142, Percent_Identity=39.4366197183099, Blast_Score=96, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6320059, Length=116, Percent_Identity=37.9310344827586, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24650130, Length=157, Percent_Identity=31.2101910828025, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24650126, Length=157, Percent_Identity=31.2101910828025, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24650128, Length=157, Percent_Identity=31.2101910828025, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 28643; Mature: 28643

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHCCCCC
>Mature Secondary Structure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HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA