Click here to switch to the map view.

The map label for this gene is acdA2 [H]

Identifier: 183219484

GI number: 183219484

Start: 56051

End: 57217

Strand: Direct

Name: acdA2 [H]

Synonym: LEPBI_I0057

Alternate gene names: 183219484

Gene position: 56051-57217 (Clockwise)

Preceding gene: 183219482

Following gene: 183219485

Centisome position: 1.56

GC content: 44.22

Gene sequence:

>1167_bases
ATGATCGACTTTTCAATCACCGATGAACAAAAAGCCCTCCGCGATTTAGCCAGAGATTTCGCAAAAAATGAAATGATTCC
CAAAGCGGAACACCATGACCACACAGGTGAATATCCAAAAGAAATTTTGAAAAAAGCATTTGATGTAGGCCTCATGAACA
TGCACATACCTGCCGAATACGGTGGAGCAGGACTCGGAGTTCTAGACGAACTCATCGCCTCAGAAGAGTTATTTTATGGA
TGTTCAGGGATGGCAACAGCGATCCTTGCCAATAACTTAGCACTCGCACCAGTTCTTCTCGGTGCTGACGATTACGTCAT
GAAAAAATTCATCCAACCAATGTCGGAAACGTTCACTCTTGCTGCCTATGCAGTGACAGAACCAGGTGCTGGATCCGATG
TTGCAGGAATTCGCACAACAGCAAAACGTGTGGGTGATGAATACATCGTCAATGGATCCAAAATGTGGATCACAAACGCA
GGTCATGCGGATTGGTTTTTTGTTTTAGCAAAAACAGATCCAAATGCAGGCCACAAAGGGATGACCGGTTTCATTGTGGA
TGCAAAAACTCCAGGGATCATCATAGGCAAAAAAGAAAAGAATATGGGACAACGCTGTTCCGACACACGCGGTGTGACGT
TTGAAGATGTCAAAGTTCCAAAAGAAAATATGATTGGGAAAGAAGGCGAAGGTTTCAAAATTGCAATGGGTGCTTTTGAC
AAAACTCGCCCCGCAGTTGCCATTGGTGCCGTTGGGGTTGCTCGCGCAGCACTTGACCATTCGATTCGTTATGCAAACAC
TCGTAATGCGTTCGGAAAACCAATTTCCGTAAATCAAGGTGTTAGTTTTATGATCGCAGAAATGGCCCGTGATATTGAAG
CTGGCCGACTCCTTTGCTGGCAATCAGCATGGCTCATCGATAATGGTTTCCGTAACACATACCAAGCATCGATTGCAAAA
GTATTCTGTGCTGACATGGCAATGCGTGTGACAACGGATGCCGTTCAAATTTTTGGCGGATACGGATTCAACGAAGAATA
CCCAGTGGAAAAATTAATGCGTGATGCAAAAATTTTCCAAATTTACGAAGGAACTTCACAAATCCAAAGAGTGATCATTT
CGAAATTCCTCAACGACGGAGTTGGGATCGAAACTCCGAACGCTTAA

Upstream 100 bases:

>100_bases
TTGGATTCAAAAGATTTTTCAACAGATTTAAGTCGCCCTAGTTTCTTGACTCATAGAGAAAATTCCAAAGTACTGTAAAA
AAACATCCATAAGGCAACCC

Downstream 100 bases:

>100_bases
AAGTTGGAATTGGGATCAGTGGATTTGAGATTCCACTCCACTGATCCTATCCGAATATGTTTTTACTCATCGATAACTAC
GATTCATTCACTTATATTTT

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MIDFSITDEQKALRDLARDFAKNEMIPKAEHHDHTGEYPKEILKKAFDVGLMNMHIPAEYGGAGLGVLDELIASEELFYG
CSGMATAILANNLALAPVLLGADDYVMKKFIQPMSETFTLAAYAVTEPGAGSDVAGIRTTAKRVGDEYIVNGSKMWITNA
GHADWFFVLAKTDPNAGHKGMTGFIVDAKTPGIIIGKKEKNMGQRCSDTRGVTFEDVKVPKENMIGKEGEGFKIAMGAFD
KTRPAVAIGAVGVARAALDHSIRYANTRNAFGKPISVNQGVSFMIAEMARDIEAGRLLCWQSAWLIDNGFRNTYQASIAK
VFCADMAMRVTTDAVQIFGGYGFNEEYPVEKLMRDAKIFQIYEGTSQIQRVIISKFLNDGVGIETPNA

Sequences:

>Translated_388_residues
MIDFSITDEQKALRDLARDFAKNEMIPKAEHHDHTGEYPKEILKKAFDVGLMNMHIPAEYGGAGLGVLDELIASEELFYG
CSGMATAILANNLALAPVLLGADDYVMKKFIQPMSETFTLAAYAVTEPGAGSDVAGIRTTAKRVGDEYIVNGSKMWITNA
GHADWFFVLAKTDPNAGHKGMTGFIVDAKTPGIIIGKKEKNMGQRCSDTRGVTFEDVKVPKENMIGKEGEGFKIAMGAFD
KTRPAVAIGAVGVARAALDHSIRYANTRNAFGKPISVNQGVSFMIAEMARDIEAGRLLCWQSAWLIDNGFRNTYQASIAK
VFCADMAMRVTTDAVQIFGGYGFNEEYPVEKLMRDAKIFQIYEGTSQIQRVIISKFLNDGVGIETPNA
>Mature_388_residues
MIDFSITDEQKALRDLARDFAKNEMIPKAEHHDHTGEYPKEILKKAFDVGLMNMHIPAEYGGAGLGVLDELIASEELFYG
CSGMATAILANNLALAPVLLGADDYVMKKFIQPMSETFTLAAYAVTEPGAGSDVAGIRTTAKRVGDEYIVNGSKMWITNA
GHADWFFVLAKTDPNAGHKGMTGFIVDAKTPGIIIGKKEKNMGQRCSDTRGVTFEDVKVPKENMIGKEGEGFKIAMGAFD
KTRPAVAIGAVGVARAALDHSIRYANTRNAFGKPISVNQGVSFMIAEMARDIEAGRLLCWQSAWLIDNGFRNTYQASIAK
VFCADMAMRVTTDAVQIFGGYGFNEEYPVEKLMRDAKIFQIYEGTSQIQRVIISKFLNDGVGIETPNA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI187960098, Length=377, Percent_Identity=57.5596816976127, Blast_Score=458, Evalue=1e-129,
Organism=Homo sapiens, GI4557231, Length=377, Percent_Identity=57.5596816976127, Blast_Score=458, Evalue=1e-129,
Organism=Homo sapiens, GI4557233, Length=373, Percent_Identity=39.4101876675603, Blast_Score=281, Evalue=9e-76,
Organism=Homo sapiens, GI4501859, Length=374, Percent_Identity=36.096256684492, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI7656849, Length=373, Percent_Identity=35.1206434316354, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI226958412, Length=378, Percent_Identity=32.5396825396825, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI226958414, Length=345, Percent_Identity=33.0434782608696, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI21361497, Length=357, Percent_Identity=34.453781512605, Blast_Score=195, Evalue=5e-50,
Organism=Homo sapiens, GI4501857, Length=373, Percent_Identity=31.3672922252011, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI76496475, Length=369, Percent_Identity=33.0623306233062, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI4557235, Length=340, Percent_Identity=33.5294117647059, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI4503943, Length=378, Percent_Identity=24.3386243386243, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI48976061, Length=362, Percent_Identity=30.1104972375691, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI211971008, Length=362, Percent_Identity=30.1104972375691, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI7669494, Length=366, Percent_Identity=24.0437158469945, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI38505218, Length=338, Percent_Identity=26.9230769230769, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI218563752, Length=202, Percent_Identity=28.2178217821782, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI87081958, Length=386, Percent_Identity=32.3834196891192, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1786223, Length=383, Percent_Identity=28.7206266318538, Blast_Score=164, Evalue=9e-42,
Organism=Escherichia coli, GI87082384, Length=271, Percent_Identity=25.830258302583, Blast_Score=89, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17570075, Length=379, Percent_Identity=56.4643799472295, Blast_Score=435, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17569725, Length=379, Percent_Identity=54.089709762533, Blast_Score=429, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17534899, Length=379, Percent_Identity=55.1451187335092, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17508101, Length=373, Percent_Identity=35.3887399463807, Blast_Score=257, Evalue=6e-69,
Organism=Caenorhabditis elegans, GI17506239, Length=376, Percent_Identity=34.0425531914894, Blast_Score=240, Evalue=9e-64,
Organism=Caenorhabditis elegans, GI17533517, Length=363, Percent_Identity=36.9146005509642, Blast_Score=237, Evalue=9e-63,
Organism=Caenorhabditis elegans, GI17538396, Length=378, Percent_Identity=33.8624338624339, Blast_Score=227, Evalue=7e-60,
Organism=Caenorhabditis elegans, GI71990804, Length=292, Percent_Identity=33.5616438356164, Blast_Score=190, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI71985184, Length=386, Percent_Identity=29.7927461139896, Blast_Score=187, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI71982178, Length=268, Percent_Identity=32.8358208955224, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17551932, Length=370, Percent_Identity=31.0810810810811, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17505929, Length=354, Percent_Identity=31.0734463276836, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI32563615, Length=226, Percent_Identity=34.5132743362832, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17531909, Length=243, Percent_Identity=34.5679012345679, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI71985192, Length=347, Percent_Identity=27.9538904899135, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI17534353, Length=374, Percent_Identity=26.2032085561497, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17562446, Length=401, Percent_Identity=26.6832917705736, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17531913, Length=179, Percent_Identity=30.1675977653631, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI86563381, Length=266, Percent_Identity=25.5639097744361, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI86563383, Length=266, Percent_Identity=25.5639097744361, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24660351, Length=376, Percent_Identity=57.1808510638298, Blast_Score=446, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24646207, Length=380, Percent_Identity=37.8947368421053, Blast_Score=282, Evalue=3e-76,
Organism=Drosophila melanogaster, GI21356377, Length=371, Percent_Identity=39.622641509434, Blast_Score=277, Evalue=7e-75,
Organism=Drosophila melanogaster, GI24666513, Length=371, Percent_Identity=34.5013477088949, Blast_Score=241, Evalue=8e-64,
Organism=Drosophila melanogaster, GI21355753, Length=380, Percent_Identity=32.3684210526316, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI281363737, Length=342, Percent_Identity=32.4561403508772, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI19920834, Length=379, Percent_Identity=26.1213720316623, Blast_Score=135, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 42324; Mature: 42324

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDFSITDEQKALRDLARDFAKNEMIPKAEHHDHTGEYPKEILKKAFDVGLMNMHIPAEY
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCHHC
GGAGLGVLDELIASEELFYGCSGMATAILANNLALAPVLLGADDYVMKKFIQPMSETFTL
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEHEEECCCHHHHHHHHHHHHHHHEE
AAYAVTEPGAGSDVAGIRTTAKRVGDEYIVNGSKMWITNAGHADWFFVLAKTDPNAGHKG
EEEEEECCCCCCCCHHHHHHHHHCCCCEEECCCEEEEEECCCCCEEEEEEECCCCCCCCC
MTGFIVDAKTPGIIIGKKEKNMGQRCSDTRGVTFEDVKVPKENMIGKEGEGFKIAMGAFD
CEEEEEECCCCCEEEECCCCCCCCCCCCCCCCEEHHCCCCHHHCCCCCCCCEEEEECCCC
KTRPAVAIGAVGVARAALDHSIRYANTRNAFGKPISVNQGVSFMIAEMARDIEAGRLLCW
CCCCCEEEHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEE
QSAWLIDNGFRNTYQASIAKVFCADMAMRVTTDAVQIFGGYGFNEEYPVEKLMRDAKIFQ
ECCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEE
IYEGTSQIQRVIISKFLNDGVGIETPNA
EECCHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MIDFSITDEQKALRDLARDFAKNEMIPKAEHHDHTGEYPKEILKKAFDVGLMNMHIPAEY
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCHHC
GGAGLGVLDELIASEELFYGCSGMATAILANNLALAPVLLGADDYVMKKFIQPMSETFTL
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEHEEECCCHHHHHHHHHHHHHHHEE
AAYAVTEPGAGSDVAGIRTTAKRVGDEYIVNGSKMWITNAGHADWFFVLAKTDPNAGHKG
EEEEEECCCCCCCCHHHHHHHHHCCCCEEECCCEEEEEECCCCCEEEEEEECCCCCCCCC
MTGFIVDAKTPGIIIGKKEKNMGQRCSDTRGVTFEDVKVPKENMIGKEGEGFKIAMGAFD
CEEEEEECCCCCEEEECCCCCCCCCCCCCCCCEEHHCCCCHHHCCCCCCCCEEEEECCCC
KTRPAVAIGAVGVARAALDHSIRYANTRNAFGKPISVNQGVSFMIAEMARDIEAGRLLCW
CCCCCEEEHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEE
QSAWLIDNGFRNTYQASIAKVFCADMAMRVTTDAVQIFGGYGFNEEYPVEKLMRDAKIFQ
ECCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEE
IYEGTSQIQRVIISKFLNDGVGIETPNA
EECCHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]