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The map label for this gene is citT [C]

Identifier: 183219653

GI number: 183219653

Start: 220435

End: 221868

Strand: Direct

Name: citT [C]

Synonym: LEPBI_I0228

Alternate gene names: 183219653

Gene position: 220435-221868 (Clockwise)

Preceding gene: 183219651

Following gene: 183219654

Centisome position: 6.12

GC content: 40.45

Gene sequence:

>1434_bases
TTGAGTCTATCGAAAAAGTATCAGGTGAGTGTAAATCGTCAAGTCACAATGATTCGAGCAGGCCTTCTATTTTCGACGCT
TTCCATTTTTCCCGCCCTGCTTGGTTGGTACCAACTTTGGTTTGGACTCACCCCCGCCCAGGAAATCAATGTAGCCATTG
CACTGGTCGTTTCTTACCTATGGGTCACAGAACTCATCCCCTTATATGTCACAGGATTTTTGGTTCTTTTTTTGGAACTG
ATTTGGCTTATTCCCGGATGGGGGCCTGGAGCTCCAAAAACGATTACTTTTTTGTCCTGTTATTTTTCTGAGACCATCTT
ACTATTCTTAGGTGGATTTGTGATCTCAAGTGCCATTCGTTTTTATGGACTGGATGTATCAATTGCTTCATTTGTGATCA
AAAATACGAAAGGTTCAGTATTTTTCCTCGTTTTATCTTTGGGATTTGCAACCGCCTTTCTCTCTTGTTTTATGAATAAC
ACAGCAACCGCTGCCATGATGTTGGGTCTTGTTTCATCGATGATGAAGTCTTTAGAGGAATCGAGTCCTCTTCGAAAATC
AATTTTGTTTATGGTTCCATTTTCTGCCAACTTAGGTGGGATTGGAACTCCAGTCGGAACCTTACCCAATGTCATTGGGA
TTGCGTATTTACAAGAAAAAGGATTTCAGATTGGTTTTTTAGATTGGATGGCATTTGCATTTCCCGTATTCATTTTATCC
GTCTTTTTACTAGCTGGAATCTTGTACATTGTGTACTTAAAAAAAGAGACTGGAATCCAATCGATCCAACGAATCCAAGT
CCAAGAACCAAATTCGAATCACTCTCGCAAAAAAAGGTATCTTTCCATTTTAGTGATTATTTTCACCATCATTGGTTGGA
TCACTTCCGATTGGCATGGTATCTCCAATGGAACGGTAGCTTTATTTCCTGTGATTGTATTTTTTGGATTTTCACTTTTG
GATTTAAACGAATTTCGAAACTTATCTTGGGATGTCCTCATCCTCATGGGTGGTGGGATTGCGCTCGGAAAGGCATTTGA
GGAAACAGGGCTTGCCAAACATTTTGTGAGTTTATTTATGTTAGGTGATTCTAGTCAGCTAGGATTGTTTTTATTTTTTT
CCATCCTTTCCCTTTTACTTTCTTGTTTTTTGAGTAATACAAGTGTTGCCAATTTGATTTTACCCATTACGATGGGTCTT
CCTACAGACCTCATTTTGCCCGCAGCCATTGGTGCGACGATAGGTGCTTCCCTCGCGATGCCTTTACCTGTTTCCACTCC
ACCCAATGCACTTGCCTTTAGTTATGGCGGGATTCGAAGCCTTGAGATGGTTAAAATTGGGGGGACCATATCCATTTTGG
CTTGGGTCATATTCACTTTGGTTGGAGGGTTGATTTTGCACCAATTGTCGATTGTCGATTTTTCCAACTTTTAA

Upstream 100 bases:

>100_bases
CCAAAACTGCTTGTTTTAAGTCGTTATAAGATATTTGCATAAAAAATGAACATTTAGAAATTTCGGGAAAGTCTCATTGT
ATTTGTTTGCTTGAAACGAA

Downstream 100 bases:

>100_bases
AAAAAAGACTTTTCCTTCTTTTCTCATCCGTTAGCCTTCTCTCGGATTATGATTCGATTCCGAAATTTTTCTCTTTTCTG
TTTATGTTCCGTTTTTTTCC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 477; Mature: 476

Protein sequence:

>477_residues
MSLSKKYQVSVNRQVTMIRAGLLFSTLSIFPALLGWYQLWFGLTPAQEINVAIALVVSYLWVTELIPLYVTGFLVLFLEL
IWLIPGWGPGAPKTITFLSCYFSETILLFLGGFVISSAIRFYGLDVSIASFVIKNTKGSVFFLVLSLGFATAFLSCFMNN
TATAAMMLGLVSSMMKSLEESSPLRKSILFMVPFSANLGGIGTPVGTLPNVIGIAYLQEKGFQIGFLDWMAFAFPVFILS
VFLLAGILYIVYLKKETGIQSIQRIQVQEPNSNHSRKKRYLSILVIIFTIIGWITSDWHGISNGTVALFPVIVFFGFSLL
DLNEFRNLSWDVLILMGGGIALGKAFEETGLAKHFVSLFMLGDSSQLGLFLFFSILSLLLSCFLSNTSVANLILPITMGL
PTDLILPAAIGATIGASLAMPLPVSTPPNALAFSYGGIRSLEMVKIGGTISILAWVIFTLVGGLILHQLSIVDFSNF

Sequences:

>Translated_477_residues
MSLSKKYQVSVNRQVTMIRAGLLFSTLSIFPALLGWYQLWFGLTPAQEINVAIALVVSYLWVTELIPLYVTGFLVLFLEL
IWLIPGWGPGAPKTITFLSCYFSETILLFLGGFVISSAIRFYGLDVSIASFVIKNTKGSVFFLVLSLGFATAFLSCFMNN
TATAAMMLGLVSSMMKSLEESSPLRKSILFMVPFSANLGGIGTPVGTLPNVIGIAYLQEKGFQIGFLDWMAFAFPVFILS
VFLLAGILYIVYLKKETGIQSIQRIQVQEPNSNHSRKKRYLSILVIIFTIIGWITSDWHGISNGTVALFPVIVFFGFSLL
DLNEFRNLSWDVLILMGGGIALGKAFEETGLAKHFVSLFMLGDSSQLGLFLFFSILSLLLSCFLSNTSVANLILPITMGL
PTDLILPAAIGATIGASLAMPLPVSTPPNALAFSYGGIRSLEMVKIGGTISILAWVIFTLVGGLILHQLSIVDFSNF
>Mature_476_residues
SLSKKYQVSVNRQVTMIRAGLLFSTLSIFPALLGWYQLWFGLTPAQEINVAIALVVSYLWVTELIPLYVTGFLVLFLELI
WLIPGWGPGAPKTITFLSCYFSETILLFLGGFVISSAIRFYGLDVSIASFVIKNTKGSVFFLVLSLGFATAFLSCFMNNT
ATAAMMLGLVSSMMKSLEESSPLRKSILFMVPFSANLGGIGTPVGTLPNVIGIAYLQEKGFQIGFLDWMAFAFPVFILSV
FLLAGILYIVYLKKETGIQSIQRIQVQEPNSNHSRKKRYLSILVIIFTIIGWITSDWHGISNGTVALFPVIVFFGFSLLD
LNEFRNLSWDVLILMGGGIALGKAFEETGLAKHFVSLFMLGDSSQLGLFLFFSILSLLLSCFLSNTSVANLILPITMGLP
TDLILPAAIGATIGASLAMPLPVSTPPNALAFSYGGIRSLEMVKIGGTISILAWVIFTLVGGLILHQLSIVDFSNF

Specific function: Responsible For The Uptake Of Citrate In Exchange To The Efflux Of Succinate. Has A Relatively Broad Specificity For C(4)- Dicarboxylates And Tricarboxylates. [C]

COG id: COG0471

COG function: function code P; Di- and tricarboxylate transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CitM (TC 2.A.11) transporter family [H]

Homologues:

Organism=Homo sapiens, GI31377715, Length=546, Percent_Identity=25.4578754578755, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI29171306, Length=519, Percent_Identity=25.0481695568401, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI4506979, Length=530, Percent_Identity=24.9056603773585, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI225637549, Length=474, Percent_Identity=24.6835443037975, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI225637552, Length=474, Percent_Identity=24.6835443037975, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI301069349, Length=319, Percent_Identity=28.2131661442006, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI58761541, Length=350, Percent_Identity=26.8571428571429, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI301069353, Length=350, Percent_Identity=26.8571428571429, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI19923838, Length=329, Percent_Identity=27.9635258358663, Blast_Score=80, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71989118, Length=510, Percent_Identity=26.8627450980392, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71988385, Length=491, Percent_Identity=23.8289205702648, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI32565804, Length=460, Percent_Identity=23.9130434782609, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17551790, Length=498, Percent_Identity=22.289156626506, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI32564681, Length=495, Percent_Identity=22.2222222222222, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319885, Length=425, Percent_Identity=28, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6322263, Length=407, Percent_Identity=27.7641277641278, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6324340, Length=419, Percent_Identity=26.7303102625298, Blast_Score=129, Evalue=9e-31,
Organism=Drosophila melanogaster, GI281362116, Length=473, Percent_Identity=26.8498942917548, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45551633, Length=487, Percent_Identity=24.6406570841889, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281366409, Length=487, Percent_Identity=24.6406570841889, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17737623, Length=487, Percent_Identity=24.6406570841889, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24666468, Length=487, Percent_Identity=24.6406570841889, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281362114, Length=472, Percent_Identity=26.6949152542373, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281362112, Length=472, Percent_Identity=26.6949152542373, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001898 [H]

Pfam domain/function: PF00939 Na_sulph_symp [H]

EC number: NA

Molecular weight: Translated: 52048; Mature: 51917

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSKKYQVSVNRQVTMIRAGLLFSTLSIFPALLGWYQLWFGLTPAQEINVAIALVVSYL
CCCCCCEEEEECCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
WVTELIPLYVTGFLVLFLELIWLIPGWGPGAPKTITFLSCYFSETILLFLGGFVISSAIR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYGLDVSIASFVIKNTKGSVFFLVLSLGFATAFLSCFMNNTATAAMMLGLVSSMMKSLEE
HHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
SSPLRKSILFMVPFSANLGGIGTPVGTLPNVIGIAYLQEKGFQIGFLDWMAFAFPVFILS
CCCHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHH
VFLLAGILYIVYLKKETGIQSIQRIQVQEPNSNHSRKKRYLSILVIIFTIIGWITSDWHG
HHHHHHHHHHHHHCCCCCHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
ISNGTVALFPVIVFFGFSLLDLNEFRNLSWDVLILMGGGIALGKAFEETGLAKHFVSLFM
CCCCHHHHHHHHHHHCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
LGDSSQLGLFLFFSILSLLLSCFLSNTSVANLILPITMGLPTDLILPAAIGATIGASLAM
CCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHEEHCCCCCHHHHHHHHHHHHHCCCCCC
PLPVSTPPNALAFSYGGIRSLEMVKIGGTISILAWVIFTLVGGLILHQLSIVDFSNF
CCCCCCCCCCEEEECCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SLSKKYQVSVNRQVTMIRAGLLFSTLSIFPALLGWYQLWFGLTPAQEINVAIALVVSYL
CCCCCEEEEECCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
WVTELIPLYVTGFLVLFLELIWLIPGWGPGAPKTITFLSCYFSETILLFLGGFVISSAIR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYGLDVSIASFVIKNTKGSVFFLVLSLGFATAFLSCFMNNTATAAMMLGLVSSMMKSLEE
HHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
SSPLRKSILFMVPFSANLGGIGTPVGTLPNVIGIAYLQEKGFQIGFLDWMAFAFPVFILS
CCCHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHH
VFLLAGILYIVYLKKETGIQSIQRIQVQEPNSNHSRKKRYLSILVIIFTIIGWITSDWHG
HHHHHHHHHHHHHCCCCCHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
ISNGTVALFPVIVFFGFSLLDLNEFRNLSWDVLILMGGGIALGKAFEETGLAKHFVSLFM
CCCCHHHHHHHHHHHCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
LGDSSQLGLFLFFSILSLLLSCFLSNTSVANLILPITMGLPTDLILPAAIGATIGASLAM
CCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHEEHCCCCCHHHHHHHHHHHHHCCCCCC
PLPVSTPPNALAFSYGGIRSLEMVKIGGTISILAWVIFTLVGGLILHQLSIVDFSNF
CCCCCCCCCCEEEECCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]