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The map label for this gene is lepB2 [H]

Identifier: 183220200

GI number: 183220200

Start: 809558

End: 810595

Strand: Direct

Name: lepB2 [H]

Synonym: LEPBI_I0790

Alternate gene names: 183220200

Gene position: 809558-810595 (Clockwise)

Preceding gene: 183220197

Following gene: 183220201

Centisome position: 22.49

GC content: 40.56

Gene sequence:

>1038_bases
ATGGGATTATTTTCCTCCATCTTTCAGACCAAATCAAAATCAGAATCCAAAGAACCAGAAAAAGAAGGGGCTGCTGCCTC
AGGGATTTCCTTTGGAATCATTGTTGTTCTCGTATTTGCTTTCAAATCATCCATATTAGATGCAAATAATATCCCCTCAG
GATCAATGATCCCTACATTAAAAATTGGGGATTTTTTATTTGTGAATAAAATGCGTTATTCATTTCGAATGCCTTTTACA
GAAAAGGAACTCTTTCGCATAGATGACCCAAAACGCGGTGACATTGTAACCTTCATACCACCTGCCACAGCTCTTGGCCA
AGAAGAGTCACGTTCTGGAATTTTTGCAAAACGATTTGTCAAACGAGTGATTGGGCTTCCTGGAGATACCATTCGGATCA
CAAGAAAATTCATAGAAACAAAAGATCGTGGTAGAGTACACTTCGCACTTGTTGAATACAAAGAGAAGGGAAGTTCTGAA
TTCAAATCGTATGAACCAAAGGAAGTGCCGATCGGAAAAGAACTTTCTGATTTGGATAATTTAGAAGCCACACAAAGGGC
TTTGTTCAAAGAAGTTAAACCTGGTTTTGAACATTATATTTTGGAAGGATTTGAAGACGACCGAAGGGCTCATATCTTTG
AATACTGCGATTTTTTACATGGTTGTGAAATCCCAGAAGGACAGTACATGGTGATGGGTGACAATCGTGACGATTCTCAT
GACTCAAGGGCTTGGGGGTTTGTCAAACGAGAGGATATTTTAGGTAAGGCACTCATTATCTATTTTTCCATCGATTGGAA
AGATTCGACCTGTGAATACAAAGATGGGCAAGAGTTGGCTGAAAAAGGACCGGAAATTGCGGAACGATTTGAAGGAGATG
CTTTGGATCGCCGATGCCATTATTCCGAAGTTTTTTCTTCACATAACGCGCGTTACCTAGGAGAAGAGTCTAGGTTTGGT
TGGATTGAAAGAACACTCCGTTACCGACTTTGGAGATTAAGCGTTCGATTTGACCGGATCGGCCGCATCTTACAGTGA

Upstream 100 bases:

>100_bases
CTCCATGTATGGTATCGTCGATTCCCGAAAATAGTACAAGTCTTTTGCGCTTTTTTTCCCCCTTTCTTGACAGAAATTTC
GAATTCCTTAGTTTCGAACC

Downstream 100 bases:

>100_bases
CCATCGACCCCAAAAAACAATCTCCTAACCAAGGGGACAAATCACCTATGGCCATGGCGGGTGCTGGATTTGAGTTTGTC
TCCTCCATCACTCTCTTTGT

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MGLFSSIFQTKSKSESKEPEKEGAAASGISFGIIVVLVFAFKSSILDANNIPSGSMIPTLKIGDFLFVNKMRYSFRMPFT
EKELFRIDDPKRGDIVTFIPPATALGQEESRSGIFAKRFVKRVIGLPGDTIRITRKFIETKDRGRVHFALVEYKEKGSSE
FKSYEPKEVPIGKELSDLDNLEATQRALFKEVKPGFEHYILEGFEDDRRAHIFEYCDFLHGCEIPEGQYMVMGDNRDDSH
DSRAWGFVKREDILGKALIIYFSIDWKDSTCEYKDGQELAEKGPEIAERFEGDALDRRCHYSEVFSSHNARYLGEESRFG
WIERTLRYRLWRLSVRFDRIGRILQ

Sequences:

>Translated_345_residues
MGLFSSIFQTKSKSESKEPEKEGAAASGISFGIIVVLVFAFKSSILDANNIPSGSMIPTLKIGDFLFVNKMRYSFRMPFT
EKELFRIDDPKRGDIVTFIPPATALGQEESRSGIFAKRFVKRVIGLPGDTIRITRKFIETKDRGRVHFALVEYKEKGSSE
FKSYEPKEVPIGKELSDLDNLEATQRALFKEVKPGFEHYILEGFEDDRRAHIFEYCDFLHGCEIPEGQYMVMGDNRDDSH
DSRAWGFVKREDILGKALIIYFSIDWKDSTCEYKDGQELAEKGPEIAERFEGDALDRRCHYSEVFSSHNARYLGEESRFG
WIERTLRYRLWRLSVRFDRIGRILQ
>Mature_344_residues
GLFSSIFQTKSKSESKEPEKEGAAASGISFGIIVVLVFAFKSSILDANNIPSGSMIPTLKIGDFLFVNKMRYSFRMPFTE
KELFRIDDPKRGDIVTFIPPATALGQEESRSGIFAKRFVKRVIGLPGDTIRITRKFIETKDRGRVHFALVEYKEKGSSEF
KSYEPKEVPIGKELSDLDNLEATQRALFKEVKPGFEHYILEGFEDDRRAHIFEYCDFLHGCEIPEGQYMVMGDNRDDSHD
SRAWGFVKREDILGKALIIYFSIDWKDSTCEYKDGQELAEKGPEIAERFEGDALDRRCHYSEVFSSHNARYLGEESRFGW
IERTLRYRLWRLSVRFDRIGRILQ

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=287, Percent_Identity=30.6620209059233, Blast_Score=107, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR019533
- InterPro:   IPR019766 [H]

Pfam domain/function: PF00717 Peptidase_S24; PF10502 Peptidase_S26 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 39833; Mature: 39702

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLFSSIFQTKSKSESKEPEKEGAAASGISFGIIVVLVFAFKSSILDANNIPSGSMIPTL
CCHHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
KIGDFLFVNKMRYSFRMPFTEKELFRIDDPKRGDIVTFIPPATALGQEESRSGIFAKRFV
ECCCEEEEEHHHHEEECCCCHHHHEECCCCCCCCEEEEECCHHHCCCCHHCCCHHHHHHH
KRVIGLPGDTIRITRKFIETKDRGRVHFALVEYKEKGSSEFKSYEPKEVPIGKELSDLDN
HHHHCCCCCHHHHHHHHHCCCCCCCEEEEEEEEHHCCCHHHHCCCCCCCCCCCCHHHHHH
LEATQRALFKEVKPGFEHYILEGFEDDRRAHIFEYCDFLHGCEIPEGQYMVMGDNRDDSH
HHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCC
DSRAWGFVKREDILGKALIIYFSIDWKDSTCEYKDGQELAEKGPEIAERFEGDALDRRCH
CCHHHCCHHHHHHCCEEEEEEEEECCCCCCCCCCCCHHHHHCCHHHHHHHCCCHHHHHHH
YSEVFSSHNARYLGEESRFGWIERTLRYRLWRLSVRFDRIGRILQ
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GLFSSIFQTKSKSESKEPEKEGAAASGISFGIIVVLVFAFKSSILDANNIPSGSMIPTL
CHHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
KIGDFLFVNKMRYSFRMPFTEKELFRIDDPKRGDIVTFIPPATALGQEESRSGIFAKRFV
ECCCEEEEEHHHHEEECCCCHHHHEECCCCCCCCEEEEECCHHHCCCCHHCCCHHHHHHH
KRVIGLPGDTIRITRKFIETKDRGRVHFALVEYKEKGSSEFKSYEPKEVPIGKELSDLDN
HHHHCCCCCHHHHHHHHHCCCCCCCEEEEEEEEHHCCCHHHHCCCCCCCCCCCCHHHHHH
LEATQRALFKEVKPGFEHYILEGFEDDRRAHIFEYCDFLHGCEIPEGQYMVMGDNRDDSH
HHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCC
DSRAWGFVKREDILGKALIIYFSIDWKDSTCEYKDGQELAEKGPEIAERFEGDALDRRCH
CCHHHCCHHHHHHCCEEEEEEEEECCCCCCCCCCCCHHHHHCCHHHHHHHCCCHHHHHHH
YSEVFSSHNARYLGEESRFGWIERTLRYRLWRLSVRFDRIGRILQ
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10993077 [H]