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The map label for this gene is 183220176

Identifier: 183220176

GI number: 183220176

Start: 781911

End: 782810

Strand: Direct

Name: 183220176

Synonym: LEPBI_I0765

Alternate gene names: NA

Gene position: 781911-782810 (Clockwise)

Preceding gene: 183220174

Following gene: 183220177

Centisome position: 21.72

GC content: 36.44

Gene sequence:

>900_bases
ATGGCATCAAATGCACTCGCTCTCATTTACCATTCTTCGTACAACCTCGAATTACCTGGTCATGTTTTCCCTGCTCATAA
GTATTCCCATCTTTATAACCGTGTCAAACGGGATCCAGTGTATGCATCTTGGGATATTCTTTTACCCAAAAAAGTTGATG
ATGCTGATTTAGAGTTAGTTCACACAAAAGAATATTTGGATGATCTTTTTAGTTACGAACACACACCAAGGACTATGTAT
TCCGAACTTCCATTAAATCGAAGTATTGTGGAAAGTTTTATGTATGGTGTGGGTGGGACAGTCCTTGCAAGTGAACTTTC
CGACAAACACCAATTTGCTTTTAATATGGGTGGTGGATACCATCATAGTTTTCCTGACAGAGCAGAGGGATTTTGTTATT
TAAATGACGTTGCCATTGCGGTTAAGAAACAAAAAGAAACAAAGCCGGATATCAATGCACTCATCATTGACCTAGATTTA
CACCAAGGCAATGGCAATTCGTATATTTTTCAATATGATGACAAAGTTTTCACATTTTCGATGCACCAAGGGAACCTTTA
CCCCAAGAAAGAAATATCTAACTTAGATGTGAATTTAGAACCCAATACCAAAGATGATGAATACCTTTCGATCCTAGAAA
CTTCTTTAAACCAAATACGAAAGGATTTTGATTCCAATATCATTTATTATGTTGCAGGTGCCGATCCATATGAAGATGAT
TCACTTGGAGAACTAAAAATATCCATGAAAGGTTTAAAAGAAAGAGATTTGATGGTTAGAAAATTTGCTGAATCATTAAA
CATCCCTTGTGTTGTCACCTTGGCGGGTGGATATGCAAGAGACTTTCGTGATACAGTTGAAATTCACTTTAACACAATCA
CAGCTTTTGGTGAAAAATAA

Upstream 100 bases:

>100_bases
TTCCAGCATAGACCCTAAACTTGGCTTTTTTGTTTTTTCCTGCAAGTAATTTGTATGGATTGAATTGACTTGTGTCATTT
TTCGCAAAAATATCAATTTA

Downstream 100 bases:

>100_bases
TGGGAGTATTTTCTTCAACAGACAAAAAGAAAAACCAGAGCGATTGGTTGAGTCTGGACGATTTGTCTTTGGTTGATGTA
TCAAAAGAATTAAATACCTC

Product: putative arginase/deacetylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MASNALALIYHSSYNLELPGHVFPAHKYSHLYNRVKRDPVYASWDILLPKKVDDADLELVHTKEYLDDLFSYEHTPRTMY
SELPLNRSIVESFMYGVGGTVLASELSDKHQFAFNMGGGYHHSFPDRAEGFCYLNDVAIAVKKQKETKPDINALIIDLDL
HQGNGNSYIFQYDDKVFTFSMHQGNLYPKKEISNLDVNLEPNTKDDEYLSILETSLNQIRKDFDSNIIYYVAGADPYEDD
SLGELKISMKGLKERDLMVRKFAESLNIPCVVTLAGGYARDFRDTVEIHFNTITAFGEK

Sequences:

>Translated_299_residues
MASNALALIYHSSYNLELPGHVFPAHKYSHLYNRVKRDPVYASWDILLPKKVDDADLELVHTKEYLDDLFSYEHTPRTMY
SELPLNRSIVESFMYGVGGTVLASELSDKHQFAFNMGGGYHHSFPDRAEGFCYLNDVAIAVKKQKETKPDINALIIDLDL
HQGNGNSYIFQYDDKVFTFSMHQGNLYPKKEISNLDVNLEPNTKDDEYLSILETSLNQIRKDFDSNIIYYVAGADPYEDD
SLGELKISMKGLKERDLMVRKFAESLNIPCVVTLAGGYARDFRDTVEIHFNTITAFGEK
>Mature_298_residues
ASNALALIYHSSYNLELPGHVFPAHKYSHLYNRVKRDPVYASWDILLPKKVDDADLELVHTKEYLDDLFSYEHTPRTMYS
ELPLNRSIVESFMYGVGGTVLASELSDKHQFAFNMGGGYHHSFPDRAEGFCYLNDVAIAVKKQKETKPDINALIIDLDLH
QGNGNSYIFQYDDKVFTFSMHQGNLYPKKEISNLDVNLEPNTKDDEYLSILETSLNQIRKDFDSNIIYYVAGADPYEDDS
LGELKISMKGLKERDLMVRKFAESLNIPCVVTLAGGYARDFRDTVEIHFNTITAFGEK

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI217272877, Length=289, Percent_Identity=31.1418685121107, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI209862883, Length=265, Percent_Identity=31.3207547169811, Blast_Score=144, Evalue=7e-35,
Organism=Homo sapiens, GI13128860, Length=284, Percent_Identity=25, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI13128862, Length=287, Percent_Identity=26.1324041811847, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI8923769, Length=276, Percent_Identity=23.1884057971014, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI293336691, Length=267, Percent_Identity=24.3445692883895, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI30795202, Length=150, Percent_Identity=31.3333333333333, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI30795204, Length=150, Percent_Identity=31.3333333333333, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI17158039, Length=150, Percent_Identity=31.3333333333333, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI13128864, Length=263, Percent_Identity=24.3346007604563, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI148539870, Length=160, Percent_Identity=30.625, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI169234807, Length=160, Percent_Identity=30.625, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI262073092, Length=192, Percent_Identity=27.0833333333333, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI62750349, Length=277, Percent_Identity=24.9097472924188, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI62750347, Length=277, Percent_Identity=24.9097472924188, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI262073088, Length=171, Percent_Identity=25.1461988304094, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193207430, Length=297, Percent_Identity=30.6397306397306, Blast_Score=131, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17561978, Length=284, Percent_Identity=26.056338028169, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17534739, Length=256, Percent_Identity=26.953125, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17508561, Length=284, Percent_Identity=23.2394366197183, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17540332, Length=254, Percent_Identity=25.1968503937008, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193206283, Length=254, Percent_Identity=25.1968503937008, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17540334, Length=254, Percent_Identity=25.1968503937008, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17537347, Length=256, Percent_Identity=25.390625, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI193209491, Length=337, Percent_Identity=24.9258160237389, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323999, Length=284, Percent_Identity=25.7042253521127, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321244, Length=187, Percent_Identity=30.4812834224599, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6325325, Length=188, Percent_Identity=28.1914893617021, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324307, Length=252, Percent_Identity=27.3809523809524, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24649807, Length=296, Percent_Identity=31.0810810810811, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24657891, Length=284, Percent_Identity=25.7042253521127, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24644244, Length=291, Percent_Identity=25.7731958762887, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI281360899, Length=175, Percent_Identity=30.8571428571429, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24642142, Length=175, Percent_Identity=30.8571428571429, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24642144, Length=175, Percent_Identity=30.8571428571429, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24642146, Length=175, Percent_Identity=30.8571428571429, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24641720, Length=179, Percent_Identity=28.4916201117318, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI281360799, Length=179, Percent_Identity=28.4916201117318, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281360801, Length=179, Percent_Identity=28.4916201117318, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 34136; Mature: 34005

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASNALALIYHSSYNLELPGHVFPAHKYSHLYNRVKRDPVYASWDILLPKKVDDADLELV
CCCCEEEEEEECCCCEECCCCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEE
HTKEYLDDLFSYEHTPRTMYSELPLNRSIVESFMYGVGGTVLASELSDKHQFAFNMGGGY
EHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCCC
HHSFPDRAEGFCYLNDVAIAVKKQKETKPDINALIIDLDLHQGNGNSYIFQYDDKVFTFS
CCCCCCCCCCEEEEEEEEEEEECCCCCCCCCEEEEEEEEEEECCCCEEEEEECCEEEEEE
MHQGNLYPKKEISNLDVNLEPNTKDDEYLSILETSLNQIRKDFDSNIIYYVAGADPYEDD
ECCCCCCCCHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
SLGELKISMKGLKERDLMVRKFAESLNIPCVVTLAGGYARDFRDTVEIHFNTITAFGEK
CCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCHHCCCCEEEEEEEEEEECCCC
>Mature Secondary Structure 
ASNALALIYHSSYNLELPGHVFPAHKYSHLYNRVKRDPVYASWDILLPKKVDDADLELV
CCCEEEEEEECCCCEECCCCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEE
HTKEYLDDLFSYEHTPRTMYSELPLNRSIVESFMYGVGGTVLASELSDKHQFAFNMGGGY
EHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCCC
HHSFPDRAEGFCYLNDVAIAVKKQKETKPDINALIIDLDLHQGNGNSYIFQYDDKVFTFS
CCCCCCCCCCEEEEEEEEEEEECCCCCCCCCEEEEEEEEEEECCCCEEEEEECCEEEEEE
MHQGNLYPKKEISNLDVNLEPNTKDDEYLSILETSLNQIRKDFDSNIIYYVAGADPYEDD
ECCCCCCCCHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
SLGELKISMKGLKERDLMVRKFAESLNIPCVVTLAGGYARDFRDTVEIHFNTITAFGEK
CCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCHHCCCCEEEEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7678591 [H]