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The map label for this gene is rpfC [H]

Identifier: 183220306

GI number: 183220306

Start: 922840

End: 924807

Strand: Direct

Name: rpfC [H]

Synonym: LEPBI_I0901

Alternate gene names: 183220306

Gene position: 922840-924807 (Clockwise)

Preceding gene: 183220305

Following gene: 183220307

Centisome position: 25.64

GC content: 37.04

Gene sequence:

>1968_bases
ATGCACCAAAATATACCGAAGGAAGCATATTCATCACTCATCCTTCAATACTTTTATGATGCGGTCATCGTCATAGATTT
AAAGTTTCATATCACCAGTTGGAATCTTGCTGCGGAACGCATTTACGGTTACAAAGCAGAAGAGGCTTTGGGTTCATCCA
CCATCGATGTTTTAAAGACTATTTTTGCAGAAGGGGAACGGGAGAAAAGTATCGCCCAGCTACAGGCATACGGAATTTGG
CAAGGAGAGGTGTTCCAACATAAAAAGGACGGAACAAAATTAAAAATTCGCTCTGCTGCGAGTTTCCTAAAAGATAAAGA
AGGTGCCACAATCGGTGTCATCGCCATCAACCGAGACATTACGGAAGAAAATCGGATCCAAGAAAATCTGGCTGAAAGTG
AAGAAAGATTTCGAATGAGTTTTGAAAACGCTGGCATTGGTGTCTGCCTTCTTGACTTAGATGGAAAATTTTTAAGAGTG
AATAAAAAAATCCAATCGATGTTAGGTTATTCAGAGGTAGAACTCATTGGAAGGCCATCCAAAGAATTTGCTTACAAAGA
AGATCAAAGTATCTTCCACCAATACCGCGAATCTGCTTTAAAAGGCAAAGATGTAGATGTTGTCTATGAAAAACGATACG
TTTCTAAAACCAATCAAATCCTATGGATCGAAATTTCTAATTCACTTGTAAAAGACCGAAATGGATCACCATTATACTTT
GTTGTCCATTTTAATGATATTACAGATCGTAAAAATGCAGAAATTCATTTGATACAAGCAAAAAAAGAAGCTGAACGAGC
AAACCAAGCAAAGTCAGACTTTGTTGCCAACATGAGTCATGAAATTCGAACTCCACTCAATGGTGTGATTGGATTTAATG
AATTGTTGATGACTACCAATTTGGATTCGGACCAAAAAGAATACGTAAAAAATGCGATCAGCAGTGCACATGGTCTCCTC
GGGATCATCAACGATATTTTAGATATTTCCAAAATAGAAGCCGGAAAATTAGTTTTAAACGAAACCATTTCAAATTTAAA
ACATATCGTAAAAGATTCGTTAGGTGTCCTTCAGTGGAGAGCGAAAGAAAAAAATATCCAATTAGATTTTGAAGTTAATC
CCAAATTGCCAGAATGGATCGTTGTTGATGCGACGCGACTTAGACAAATTTTAATCAACTTACTTGGAAATGCAGTTAAG
TTCACAGAGAAAGGAAGTGTGATTTTAAAAATAGATTCAGAGATTGCTGAGAATGAAAAAATTAAACTCAATTTTTCGAT
CAAGGATACTGGTATCGGTATTCCTGAATCTCATAAACCAAATCTATTCCAATCCTTTTGGCAAGGAGAATCAAACTCGA
CTCGCCGATTTGGGGGAACAGGACTGGGACTTCGGATCACCAAATCATTACTCGATCTCATGGGTGGTCAGATTGATTTT
TCTTCTGAAGAAGGCAAAGGTACTGAGTTTCGATTTAGCATCGAGTGTTTGACTTTGGAAAATGCAAATCTAAGTGATGC
AGAGAATGAAAATTTTCAGAAGGACATTTGGGAAAACATCAATCAATACAAACTCTTAGATGTTTCACCTAAAATTTTAA
TCGCAGAAGACAATTTGATGAATCGGGATCTTCTAAATCGGATGATATTGAAATACATACCAAAAGCCATTTTATTTGAA
GCCAGAAATGGTGTTGAAGCAGTGCGAATGAGTCATGAACTCAAACCCCAATTGATTTTTATGGATGTCCAAATGCCTGA
AATGGATGGATTGGAAGCGACAACAATCATCCGAAAAAACAAATCGAATGAACATATTCCCATCATCGCTTTAACCGCTG
GTGCATTGTATGAGGAGAGGAAAAAATGTTTTGATGTGGGAATGGATCATTTTTTGACCAAACCGATCGATATTTTGGCG
CTGAACCAAGTCTTATTTCACTATTTGAATGCAACTAAACTCGATTAG

Upstream 100 bases:

>100_bases
CGCAAGGTTGTAGGGAAGTTGTAGGTTTCGTTTTGAATTGAATTATTTTTTTTTGGATTCAGTTGCTATTTTTCAAAAAT
TCCCCCGATATTGATCTACG

Downstream 100 bases:

>100_bases
AGTAGCAAAATCTTTCTCCTTTCGTCATTTTGTCCAAAATGAGACGATTTCCTTTTTTAACATATCTTGGTCCTGGTCTT
CTCTATGCAGGCGCTGCAGT

Product: two-component sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 655; Mature: 655

Protein sequence:

>655_residues
MHQNIPKEAYSSLILQYFYDAVIVIDLKFHITSWNLAAERIYGYKAEEALGSSTIDVLKTIFAEGEREKSIAQLQAYGIW
QGEVFQHKKDGTKLKIRSAASFLKDKEGATIGVIAINRDITEENRIQENLAESEERFRMSFENAGIGVCLLDLDGKFLRV
NKKIQSMLGYSEVELIGRPSKEFAYKEDQSIFHQYRESALKGKDVDVVYEKRYVSKTNQILWIEISNSLVKDRNGSPLYF
VVHFNDITDRKNAEIHLIQAKKEAERANQAKSDFVANMSHEIRTPLNGVIGFNELLMTTNLDSDQKEYVKNAISSAHGLL
GIINDILDISKIEAGKLVLNETISNLKHIVKDSLGVLQWRAKEKNIQLDFEVNPKLPEWIVVDATRLRQILINLLGNAVK
FTEKGSVILKIDSEIAENEKIKLNFSIKDTGIGIPESHKPNLFQSFWQGESNSTRRFGGTGLGLRITKSLLDLMGGQIDF
SSEEGKGTEFRFSIECLTLENANLSDAENENFQKDIWENINQYKLLDVSPKILIAEDNLMNRDLLNRMILKYIPKAILFE
ARNGVEAVRMSHELKPQLIFMDVQMPEMDGLEATTIIRKNKSNEHIPIIALTAGALYEERKKCFDVGMDHFLTKPIDILA
LNQVLFHYLNATKLD

Sequences:

>Translated_655_residues
MHQNIPKEAYSSLILQYFYDAVIVIDLKFHITSWNLAAERIYGYKAEEALGSSTIDVLKTIFAEGEREKSIAQLQAYGIW
QGEVFQHKKDGTKLKIRSAASFLKDKEGATIGVIAINRDITEENRIQENLAESEERFRMSFENAGIGVCLLDLDGKFLRV
NKKIQSMLGYSEVELIGRPSKEFAYKEDQSIFHQYRESALKGKDVDVVYEKRYVSKTNQILWIEISNSLVKDRNGSPLYF
VVHFNDITDRKNAEIHLIQAKKEAERANQAKSDFVANMSHEIRTPLNGVIGFNELLMTTNLDSDQKEYVKNAISSAHGLL
GIINDILDISKIEAGKLVLNETISNLKHIVKDSLGVLQWRAKEKNIQLDFEVNPKLPEWIVVDATRLRQILINLLGNAVK
FTEKGSVILKIDSEIAENEKIKLNFSIKDTGIGIPESHKPNLFQSFWQGESNSTRRFGGTGLGLRITKSLLDLMGGQIDF
SSEEGKGTEFRFSIECLTLENANLSDAENENFQKDIWENINQYKLLDVSPKILIAEDNLMNRDLLNRMILKYIPKAILFE
ARNGVEAVRMSHELKPQLIFMDVQMPEMDGLEATTIIRKNKSNEHIPIIALTAGALYEERKKCFDVGMDHFLTKPIDILA
LNQVLFHYLNATKLD
>Mature_655_residues
MHQNIPKEAYSSLILQYFYDAVIVIDLKFHITSWNLAAERIYGYKAEEALGSSTIDVLKTIFAEGEREKSIAQLQAYGIW
QGEVFQHKKDGTKLKIRSAASFLKDKEGATIGVIAINRDITEENRIQENLAESEERFRMSFENAGIGVCLLDLDGKFLRV
NKKIQSMLGYSEVELIGRPSKEFAYKEDQSIFHQYRESALKGKDVDVVYEKRYVSKTNQILWIEISNSLVKDRNGSPLYF
VVHFNDITDRKNAEIHLIQAKKEAERANQAKSDFVANMSHEIRTPLNGVIGFNELLMTTNLDSDQKEYVKNAISSAHGLL
GIINDILDISKIEAGKLVLNETISNLKHIVKDSLGVLQWRAKEKNIQLDFEVNPKLPEWIVVDATRLRQILINLLGNAVK
FTEKGSVILKIDSEIAENEKIKLNFSIKDTGIGIPESHKPNLFQSFWQGESNSTRRFGGTGLGLRITKSLLDLMGGQIDF
SSEEGKGTEFRFSIECLTLENANLSDAENENFQKDIWENINQYKLLDVSPKILIAEDNLMNRDLLNRMILKYIPKAILFE
ARNGVEAVRMSHELKPQLIFMDVQMPEMDGLEATTIIRKNKSNEHIPIIALTAGALYEERKKCFDVGMDHFLTKPIDILA
LNQVLFHYLNATKLD

Specific function: Involved in the positive regulation of synthesis of extracellular enzymes and polysaccharide, and hence in pathogenicity. Can restore function to the non-pathogenic mutant 8237 [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=547, Percent_Identity=29.6160877513711, Blast_Score=217, Evalue=2e-57,
Organism=Escherichia coli, GI1789149, Length=244, Percent_Identity=43.8524590163934, Blast_Score=216, Evalue=4e-57,
Organism=Escherichia coli, GI1788713, Length=459, Percent_Identity=31.5904139433551, Blast_Score=176, Evalue=5e-45,
Organism=Escherichia coli, GI87081816, Length=396, Percent_Identity=29.5454545454545, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI145693157, Length=489, Percent_Identity=28.0163599182004, Blast_Score=152, Evalue=7e-38,
Organism=Escherichia coli, GI1788549, Length=372, Percent_Identity=24.4623655913978, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786912, Length=265, Percent_Identity=30.9433962264151, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1786600, Length=240, Percent_Identity=30.4166666666667, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1790300, Length=239, Percent_Identity=29.2887029288703, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1788381, Length=128, Percent_Identity=32.8125, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790436, Length=222, Percent_Identity=28.8288288288288, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI1788393, Length=226, Percent_Identity=26.9911504424779, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87082128, Length=230, Percent_Identity=28.2608695652174, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1786783, Length=227, Percent_Identity=24.6696035242291, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788279, Length=220, Percent_Identity=26.3636363636364, Blast_Score=76, Evalue=8e-15,
Organism=Escherichia coli, GI1787894, Length=255, Percent_Identity=25.4901960784314, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322044, Length=131, Percent_Identity=39.6946564885496, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 74483; Mature: 74483

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHQNIPKEAYSSLILQYFYDAVIVIDLKFHITSWNLAAERIYGYKAEEALGSSTIDVLKT
CCCCCCHHHHHHHHHHHHHCEEEEEEEEEEEEECCHHHHHHCCCCHHHHHCCHHHHHHHH
IFAEGEREKSIAQLQAYGIWQGEVFQHKKDGTKLKIRSAASFLKDKEGATIGVIAINRDI
HHHCCCCHHHHHHHHHHCCCCCHHHHHCCCCCEEEEHHHHHHHHCCCCCEEEEEEEECCC
TEENRIQENLAESEERFRMSFENAGIGVCLLDLDGKFLRVNKKIQSMLGYSEVELIGRPS
CHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEHHHHHHHHHCCCHHHEECCCC
KEFAYKEDQSIFHQYRESALKGKDVDVVYEKRYVSKTNQILWIEISNSLVKDRNGSPLYF
HHHCCCHHHHHHHHHHHHHCCCCCCEEEEHHHHHCCCCCEEEEEECCCHHCCCCCCEEEE
VVHFNDITDRKNAEIHLIQAKKEAERANQAKSDFVANMSHEIRTPLNGVIGFNELLMTTN
EEEECCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCHHHHCCCHHHHCCCCCEEEECC
LDSDQKEYVKNAISSAHGLLGIINDILDISKIEAGKLVLNETISNLKHIVKDSLGVLQWR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEEE
AKEKNIQLDFEVNPKLPEWIVVDATRLRQILINLLGNAVKFTEKGSVILKIDSEIAENEK
ECCCCEEEEEEECCCCCCEEEECHHHHHHHHHHHHCCCEEEECCCCEEEEECCCCCCCCE
IKLNFSIKDTGIGIPESHKPNLFQSFWQGESNSTRRFGGTGLGLRITKSLLDLMGGQIDF
EEEEEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEE
SSEEGKGTEFRFSIECLTLENANLSDAENENFQKDIWENINQYKLLDVSPKILIAEDNLM
CCCCCCCCEEEEEEEEEEEECCCCCCCCCCCHHHHHHCCCCCEEEEECCCCEEEECCCCC
NRDLLNRMILKYIPKAILFEARNGVEAVRMSHELKPQLIFMDVQMPEMDGLEATTIIRKN
CHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEEEC
KSNEHIPIIALTAGALYEERKKCFDVGMDHFLTKPIDILALNQVLFHYLNATKLD
CCCCCCEEEEEECHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MHQNIPKEAYSSLILQYFYDAVIVIDLKFHITSWNLAAERIYGYKAEEALGSSTIDVLKT
CCCCCCHHHHHHHHHHHHHCEEEEEEEEEEEEECCHHHHHHCCCCHHHHHCCHHHHHHHH
IFAEGEREKSIAQLQAYGIWQGEVFQHKKDGTKLKIRSAASFLKDKEGATIGVIAINRDI
HHHCCCCHHHHHHHHHHCCCCCHHHHHCCCCCEEEEHHHHHHHHCCCCCEEEEEEEECCC
TEENRIQENLAESEERFRMSFENAGIGVCLLDLDGKFLRVNKKIQSMLGYSEVELIGRPS
CHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEHHHHHHHHHCCCHHHEECCCC
KEFAYKEDQSIFHQYRESALKGKDVDVVYEKRYVSKTNQILWIEISNSLVKDRNGSPLYF
HHHCCCHHHHHHHHHHHHHCCCCCCEEEEHHHHHCCCCCEEEEEECCCHHCCCCCCEEEE
VVHFNDITDRKNAEIHLIQAKKEAERANQAKSDFVANMSHEIRTPLNGVIGFNELLMTTN
EEEECCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCHHHHCCCHHHHCCCCCEEEECC
LDSDQKEYVKNAISSAHGLLGIINDILDISKIEAGKLVLNETISNLKHIVKDSLGVLQWR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEEE
AKEKNIQLDFEVNPKLPEWIVVDATRLRQILINLLGNAVKFTEKGSVILKIDSEIAENEK
ECCCCEEEEEEECCCCCCEEEECHHHHHHHHHHHHCCCEEEECCCCEEEEECCCCCCCCE
IKLNFSIKDTGIGIPESHKPNLFQSFWQGESNSTRRFGGTGLGLRITKSLLDLMGGQIDF
EEEEEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEE
SSEEGKGTEFRFSIECLTLENANLSDAENENFQKDIWENINQYKLLDVSPKILIAEDNLM
CCCCCCCCEEEEEEEEEEEECCCCCCCCCCCHHHHHHCCCCCEEEEECCCCEEEECCCCC
NRDLLNRMILKYIPKAILFEARNGVEAVRMSHELKPQLIFMDVQMPEMDGLEATTIIRKN
CHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEEEC
KSNEHIPIIALTAGALYEERKKCFDVGMDHFLTKPIDILALNQVLFHYLNATKLD
CCCCCCEEEEEECHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1645442 [H]