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The map label for this gene is gmk [H]

Identifier: 183220355

GI number: 183220355

Start: 982561

End: 983124

Strand: Direct

Name: gmk [H]

Synonym: LEPBI_I0951

Alternate gene names: 183220355

Gene position: 982561-983124 (Clockwise)

Preceding gene: 183220354

Following gene: 183220358

Centisome position: 27.3

GC content: 41.49

Gene sequence:

>564_bases
TTGAAAGCTGTCCCGAATTTATATATCATTTCCTCGGTGGCTGGTGGTGGGAAATCGACCATCATCCAAGCACTCTTAAA
AGAAAACCCTGAGTTTTATTTTTCGATCTCGTGTACAACACGTGACCCAAGGCCTGGGGATGAGGAAGGAAAAACATATT
ACTTTTTAACCATACCTGAATTCCAAAAAAAAATTGCCGATGGTGAATTTTACGAATGGGCTGAAGTCCATGGCAATTAT
TACGGAACACCAAAGGCTCCCATTTTAGATGCCATAAAGGAACACCGAGTGGCACTTATGGATTTAGATGTCCAAGGAGC
CAAATCAGTCAAACAACTAAGGCCTGAGTCGGTTACCATTTTTATCGAACCACCAAGCCGGGAAATTTGGATTGAGAGAC
TCATCAGACGAGGGACGGATTCCAAAACGAGTATCGAAAAACGGATAGAAAATGGGATCATCGAATTAGATGAAGCACCT
AGCTTTGATTATGTGGTCATAAATGATCGCTTAGAAGATGCCATTACTGAAGTAAAGGCCATCCTTTGTGGAACCAAATC
ATAA

Upstream 100 bases:

>100_bases
CAGGCCATATCCTCCTCTCTGCGATTCGACCAGAAAGTTTGTCCAAACGATTGGAAACAGGGGACAACCACATTGGAGAA
GGGGAAGAGGAGTCGGAAGA

Downstream 100 bases:

>100_bases
GAATCAATTCATAATTCTGATTTGGGACATCGTATCACTTGGATCAATACCGATGTAAAAACACTTTCTCTTACGGCTCT
TCGTTTTCCTCATCGATACT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MKAVPNLYIISSVAGGGKSTIIQALLKENPEFYFSISCTTRDPRPGDEEGKTYYFLTIPEFQKKIADGEFYEWAEVHGNY
YGTPKAPILDAIKEHRVALMDLDVQGAKSVKQLRPESVTIFIEPPSREIWIERLIRRGTDSKTSIEKRIENGIIELDEAP
SFDYVVINDRLEDAITEVKAILCGTKS

Sequences:

>Translated_187_residues
MKAVPNLYIISSVAGGGKSTIIQALLKENPEFYFSISCTTRDPRPGDEEGKTYYFLTIPEFQKKIADGEFYEWAEVHGNY
YGTPKAPILDAIKEHRVALMDLDVQGAKSVKQLRPESVTIFIEPPSREIWIERLIRRGTDSKTSIEKRIENGIIELDEAP
SFDYVVINDRLEDAITEVKAILCGTKS
>Mature_187_residues
MKAVPNLYIISSVAGGGKSTIIQALLKENPEFYFSISCTTRDPRPGDEEGKTYYFLTIPEFQKKIADGEFYEWAEVHGNY
YGTPKAPILDAIKEHRVALMDLDVQGAKSVKQLRPESVTIFIEPPSREIWIERLIRRGTDSKTSIEKRIENGIIELDEAP
SFDYVVINDRLEDAITEVKAILCGTKS

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=185, Percent_Identity=39.4594594594595, Blast_Score=136, Evalue=1e-32,
Organism=Homo sapiens, GI4504221, Length=185, Percent_Identity=39.4594594594595, Blast_Score=136, Evalue=1e-32,
Organism=Homo sapiens, GI226874831, Length=185, Percent_Identity=39.4594594594595, Blast_Score=136, Evalue=1e-32,
Organism=Homo sapiens, GI4505237, Length=172, Percent_Identity=27.906976744186, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI262118259, Length=172, Percent_Identity=27.906976744186, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI262118255, Length=172, Percent_Identity=27.906976744186, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI262118263, Length=172, Percent_Identity=27.906976744186, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI38570142, Length=168, Percent_Identity=29.7619047619048, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI186700627, Length=173, Percent_Identity=24.2774566473988, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI186700629, Length=173, Percent_Identity=24.2774566473988, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI186972120, Length=173, Percent_Identity=24.2774566473988, Blast_Score=66, Evalue=1e-11,
Organism=Homo sapiens, GI111154074, Length=176, Percent_Identity=26.7045454545455, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI21361598, Length=181, Percent_Identity=24.3093922651934, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1790080, Length=183, Percent_Identity=40.9836065573771, Blast_Score=145, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI193203132, Length=179, Percent_Identity=37.9888268156425, Blast_Score=130, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17508835, Length=179, Percent_Identity=37.9888268156425, Blast_Score=129, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI71988041, Length=176, Percent_Identity=24.4318181818182, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71988048, Length=176, Percent_Identity=24.4318181818182, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=41.5300546448087, Blast_Score=134, Evalue=8e-33,
Organism=Drosophila melanogaster, GI21356141, Length=168, Percent_Identity=38.0952380952381, Blast_Score=114, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 21116; Mature: 21116

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVPNLYIISSVAGGGKSTIIQALLKENPEFYFSISCTTRDPRPGDEEGKTYYFLTIPE
CCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCEEEEEECHH
FQKKIADGEFYEWAEVHGNYYGTPKAPILDAIKEHRVALMDLDVQGAKSVKQLRPESVTI
HHHHHCCCCCEEHHHHCCCCCCCCCCHHHHHHHHCCEEEEEECCCCHHHHHHCCCCEEEE
FIEPPSREIWIERLIRRGTDSKTSIEKRIENGIIELDEAPSFDYVVINDRLEDAITEVKA
EEECCCHHHHHHHHHHCCCCCHHHHHHHHHCCCEEECCCCCCCEEEECCHHHHHHHHHHH
ILCGTKS
HHCCCCC
>Mature Secondary Structure
MKAVPNLYIISSVAGGGKSTIIQALLKENPEFYFSISCTTRDPRPGDEEGKTYYFLTIPE
CCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCEEEEEECHH
FQKKIADGEFYEWAEVHGNYYGTPKAPILDAIKEHRVALMDLDVQGAKSVKQLRPESVTI
HHHHHCCCCCEEHHHHCCCCCCCCCCHHHHHHHHCCEEEEEECCCCHHHHHHCCCCEEEE
FIEPPSREIWIERLIRRGTDSKTSIEKRIENGIIELDEAPSFDYVVINDRLEDAITEVKA
EEECCCHHHHHHHHHHCCCCCHHHHHHHHHCCCEEECCCCCCCEEEECCHHHHHHHHHHH
ILCGTKS
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA