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The map label for this gene is lytR [H]

Identifier: 183220488

GI number: 183220488

Start: 1137113

End: 1137817

Strand: Direct

Name: lytR [H]

Synonym: LEPBI_I1087

Alternate gene names: 183220488

Gene position: 1137113-1137817 (Clockwise)

Preceding gene: 183220487

Following gene: 183220492

Centisome position: 31.59

GC content: 33.62

Gene sequence:

>705_bases
TTGAAAATATTAATTGTAGAAGACGAGGAAGTAGCCGCAAGGGGTCTAGAGCGCTTGTTACGTGAACTTTTGGGTAAAAA
AATCTCGTCTTTACATGTAGAAAAAAGTTTATTAGGTTCACGATGTTTCCTCCAAGAGAATCCGATAGATTTATTATTTT
TGGATTTAAATTTAGATGGTGATTTTGGATTTGATTTACTTAAAGAGTCATCAGCTGCATCTTTTATCACAATCATAACC
TCAGGGAATACGGCAGAAGCAATTCTAGCTTTTGAATATGGTGTTTTGGATTTTGTTCCAAAACCAATTTCGAGAGAAAG
ACTGGAGAAGGCTCTCAAAAAATATTTTTCCAACTCCGGTCAGAATCAAACCAAATACATTGGAATCAAAGAGGATCATC
ATTTGAAACTGATCCCAACAAAAGAAATTTTGTACATCGAGGCTGATGATAAAAAGGTAAAACTGTTTCAAAAAAATGGA
AAGATAGTATCACATTATAAAAGTTTAGAGTTATTATCCAAAATTTTACCTGGCAATTTTAAAAGGATCCATCGATCTTA
CATTGTAAACCAAAGGTACATCAATCAGATTTTAGTTTCCCCTGGAGGATCCTATCAAGTGGAACTCGTGACAGGTATCA
AATTAAAAATGGGTAGAAATTATTATAAGGATTTGAAAGCCACTTTGTATGCAAAGGTTAGCTGA

Upstream 100 bases:

>100_bases
TCCATGCGAACCTTAAACTCATACCAAGCTATGATTGGAGTTTTTGTGAATTTATCAAATGTTCAATACCGATTAGAACA
ATATTAATACGAGGATTTTT

Downstream 100 bases:

>100_bases
TCTAAATTCACGATCTTTCGCCGATTTCTTTCAAAAGACAAATATATTGAATACAATGAAAAACCATCCTAATTGAATGG
TTTTTCATAATATTAGTAAA

Product: putative two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MKILIVEDEEVAARGLERLLRELLGKKISSLHVEKSLLGSRCFLQENPIDLLFLDLNLDGDFGFDLLKESSAASFITIIT
SGNTAEAILAFEYGVLDFVPKPISRERLEKALKKYFSNSGQNQTKYIGIKEDHHLKLIPTKEILYIEADDKKVKLFQKNG
KIVSHYKSLELLSKILPGNFKRIHRSYIVNQRYINQILVSPGGSYQVELVTGIKLKMGRNYYKDLKATLYAKVS

Sequences:

>Translated_234_residues
MKILIVEDEEVAARGLERLLRELLGKKISSLHVEKSLLGSRCFLQENPIDLLFLDLNLDGDFGFDLLKESSAASFITIIT
SGNTAEAILAFEYGVLDFVPKPISRERLEKALKKYFSNSGQNQTKYIGIKEDHHLKLIPTKEILYIEADDKKVKLFQKNG
KIVSHYKSLELLSKILPGNFKRIHRSYIVNQRYINQILVSPGGSYQVELVTGIKLKMGRNYYKDLKATLYAKVS
>Mature_234_residues
MKILIVEDEEVAARGLERLLRELLGKKISSLHVEKSLLGSRCFLQENPIDLLFLDLNLDGDFGFDLLKESSAASFITIIT
SGNTAEAILAFEYGVLDFVPKPISRERLEKALKKYFSNSGQNQTKYIGIKEDHHLKLIPTKEILYIEADDKKVKLFQKNG
KIVSHYKSLELLSKILPGNFKRIHRSYIVNQRYINQILVSPGGSYQVELVTGIKLKMGRNYYKDLKATLYAKVS

Specific function: Member of the two-component regulatory system lytR/lytS that regulates genes involved in autolysis and cell wall metabolism. Regulates the activity of the cell wall-associated murein hydrolase through regulation of lrgA and lrgB [H]

COG id: COG3279

COG function: function code KT; Response regulator of the LytR/AlgR family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788724, Length=217, Percent_Identity=30.4147465437788, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082052, Length=241, Percent_Identity=25.3112033195021, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR007492
- InterPro:   IPR001789 [H]

Pfam domain/function: PF04397 LytTR; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 26638; Mature: 26638

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50930 HTH_LYTTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILIVEDEEVAARGLERLLRELLGKKISSLHVEKSLLGSRCFLQENPIDLLFLDLNLDG
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEEEECCC
DFGFDLLKESSAASFITIITSGNTAEAILAFEYGVLDFVPKPISRERLEKALKKYFSNSG
CCCHHHHHCCCCCEEEEEEECCCCCEEEEEEECCHHHHCCCCCCHHHHHHHHHHHHCCCC
QNQTKYIGIKEDHHLKLIPTKEILYIEADDKKVKLFQKNGKIVSHYKSLELLSKILPGNF
CCCEEEEEECCCCCEEEECCCEEEEEECCCCEEEEEECCCCEEHHHHHHHHHHHHCCCCH
KRIHRSYIVNQRYINQILVSPGGSYQVELVTGIKLKMGRNYYKDLKATLYAKVS
HHHHHHHHHHHHHHHHEEECCCCCEEEEEEEEEEEECCCCHHHHHHHHEEEECC
>Mature Secondary Structure
MKILIVEDEEVAARGLERLLRELLGKKISSLHVEKSLLGSRCFLQENPIDLLFLDLNLDG
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEEEECCC
DFGFDLLKESSAASFITIITSGNTAEAILAFEYGVLDFVPKPISRERLEKALKKYFSNSG
CCCHHHHHCCCCCEEEEEEECCCCCEEEEEEECCHHHHCCCCCCHHHHHHHHHHHHCCCC
QNQTKYIGIKEDHHLKLIPTKEILYIEADDKKVKLFQKNGKIVSHYKSLELLSKILPGNF
CCCEEEEEECCCCCEEEECCCEEEEEECCCCEEEEEECCCCEEHHHHHHHHHHHHCCCCH
KRIHRSYIVNQRYINQILVSPGGSYQVELVTGIKLKMGRNYYKDLKATLYAKVS
HHHHHHHHHHHHHHHHEEECCCCCEEEEEEEEEEEECCCCHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA