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The map label for this gene is walR [H]

Identifier: 182677228

GI number: 182677228

Start: 268501

End: 269187

Strand: Direct

Name: walR [H]

Synonym: Bind_0229

Alternate gene names: 182677228

Gene position: 268501-269187 (Clockwise)

Preceding gene: 182677226

Following gene: 182677229

Centisome position: 6.44

GC content: 57.21

Gene sequence:

>687_bases
ATGTCGCAGGTTCTCAAGATCCTCATCGTCGACGATGATAGCGATCTCCGTTCGGCCCTCTCCGAACAATTCGCCTTGCA
TGAGGAATTCACCATTCTGCCCGCCGAGACCGCGCAAGCAGCCCTCGCTGTGATCCATCAGGAGACGCCGGATCTCATCC
TCATGGATGTTGGCTTGCCCGATATGGATGGGCGCGACGCGGTCAAGCAGATGCGGGAGGAGGGATTCAAAAATCCGGTC
ATCATGCTCACAGGCCATGATTCTGAAGGCGACACGGTGCAAGGATTGGATGCCGGCGCCAATGATTATGTGACGAAACC
CTTCCGCTTCGCCGTCCTGCTCGCGCGGATCCGCGCTCATCTGCGTCAGCATGAAAGCAGCGACGAGGCTATGTTCCGCA
TCGGGCATTATACATTCCAGCCGGGCGCCAAACATCTCATCAACGAGAAGGGCTCCAAGCTGCGGCTGACCGAGAAGGAA
ACCGCGATCTTGCGTTTCCTCTATCGCGCCGGCCAGACCGTTGTCACCCGAGACGTCTTGTTGCGCGAGGTCTGGGGCTA
TAATGCCAATGTGACGACGCATACACTGGAAACACATATTTACCGGCTGCGCCAGAAGATCGAGGAAGATCCCGCCAAGG
CGCAATTGCTGATCACGGAGACCGGCGGCTATAAATTGGTGCCGTGA

Upstream 100 bases:

>100_bases
AGCGATGGCGCACTGGCCTGGGCACGAACGTCGCTCAGCGTGTCAAAAAGGCGCGAATTTCGAGGAGCGCCCGGACGCCG
TCTTTAAGGACTCACTCTCT

Downstream 100 bases:

>100_bases
CCTTGATGATCCAACGCTGTTGTCTGGGGCTTGCGCGAGGCTTGTAGCGCTGCTCCAAACAGTCGTTTTGATGCCATTCC
ATGCTTGCTCGAAAATGGGA

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MSQVLKILIVDDDSDLRSALSEQFALHEEFTILPAETAQAALAVIHQETPDLILMDVGLPDMDGRDAVKQMREEGFKNPV
IMLTGHDSEGDTVQGLDAGANDYVTKPFRFAVLLARIRAHLRQHESSDEAMFRIGHYTFQPGAKHLINEKGSKLRLTEKE
TAILRFLYRAGQTVVTRDVLLREVWGYNANVTTHTLETHIYRLRQKIEEDPAKAQLLITETGGYKLVP

Sequences:

>Translated_228_residues
MSQVLKILIVDDDSDLRSALSEQFALHEEFTILPAETAQAALAVIHQETPDLILMDVGLPDMDGRDAVKQMREEGFKNPV
IMLTGHDSEGDTVQGLDAGANDYVTKPFRFAVLLARIRAHLRQHESSDEAMFRIGHYTFQPGAKHLINEKGSKLRLTEKE
TAILRFLYRAGQTVVTRDVLLREVWGYNANVTTHTLETHIYRLRQKIEEDPAKAQLLITETGGYKLVP
>Mature_227_residues
SQVLKILIVDDDSDLRSALSEQFALHEEFTILPAETAQAALAVIHQETPDLILMDVGLPDMDGRDAVKQMREEGFKNPVI
MLTGHDSEGDTVQGLDAGANDYVTKPFRFAVLLARIRAHLRQHESSDEAMFRIGHYTFQPGAKHLINEKGSKLRLTEKET
AILRFLYRAGQTVVTRDVLLREVWGYNANVTTHTLETHIYRLRQKIEEDPAKAQLLITETGGYKLVP

Specific function: Member of the two-component regulatory system walK/walR that regulates genes involved in autolysis, biofilm formation and cell wall metabolism [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=35.5555555555556, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1790552, Length=229, Percent_Identity=35.8078602620087, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=33.4821428571429, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI1789809, Length=236, Percent_Identity=33.0508474576271, Blast_Score=120, Evalue=5e-29,
Organism=Escherichia coli, GI1789402, Length=210, Percent_Identity=30, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=31.5555555555556, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=30.0884955752212, Blast_Score=103, Evalue=7e-24,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=29.5964125560538, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1790860, Length=205, Percent_Identity=31.7073170731707, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI2367329, Length=212, Percent_Identity=35.377358490566, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI1788550, Length=260, Percent_Identity=27.3076923076923, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787229, Length=230, Percent_Identity=29.1304347826087, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=29.6943231441048, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1790863, Length=235, Percent_Identity=26.8085106382979, Blast_Score=80, Evalue=8e-17,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=27.9661016949153, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1790299, Length=102, Percent_Identity=34.3137254901961, Blast_Score=64, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25707; Mature: 25575

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQVLKILIVDDDSDLRSALSEQFALHEEFTILPAETAQAALAVIHQETPDLILMDVGLP
CCCCEEEEEEECCHHHHHHHHHHHHHHHCEEEECCHHHHHHHHHHHCCCCCEEEEECCCC
DMDGRDAVKQMREEGFKNPVIMLTGHDSEGDTVQGLDAGANDYVTKPFRFAVLLARIRAH
CCCCHHHHHHHHHCCCCCCEEEEECCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHH
LRQHESSDEAMFRIGHYTFQPGAKHLINEKGSKLRLTEKETAILRFLYRAGQTVVTRDVL
HHHCCCCCHHEEEECCEEECCCHHHHHHCCCCEEEECHHHHHHHHHHHHCCCHHHHHHHH
LREVWGYNANVTTHTLETHIYRLRQKIEEDPAKAQLLITETGGYKLVP
HHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEECC
>Mature Secondary Structure 
SQVLKILIVDDDSDLRSALSEQFALHEEFTILPAETAQAALAVIHQETPDLILMDVGLP
CCCEEEEEEECCHHHHHHHHHHHHHHHCEEEECCHHHHHHHHHHHCCCCCEEEEECCCC
DMDGRDAVKQMREEGFKNPVIMLTGHDSEGDTVQGLDAGANDYVTKPFRFAVLLARIRAH
CCCCHHHHHHHHHCCCCCCEEEEECCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHH
LRQHESSDEAMFRIGHYTFQPGAKHLINEKGSKLRLTEKETAILRFLYRAGQTVVTRDVL
HHHCCCCCHHEEEECCEEECCCHHHHHHCCCCEEEECHHHHHHHHHHHHCCCHHHHHHHH
LREVWGYNANVTTHTLETHIYRLRQKIEEDPAKAQLLITETGGYKLVP
HHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA