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The map label for this gene is prlC [H]

Identifier: 183220383

GI number: 183220383

Start: 1014066

End: 1016012

Strand: Reverse

Name: prlC [H]

Synonym: LEPBI_I0979

Alternate gene names: 183220383

Gene position: 1016012-1014066 (Counterclockwise)

Preceding gene: 183220385

Following gene: 183220380

Centisome position: 28.23

GC content: 38.67

Gene sequence:

>1947_bases
ATGTTTCCCGAATTTCATTCAAACAATCTATTAGAAAAAGAATCGACCATTTTAAAGAAAATGGAGTCCAACAAAGAGTT
CATCCAATCCTTACTCAAACAACCAAACGGTTCCTTCCAAACTTTTTTAAAACCTTACCAAAGGGTTCAAACCGAACTTG
GAGATTTAGTAACGGAAATCTCTCATCTCAACTCAGTGAAAAACAGTGAAGAAAGCCAAACCATCTATAGTCGATTGTTA
CCGAAACTCAGCGAGTATTACACTGACCTTGGCCAAAACGAAGAAATTTTCTCTGCACTACTTCACATCCAATCCACAGA
CAAAACTGTAAACTCAGAACAAATCAAAGTATTGGAAAATGAAATCAGAGACTTTCGATTGTCTGGCGTTGGGCTCGATT
CAAACACCAAAGAAGAACTCAAAAACATCCGCATCAAATTATCAGATTTAACCAACCAATTTTCTCAGAATGTCCTCAAT
GCTACCAATGCATTTGCTCTCTATTTGAATGAAGAAGATGTAAAAGGAATCCCAGAGAGTGACAAAATATCTGCAAAACA
ACCAGATGGTACCTATAAGTTTACACTTCATTTCCCATCTTACATCGCTTATATGACATACGGTGAAAATAGAAAGATTC
GAAAAGAGATGTATGATGCATACTGTACAAGGGCACCCGAGAACGGAAAACTCATTGAAGAAATTTTAAGTTTAAGAGAT
AAAGAAGCAAAACTTTTGGGATTTGAGACCTATGCACATTTGAGTTTGGCAACAAAGGTTGCGAATGAGCCTGAAGAAGT
GATCCAATTCCTGGACCACCTCGCAAAAAAAGCAAAACCCATTGCCCAAAAAGAATACAAAGAAATCCAATCCTTTGCAA
AAAAATTAGGCCAAGGCGAAATTGAACCCTGGGACCTTACCTTCTATTCAGAAAAATTAAAAAAAGAATCCTTTTCCTAT
GATGAAGAAATCTATCGACCATATCTAGAAAAAGAAACTGTCCTCCAGGGTACGTTTCAATTTTTAGAAAATTTACTTGG
TGTTCATTTCAAACAAGTGCAAACCAATGTCTGGGAGCCATCTGTACTCTGTTATGACCTAGTGGTAGAAGGAGAAACCC
GTTCCAGGTTGTATCTTGACCTGGAAGTTCGAAGCGATAAAAAAGGTGGCGCATGGATGCACAATTGGAAACCCCACTTC
CAAGATGAAACAGGAAAAACAGAATTACCAATTGCCTTTGTAGTAGCGAGTTTTCCGAAAGCTACAGAATCGCAACCAAG
TTTACTCAGACCCAGTGATGTCGTTACCCTCTTCCATGAATTGGGTCATGCTTTGCACCATTTACTCTCCAAGGTGAAGG
AAGCTTTTGTCAGCGGAGTGAATGGAGTGGAATGGGATGCGGTTGAATTTCCTTCCCAATTTTTGGAGAACTTTGTTTAT
GAACCCAAAGTATTACAACTTTTTGCCAAACACTACCAAACAAAAGAGCCAATTCCGAACGCATACATTGATACAATGGT
AAAAGCAAAAAACTTTATGTCAGCCATGGGAGTGGTGAGACAATTGGAATTTGCGAAGTTTGATATGTTGGTTCACAAAG
AAAGTCCAAACGAAATAAGGGTGCAAGATATCCTAAACCAAGTAAGGGAGGAAATTGCCGTTGTAGTTCCTCCAACTTAT
AACAAATTTCAAAACTCATTTACCCATATCTTTGCAGGAGGGTATGCCGCTGGGTATTATTCTTACAAATGGGCAGAATT
ATTATCTGCCAATGCATTTTATTCCTTTGTGGACAAGGGTGTATTTGATTTGGAACATGCGGCACATTTTCGAAAGACCG
TTTTGGAAAAAGGTGGGTCAGCCAATGCGATGAATCTTTTCCGAGATTTTTATGGAAAAGACCCAGACATCGATGCTTTA
CTTCGATTGAACGGAATTGCCGCTTAA

Upstream 100 bases:

>100_bases
AAAGAATACAATTTTCCTTTTTTCCACTGGCTTACATTTCCTTAAACTCCATTTTGGCTTAGAAGGATTCGAAATCGAGT
CTAATTCATACGAGGTAGCG

Downstream 100 bases:

>100_bases
CGCCTGTATTGTTTTTGTGATCACTTCTTTTGGATCGGTTGACTTGATGAGTTTTCGAGTTTTCCGTTTTGAGTCCAAAA
CATAAACATAGGTAGAGTGA

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 648; Mature: 648

Protein sequence:

>648_residues
MFPEFHSNNLLEKESTILKKMESNKEFIQSLLKQPNGSFQTFLKPYQRVQTELGDLVTEISHLNSVKNSEESQTIYSRLL
PKLSEYYTDLGQNEEIFSALLHIQSTDKTVNSEQIKVLENEIRDFRLSGVGLDSNTKEELKNIRIKLSDLTNQFSQNVLN
ATNAFALYLNEEDVKGIPESDKISAKQPDGTYKFTLHFPSYIAYMTYGENRKIRKEMYDAYCTRAPENGKLIEEILSLRD
KEAKLLGFETYAHLSLATKVANEPEEVIQFLDHLAKKAKPIAQKEYKEIQSFAKKLGQGEIEPWDLTFYSEKLKKESFSY
DEEIYRPYLEKETVLQGTFQFLENLLGVHFKQVQTNVWEPSVLCYDLVVEGETRSRLYLDLEVRSDKKGGAWMHNWKPHF
QDETGKTELPIAFVVASFPKATESQPSLLRPSDVVTLFHELGHALHHLLSKVKEAFVSGVNGVEWDAVEFPSQFLENFVY
EPKVLQLFAKHYQTKEPIPNAYIDTMVKAKNFMSAMGVVRQLEFAKFDMLVHKESPNEIRVQDILNQVREEIAVVVPPTY
NKFQNSFTHIFAGGYAAGYYSYKWAELLSANAFYSFVDKGVFDLEHAAHFRKTVLEKGGSANAMNLFRDFYGKDPDIDAL
LRLNGIAA

Sequences:

>Translated_648_residues
MFPEFHSNNLLEKESTILKKMESNKEFIQSLLKQPNGSFQTFLKPYQRVQTELGDLVTEISHLNSVKNSEESQTIYSRLL
PKLSEYYTDLGQNEEIFSALLHIQSTDKTVNSEQIKVLENEIRDFRLSGVGLDSNTKEELKNIRIKLSDLTNQFSQNVLN
ATNAFALYLNEEDVKGIPESDKISAKQPDGTYKFTLHFPSYIAYMTYGENRKIRKEMYDAYCTRAPENGKLIEEILSLRD
KEAKLLGFETYAHLSLATKVANEPEEVIQFLDHLAKKAKPIAQKEYKEIQSFAKKLGQGEIEPWDLTFYSEKLKKESFSY
DEEIYRPYLEKETVLQGTFQFLENLLGVHFKQVQTNVWEPSVLCYDLVVEGETRSRLYLDLEVRSDKKGGAWMHNWKPHF
QDETGKTELPIAFVVASFPKATESQPSLLRPSDVVTLFHELGHALHHLLSKVKEAFVSGVNGVEWDAVEFPSQFLENFVY
EPKVLQLFAKHYQTKEPIPNAYIDTMVKAKNFMSAMGVVRQLEFAKFDMLVHKESPNEIRVQDILNQVREEIAVVVPPTY
NKFQNSFTHIFAGGYAAGYYSYKWAELLSANAFYSFVDKGVFDLEHAAHFRKTVLEKGGSANAMNLFRDFYGKDPDIDAL
LRLNGIAA
>Mature_648_residues
MFPEFHSNNLLEKESTILKKMESNKEFIQSLLKQPNGSFQTFLKPYQRVQTELGDLVTEISHLNSVKNSEESQTIYSRLL
PKLSEYYTDLGQNEEIFSALLHIQSTDKTVNSEQIKVLENEIRDFRLSGVGLDSNTKEELKNIRIKLSDLTNQFSQNVLN
ATNAFALYLNEEDVKGIPESDKISAKQPDGTYKFTLHFPSYIAYMTYGENRKIRKEMYDAYCTRAPENGKLIEEILSLRD
KEAKLLGFETYAHLSLATKVANEPEEVIQFLDHLAKKAKPIAQKEYKEIQSFAKKLGQGEIEPWDLTFYSEKLKKESFSY
DEEIYRPYLEKETVLQGTFQFLENLLGVHFKQVQTNVWEPSVLCYDLVVEGETRSRLYLDLEVRSDKKGGAWMHNWKPHF
QDETGKTELPIAFVVASFPKATESQPSLLRPSDVVTLFHELGHALHHLLSKVKEAFVSGVNGVEWDAVEFPSQFLENFVY
EPKVLQLFAKHYQTKEPIPNAYIDTMVKAKNFMSAMGVVRQLEFAKFDMLVHKESPNEIRVQDILNQVREEIAVVVPPTY
NKFQNSFTHIFAGGYAAGYYSYKWAELLSANAFYSFVDKGVFDLEHAAHFRKTVLEKGGSANAMNLFRDFYGKDPDIDAL
LRLNGIAA

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=597, Percent_Identity=30.3182579564489, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI14149738, Length=583, Percent_Identity=30.7032590051458, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI156105687, Length=567, Percent_Identity=26.63139329806, Blast_Score=211, Evalue=2e-54,
Organism=Escherichia coli, GI1789913, Length=654, Percent_Identity=40.2140672782875, Blast_Score=513, Evalue=1e-146,
Organism=Escherichia coli, GI1787819, Length=621, Percent_Identity=30.2737520128824, Blast_Score=249, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI71999758, Length=576, Percent_Identity=21.3541666666667, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI32565901, Length=613, Percent_Identity=22.1859706362153, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319793, Length=656, Percent_Identity=29.4207317073171, Blast_Score=284, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6322715, Length=584, Percent_Identity=24.3150684931507, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21356111, Length=576, Percent_Identity=25.3472222222222, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI20129717, Length=611, Percent_Identity=24.2225859247136, Blast_Score=164, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 74437; Mature: 74437

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPEFHSNNLLEKESTILKKMESNKEFIQSLLKQPNGSFQTFLKPYQRVQTELGDLVTEI
CCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
SHLNSVKNSEESQTIYSRLLPKLSEYYTDLGQNEEIFSALLHIQSTDKTVNSEQIKVLEN
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHH
EIRDFRLSGVGLDSNTKEELKNIRIKLSDLTNQFSQNVLNATNAFALYLNEEDVKGIPES
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCC
DKISAKQPDGTYKFTLHFPSYIAYMTYGENRKIRKEMYDAYCTRAPENGKLIEEILSLRD
CCCCCCCCCCCEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
KEAKLLGFETYAHLSLATKVANEPEEVIQFLDHLAKKAKPIAQKEYKEIQSFAKKLGQGE
CCHHHEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
IEPWDLTFYSEKLKKESFSYDEEIYRPYLEKETVLQGTFQFLENLLGVHFKQVQTNVWEP
CCCCEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SVLCYDLVVEGETRSRLYLDLEVRSDKKGGAWMHNWKPHFQDETGKTELPIAFVVASFPK
CEEEEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCC
ATESQPSLLRPSDVVTLFHELGHALHHLLSKVKEAFVSGVNGVEWDAVEFPSQFLENFVY
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCC
EPKVLQLFAKHYQTKEPIPNAYIDTMVKAKNFMSAMGVVRQLEFAKFDMLVHKESPNEIR
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEE
VQDILNQVREEIAVVVPPTYNKFQNSFTHIFAGGYAAGYYSYKWAELLSANAFYSFVDKG
HHHHHHHHHHHCEEEECCCHHHHHHHHHHHHCCCHHHCHHHHHHHHHHHHHHHHHHHHCC
VFDLEHAAHFRKTVLEKGGSANAMNLFRDFYGKDPDIDALLRLNGIAA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCC
>Mature Secondary Structure
MFPEFHSNNLLEKESTILKKMESNKEFIQSLLKQPNGSFQTFLKPYQRVQTELGDLVTEI
CCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
SHLNSVKNSEESQTIYSRLLPKLSEYYTDLGQNEEIFSALLHIQSTDKTVNSEQIKVLEN
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHH
EIRDFRLSGVGLDSNTKEELKNIRIKLSDLTNQFSQNVLNATNAFALYLNEEDVKGIPES
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCC
DKISAKQPDGTYKFTLHFPSYIAYMTYGENRKIRKEMYDAYCTRAPENGKLIEEILSLRD
CCCCCCCCCCCEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
KEAKLLGFETYAHLSLATKVANEPEEVIQFLDHLAKKAKPIAQKEYKEIQSFAKKLGQGE
CCHHHEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
IEPWDLTFYSEKLKKESFSYDEEIYRPYLEKETVLQGTFQFLENLLGVHFKQVQTNVWEP
CCCCEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SVLCYDLVVEGETRSRLYLDLEVRSDKKGGAWMHNWKPHFQDETGKTELPIAFVVASFPK
CEEEEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCC
ATESQPSLLRPSDVVTLFHELGHALHHLLSKVKEAFVSGVNGVEWDAVEFPSQFLENFVY
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCC
EPKVLQLFAKHYQTKEPIPNAYIDTMVKAKNFMSAMGVVRQLEFAKFDMLVHKESPNEIR
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEE
VQDILNQVREEIAVVVPPTYNKFQNSFTHIFAGGYAAGYYSYKWAELLSANAFYSFVDKG
HHHHHHHHHHHCEEEECCCHHHHHHHHHHHHCCCHHHCHHHHHHHHHHHHHHHHHHHHCC
VFDLEHAAHFRKTVLEKGGSANAMNLFRDFYGKDPDIDALLRLNGIAA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]